#NEXUS [Eyun S (2016) Phylogenomic analysis of Copepoda (Arthropoda, Crustacea) reveals unexpected similarities with earlier proposed morphological phylogenies. BMC Evolutionary Biology] BEGIN DATA; DIMENSIONS NTAX=18 NCHAR=16710; FORMAT DATATYPE=PROTEIN INTERLEAVE MISSING=-; MATRIX Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff MD----TSLDAKAIRKIFLD FFIEKKTHIYVHSSSTIPHD DPTLLFANAGMNQFKPVFVG TADPNSDMAKWTRVVNTQKC IRAGGKHNDLDDVGKDVYHH Lcyp -------------------- -------------------- ----------MNQFKPLFLG TVDPNSEMAKYKRVANTQKC IRAGGKHNDLDDVGKDVYHH Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra MC----ANMKASEVRQKYMD FFMKKKSHIYVHSSSTIPHD DPTLLFANAGMNQFKPIFLG TVDPNSEMSKWTRVVNTQKC IRAGGKHNDLDDVGKDVYHH Hazt --------MLLKEVRSTFVE YFQKKHAHVYVHSSPTIPHD DPTLLFANAGMNQFKPIFLG NVDPSSDMARLKRAVNSQKC IRAGGKHNDLDDVGKDLYHH Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos MD----TSLKAAKIRQIFLD FFMQKKEHTYVHSSSTIPLD DPTLLFANAGMNQFKPVFVG TVDPNSDMAKWKRVVNTQKC IRAGGKHNDLDDVGKDVYHH Dmel MK----L-LTAKEVRNAYLD FFKEQ-KHIYVHSSSTIPLD DPTLLFANAGMNQFKPIFLG TADPNSEMSKWVRVANTQKC IRAGGKHNDLDDVGKDVYHH Tcas MD----ISMSAKDVRNAYIN FFKEK-NHDYVHSSSTIPLD DPTLLFTNAGMNQFKPIFLG TVDPNSDLAKLTRAVNSQKC IRAGGKHNDLDDVGKDVYHH Pmon --------MKSSEVRETFYN FFKEKHQHTYVHSSPTIPHD DPTLLFANAGMNQFKPIFLG TVDPSSDMANYVRAVNSQKC IRAGGKHNDLDDVGKDVYHH Smar MN----ASLTSKQIRQMFLD FFTEKYNHTYVHSSVVIPYD DPTLLFANAGMNQFKPIFLG SVDPNSQMSKWVRAVNTQKC IRAGGKHNDLDDVGKDVYHH Tcal MSARAPPPTQASEVRQAFMD FFKHSHKHTYWHSSSTIPLD DPTLLFTNAGMCQFKPIFVG SVDPNVDMAKLSRACNSQKC IRAGGKHNDLDDVGKDVYHH Crog MD----SSMKGDEIRQLYLD FFTKKKGHTYYHSSSTIPLD DPTLLFINAGMNQFKSIFVG TIDPNNDKAKLVRAVNSQKC VRAGGKHNDLEDVGKDSYHH Dpul MD----TSLSAAKIRQMYMD FFIEKKSHIYVHSSSTIPKD DPTLLFANAGMNQFKPLFLG TVDPNSDMSKWIRVVNTQKC IRAGGKHNDLDDVGKDVYHH Aver -------------------- -------------------- -------------------- -------------------- ----ETGPCGPCSEIHF--- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff TFFEMLGNWSFGDYFKKEIC TWSWELLTEVFKLDPARLYV TYFGGDEASGLQPDLEAKQL WLDLGVGESRILPGNMKDNF WEMGDTGPCGPCSEIHY--- Lcyp TFFEMLGNWSFADYFKEEAI RMAMDLLLNEFKIDKERLYA TYFEGNESAGLQPDLETKEI WKKY-LPEDHILKGNMKDNF WEMGETGPCGPCTEIHF--- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra TFFEMLGNWSFGDYFKKEIC TWAWEFLTEDLNLSKDRLYV SYFGGNASLGLDPDLEAKEI WLNLGVDKSRIIPGTMSDNF WEMGETGPCGPCSEIHF--- Hazt TFFEMLGNWSFGDYFKDEIC SWSWDLLTNVYKLPKDRLYV TYFGGEPSQQLEPDLECRQK WLDLGVPAEHILPGSMKDNF WEMGDTGPCGPCSEIHF--- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos TFFEMLGNWSFGDYFKLEIC TWAWELLTQVYKIPSERLYV TYFGGEPSAGLEPDLEAKQI WMNLGVPEARILPGNMKDNF WEMGETGPCGPCSEIHY--- Dmel TFFEMLGNWSFGDYFKKEIC SWAWEFLTQRLALPKDRLYV TYFGGDAASGLEPDLECKQM WLDLGLKPEHILPGSMKDNF WEMGETGPCGPCSELHF--- Tcas TFFEMMGNWSFGDYFKKEIC AWAWEFLTKRLHLPGDRLYV TYFGGDKAAGLEPDNECKQI WLGLGVPESHVLPGSMKDNF WEMGETGPCGPCSELHF--- Pmon TFFEMLGNWSFGDYFKKEVC AWAWDLLVNVYKLPKERLYV TYFGGFPEQGLEPDLECKQI WMDLGVPEDRVLPGDMKDNF WEMGDTGPCGPCSEIHF--- Smar TFFEMLGNWSFGDYFKLEVC NWAWELLTEVYKIPKDRLYV TYFGGQPEMGLEPDNECRDI WLSP----DRILPFGMKDNF WEMGETGPCGPCSEIHF--- Tcal TFFEMLGNWSFGDYFKTEIC TWAWEFLTEVCQLPKDRLYV TYFGGEASANLEPDLECKNL WLSLGVPESKILPGNMKDNF WEMGDTGPCGPCSEIHY--- Crog TFFEMLGNWSFGDYFKKEIC EWSWEFLTKELKMPADRLYV TYFGGDDKTGLEPDLECKKI WLDLGVPEERILPGNMKDNF WEMGDTGPCGPCSEIHF--- Dpul TFFEMLGNWSFGDYFKKEVC TWAWELLTDVFQLPKDRLYV TYFGGNENAGLQPDEECRQI WLSLGLPAERILPGSMKDNF WEMGDVGPCGPCSEIHF--- Aver DRI-GGRDAAHLVNMDDPDV LEIWNLVFIQFNREQDSTLR SLPAKHIDCGMGFERLVSVI QNKRSNYDTDIFVPIFQAIE KESGVGVPYKGRVGDDDTDK Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff DRIGGGRDAAHLVNMDDPDV LEIWNLVFMQYNREQDKSLK QLPNKHIDCGMGFERLVSVV QDKRSNYDTDLFLPFFQHIQ AGTGVRA-YAGRVGAEDTDG Lcyp DRI-GGRNAAHLVNQDDPDV LEIWNLVFIQYNREQDGSLL LLPNKHVDTGMGFERLTSVI QQKRSNYDTDIFVPIFDAIH KGTGTRP-YTGKVGAEDVDK Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra DRI-GGRDAADLVNKDDPDV LEIWNLVFMTYNRESDGTLK YLPKKHIDCGLGLERLVSVV QEKRSNYDTDLFVPLFDAIQ KGTSMQA-YSGKVGVEDKEG Hazt DRI-GGRDASSLVNQDDPDV LEIWNLVFIQFNRESNGQLK SLPKKHIDCGLGLERLASIM QDKRSNYDTDAFLPIFVKIQ ELTGARP-YTGMIGKADSDC Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos DRI-G--------------X XEIWNLVFMQYNREADKSLR PLPNKHIDCGMGLERLISVI QDKRSNYDTDMFTPLFDAIQ KGTGAPA-YGGKVGAEDADG Dmel DRI-GGRSVPELVNMDDPDV LEIWNLVFIQYNRESDGSLK QLPKKHIDCGMGFERLVSVI QNKRSNYDTDLFVPLFDAIQ AGTGAPP-YQGRVGADDVDG Tcas DRI-GGRDVPELVNQDDPDV LEIWNLVFIQYNRESDGSLK FLPKKHIDCGLGLERLVSIM QNKRSNYDTDLFLPLFDAIQ KGTGAPP-YGGKIGDADKDG Pmon DRI-GGRHVAHLVNMDDPDV LEIWNLVFIQFNRESDGTLK NLPKKHIDCGMGLERLTSIL QNKRSNYDTDLFLPIFETIQ KLTSVRP-YSGKVGKDDADG Smar DRI-GNRDAKDLVNADVPDV LEIWNLVFIQFNRETDGSLR PLPKKHIDCGMGLERLVSVI QQKSSNYDTDFFVPIFNAIQ QATNGAP-YGGRVGDEDVNS Tcal DRI-GGRDAAHLVNMDDPDV LEIWNLVFMQFNREQDKSLK SLPRKHIDCGMGFERLVSVL QNKRSNYDTDIFVPIFEAIQ KATGVPA-YQGKLGSEDPDK Crog DRI-GGRNAADMVNQDDPMV LEIWNLVFIQFNREADKSLK PLPKKHIDCGLGLERLVSAI QNKPSNYDTDLFSPLFEAIQ ERSGANTPYGGKFGDEDPEQ Dpul DRI-GGRDAAHLVNMDDPDV LEIWNLVFMTFNRETDSSLK PLPRKHIDCGMGFERLVSVI QDKRSNYDTDIFQPIFEAIQ KGTNAPA-YQGKVGAEDVNG Aver IDMAYRVVADHIRTLTVALS DGGRPDNVGRGYVLRRILRR GIRYSSEKLNAKPGFFAALV DTVVQLLGEFFPEVGKDPES IKNIINEEETQFLKTLNRGH Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff IDMAYRVLADHARTLTIALS DGGRPDNVGRGYVLRRILRR GVRYASEKLGAKPGFFASLV HTVVQVLGETFPEVKKDPQT VIDIINEEETQFLKTLSRGQ Lcyp IDMAYRVVADHIRTLVIAIS DGGRPDNIGRGYVLRRILRR AIRFAIKKLNAKPNFLADLV DVVVELLGDAFPEVRKDPQF VKEVINEEETQFLKTLTRGQ Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra IDMAYRVVADHIRTLTIALS DGGRPDNVGRGYVLRRILRR GVRYATEKLKAKPGFFGSLV HVVVDILGDTFSEIKKDPET IISIIDEEERQFLKTLSRGK Hazt VDMAYRVLADHARTLTVALS DGGMPDNVGRGYVLRRILRR AVRFASEKLGAKPGVFAELV DVVVDLLQDAFPELAKDSSY VKDVINEEERQFLKTLERGR Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos IDMAYRVLADHARTLTISLS DGGRPDNVGRGYVLRRILRR GVRYATEVLKAKPGFFGSLV HTVVELLSDTFPEIKKDPQA VIDVINEEETQFLKTLSRGQ Dmel IDMAYRVLADHARTITIALA DGGTPDNTGRGYVLRRILRR AVRYATEKLNAKPGFFATLV NTVVDLLGDAFPEVKKDPQH IIDIINEEELQFLKTLTRGR Tcas IDMAYRVLADHARTITIALS DGGNPDNTGRGYVLRRILRR AVRYATEKLNAKPGFFSTLV NTVVEILGDTFPEVCKDPQS IIDTINEEEEQFLKTLSRGR Pmon VDMAYRVLADHIRTLTIALS DGGMPDNAGRGYVLRRILRR GIRYATEVLGMKPGMFASLV DVVVQILKDAFPEVAKDPEF VKDVINEEELQFLKTLDRGH Smar IDMAYRVLADHVRTITIALS DGGRPDNTGRGYVLRRILRR AVRYAHEKLNAKPGLFSSLV DVVVENLGSTFPEITKDPEL VKEIINEEENQFLKTLTRGH Tcal LDMAYRVIADHIRTLTIALA DGGRPDNVGRGYVLRRILRR AIRFATEKLDAKPGFLSGLV DEVVQLLGDSFPELKKDPQS TKDIIDEEEIQFLKTLSRGR Crog IDMAYRVVADHIRTLTIVIA DGGRPDNVGRGYVLRRILRR GIRFATEKLNASPGFFGSLV DVVVSLLGQTFPELTKDPQT IKDVINEEEVQFLKTLNRGR Dpul VDMAYRVLADHARTLTIALS DGGRPDNVGRGYVLRRVLRR GVRYATEKLNAKPGFFASLV PTVCQVLGPTFPEVNRDPQL VIDIINDEETQFLKTLTRGR Aver KLLDRTIAKLPQGTKVLPGD IAWRL--------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff KLLDRTISKL-EGAKELPGD IAWRLYDTYGFPVDLTQLMC EERGLQVDMNSYESCKAAAQ LASQGKGAGAEDTISLDVHS INELKEK-SFQPTDDSFKYA Lcyp KLLEKTISKLGDGCKVFPGD VAWRLYDTYGFPFDLTQLMC EESGLSIDKVKYEEAKLEAQ TRSQATGTQAVDEIMLDVHS IDELKSK-LYLPTNDAPKYD Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra SLLERTVAKL-GDSKVLPGN IAWRLYDTYGFPFDLTQLMC EERGLTVDQAVYEESKKEAQ RLSQGKGSGIEDTISFDVHS ITELQDKMKLPPTDDSSKYS Hazt KLLHRTVGKL-GVSKLIPGD VAWRLYDTYGFPVDLTQLMA EENDLNVDMDAFETCKKEAQ ERSRGEAKDRDDSYRLDVHA IEELKSR-GIPFTDDSQKYD Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos KLLDRTIGKLASGCKQLPGD IAWRLYDTYGFPVDLTQLMC EERGIEVDIAGYEDRK---- -------------------- -------------------- Dmel NLLNRTIEKL-GNQTTIPGD VAWRLYDTYGFPVDLTQLMA EEKSLKIDMDGYEAAKHNSY VLSQGKGASKIEEINLDVHA ISQLQEQ-GVPPTNDTFKYK Tcas NLLNRTITKL-GDSKTLPGD VAWRLYDTYGFPVDLTQLMA EEKGLNVDMAVYEESKKLAQ IASQGKGSGVEDTINLDVHA ITELQNL-GVPPTDDAPKYN Pmon KLLKRTIDKL-GGSTVVPGD VAWRLYDTYGFPVDLTQLMA EEKGLAVDMEKFEVSKKEAQ EKSRGENKDKDNSFRLDVHA IEDLKDR-KVPFTDDSFKYM Smar ILIERTMAKMPAGINVFPGD LAWRLYDTYGFPIDLTQLMT IEKGMTVDMDGYEGAKKAAQ LMSQGKGGGVEDELKLDIHA IAELQDM-KVPATDDSYKYN Tcal KLLDRTIAKLPEGTKVLPGD IAWRLYDTYGFPVDLTELMS EERGLKVDLEAYEVAKQAAQ LASQGISGTVEDKLALDVHA ITELNDK-SVEPTDDLPKYA Crog KLLDRTIGKM--ESKVLSGD VAWRLYDTYGFPIDLTQLMV EERGMSVDTVGYEEAKAKAV LMSQGKGGAAEDRLALDVHS IQELQDK-SMKTTNDSFKYN Dpul DLLERTISKL-NGQTTLPGD VAWRLYDTYGFPVDLTQLMS EEKGLSIDMVAYEEAKKQAQ LLSQGKGSGVDDTIAFDVHA ITELQNK-GVPPTDDSFKYN Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- --MTCET-----NEDLEFAV TEVHTQGGYVVHIGRLISGT Eaff YEAESSSKDSRYKFHACTAK ILGIRHSKQFVDSVSSGQEC GVLLDRTCFYAEQGGQIYDE GFLV--------NGENEMKV NNVQVRGGYVLHMGTV-EGT Lcyp YEFG--TSGNEYELRPCKAV IKAIRASKKFVDEIKAGQEC GLLLDQTSFYAEQGGQTYDE GYITKEG--ASEDEQLEFVV NNVQVRGGYILHIG------ Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra YQVR-DNDAGVYEFGSCTAK VVALRANKQFVNEVTSGEEC GVLLDRTCFYAEAGGQIYDT GFITKQE-----DDGTECMV NNVQVRGGYVLHICKT-EGK Hazt YKAG-NSPDADYSFGSCLGK IVAIRMNGHFVEEVKSGDRC GIVTDRTCFYAESGGQLSDE GFMVKND-----DDSTEFKV ENAEIKGGFVCHVGVV-EGT Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------S Dmel YEAVSDERDSAYNYGVCNSK IVALRFENQFVNEITSGQKA GIVLDKTNFYAESGGQIYDQ GALVKVN-----DEANEFLV DRVYNRGGYILHIGVV-EGT Tcas YIAG-SGINEEYKFELCHST VIALRHNKQFVEQVHTGQEC GILLDKTNFYAEQGGQIYDT GYIVKIG-----DESVEFSV KNVQVRGGYVIHIGSL-EGT Pmon YTAG-EAVDSPYNFEGTNSK VIAIRYNNQFVDEVKSGYRC GIVLDKTNFYAESGGQVYDE GFMVKIG-----DEETEFKV ESVEVKGGFVCHIGVV-EGT Smar YVAD---ENSEYKFEPFTGA IVALRKNKTFVEEISDGGEC GVIFDCTCFYAEQGGQTYDE GFMVKECDGGQNDDEAEFKV KNVQVKGGYILHIGNI-EGK Tcal YHAESDDPKANYVFEACQGK VVALRKDKKFVDMVEN-EEC GVLLDRTCFYAESGGQIFDE GFMVKEG-----DESVEFKV KNVQVRAGYVLHQGHI-EGQ Crog YKEKSPEPDSDYEFNGIEAT ILALRFDKKFVDSISCGTEC GIILDQTSFYSEQGGQIYDE GFIVKAD-----DDSVEFKV TNVQVRAGYVLHVGTLGEGT Dpul YKSVSDAVDSPYEFDVCTSK VIAIRFQKAFHEEVSSGVEC GILLDRTSFYAESGGQAYDE GFITKIG-----DEGTEFTV KNVQVRGGYVIHLGNV-EGT Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca LRVGDKLKLAIDEQRRKLVM NNHTGTHILNFALRKVLTAE ADQRGSLVAPDRLRFDFANK KPMSPAEVKAAEQSAVELIS KNGEVYAKDSPLSIAKAIQG Eaff LKLGDTVELSVDEERRKNVM NNHTGTHILNFALRQVLSSD ADQKGSLVAPDKLRFDFTSK AAMSPAQVKNVEEIVNNVIN KNQEIYAKEASLAVAKTIQG Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra LQVGDAVNLSIDTERRRLIM ANHTGTHILNFALMKTLGDE VDQKGSLVAPDRLRFDFSKK SAMTTKQILETELKSQEVIK QNNEIYFKDSNLSTAKSIQG Hazt LKIGDEVAITFDGVRRKLLM NNHTGTHILNFALRQVLSAD ADQKGSLVAPDRLRFDFSSK GAMTVEQVKRAEQIAVEMVK SNSQVYAKTSSLAVAKSIVG Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos VXVGDKVQLSIDEDRRRNVM SNHSGTHILNFALRQVLSAE ADQRGSLVAPERLRFDFTNK SAMTVAQVKQVEQIANAMID RNEEIYAKEAPLAIAKTIQG Dmel LKVGDELELHIDVERRWLTM KNHSATHALNHCLLQVLGKD TEQKGSLVVPEKLRFDFNSK AAMTIEQVSKTEQLTKEMVY KNVPIYAKESKLALAKKIRG Tcas LKKGDKVALHVDSARRRLIM NNHTGTHVLNYALRKVLGTE ADQRGSLVAPDRLRFDFTNK GAMTVDQVKNTELNSKELIS RNDQVFAKESNLAVAKTIRG Pmon IKLGDEMNMSIDWERRRHLM NNHTGTHILNFALRQVLSSE ADQRGSLVAPDRLRFDFTNK GAMTVDQVKKTEEICRQMVK ENKPVYAKTASLYVAKSIQG Smar LKVGDKMKML---NKRRLVM NNHTGTHVLNFALRQVLTAD ADQKGSLVAPNRLRFDFTAK SAMTPKQVKDTETIANEMIA KNEAVYAKEAPLAAAKAIQG Tcal LKVGEVLNLQIDAIRRKNVM NNHTGTHILNFALLASLDCE PEQRGSLVAPDKLRFDFTAK KALTIEQVKKVETKANEMIA RNEEVFAKESPLAVAKAILG Crog IKVGDKVALQIDTIRRQNVM KNHTGTHVLNFALRQVLEGD SDQKGSLVAPDKLRFDFTCK KAMTTDQVKAVELCVNEIIR KNEEIFAKEASLAVAKTIQG Dpul LRVGDEVKLSIDQSRRRLIM SNHTGTHVLNYALRQVVGNE ADQRGSLVAPDRMRFDFTNK AAMTVDQVKQTERIANEMIR KNQEVYAKESSLVVAKAVQG Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca LRAVFNETYPDPVRVVSIGV PVDDLMADPSSPAGSLTSIE FCGGTHLKRAGHVGDFVITT EEAIAKGIRRIVALTGPEAA KALKKAEHYQNEVNRIKAEG Eaff LRAVFDETYPDPVRVVSVGV PVVDLEKDPNNPAGTQTSVE FCGGTHLRRAGHIEHMVIAS EEAIAKGIRRIVALTGPEAK KALAKEKLLLGELEKVKTKV Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra LRAVFGETYPDPVRVVSIGV PVEKLEADPNSPIGLNTSIE FCGGTHLHNSSHVGDFVIAS EEAIAKGIRRIVALTGPEAT KAIKKADRLLVNI---RELV Hazt LRAVFGEVYPDPVRVVSVGI PVEDLEKDPQSPAGNKTSIE FCGGTHLLRSGHVGHFVIAV EEAIAKGIRRIVALTGPEAQ KAINRGALLQNKVNQLTQTL Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos LRAVFDETYPDPVRVVSVGV PVQDFEKDPNNPKGSQTSVE FCGGTHLRRAGHAEHMVIQS EEAIAKGIRRIVALTGPEAK KARAKERLLEADVVKVKALA Dmel LRSVFDEVYPDPVRVISFGV PVDELEQNPDSEAGEQTSVE FCGGTHLRRSGHIMDFVISS EEAIAKGIRRIVALTGPEAL KALKKSEAFEQEIVRLKATI Tcas LRAVFEETYPDPVRIVSIGI PVEKLEVDPFGPAGDNTSIE FCGGTHLKYSGHIGDFVIAS EEAIAKGIRRIVALTGPEAT KALKRTEYLENCLNDIKFLV Pmon LRAVFGEVYPDPVRVVSIGI PVETLEADPQSPAGSVTSIE FCGGTHLLRAGHAGDFVIVS EEAIAKGIRRIVAFTGPEAV KALNKASHLENEVNKLKKRI Smar LRAMFSETYPDPVRIVSIGI PVEDLLDDPLGPGGNKTSVE FCGGTHLIRCGHIGDFVIAS EEAIAAGNRRIVALTGPEAT KARNKAALLQNNVNKLKLLI Tcal LRAVFDETYPDPVRVVSVGV PVETMEADPSSPAGCKTSVE FCGGTHLKRSGHTGHFIVAS EEAIAKGIRRIIALTGPEAV KAIQKAQLLQSQMESVKATI Crog LRAVFDETYPDPVRVVSVGI PVEKMEADPTGPAGSVTSVE FCGGTHLKRAGHLQEFVIAS EEAIAKGIRRILALTGLEAK KASLKAQQLQVKVDKASEVI Dpul LRAVFEETYPDPVRVVSIGI PVEQLEADPANPAGNSTSIE FCGGTHVKRSGHIGDFVISA EEAIAKGIRRIVAITGPEAS KALKKADLLQKEVDAVSAKV Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca ------AKVTQAAQGKELVK QLVELTEEISQSNISYWKKD ELRTELKNLKKQLDDLDRSN KAQAQQMAIENVKKLLEQKK DSEYIVHALEVGDNAKALDA Eaff ------ESKDMGM--KEKVR LITELNDDISAATISYHKKD EMRGELKNVKKRIDDEDRNR KAAVMGDVVEAAKAILTGNP GLPYLVCELQAYANNKAIDG Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra ------EEAAVTQSPKETWK KVVDVTDEVSQAIIPYWRKE EMRNSLKVLKKSLDDRERAA RAAISAAAVEASKKIAQENK GVPFLVRALHAFNDSKALDG Hazt ------SNDSLSY--KESVK LITDLMEDINQAQIQYWLRD ELRNALDSAKKVLGDADRAR KMAVSKDAIRFVKELKAANP DVPYVVVELKAFAQNKVLND Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos ------ADKNLSIC------ -------------------- -------------------- -------------------- -------------------- Dmel ------DNDKSGKDSKSHVK EIVELTEQISHATIPYVKKD EMRNLLKGLKKTLDDKERAL RAAVSVTVVERAKTLCEANP NATVLVEQLEAFNNTKALDA Tcas ------ETDKNGEKSKELVK KIVQLTEEVSHAVIPYWKKE EIRNALKTLKKNLDDKERAA KAAVANQVVDQIKEFVKANP NLPILVKELKAFSNTKALDT Pmon ------AENNMPF--KEVVR LLTEMLNDINHAQIQHWRKE ELRKAVEAVKKVQGDADRAR KTAISKEAIQITKNVLAANP NIPYLVT------------- Smar ------NDNNESS--NVIGK QIVGLDNDISQATIPHWSKD ELRSELKKLKKILDDKDKSK KASIALEVIEQTKMLFGNDA NRPVIVHKFEAGANKKALDG Tcal ------QDAKSSLSQKEMVK LITDLTEDINSATIPYLRKY EMRNELKTVKQTIDDKDRAR KAALMTVVVDFSKALLTLNP HLPYLVYELNACAQNKVLDG Crog ------KEGKLSV--KELVK LITNLTEDISGSQISQWKKD EMRNSLKALKKTVDDKERAK MAAVVSKIVEEANALVEEHK EAPFLVKELNAFAQNKALDG Dpul DAFVSQNDKTLSV--KELSR IIVDLSDDVSQANIAYWKKD DLRNILKGLKKRADDVERAI KAAVVNDVAEAAKKLVAEQV NTPFIVHEFNAFSNSKALDG Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca ALKQVRTITPNAAAMFFSCD AEKGKVICLSSVPKDIVARG LTANGWIKEVSEVIGGKGGG REESAQAIGNNVSSLDKALE VAHNFAKLKLTC-------- Eaff ALKQVKLLSSATPTIFFSGD EDTGKILCMAYSSKEAITSG LKANEWCGSVQTLINGKGGG RPDNAQASGTNVSALNAAME AAHSFAMLKLGVEIS----- Lcyp -------------------- -------------------- -------------------- -------------------- -------------AKRGLV- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra ALKAVKVISPSTAAMFLSVD PDTNKILALCSSSK----KD LPANEWIASITPVICGKGGG RAESAQATGTNGGCMDQAIA TANQFAKMKLKIDMH----- Hazt ALKEVKNGPP---SLFISAD EDTGKILAMAAVPKDVVQKG LAADQWVKNLTELLDGKGGG RAENAQLSGTNTSALHKALR LSHEFAQQKLSCP------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel ALKQVRSQLPDAAAMFLSVD ADSKKIFCLSSVPKSAVEKG LKANEWVQHVSATLGGKGGG KPESAQASGTNYEKVDEIVQ LASKFAQSKLS--MHVEQTR Tcas ALKQVRSLSPSTSALFVTVD PDSNKMFCLASVSKEGVDKG LKANEWVQAVASKLGGKGGG KADSAQASGSNSVAVEEILQ LAKQFAESRI---MQDQ--- Pmon -------------------- -------------------- -------------------- -------------------- -------------MSHN--- Smar ALKQVKLLSPQTAAMFFSSD AESEKIICLSSVPKDVVGKG LKANEWVDKISGIIDGKGGG KEESAQATGNKISALNEAME AAKEFAKLKLNN-MT----- Tcal ALKQVKAITPNMPAMFFSAD PDDGKILCMAQVPKEVIAKG LKANEWCQQVQSLINGKGGG KPENAQASGSNVSGLKEAMK AAETYAQSKLGVSMVNT--- Crog ALKVIKS-STIPAAMLISGD ENTGKVICMAQVSKDISSK- LKANEWCKEVQSVLNGKGGG KAESAQATGTNLAGIQEAIQ MANAFAKLKLGE-M------ Dpul ALKQVKSLSPETAAIFFSVD AEANKIVVLAAAPKGANDRG LKANEWVADVSALLDGKGGG SAGSAQATGNNPAGLAEAMK KAKAFAQSKLGLDMQS---- Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------Q TKHYPQPPQSDLTLS-YQAG DYENAEKHSMQLWRQDPTNT GILLLLSSIHFQCRKYDKTA Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff -------------------- -------------------- -------------------- -------------------- -------------------- Lcyp ----------FHTSDV---- -CKMANNGLGSIA------- ---IPMSGLAELAHSEYQAG DYDNAEKHCMQIWKQEPTNT GILLLLSSIHFQCRKYDKSA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -ATHPAIQQNIILKLPE--- -QLNTAISLAELAHREYQAG DYENAERHCLLLWRQDPTNT GVLLLLSSIYFQCRKYDKSA Hazt -------------------- -------------------- -------------------- ---------MQLWRQDPTNT AILLLLSSIHFQCRKLDKSA Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel INMQSQGQSHQLPSAAHILL DQNPNSTGSNLVVKQNDI-- -QSLSSVGLLELAHREYQAV DYESAEKHCMQLWRQDSTNT GVLLLLSSIHFQCRRLDKSA Tcas --IVVDGQNHLSSGTN---- -SGLPITGSPIVLKMNDV-- -PQLSSVGLLELAHREYQAG DYENAERHCMQLWRQDQTNT GVLLLLSSIHFQCRRLDKSA Pmon -------SQPVSSADP---- -VKMVVKSNQATS--GNV-- -QHIATIGLAELAHREYQTG DYENAEKHCMQLWRQDPSNT AVLLLLSSIHFQCRRLDKSA Smar -------------------- -------------------- -TILDSTGLAELAHREYQAG DYDNAERHCMQLWRQEPNNT GVLLLLSSIHFQCRRLDKSA Tcal ----------MSTSTN---- -GSTGAGGLGTIA------- ---ISVSGLAELAHSEYQSG DYENAEKHCMQLWRQDSTNT GVLLLLSSIHFQCRKYDKSA Crog -------------------- ----PQNGVNSGS--NGG-- -LGISVSSLAELAHSEYQAG DYENAEKHCMQLWRQDPSNT GVLLLLSSIHFQCRAYDKSA Dpul -------------------- -LQNQQIVGGIVLKIPD--- --QLSSFSLAELAHREYQAG DYENAERHCMQLWRQDPTNT GVLLLLSSIHFQCRRYDKSA Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin HFSTLAIKQNPLLAEAYSNL GNVYKEKGQLQEALDNYRHA VRLKPDFIDGYINLAAALVA AGDMEGAVQAYVSSLQYNP- -----DLYCVRSDLGNLLKA Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff -------------------- -------------------- -------------------- -------------------- -------------------- Lcyp HFSSMAIKQNPHLAEAYSNL GNVYKERGQLQEALDNYRHA VRLKPDFIDGYINLAAALVA AGDMEGAVQAYVSALQYNP- -----DLYCVRSDLGNLLKA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra QFSSLAIKQNPLLAEAYSNL GNVFKEKGQLSEALEHYRRG VRLKPDFIDGYINLAAALVA AGDMEGAVQAYVSALQYNP- -----DLYCVRSDLGNLLKA Hazt HFSMLAIKQNPMLAEAYSNL GNVYKERGQLQEALENYRHA VRLKPDFIDGEVSPGGLIM- -------------------- ------LCQVRRTAG----- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- ---------CSSDLGNLLKA Dmel QFSTLAIKQNPVLAEAYSNL GNVFKERGQLQEALDNYRRA VRLKPDFIDGYINLAAALVA ARDMESAVQAYITALQYNP- -----DLYCVRSDLGNLLKA Tcas HFSTLAIKQNPLLAEAYSNL GNVYKERSQLQEALDNYRHA VRLKPDFIDGYINLAAALVA AGDMEQAVQAYITALQYNP- -----DLYCVRSDLGNLLKA Pmon HFSMLAIKNNPMLAEAYSNL GNVYKERGQLQEALENYRHA VRLKPDFIDGYINLAAALVA ANDMEQAVQAYVSALQYNPK ---AEDLYCVRSDLGNLLKA Smar HFSTLAIKQNPMLAEAYSNL GNVYKERGQLQEALDNYRHA VRLKPDFIDGYINLAAALVA AGDMEQAVQAYVSALQYNPV SIECIDLYCVRSDLGNLLKA Tcal HFSNLAIKQNPLLAEAYSNL GNVYKERGQLPEALENYRYA VRLKPDFIDGYINLAAALVA AGDMEGAVQAYVSALQYNP- -----DLYCVRSDLGNLLKA Crog HFSSLAIKQNPLLAEAYSNL GNVYKERSQLQEALENYRHA VRLKPDFIDGYINLAAALVA ASDMEGAVQAYVSALQYNP- -----DLYCVRSDLGNLLKA Dpul QFSTYAIKQNPLLAEAYSNL GNVFKERGQLAEALDNYRHA VRLKPDFIDGYINLAAALVA AGDMEGAVQAYVSALQYNP- -----DLYCVRSDLGNLLKA Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin LGRLDEAKACYLKAIETRPD FAVAWSNLGCVFNAQGEIWL AIHHFEKAVALDPNFLDAYI NLGNVLKEARIFDRAVAAYL RALNLSPNHAVVHGNLACVL Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff -------------------- -------------------- -------------------- -------------RAVAAYL RALNLSPNHAVVHGNLACVY Lcyp LGRLEEAKACYLKAIETRPD FAVAWSNLGCVFNAQGEIWL AIHHFEKAVCLDPNFLDAYI NLGNVLKEARIFDRAVAAYL RALNLSPNHAVVHGNLACVY Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra LGRLDEAKGCYLKAIETRPD FAVAWSNLGCVFNAQGELWL AIHHFEKAVTLDPNFLDAYI NLGNVLKEARIFDRAVAAYL RALNLSPNHAVVHGNLACVY Hazt -------------LTAPRPD FAVAWSNLGCVFNAQGEIWL AIHHFEKAVALDPNFLDAYI NLGNVLKEARIFDRAVAAYL RALNLSPNHAVVHGNLACVY Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos LGRLDEAKACYLKAIETRPD FAVAWSNLGCVFNAQGEIWL AIHHFEKAVALDPNFLDAYI NLGNVLKEARIFDRAVAAYL RALNLSPNHAVVHGNLACVY Dmel LGRLEEAKACYLKAIETCPG FAVAWSNLGCVFNAQGEIWL AIHHFEKAVTLDPNFLDAYI NLGNVLKEARIFDRAVAAYL RALNLSPNNAVVHGNLACVY Tcas LGRLDEAKACYLKAIETRPD FAVAWSNLGCVFNAQGEIWL AIHHFEKAVGLDPNFLDAYI NLGNVLKEARIFDRAVAAYL RALNLSPNNAVVHGNLACVY Pmon LGRLDEAKACYLKAIETRPD FAVAWSNLGCVFNAQGEIWL AIHHFEKAVALDPNFLDAYI NLGNVLKEARIFDRAVAAYL RALNLSPNHAVVHGNLACVY Smar LGRLDEAKACYLKAIETRPD FAVAWSNLGCVFNAQGEIWL AIHHFEKAVALDPNFLDAYI NLGNVLKEARIFDRAVAAYL RALNLSPNHAVVHGNLACVY Tcal LGRLDEAKACYLKAIETRPD FAVAWSNLGCVFNAQGEIWL AIHHFEKAVALDPNFLDAYI NLGNVLKEARIFDRAVAAYL RALNLSPNHAVVHGNLACVY Crog LGRLDEAKACYLKSIETRPD FAVAWSNLGCVFNAQGEIWL AIHHFEKAVALDPNFLDAYI NLGNVLKEARIFDRAVAAYL RALNLSPNHAVVHGNLACVY Dpul LGRLDEAKACYLKAIETRGD FAVAWSNLGCVFNAQGDIWL AIHHFEKAVTLDPNFLDAYI NLGNVLKEARIFDRAVAAYL RALNLSPNHAVVHGNMACVY Aver ----LIDLAIDTYRRAIELQ PNFPDAYCNLANALKEKGLV AESEECYNTALRLNPSHADS LNNLANIKREQGYIEEATRL YLKALEVFPEFAAAHSNXAS Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff YEQGLIDLAVDTYRRAIELQ PNFPDAYCNLANALKEKGLV VESEECYNTALQLSPTHADS LNNLANIKREQGYIEEATRL YLKALEVFPEFAAAHSNLAS Lcyp YEQGLIDLAIDTYRRAIELQ PNFPDAYCNLANALKEKGMV PESEECYNTALKLNPSHADS LNNLANIKREQGFIEEATRC YLKALEVFPEFAAAHSNLAS Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra YEQGLIDLAIDTYKRAIELQ PNFPDAYCNLANALKEKGMV QEAEDCYNTALRLCPSHADS LNNLANIKREQGYIEEATRL YLKALDVFPEFAAAHSNLAS Hazt YEQGLIDLAIDTYRRAIELQ PNFPDAYCNLANALKEKGQV SEAEECYNTALQLCPTHADS LNNLANIKREQGHTEEATRL YLKALEVFPEFAAAHSNLAS Meda ----LIDLAIDTYRRAIELQ PNFPDAYCNLANALKEKGLV AESEECYNTALRLNPSHADS LNNLANIKREQGYIEEATRL YLKALEVFPEFAAAHSNLAS Afos YEQGLIDLAIDTYRRA---- -------------------- ---------ALQLSPTHADS LNNLANIKREQGFIEEATRL YLKALEVFPEFAAAHSNLAS Dmel YEQGLIDLAIDTYRRAIELQ PNFPDAYCNLANALKEKGQV KEAEDCYNTALRLCSNHADS LNNLANIKREQGYIEEATRL YLKALEVFPDFAAAHSNLAS Tcas YEQGLIDLAIDTYRRAIELQ PNFPDAYCNLANALKEKGQV AEAEECYNTALRLCPSHADS LNNLANIKREQGYIEEATRL YLKALEVFPEFAAAHSNLAS Pmon YEQGLIDLAIDTYRRAIELQ PNFPDAYCNLANALKEKGQV TEAEECYNTALRLCPTHADS LNNLANIKREQGYTEDATRL YLKALEVFPEFAAAHSNLAS Smar YEQGLIDLAIDTYRRAIELQ PNFPDAYCNLANALKEKGQV NEAEECYNTALQLCPTHADS LNNLANIKREQGFTEEATRL YLKALEVFPEFAAAHSNLAS Tcal YEQGLIDLAVDTYRRAIELQ PNFPDAYCNLANALKEKGLV QDSEECYNTALRLCPTHADS LNNLANIKREQGYIEEATRL YLKALEVFPEFAAAHSNLAS Crog YEQGLIDLAIDTYRRAIDLQ PNFPDAYCNLANALKEKGQV FEAEECYNTALRLSPTHADS LNNLANIKREQGFIEEATRL YLKALEVFPEFAAAHSNLAS Dpul YEQGLIDLAIDTYRRAIELQ PHFPDAYCNLANALKEKGQV QDAEDCYSTALRLCPAHADS LNNLANIKREQGFIEEATRL YLKALDVFPDFAAAHSNLAS Aver ILQQQGKLNEALMHYKEAIR IQPAFADAYSNMGNTLKEMH DIQGALQCYTRAIQINPAFA DAHSNLASVHKDSGNIPEAI Q----SYRTALKLKPNFPDA Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff ILQQQGKLNEALLHYKEAIR IQPAFADAYSNMGNTLKEMH DVQGALQCYSRAIQINPAFA DAHSNLASVHKDSGNIPEAI Q----SYRTALKLKPDFPDA Lcyp ILQQQGKLNEALMHYKEAIR IQPTFADAYSNMGNTLKEMH DTHGALQCYTRAIHINPGFA DAHSNLASVHKDSGNIPEAI Q----SYRTALKLKPNFPDA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra VLQQQGKLNEALMHYKEAIR IQPTFADAYSNMGNTLKEMG DINGALQCYTRAIQINPGFA DAHSNLASIHKDSGNIPEAI Q----SYKTALKLKPDFPDA Hazt ILQQQGKLNEALMHYKEAIR IQPTFADAYSNMGNTLKEMQ DIQGALQCYTRAIQINPAFA DAHSNLASIHKDSGNIPEAI QVNLSSYKTALKLKPDFPDA Meda ILQQQGKLNEALMHYKEAIR IQPAFADAYSNMGNTLKEMH DIQGALQCYTRAIQINPAFA DAHSNLASVHKDSGNIPEAI Q----SYRTALKLKPNFPDA Afos ILQQQGKLNEALLHYKEAIR IQPAFADAYSNMGNTLKEMH DVSGALQCYSRAIQINPAFA DAHSNLASVHKDSGNIPEAI Q----SYRTALKLKPDFPDA Dmel VLQQQGKLKEALMHYKEAIR IQPTFADAYSNMGNTLKELQ DVSGALQCYTRAIQINPAFA DAHSNLASIHKDSGNIPEAI Q----SYRTALKLKPDFPDA Tcas VLQQQGKLNEALMHYKEAIR IQPTFADAYSNMGNTLKEMQ DVSGALQCYTRAIQINPAFA DAHSNLASIHKDSGNIPEAI Q----SYRTALKLKPDFPDA Pmon ILQQQGKLNEALMHYKEAIR IQPTFADAYSNMGNTLKEMQ DIQGALQCYTRAIQINPAFA DAHSNLASIHKDSGNIPEAI Q----SYRTALKLKPDFPDA Smar VLQQQGKLNEALMHYKEAIR IQPTFADAYSNMGNTLKEMQ DIQGALQCYTRAIQINPAFA DAHSNLASIHKDSGNIPEAI A----SYRTALKLKPDFPDA Tcal ILQQQGKLNEALMHYKEAIR IQPAFADAYSNMGNTLKEMH DVQGALQCYTRAIQINPAFA DAHSNLASVHKDSGNIPEAI Q----SYRTALKLKPNFPDA Crog ILQQQGKLNEALMHYKEAIR IQPAFADAYSNMGNTLKEMH DVQGALQCYTRAIQINPAFA DAHSNLASVHKDSGNIPEAI Q----SYRTALKLKPNFPDA Dpul VLQQQGKLNEALMHYKEAIR IQPSFADAYSNMGNTLKEMQ DINGALQCYTRAIQINPAFA DAHSNLASIHKDSGQIPEAI Q----SYRTALKLKPDFPDA Aver YCNLAHCLQIVCDWTDYSAR MKTLVNIVGDQLEKNRLPSV HPHHSMLYPLSHDFRKAIAN RHAQLCIEKVSVLHRNMYKF ARNLSSDGRIRIGYVS---- Csin -------------------- ---IVSIVADQLDKNRLPSV HPHHSMLYPLSHHFRKAIAG RHAQLCLEKIQVLHKPPYRF SSNLAPDGRLRIGYVSSDFG Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff YCNLAHCLQIVCDWTDYNSR MKKIVAIVGDQLEKNRLPSV HPHHSMLYPLTHEYRKGIAA RHAQLCLEKIQVLHKPLYKF SPNLSPDGRLRIGYVSSDFG Lcyp YCNLSHCLQIVCDWTDYNNR MKTLVSIVADQLEKNRLPSV HPHHSMLYPLSHEFRKAIAN KHAQLCIEKVSVLHKPPYKF SRVLPVDGRIRIGYVSSDFG Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra FCNLSHCLQIVCDWTDYESR MTKLISIVGDQLQRNRLPSV HPHHSMLYPLSHDYRKAIGE RHANLCIEKVMILHKPPYKF SRDLPNGTRLRIGYVSSDFG Hazt YCNLAHCLQIVCDWTNYDAR MKKLVTIVGEQLERNRLPSV HPHHSMLYPLSHEYRKAIAA RHANLCIEKITVLHKPPYKF PSRRASDGRLRIGYVSSDFG Meda YCNLAHCLQIVCDWTDYPAR MKTLVNIVADQLEKNRLPSV HPHHSMLYPLSHDYRKAIAN RHAQLCIEKVSVLHRPPYKF SRSLTMDGRIRIGYVSS--- Afos YCNLAHCLQIVCDWTDYNSR MKKIVSIVGDQLEKNRLPSV HPHHSMLYPLSHEYRKGIAA RHAQLCLEKIQVLHKGAYKF SGNLAPDGRLRIGYVSSDFG Dmel YCNLAHCLQIVCDWTDYDIR MKKLVSIVTEQLEKNRLPSV HPHHSMLYPLTHDCRKAIAA RHANLCLEKVHVLHKKPYNF LKKLPTKGRLRIGYLSSDFG Tcas YCNLAHCLQIVCDWTDYDAR MKKLVSIVADQLEKNRLPSV HPHHSMLYPLSHEFRKAIAA RHANLCLEKIHVLHKHPYKF TTEL--KGRLRVGYVSSDFG Pmon YCNLAHCLQIVCDWTDYDAR MKKLVSIVGEQLERNRLPSV HPHHSMLYPLSHEYRKAIAN RHANLCMEKINVLHKQPYKY PSELTSDGRIRIGYVSSDFG Smar YCNLAHCLQIVCDWTDYESR MKKLVLIVGEQLEKNRLPSV HPHHSMLYPLSHEFRKAIAA RHANLCLEKILVLHKPPYKH PKDL-NGGRLRIGYVSSDFG Tcal YCNLAHCLQIVCDWTDYAGR QKSLISIVGDQLEKNRLPSV HPHHSMLYPLSHEFRKNIAN RHAQLCLEKISVLHKPAYKF PMKL--NGRLRIGYVSSDFG Crog YCNLAHCLQIVCDWTDYAAR QKNLVAIVAEQLDKNRLPSV HPHHSMLYPLNHSYRKAIAS RHAQLCLEKIAVLHKQPYKF SSEP--MKRLKIGYVSSDFG Dpul YCNLAHCLQIVCDWTDYETR MKRLIHIVGEQLERNRLPSV HPHHSMLYPLSHEYRKAIAA RHANLCVEKILILHKANFKY PKELATNGRLRIGYVSSDFG Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin NHPTSHLMQSIPGVHNRARV EIFCYSLSPDDGTTFRQKVS REAEHFIDLSAIQCNGKAAD RIYQDGIHVLVNMNGYTKGA RNESLFALRPAPIQAMWLGY Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff NHPTSHLMQSVPGFHDRSRV EIFCYSLSPDDGTAFRQKVF AEAEHFIDLSAVPCNGKAAD RIYQDGIHILVNMNGYTKGA RNE-IFALRPAPIQAMWLGY Lcyp NHPTSHLMQSIPGMHDRSKV EIFCYSLAPDDNTTFRQKNS KESEHFVDLSSVLCNGEVAD RIYQDGIHILLNMNGYTKGA RNE-IFALRPAPIQVMWLGY Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra NHPTSHLMQSLPGFHNRSKV EVFCYSLAPDDGTNFRAKVS REAEHFADLSQVTCNGKAAD RIYADGIHILVNMNGYTKGA RNE-IFALKPAPIQVMWLGY Hazt NHPTSHLMQSIPGLHDRSRV EIFCYALSPDDGTTFRSKIA REAEHFVDLSQIPCNGKAAD RINQDGIHILVNMNGYTKGA RNE-IFALRPAPVQAMWLGY Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos NHPTSHLMQSVPGNHDKSRV EIFCYSLSPDDGTTFRQRVA NDAEHFIDLSSIQCNGKAAD RIYADGIHILLNMNGYTKGA RNE-IFALRPAPIQAMWLGY Dmel NHPTSHLMQSVPGLHDRSKV EIFCYALSPDDGTTFRHKIS RESENFVDLSQIPCNGKAAD KIFNDGIHILVNMNGYTKGA RNE-IFALRPAPIQVMWLGY Tcas NHPTSHLMQSVPGLHDRSRV EIFCYALSQDDGTTFRSKIS REAEHFIDLSQIPCNGKAAD RIHADGIHILVNMNGYTKGA RNE-IFALKPAPVQVMWLGY Pmon NHPTSHLMQSIPGLHDKSRV EIFCYALSPDDGTTFRSKIT REAEHFIDLSQIPCNGKAAD RINQDGIHILVNMNGYTKGA RNE-IFALRPAPVQVMWLGY Smar NHPTSHLMQSIPGLHGRESV EVFCYSLSPDDGTTFRSKIS NESEHFVDLSQIPCNGKAAD RIHSDGVHILVNMNGYTKGA RNE-IFALKPAPIQVMWLGY Tcal NHPTSHLMQSIPGVHNREKV EVFCYSLAPDDSTSFRQKIG REAEHFIDLSTLPCNGKAAD RIYQDGIHILVNMNGYTKGA RNE-IFALRPAPIQAMWLGY Crog NHPTSHLMQSIPGLHNRDNV EIFCYSLAADDNTKFRQKIS AGADHFIDLSQVPCNGKAAD RIHADGIHILINMNGYTKGA RNE-IFALRPAPLQVMWLGY Dpul NHPTSHLMQSVPGFHERSRV EIFCYSLSPDDGTTFRAKIA RESEHFVDLSQIICNGKAAD RINADGIHILVNMNGYTKGA RNE-IFAMRPAPIQVMWLGY Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin PGTSGASFMDYIITDAQTSP VHLADQYSEKLAFLPNTFFI GDHMRMFPHLKERIIMADS- --TNPG-GN--VQDNVAVIN AVDIDPLKDVAHMT-QVIMR Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff PGTSGASFMDYIITDKQTSP LQIASQY------------- -------------------- -------------------- -------------------- Lcyp PGTSGAPFMDYIITDEQTSP LELAYQYSEKLAYMPNTFFI GDHKQMFPHLTERIIMAAKN EIKDGCLDG-PVFDNRAVLN AIDTTPILEKADIK-QVTVA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra PGTSGASFMDYIITDKVTSP LHLAHQYSEKLAYMPKTFFI GDHKQMFPHMKERVVIQDR- --EKLSSNLPAIADNVAVIN GTDLSPLYERTDVR-RVTET Hazt PGTSGASFMDYLITDGVTSP VKLAAQYTEKLAYMKDTFFV GDHQQMFPHLKERVLIKSVE SIKNIDNEP--LKDTVALLN TADLSPVMESADLM-RVAEI Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos PGTSGASYMDYIITDKQTSP VHLASQYSENLAYMPNTFFI GDHMRMFPHLQERIVMADA- --DNTVNGH--VQDNVAVIN AVNPEPIKNVASLI-KVTM- Dmel PGTSGASFMDYIITDSVTSP LELAYQYSEKLSYMPHTYFI GDHKQMFPHLKERIIVCDK- --QQSS-----VVDNVTVIN ATDLSPLVENTDVK-EIKEV Tcas PGTSGASFMDYLVTDAVTSP VELASQYSEKLAYMPYTYFV GDHRQMFPHLKERLIVSDK- --NNSTNSN--LADNVAIIN ATDLSPLVESTEVK-EIKEV Pmon PGTSGAPFMDYLITDRITSP MKLSTQYSEKLAFMPDTFFV GDHKHMFPHLKERVLIESVD NPKLLNNEG--IKDTVALIN TTDLSPVIESAEVM-TIKEV Smar PGTSGAPFMDFLITDRVTSP IEVSQQYSEKLAYMPNTFFI GDHRHMFPHMVERAVINTK- --DNLSKKL-DVPDNVAIVN ATDLSPIIEKADVKVKICEV Tcal PGTSGAPFMDYIITDKQTSP LELASQYSEKLAYMPHTFFI GDHKQMFPHLGERIIMSGK- ---NINCEGMPVKDNVAVIN AVDTAPIFENAQIR-EIKQT Crog PGTSGAPFMDYLLTDKQTSP LELSSQYSEKLVYMPDSFFI GDHMQMFPHLTERIIMAGV- --KKSSSDD--LSDTVAVIN TLDKTDLLEKTSVV-QACLS Dpul PGTSGASYMDYIITDRVTSP LELASQFSEKLAYMPKTFFV GDHRQMFPHLKERLIITSS- ----SDKGK--VADNVALVN GTDLSPILERTEIK-KVTEV Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin ANTRMK-----QR------- --PMLWLNFPPPRELTLSMD NCKTSVNGVNIQNGLA-TQI NAKAATGEEIPDQIMVTTRQ QYGLPDDAVVYCNFNQLYKI Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff -------------------- -------------------- -------------------- -------------------- RYSF---------------- Lcyp G-----------------EN EYTIAQLPTTQAISKMILNG QFETNVNGLTLQNGL-TNQL SSKAATGEVVPENILVTSRQ QYGLPDDAIVYCNFNQLYKI Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra ISSSTT-----TTFEAPVVV SLTVAQLPTMQPIETMIGAG QIQTSVNGVVVQNGLATPQA HTRAATGEEVPQNIVVTTRQ QYGLPEACVVYCNFNQLYKI Hazt VKPITSGVNGTKTSE-PIEV SMTVAQLSSTAPIQTMISSG QVQATVNGMVVQNGLATTQI NNKAATGEEVPQNILVTTRQ QYGLPDDAIVFCNFNQLYKI Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos --------EGKHKDE-TVKA SVTVAELSTTQPISSMILNG QLQTNVDGLNIQNGLA-TQI NAKAATGEEIPDQIMVTTRQ QYGLPDDAVIYCNFNQLYKI Dmel V----------NAQK-PVEI THKVAELPNTTQIVSMIATG QVQTSLNGVVVQNGLATTQT NNKAATGEEVPQNIVITTRR QYMLPDDAVVYCNFNQLYKI Tcas V----------KAAK-MVEI SLKVAELPTTTPIENMIASG QVQTSLNGVVVQNGLATTQT NNKAATGEEVPQNIVITTRQ QYGLPDDAVVYCNFNQLYKI Pmon VNPATT-----KE---SVEV AVTVAQLPSTAPIESMIQAG QVQATVNGLLVQNGLATTQM NNKAATGEEPPQNILVTTRK QYGLPEDAVIYCNFNQLYKI Smar VVPSTS--GDGKPAK-PVEI ATTVIELPTTTPIQTMISTG QLQTSLNGIVVQNGLTTTQT NTKTATGEEVPQTILVTTRL QYGLPEDEVVYCNFNQLYKI Tcal EMVGDK-----KDT--QVEV RVTIAQLPTTMAIESMIQNG QVQTSVNGIMIQNGLTTNLL SAKAATGEEVPEQIMVTTRK QYGLPEDAVVYCNFNQLYKI Crog GIAGGE-----NNQE-VVEV KVAVAELPTTMAIDSMIQNG QVQTSVNGLTIQNGVTTNLL SAKTATGEEVPESILITSRQ QYGLPLDGIVFCNFNQLYKI Dpul VTPTTT-----TGLDAPVQV SLTVAQLTTMDPIETMIGSG QVQTSVNGVVVQNGLATNQA NTRAATGEEVPQSIVVTTRQ QYGLPDDAIIYCNFNQLYKI Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin DPSTLKMWVNILNRVPNSVI VWLLRFPQVGETNIHVAAQQ MGLKNGKLIFSNVAAKEEHV RRGQLADVCLDTPLCNGHTT GMDVLWAGTPMVTLPGETLA Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff -------------------- -------------------- -------------------- -------------------- -------------------- Lcyp DPPTLKMWVEILNNVPKGVL -WLLRFPQVGETNILVAAQQ MGLRSGAIIFSNVAAKEEHV RRGQLADVCLDTPLCNGHTT GMDVLWAGTPMVTLPGETLA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra DPATLKMWVNILKRVPNSIL -WLLRFPAVGETNLLHAVQN MGLPSNRVLFSNVAAKEEHV RRGQLADVCLDTPLCNGHTT GMDVLWAGTPMVTLPGETLA Hazt DPSTLQMWCNILKRVPKGVM -WLLRFPGHGEANLLAQAQQ LGIGPGRIIFSNVAAKEEHV RRGQLVDVCLDTPLCNGHTT GMDVLWAGTPMVTLMGETLA Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos DPGTLKMWVNILNRVPNSVL -WLLRFPQVGETNIHVAAQQ MGLKNGKIIFSNVAAKEEHV RRGQLADVCLDTPLCNGHTT GMDVLWAGTPMVTLTGETLA Dmel DPQTLESWVEILKNVPKSVL -WLLRFPAVGEQNIKKTVSD FGISPDRVIFSNVAAKEEHV RRGQLADICLDTPLCNGHTT SMDVLWTGTPVVTLPGETLA Tcas DPMTLHMWVNILKAVPNSVL -WLLRFPAVGEPNLQATAQQ LGLPPGRILFSNVAAKEEHV RRGQLADVCLDTPLCNGHTT SMDVLWTGTPVVTFPGETLA Pmon DPSTLQMWCNILKRVPKSVV -WLLRFPAHGEANILAQAQQ LGVGAGRIIFSNVAAKEEHV RRGQLADVCLDTPLCNGHTT GMDVLWAGTPMITLSGETLA Smar DPATLRMWVNILKRVPRSVL -WLLRFPAVGESNVLAAATQ MGLPAGKIIFSNVAPKEEHV RRGQLSDVCLDTPLCNGHTT GMDVLWAGTPMVTLPGETLA Tcal DPATLKMWVNILNNVPNAVM -WLLRFPQVGETNILVAAQQ MGLRNGSIIFSNVAAKEEHV RRGQLADVCLDTPLCNGHTT GMDVLWAGTPMVTLPGETLA Crog DPPTLKMWVAILNAVPHSVL -WLLRFPQVGETNLQVAAQQ MGLRAGAIIFSNVAAKEEHV RRGQLADVCLDTPLCNGHTT GMDVLWAGTPMVTLPGETLA Dpul DPPTLQMWVNILKRVPNAVL -WLLRFPTVGETNMLATAQA LGLGSGRILFSNVAAKEEHV RRGQLADICLDTPLCNGHTT GMDVLWAGTPMVTLPGETLA Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin SRVASSQLCTLDLEELVAKN PQDYENIAVKLGNDKEYRRA IRAKVWDGRISSPLFDVRVY AKDLEDLVYKMFEKFRKGEK INHITQ-------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff -------------------- -------------------- -------------------- -------------------- -------------------- Lcyp SRVASSELKALGCPELIAKS KEEYVKIAVRLGNDPDFLRA TRAKVWTSRTDSPLFNVKRY TADLERLFKVLWDKFQRGEK PDHVK------V-------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra SRVAASQLSTLGCPELIASS PKEYEDIAVRLGNDREYLKA MRAKVWKMRADSPLFDVKIY ASDMERLYYRLWERYSRGEK ADHTTDLEN----------- Hazt SRVAASQLTCLGVSELIATT RHQYQDIAVKLGTDHDYLKA IRSRVWEARLSSPLFNCKTY ASNLENLFDAMWDKYLSGDE PDHLTEY------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos SRVASSQLTTLGLPELVADK REDYENIAVKLGTDREYLRV IRARVWQGRLKS-------- -------------------- -------------------- Dmel SRVAASQLATLGCPELIART REEYQNIAIRLGTKKKKKK- -------------------- -------------------- -------------------- Tcas SRVAASQLATLGCPELIARS RQEYQEIAIKLGTDKEYLKA MRHKVWAARTTSPLFDCKQY AQGLELLYCKMWERFAAGLK PDHITDTTAKK--------- Pmon SRVAASQLHCLGCPELVAQT RQEYEDIACKLGNDREYLKA TRAKVWKARIDSPLFDCKTY ATNLERLFGRMWKKYSGGEK PDHITEW------------- Smar SRVAASQLTTLGCPELIAKS RQDYEEIAIRLGTDKELLKA TRAKVWGSRIKTPLFNMKKY AFDLEQLFYRMWEQYDSGRR FRHITDWNQEKILSGKDFEL Tcal SRVASSQLVALGCPELIAKD RSDYEKIAIRLGNDKEFLRG TRAKVWKYRIDSPLFCVKTY AANIEKLFYKMWERHERGEK PDHVTELSIY---------- Crog SRVASSQLMALGCPELIAKD RKEFENIAIKLGTDKDFLRG IRAKVWKARMESPVFNVKTY ASNLERTFKLMWNKYAAGEK PDHITELANY---------- Dpul SRVAASQLTTIGCPELIASS PQEYEDIAVKLGTDSEYLKA IRAKVWIRRSDSPLFNCQIY AHDMERLFARMWQRHASGEK PNHITQWDDAE--------- Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- ------------MGTTLLDI IQSGVENLDSDVGLCAPDAE SHTLFAGLFNPVIEDYHGGF Eaff ----------PDTEYVEAGF DKLQGDPECHSLLKKHLSKE ILDDLKNKKTESFKSSLKDV IQSGIENLDSGIGVYAPDAE SYMIFAALFDPIIEEYHGGF Lcyp -----E---------MEEGF LKLQEAEHCQSLLKKYLTPQ LFTKLKGAKTPTFGSTLLDV IQSGMDNLDSGIGVYAPDAE AYEVFADLFNPIIEDYHGGF Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos --------NQKIAQYL---- -----MQESRSLLKKYLTPD LVNSLMSAKTKSYQSSLFDV VKSGIVNPDSSVGVFAPDVE AYTVFKDLLLPIIKDYHKLP Dmel ------MVDAAVLAKLEEGY AKL-AASDSKSLLKKYLTKE VFDNLKNKVTPTFKSTLLDV IQSGLENHDSGVGIYAPDAE AYTVFADLFDPIIEDYHGGF Tcas ------MVDAAVLEKLEAGF KKL-EASDSKSLLKKYLTRE LFDKLKTKKT-SFGSTLLDV IQSGLENHDSGIGIYAPDAD SYSVFADLFDPIIEDYHGGF Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar RSMGRF-------------F KKLQGAGDCKSLLKKYLTQP VFDDLKTKKT-AMGATLQDI IQSGVANLDSGVGVYAPDAE SYTLFAGLFNPIIEDYHGGF Tcal -------------------- --LQEAEDCQSLLKKHLTKE ILDELKILKTRTFGSTLKDV IQSGIENIDSGVGVYAPDPE AYGVFANLFDPIIEDYHGGF Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul ------MVDAAVSEKLEAGF QKLQEATNCKSLLKKHLTRE IFDKIKDLKT-SFGSTLLDV IQSGVENLDSGFGVYAPDAE AYSVFNDLFEPMICDYHTGF Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca KATDKHSLTNFGDLSTLANV DPDDQFVVSIGVRCGHSLQG CPFNPCLTEAQYREMEEKVR STLRMLEGELKVTYYPL--- -DKTQQQLIDDHFLFKEGAH Eaff GAEAMHPESDFGAPEEFGNL DPDGKYIVSTRIRCGRSIDG LPFNPNMKEDDYKELETKAQ AAFISLPETHAGTYYPLTGM EEETQKQLIDDHFLFKEGDR Lcyp GPDNYHPEPDFGDPSVFADL DPDAQYIVSTRIRCGRSVAG MPFNPNMTEHHYKYLERILK DVLEGMDDDLAGTYYSLEGM DKVVQHRLIDDHFLFKEGDR Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos EGFSGQPPQTWGEVSQIGKF GAE---VLSTRIRIARSLKG FPLNSKMTKQNLLDLEHKVQ QV---LEQNFHGKYHSLAKM SQDFRQDLVNRHFMFEDCDR Dmel KKTDKHPASNFGDVSTFGNV DPTNEYVISTRVRCGRSMQG YPFNPCLTEAQYKEMESKVS STLSGLEGELKGKFYPLTGM EKAVQQQLIDDHFLFKEGDR Tcas KKTDKHPPKDWGDVNAFGNL DPAGEFVVSTRVRCGRSLEG YPFNPCLTEEQYKEMEQKVS STLSGLEGELKGTFYPLTGM SKEVQQKLIDDHFLFKEGDR Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar KSTDKHPAKDFGDVSALGDL DPEGAFVISTRVRCGRSLQG YPFNPCLTEAQYKEMEEKVS STLSGLTGELKGTYYPLTGM SKEVQQKLIDDHFLFKEGDR Tcal SKSQKHPPSHFGNPEDFGDL DPDREFIVSTRIRCGRSIEG FPFNPNMKKEDYENMEKLVS ETLEKFDGELKGTYHSLESM SPETQRELVDQHYLFKQGDR Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul KPGDAHPPRDFGDLETFGNL DPEGAFIVSTRVRCGRSLAG YAFNPCLTEANYKEMEEKVV ASLSSLEGELKGTYFPLTGM TKEVQTQLIQDRFLFKEGDR Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca FLQAAIAA------------ --------------IKTIKT HLRSVVG------------- -------------------- -AFCPTNLGTTIRASVHIKV Eaff FLQAAHASEFWPTGRGIFHD NEKKFLVWVGEEDHLRIISM QEGGDVGQVYSRLVQGVQEL GKTMT------FAHSPRFGW LTFCPTNLGTTIRASVHIKL Lcyp FLQSANACRFWPVGRGIFHN ANKTFLVWCAEEDHLRIISM QNGGHVGEVYERLVRAMRYF ETQLQ------FARDDRLGF LTFCPTNLGTTIRASVHIKL Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos FNKGGGGCDFWPTGRGIFLS SDEKFLVWINEEDHLRIISM DKGGDLNAIYDRLVKSMKIL EKNIE------FSRDPYLGF HTFCPTNLGTTLRASVHIKF Dmel FLQAANACRFWPSGRGIYHN DAKTFLVWCNEEDHLRIISM QQGGDLGQIYKRLVTAVNEI EKRVP------FSHDDRLGF LTFCPTNLGTTIRASVHIKV Tcas FLQAANACRFWPTGRGIFHN DAKTFLVWCNEEDHLRIISM QMGGDLGQVYRRLVTGVNDI EKRLP------FSHSDRFGF LTFCPTNLGTTVRASVHIKV Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar FLQEANACRYWPAGRGIYHN DAKTFLVWCNEEDHLRIISM QMGGNLKEVFARLTNAVNEI EKRLP------FSHDDRLGF LTFCPTNLGTTIRASVHIKL Tcal FLEAANAIRHWPSGRGIFFN DERSFLVWCGEEDHLRIISM QNGGHVGEVYGRLVRALEEM EKEFK------YSHDERLGF LTFCPTNLGTTIRASVHIKL Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul FLQAANACRYWPTGRGIYHN VDKTFLVWCNEEDHLRIISM QKGGDLKAVYARLVNAINEI EKRIP------FSHHDKYGF LTFCPTNLGTTIRASVHIAL Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca PKLAADK--AKLESIAAKYN LQVRGTRGEHTESEGGVYDI SNKRRMGLTEYQAVKEMQDG ILELIRLEKAA-------MP AVRGDGIRGLAVFISDIRNC Eaff PLLAAKG-MENLQSVADQFN LQVRGSAGEHSEADGGLYDI SNKERLGLTEFQAVEKMYKG VEELIRLEKELEE-----MP AVRGDGMRGLAVFISDIRNC Lcyp PRLAANG-HEQLQAVANRFQ LQVRGSSGEHSSAIGGIYDV SNRERLGLTEFEAVQKMYHG VAELIRLEQEL-------MP TVRGDGMRGLAVFISDIRNC Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- ------MRGLAVFISDIRNC Afra -------------------- -------------------- -------------------- -----------------MMP AVKGDGMRGLAVFISDIRNC Hazt -------------------- -------------------- -------------------- ------------------MP AVRGDGMRGLAVFISDIRNC Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos NNLKLSE----VKEEAKKLD LQVRGTHGEHSDVRGGVMDI SNARRLGLTEFQAISQVYNG VNKILALDRDKIL------- -------------------- Dmel PKLASNK--AKLEEVAAKYN LQVRGTRGEHTEAEGGVYDI SNKRRMGLTEFEAVKEMYDG ITELIKLEKSL-------MA PVRGDGMRGLAVFISDIRNC Tcas PKLAANK--AKLDEVAAKFN LQVRGTRGEHTEAEGGVYDI SNKRRMGLTEFDAVKEMYDG ISEIIKMEKEL-------MP AVRGDGMRGLAVFISDIRNC Pmon -------------------- -------------------- -------------------- ------------------MP AVRGDGMRGLAVFISDIRNC Smar PKLAQNR--DKLEEIASKFN LQVRGTSGEHTESVGGVYDI SNKRRMGLTEYQAVKEMNDG ILEMIKMEKAA-------MP AVRGDGMRGLAVFISDIRNC Tcal PRLAAEGGIEMLQKHGDEHQ LQVRGSSGEHSEAVGGLYDI SNRERMGLTEYQAVKKMYEG VSELIKMEKALIAKDEG-MP AVRGDGMRGLAVFISDIRNC Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul PKLAADL--AKLEEAAGKFN LQVRGTAGEHTEAEGGVYDI SNKRRMGLTEYQAVKEMYDG LQELIRMEKEAA------MP AVRGDGMRGLAVFISDIRNC Aver -------------------- -------------------- --------------EAVNLL SSNKYXXKQIGYLFISVLIS QNSDLINLINQSIKNDLGSR Csin -------------------- --GDKTLDGYQKKKYVCKLL FIFLLGHDIDFGQIEAVNLL SSNKYTEKQIGYLFISVLIS GNSELIQLIVQSIKNDLASR Isca KSKEAEIKRINKELANIRSK FKGDKTLDGYQKKKYVCKLL FIFLLGHDIDFGHMEAVNLL SSNKYSEKQIGYLFISVLLN ENSELMRLIIQSIKNDLCAR Eaff KSKEAEVKRINKELANIRNK FKGDKTLDGYQKKKYVCKLL FIFLLGHDIDFGQMEAVNLL SSNKYTEKQIGYLFISVLIS GNSELIQLIVQSIKNDLAAR Lcyp KSKEAEVKRINKELANIRSK FKGDKTLDGYQKKKYVCKLL FIFLLGHDIDFGHMEAVNLL SSNKYTEKQIGYLFISVLIS QNSDLINLVNQSIKNDLASR Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp KSKEAEIKRINKELANIRGK FKGDKTLDGYQKKKYVCKLL FIFLLGHDIDFGHMEAVNLL SSNKYTEKQIGYLFISVLIN TNSDLIKLIIQNIKNDLASK Afra KSKEAEIKRINKELANIRSK FKGDKTLDGYQKKKYVCKLL FIFLLGHDIDFGQMEAVNLL SSNKYTEKQIGYLFISVIIN TNSSLIQLIMQSIKNDLQSR Hazt KSKENEVKRINKELANIRSK FKGDKTLDGYQKKKYVCKLL FIFLLGHDIDFGHMEAVNLL SSNKYTEKQIGYLFISVLVN TNSDLIKLIVQNIKNDLNSR Meda -------------------- -------------------- --------------EAVNLL SSNKYTEKQIGYLFISVLIS QNSDLINLINQSIKNDLGSR Afos -------------------- -------------------- -------------------- -------------------- -----------SIKNDLNSR Dmel KSKEAEVKRINKELANIRSK FKGDKTLDGYQKKKYVCKLL FIFLLGHDIDFGHMEAVNLL SSNKYSEKQIGYLFISVLVN TNSDLIRLIIQSIKNDLQSR Tcas KSKEAEIKRINKELANIRSK FKGDKTLDGYQKKKYVCKLL FIFLLGHDIDFGHMEAVNLL SSNKYSEKQIGYLFISVLVN TNSELIKLIIQSIKNDLASR Pmon KSKEAEVKRINKELANIRSK FKGDKTLDGYQKKKYVCKLL FIFLLGHDIDFGHMEAVNLL SSNKYTEKQIGYLFISVLVN TNSDLIKLIVQSIKNDLGSR Smar KSKEAEIKRINKELANIRSK FKGDKTLDGYQKKKYVCKLL FIFLLGHDIDFGHMEA---- ----------GYLFISVLVN ANSDLLRLIVQSIRNDLSSR Tcal KSKEAEVKRINKELANIRSK FKGDKTLDGYQKKKYVCKLL FIFLLGHDIDFGHMEAVNLL SSNKYTEKQIGYLFISVLIS QNSDLINLINQSIKNDLSSR Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul KSKEAEIKRINKELANIRSK FKGDKTLDGYQKKKYVCKLL FIFLLGHDIDFGHMEAVNLL SSNKYTEKQIGYLFISVLVN TNSDLIRLIIQSIKNDLASR Aver NPVHVNLALQCIANIGSKDM AEAFGXDIPKLLVSGDXLDV VKQXAALCLLRXFRTDPSII PGGEWTXRIIHLLNDQHMGV VTAASSLIDALVKRNPDEYK Csin NPVHVSLDLQCIASIGSKDM AEAFGQEIPKLLVSG----V STQS---------------- -------------------- -------------------- Isca NPIHVNLALQCIANIGSREM AETFGGEIPKLLVSGDTIDV VKQSAALCLLRLLRTLPDIT PSGEWTSRIIHLLNDQHMGV VTAAVSLIDALVKKNPDEYK Eaff NPVHVSLALQCIANIGSKDM AEAFGSEIPKLLVSGDTLDV VKQSAALCLLRLFRTDPSVI PSGEWTTRIVHLLNDHHMGV VTAAASLIDALVKKNPEEYK Lcyp NPVHVNLALQCIANIGSKDM AEAFGNDIPKLLVSGDTLDV VKQSAALCLLRLFRTEPGII PGGEWTSRIIHLLNDQHMGV VTAASSLIDALVKKNPDEYK Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp NPVHVNLAMQCIANIGSKDM AEAFGQEIPRLLVSADAIDV VKQSAALG------------ -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- ---------------PDEYK Hazt NPVHVNLALQCIANIGSKEM AEAFGHDIPKLLVSGETMDV VKQSAALCLLRLFRTNPDII PGGEWTSRIIHLLNDQHLGV VTAASSLIEALVKLNPDEYK Meda NPVHVNLALQCIANIGSKDM AEAFGSEIPKLLVSGDTLDV VKQSAALCLLRLFRTDPTII PGGEWTSRIIHLLNDQHMGV VTAASSLIDALVKKNPDEYK Afos NPVHVSLALQCIANIGSKDM AEAFGVEIPKLLVSGDTLDV VKQSAALCLLRLFRTDPAVI PSGEWTTRIIHLLNDHHMGV VTAAASLIDALVKKNPDEYK Dmel NPVHVNLALQCIANIGSRDM AESFSNEIPKLLVSGDTMDV VKQSAALCLLRLFRSSPDII PGGEWTSRIIHLLNDQHMGV VTAATSLIDALVKRNPDEYK Tcas NPIHVNLALQCIANIGSREM AEAFGNEIPKLLVSGDTMDV VKQSAALCLLRLFRTSQEII PGGEWTSRIIHLLNDQHMGV VTAATSLIDALVKKNPEEYK Pmon NPVHVNLALQCIANIGSKEM ADAFGTDIPKLLVSGETMDV VKQSAALCLLRLFRTTQEII PGGEWTSRIIHLLNDQHMGV VTAACSLIEALVKKNPDEYK Smar NPIHVNLALQCIANIGSKEM AEAFGTEIPKLLISGDTIDV VKQGAALCLLRLFRTTPEII PSGEWTSRIIHLLNDQHMGV VTAATSLIDALVKKNPDEYK Tcal NPVHISLALQCIANIGSKDM AEVFAPDIPKLLVSGDTLDV VKQSAALCLLRLFRTDPSII PGGEWTSRIIHLLNDQHMGV VTAASSLIDALVKKNPDEYK Crog ---------QCIANIGSKDM AEAFSNDIPRLLVSGETLDV VKQSAALCLLRLFRTDPNII PEGEWTSRIIHLLNDQHMGV VTAATSLIDALVKKNADEYK Dpul NPIHVNLALQCIANIGSKEM AETFGTEIPKLLVSGDTMDV VKQSAALCLLRLLRTCPEVI PSGEWTSRIIHLLNDQHLGV VTAAASLIEALVKRNTDEYK Aver GCVSLAVSRLSRIXTSSYTX F------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca GCVSLAVSRLSRIVTASYTD LQDYTYYFVPAPWLSMKLLR LLQNY-PPPDDPGVRGRLNE CLETILNKAQEPPKSKKVQH SNAKNAVLFEAISLIIHMDR Eaff GCISLAVSRLSRIVTSSYTD FQDYTYYFVPAPWLSVKILR LLQNY-PPPEDPGVRARLTE CLETILNKAGEPLKSKKVQH SNAKNAVLFEAISLIIHNDS Lcyp GCVSLAVSRLSRIVTSSYTD FQDYTYYFVPAPWLSVKLLR LLQNY-PPPEDPGVRGRLNE CLETILNKAQEPPKSKKVQH SNAKNSVLFEAISLIIHNDS Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------RSVNRLR LLQNY-PPPDDPGVRGRLNE CLETILNKAQEPPKSKKVQH SNAKNAVLMEAISLIIHSDS Afra ACVGLAVSRLSRIVTSSYTD LQDYTYYFVPAPWLSVKLLR LLQNY-PPPDDPGIRGRLTE CLETILNKAQEPPKSKKVQH SNAKNAVLFEAISLIIHMDS Hazt GCVSLAVSRLSRIITASYTD LQDYTYYFVPAPWLSVKLLR LLQHY-PPPEDPGVRGRLNE CLDAILNKAQEPPKSKKVQH SNAKNAVLFEAISIIIHSDS Meda GCVSLAVSRLSRIVTSSYTD F------------------- -------------------- -------------------- -------------------- Afos GCVSLAVSRLSRIVTSSYTD FQDYTYYFVPAPWLSVKILR LLQNY-PPPEDPGVRSRLTE CLETILNKAGEPLKSKKVQH SNAKNAVLFEAISLIIHNDS Dmel GCVNLAVSRLSRIVTASYTD LQDYTYYFVPAPWLSVKLLR LLQNYNPVTEEAGVRARLNE TLETILNKAQEPPKSKKVQH SNAKNAVLFEAINLIIHSDS Tcas GCVSLAVSRLSRIVTASYTD LQDYTYYFVPAPWLSVKLLR LLQNYTPPAEDPGVRGRLNE CLETILNKAQEPPKSKKVQH SNAKNAVLFEAISLIIHNDS Pmon GCVSLAVSRLSRIVTASYTD LQDYTYYFVPAPWLSVKLLR LLQHY-PPPEDPGVRGRLNE CLDTILNKAQEPPKSKKVQH SNAKNAVLFEAISIIIHSDS Smar GCVSLAVSRLSRIVTASYTD LQDYTYYFVPAPWLSVKLLR LLQNY-PPPEDPGVRGRLTE CLETILNKAQEPPKSKKVQH SNAKNAVLFEAISLIIHMDS Tcal GCVPLAVSRLSRIVTASYQD FQDYTYYFVPAPWLSVKLLR LLQNY-AAPEDPGVRGRLNE CLETILNKAQEPPKSKKVQH SNAKNSVLFEAISLIIHNDS Crog GCVSLAVSRLSRIVTSNYQD FQDYTYYFVPAPWLSVKLLR LLQNY-PSPEDPGVRSRLNE CLDNILNKAQEPPKSKKVQH SNAKNAVLFEAISLIIHNDS Dpul GCVSLAVSRLSRIVTASYTD LQDYTYYFVPAPWLSVKLLR LLQNY-PPPEDAGVRGRLTE CLETILNKAQEPPKSKKVQH SNAKNAVLFEAISLIIHADS Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca LGAVIEPNLLVRACNQLGQF LQHRETNLRYLALESLCLLA TSEFSHEAVKKHQETV---- ------VNALKTERDVSVRQ RAVDLLYAMCDKSNAEEIVA Eaff -----EPNLLVRACNQLGQF LSHRETNLRYLALESMCILA TSEFSHEAVKKHQETV---- ------ISALKTERDVSVRQ RAVDLLYAMCDRTNSEEIVL Lcyp -----EPNLLVRACNQLGQF LSHRETNLRYLALESMCLLA TSEFSHEAVKKHQETV---- ------INALKTERDVSVRQ RAVDLLYAMCDRTNSEEIVL Lsal -------------------- -------------------- -------------------- -----------------VRQ RAVDLLYAMCDRTNAEDIVL Aamp -----EPQLLVRACNQLGQF LTHRETNLRYLALESMCLLA TSEFSHEAVKKHQETVINAL KTEVGEINALKTERDVSVRQ RAVDLLYAMCDRTNAETIVQ Afra -----DASLLVRACNQLGQF LSHRETNLRYLALESMCTLA ASEFSHEAVKKHQETV---- ------INALKTERDVSVRQ RAVDLLYAMCDKTNAEEIVQ Hazt -----EAALLVRACNQLGQF LSHRETNLRYLALETMCLLA TSEFSHEAVKKHQETV---- ------INSLKTERDVSVRQ RAVDLLYAMCDRTNAEQIVH Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -----EPNLLVRACNQLGQF LSHRETNLRYLALESMCILA TSEFSHEAVKKHQETV---- ------ISALKTERDVSVRQ RAVDLLYAMCDRTNSEEIVL Dmel -----EPNLLVRACNQLGQF LSNRETNLRYLALESMCHLA TSEFSHEEVKKHQEVV---- ------ILSMKMEKDVSVRQ MAVDLLYAMCDRGNAEEIVQ Tcas -----EANLLVRACNQLGQF LSNRETNLRYLALESMCHLA TSEFSHEAVKKHQEVV---- ------ILSMKMEKDVSVRQ QAVDLLYAMCDKSNAEEIVQ Pmon -----EPNLLVRGCNQLGQF LSHRETNLRYLALETMCLLA TSEFSHEAVKKHQETV---- ------INALKTERDVSVRQ RAVDLLYAMCDRSNAEEIVQ Smar -----EPQLLVRACNQLGQF LQHRETNLRYLALESMCVLA TSEFSHEAVKKHQETV---- ------VTALKTERDVSVRQ RAVDLLYAMCDKTNAEEIVQ Tcal -----EPNLLVRACNQLGQF LSHRETNLRYLALESMCLLA TSEFSHEAVKKHQETV---- ------INALKTERDVSVRQ RAVDLLYAMCDRSNSEDIVL Crog -----EPNLLVRACNQLGQF LIHRETNLRYLALESMCLLA TSELSHEAVKKHQDTV---- ------IKALKTERDVSVRQ RAVDLLYAMCDRTNAEDIVL Dpul -----DATLLVRGCNQLGQF LSHRETNLRYLALESLCLLA TSEFSHDSVKKHQETV---- ------INALKTERDVSVRQ RAVDLLYAMCDKSNAEEIVQ Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca EMLAYLETADYSIREEMVLK VAILAEKYASDYTWYVDVIL NLIRIAGDYVSEEVWYRVIQ IVINREDVQGYAAKTVFE-- ------------------AL Eaff EMLGYLETADYSIREEMVLK VAVLAEKYATDYKWYVDVIL NLIRLAGDYVSEEVWYRVIQ IVINRDDVQGYAAKTVFE-- ------------------AL Lcyp EMLTYLETADYSIREEMVLK VAILAEKYATDYKWYVDVIL NLIRLAGDYVSEEVWYRVIQ IVVNREDVQGYAAKTVFE-- ------------------AL Lsal EMLTYLESADYSIREEMVLK VAILAEKYATDYKWYVDVIL NLIRLAGDYVSEEVWYRVIQ IVINRDDVQGYAAKTVFEVF QIFIKLTLFPINLYSFFRAL Aamp EMLNYLESADYSIREEMVLK VAILAEKYAMDYTWYVDVIL NLIRIAGDYVSEEVWYRVIQ IVVNREDVQGYAAKTVFE-- ------------------AL Afra EMLNYLETADYSIREEMVLK VAILAEKYATDYTWYVDVIL NLIRIAGDYVSDEVWFRVIQ IVINREDVQGYAAKTVFE-- ------------------AL Hazt EMLNYLESADYSIREEMVLK VAILAEKYAGDYTWYVDVIL NLIRIAGDYVSEEVWYRVIQ IVVNREDVQGYAAKTVFE-- ------------------AL Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos EMLSYLETADYSIREEMVLK VAVLAEKYATDYKWYVDVIL NLIRLAGDYVSEEVWYRVIQ IVINRDDVQGYAAKTVFE-- ------------------AL Dmel EMLNYLETADYSIREEMVLK VAILAEKYATDYTWYVDVIL NLIRIAGDYVSEEVWYRVIQ IVINREEVQGYAAKTVFE-- ------------------AL Tcas EMLNYLETADYSIREEMVLK VAILAEKYATDYTWYVDVIL NLIRIAGDYVSEEVWYRVIQ IVINRDEVQGYAAKTVFE-- ------------------AL Pmon EMLNYLETADYSIREEMVLK VAILAEKYAQDYTWYVDVIL NLIRIAGDYVSEEVWYRVIQ IVVNREDVQGYAAKTVFE-- ------------------AL Smar EMLNYLETADYSIREEMVLK VAILAEKYATDYTWYVDVIL NLIRIAGDYVSEEVWYRVIQ IVVNREDVQGYAAKTVFE-- ------------------TL Tcal EMLTYLETADYSIREEMVLK VAILAEKYATDYKWYVDVIL NLIRLAGDYVSEEVWYRVIQ IVINRDDVQGYAAKTVFE-- ------------------AL Crog EMLTYLESADYSIREEMVLK VAILAEKYATDYKWYVDVIL NLIRLAGDYVSEEVWYRVIQ IVINRDDVQGYAAKTVFE-- ------------------AL Dpul EMLNYLETADYSIREEMVLK VAILAEKYATDYTWYVDVIL NLIRIAGDYVSDEVWFRVIQ IVINRDDVQGYAAKTVFE-- ------------------AL Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca QAPACHENMVKVAGYILGEF GNLIAGDQRSSPLIQFQLLH SKYHLCSASTRALLLTTYVK FINLFPEIKMDIQNILRSNS NIRCADSELQQRAVEYLNLS Eaff QSPACHENMVKVGGYILGEF GNLIAGDERSSPRVQLLLLH SKFHLCSSMTRALLLSTYVK FINLFPEIKQQIQDIFVADS NLRSSDVELQQRASEYLALS Lcyp QAPACHENMVKVGGYILGEF GNLIAGDQRSSPIVQFRLLH SKYHLCSLSTRALLLTTYIK FINLFPEIKAHIQTVFQMDS NLKSADAELQQRACEYLSLS Lsal QAPACHENMVKVGGYILGEF GNLIAGDERSSPMVQFRLLH SKYHLCSSSTRALLLTTYIK FINLFPEIRKEIQDVF---- -----------CASEYLALS Aamp QAPACHENMVKVGGYILGEF GNLIAGDARSAPAVQFKLLH SKYHLCSAPTRALLLSTYVK YINLFPEIKSQIQDVLHSDN NLRSADAELQQRASEYLSLS Afra QAQACHENMVKVGAYILGEF GNLIAGDQRSAPAVQFQLLH SKYHLCAPGTRALLLTTYVK FVNLFPEIKGMIQDVFKSDS NLKSSDAELQQRAAEYLQLS Hazt QAPACHENMVKVGGYILGEF GNLIAGDKRSAPQVQFQLLH SKYHLCSASTRALLLTTYIK FINLFPEIKTEIQNILKCDS NLRCSDAELQQRASEYLHLS Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos QAQACHENMVKVGGYILGEF GNLIAGDSRSSPSVQLHLLH SKYHLCSPITRALLLSTYVK FINLFPEIKQQIQDIFVADS NLKSADVELQQRASEYLALS Dmel QAPACHENMVKVGGYILGEF GNLIAGDSRSAPLVQFKLLH SKYHLCSPMTRALLLSTYIK FINLFPEIRTNIQDVFRQHS NLRSADAELQQRASEYLQLS Tcas QAPACHENMVKVGGYILGEF GNLIAGDQRSSPSVQFQLLH SKYHLCSPMTRALLLSTYIK FINLFPEIRTQVQEVFKQHS NLRSADAELQQRASEYLQLS Pmon QAPACHENMVKVGGYILGEF GNLIAGDSRSAPAVQFQLLH SKYHLCSPGTRALLLTTYIK FINLFPEIKTQIQDVLKSNS NLRSSDAELQQRASEYLHLS Smar QAPACHENMVKVGGYILGEF GNLIAGDQRSSPIVQFQLLH SKYHLCSATTRALLLSTYIK FVNLFPEIKQTIQDVLSSDN NLRSADAELQQRASEYLQLS Tcal QAPACHENMVKVGGYILGEF GNLIAGDQRSSPAVQFRLLH SKYHLCSSSTRALLLTTYVK FINLFPEIKDQIQKVLSQDS NLRNADAELQQRASEYLQLS Crog QAPACHENMVKVGGYILGEF GNLIAGDDRSSSMVQFRLLH SKYHLCSSSTRALLLTTYIK FINLFPEIRREIQGVFSVDS NLRSADAELQQRASEYLALS Dpul QAPACHENMVKVGSYVLGEF GNLIAGDQRSSPAVQFQLLH SKYHLCSANTRALLLTTYVK FVNLFPEIKHLIQDVFKADN NLRSADAELQQRASEYLQLS Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca QIASPDVLATVLEEMPPFPE RESS-ILAILKRKKPGMTEG INA------SNKENLRAAPL LAD---GAA------TNRAA PATMDLLGLSLEPAALAGQP Eaff KITSLDVLATVLEEMPPFPE KESNGILNLLKKKRPGRVPN NPG-----LLSGEE-STKEK STN---GIS------VQRDE SGSADLLGLGMENG------ Lcyp KVASLDVLATVLEEMPPFPE KEVGGLLNLLKRKRPGRVPE NAE-----LKSGAG-SEAAV VQV--KHVTNNLSLDGAANV SGSADLLGLGL--GVLD--- Lsal KITSLDVLATVLEEMPPFPE KESCGLLNLLKKKRPGRVPH NPE-----IKASGD-DTVAN NKI---------SIEPPSNG GGSADLLVLGDTSVPSAN-- Aamp VHATTDVLATVLEEMPPFPE RESS-ILAIL-KKKSGRIPD ISK----------------- -------------------- -----------TPRAANP-- Afra IVASTDVLATVLEEMPPFPE RESF-ILAILKKKKPGRMVE GEP--------KEAKAPLPV AIM---S--------QQKEP GATVDLLGLSSTPTTSNG-- Hazt LVTSTDVLVSTFSEL----- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos KITSLDVLATVLEEMPPFPE KESSGILNLLQKKRPGRVPE NAG-----ILNK---SLDKE KTT---NG------------ -------GLATTAANN---- Dmel IVASTDVLATVLEEMPSFPE RESS-ILAVLKKKKPGRVPE NEI--------RESKSPAPL TSAAQNNALVNNSHSKLNNS NANTDLLGLSTPPSNNI--- Tcas IIASSDVLATVLEEMPAFPE RESS-ILAVLKKKKPGRVPE NEI--------KENKSPTPV TNH---NND------VNNSS AVSGDLLGLSTPPTAQP--- Pmon VITTTDVLATVLEEMPPFTE KESS-ILAVL-KKKSGRMSA QEAQREARVQAREG-NAAPA VEK---TQT------AQMNN STSADLLGLSTPPANQ---- Smar SIASTDVLATVLEEMPPFPE RESS-ILAILKKKKPGRVSE SDV--------KEHKMPVIN SAH---GDH---VESATPSS VTSADLLGLSTPPSLPP--- Tcal NVTSLDVLATVLEEMPPFPE KESSGLLNLLKKKRPGRVPE NPE-----IKSGEE-GGSSK PQA---IISGGIPPPSAGNG GASADLLGLGFDGGNGD--- Crog KVTSLDVLATVLEEMPPFPE KESCGLLNLLKKKRPGRVPH NPE-----IKSEDD-GSSAT GKQ---SDV---SAPPPSTT NGSADLLGLGDTTTTSSVTG Dpul IVASTDVLATVLEEMPPFPE RESS-ILAILKKKKPGRVAE PGTAGNDSATPKERKSPALN SMG---NHS------THNTS NQSTDLLGLTSPSG------ Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- NGS-GTVTNNIQKFYCKNNG VLYENDIIQIGVKTECRSNL ARLALFYGNKTNHPFMNFKP Isca APTNGTTACLVDVFEDSSSG --------IQGGTAVV---- ----VSNEEGLKKFVCKHNG ILFENDLLQIGVKAEFRQNL GRVGLFYGNKTVSQFQSFLP Eaff -------------------- ------------TSNG---- VES-EEVTNNILKFYCKSNG VLYENSLIQIGVKTECRSNL ARLALFYGNKTNLPFMNFQP Lcyp SSAANGTA------------ ------------KSNG---- INGFDTPVHNLSKFYCKNNG VLYEDTIIQIGVKTECRSNL ARLALFYGNKTGSPFHNFQP Lsal TVAVNGND--LDLGG----- -------------------- ----DSPTDNIKK------- -------------------- -------------------- Aamp HASEHPASPAGGDYGAAA-- -------------------- AAV-HDQQAAVKKFICKNNG VLFENDILQIGIKSEYRLNL GRVGIFFGNKTPMALTGFST Afra PTTSNGAASLVDVFGDQPAA --------PTPP-------- IST-ADTTDNYKKFLFKNNG VLFENDLVQIGVKSEFRQSL GRMGLYIGNKTNQALSNFTS Hazt -------------------- -------------------- -------------FV----- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos SAAAALDEGLINIGGDSGPT --------TNGYGAEN---- GGE-NAVTNNIQKFFCKNNG VLFENSYIQIGVKTECRSNL ARLALFYGNKTNLPFLNFVS Dmel GSGSNSNSTLIDVLGDMYGS --------NS---------- NNN-SSAVYNTKKFLFKNNG VLFENEMLQIGVKSEFRQNL GRLGLFYGNKTQVPLTNFNP Tcas --NSGNTGVLLDVLGDIYGG --------KQANNSNS---- ATQ-PVNMYNPKKFVCKNNG VLFESDLIQIGVKSEFRQNL GRLGLFYGNKTNVPLQNFVP Pmon NNTQSNTGVLVDVLGDLYGG GGSGGGSNTNTHNGTAAPAP AST-SGATDNIKKFVCKNNG VLYENDIIQIGIKSEFRQNL GRIGIFYGNKTSMPLQAFCP Smar TKPLSNTDMLVDVFGDPYGP --------ATN-NVAN---- NGT-SAVEDHLKKFVCKNNG VLFENELLQIGVKAEFRQNL GRIALFYGNKTSVTFSGFSA Tcal AGGSSSSM------------ ------------NGNG---- ISA-DQPTDNLKKFYCKNNG ILYENEIVQIGVKTECKANL ARLALFYGNKTSTPFINFQP Crog TAATNGSSSLNG-------- -------------------- LSD-SAPTDNIKKFYCKNNG VLYESDVIQIGVKTECRSNL ARIALFYGNKTSFPFLNFQP Dpul SSASPNPAPLVDMLADVFSS --------ASPPSVNNG--F GSS-FQPIDNLKKFACKNNG VLFENDLLQIGVKSEFRQNL GRIALYFGNKTSFALQGFSS Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin DVS----ASPALSMAILLQV KQVDSTVEAGAQFQQMVNVE CVSDFDEQPDLNLTFFYNGA PQSVSIKLPISINKFIEPTE MNGEAFFSRWKNLSLPAQE- Isca NVT----SD---SAALSIQV KPVEPAIEAGAQVEQMVNVE CVNDFPEAPGLVVQFVYCGV QQKFTLRLPVFLNKFLEPTA MNSESFFSRWKNLSSPGQE- Eaff HVS----CSPVLATQILLQV KDVDSTVEAGAQFQQMLNIE CITDFTEQPDLNLSFTYNGE RQTVNCKLPMSVNKFIEPTE MNAEAFFTRWKNLSIPSQE- Lcyp IVT----CSPELQPCVSLQV KTVDSVVEAGAQFQQMVNVE CISDFTQQPDLNLSFVCNGE AHKVPLKVPISLNKFMEPTE MNADAFFARWKNLSTPSQE- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp SVT----LPDGLTNRLTVQA KPVDDNIDGGAQVQQTVNFE LIEEYVGMPDLSVSFMYSGV QQKLHLKLPVTPNKFIEPTE MNSEAFFARWKNLSGPAQE- Afra SVD----AGVDNISKLVIQV KPIDSTIEAGAQVQQLINVE CLEEISEFPSLTVMFTYNGI QQKFNLKLPLSLNKFFEPTE MTGEIFFARWKNLNSPQQE- Hazt -------------------- -------------------- -------------------- ---------LSLN------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos RVS----CSPELSTQIMLQV KDVESTIEAGAQFQQMVNIE CVTDFYDQPDLAITFTYNGE LQTVNAKLPLSVNKFIEPAE MNA----------------- Dmel VLQ----WSAEDALKLNVQM KVVEPTLEAGAQIQQLLTAE CIEDYADAPTIEISFRYNGT QQKFSIKLPLSVNKFFEPTE MNAESFFARWKNLSGEQQR- Tcas TLS----WPDDQASKLTIQM KPVEPVLEAGAQIQQMINAE CVDDYTGAPSIVLSFLYLNV PQKITIKLPLTINKFFEPTE MNGESFFARWKNLGSTNQQR Pmon SVS----VGLAQQGKVTVQV KPVEPTIDAGAQVQQLVNCE CVEDFTGLPDLIVSFTYANV PQRLALHLPLSINKFFEPTD MNGESFFARWKNLSAPSQE- Smar DVILICLFSLMDSAQLNMQV KPADTTIEAGAQVQQYINAE CIEDFSELPLMNVQFTYNNL PQQLSLKLPITINKFFEPTE MNSESFFARWKNLSSANQE- Tcal IVT----CSPELATALVLQV KTVDSTVEAGAQFQQMVNLE CVADFTSQPDLNVSFMNSGL PYKVSCKIPISINKFMEATE MNGDSFFSRWKNLSMPQQE- Crog IVT----SSPELQNYISLQV KSVDSTVEAGAQFQQMVNVE CLSDFTSQPDISLTFTCNGS PHQVSLKLPIAINKFMEPTE MNDEAFFSRWKNLSIPSQE- Dpul SVG----TPGDLATKLILQV KPVDVNVDAGAQIQQLVNVE CVDEFLEYPTLTILFLYNGV QQRLSLKLPLTINKFFEPTE MNSEAFFTRWKNLSGSNQE- Aver -------------------- -------------------- -------------------- -------------------- ----------SGSQALKALK Csin SQKIFKAAHPMENSDATKTK LIGYGFQLLENIDPNPDNYV CAGIIHTRSLQIGCLLRLEP NKQAQMYRLTTRSSVEAVSQ HITNVLCET----------- Isca EQKIFKARFPMENES-IRSK LSGFGMQLLDGIDPNPENFV CAGIIHTRGMQIGSLLRLEP NRQAQMYRLTIRSSKDGVSK VLADLLQEHF---------- Eaff AQKIFKAKFPMEATDAAKTK LIGYGFQLLENIDPNHENYV CAGIIHTRTLQIGVLLRLEP NMQAQMYRLTVRSSKDTVSQ HIVNILGDVF---------- Lcyp AQKIFKAHNAMDSTQ-VKTK LIGYGFSLLENIDPNPENYV CAGIIHTRSLQIGCLLRLEP NSQAQMYRLTVRASKNSVSQ HICDVLTEQFSGSQCIKALK Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp AQKIFKAKLPMDAS--LGGR LAGFGMQLLEGVDPNPENFV CAGILHGRGVQVGSLLRLEP NKQAQMYR------------ -------------------- Afra CQKIFKANYPIDTAA-SRAK LSGFGIQLLDGIDPNPDNFV GAGIIHTKTQQVGCLLRLEP NKQAQMYRLTIRSSKSTCAQ IMSNLLLDQF---------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- ----------SGSQALKALK Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel SQKVFKAAQPLDLPG-ARNK LMGFGMQLLDQVDPNPDNMV CAGIIHTQSQQVGCLMRLEP NKQAQMFRLTVRASKETVTR EICDLLTDQFSGSQAIKAMR Tcas SQKIFRATQQMDLQA-ARTK IMGFGMQLLDGIDPNPDNFV CAGIIHMRSQQVGCLLRLEP NKSAQMYRLTVRSSKESVSI EICDLLADQFSGSQAIKALR Pmon AQKIFKCSGAMETAA-IKTK LLGFGMQLLEDIDPNPENFV CAAIIHTRTQQIGCLLRLEP NRQAQMYRLTIRASKESTSG ILAELLAEQF---------- Smar VQRIFKAVQPMDSEM-AKAK LLGFGIQLLEGVDPNPDNFV CAGIIHMRSTQIGCLLRLEP NRQAQMYRLTIRTSKESISK ELSELLGNQFSGSQAIKALR Tcal SQKIFKGSLPMDPTQ-TKTK LIGYGFSLLENVDPNPENFV CAGIVHTRSLQIGCLLRLEP NSQAHMYRLTVRSSKDSVAQ HMCEVLADQF---------- Crog MQNVFKANYPMDNTQ-VKTK LIGYGFSLLENIDPNPENFV CAGIVHTRFVQIGCLLRLEP NNLANMYRLTVRTSKDTVSQ HICAVLTEQFA--------- Dpul AQKIFQATQPIDASH-IRTK LIGTGMKLLDGIDPNPENYV SAGIIHTRTQQIGCLLRLEP NRQAQMYRLTIRSSKDSVAK LICDLLCDQFSGSQAIKALK Aver EEGIATILINPNIATVQTTV GMADKIYSLPINPEYVEQVL ESERPDGVLLTFGGQTALNC GVELERRGVFRKYKVRILGT PVQSIIDSEDRKIFAERVAE Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff -------------------- -------------------- -------------------- -------------------- -------------------- Lcyp EENIETILINPNIATVQTMD NFADHVYFLPVTPERVLEVI EKERPDSIIVTFGGQTALNV GVALHDSGKLKEHNVRVLGT Q------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda EEGITTVLINPNIATVQTTV GMADKIYSLPINPEYVEQVI ESERPDGVLLSFGGQTGLNC GVELERKGVFRKFGVRILGT PVQSIIDSEDRKIFAERVAE Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel ESNIQTVLINPNIATVQTSK GMADKCYFLPLTPHYVEQVI KSERPNGVLLTFGGQTALNC GVQLERAGVFSKYNVRILGT PIQSIIETEDRKLFAERVNE Tcas EENIQTVLINPNIATVQTSK GLADKVYFLPLVPDYVEQVI RVERPGGVLLTFGGQTGLNC GVELQKAGIFDKYNIQILGT PIQAIIDTEDRKIFTERIAA Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar EEKIQTVLINPNIATVQTSK GLADTVYFLPITEHYVEEVI KSERPDGILLTFGGQTALNC GLKLNESKILSKYHVQVLGT PISSIQNSEDRKVFSSIMAE Tcal -------------------- -------------------- -------------------- -------------------- -------------------- Crog -------------------- --------LPI--------- -------------------- -------------------- -------------------- Dpul EEGIHSILINPNIATVQTSK GMADKVYFLPITPHYVKQVI RQERPEGILLTFGGQTALNC GIELNKSGILEKYGVKVLGT PIQSIIDSEDRKLFAEKVAE Aver IGEEVAPSEIVDNMEDALRS SERLGYPVLVRAAFALGGLG SGFADNADELRALAKKA--F AHSSQVIIDKSLKGWKEIEY EVVRDRFDNCIT-------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff -------------------- -------------------- -------------------- -------------------- -------------------- Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda IGEEVAPSVIVENMEDALRS SEHLGYPVLVRAAFALGGLG SGFADDPDELRALAKKA--F AHSSQVIIDKSLKGWKEIEY EVVRDRFDNCIT-------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel IGEQVAPSEAVYSVAQALDA ASRLGYPVMARAAFSLGGLG SGFANNEEELQSLAQQA--L AHSSQLIVDKSLKGWKEVEY EVVRDAYNNCITVCNMENFD Tcas IGEKVAPSMAAHSVEEALEA AEQLGYPVMARAAFSLGGLG SGFANSKDELKTLAVQA--L AHSSQLIIDKSLKGWKEVEY EVVRDAFDNCITVCNMENVD Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar IGEKVAPSASVSDDEHAIAV AEELGYPVLVRADFALGGLG SGFANNKEELLTILRQA--F IHSNQVLVDKSLKGWKEVEY EVVRDAYDNCITVCNMENVD Tcal -------------------- -------------------- -------------------- -------------------- -------------------- Crog -------------------S AKELGYPVLARAAYALGGLG SGFANNEEELRKLTPSS--F AHSSQVILDKSLKGWKEIEY EVVRDAYDNCITVCNMENLD Dpul VGERVAPSAAAYSFEEALDA AEKLGYPVLARAAYTLGGLG SGFADNPEQLRSLAQSA--F AHSNQLIIDKSLKGWKEVEY EVVRDAFNNCVTVCNMENVD Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff -------------------- -------------------- -------------------- -------------------- -------------------- Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel PLGIHTGESIVVAPSQTLSD REYQMLRSTALKVIRHFGV- VGECNIQYALCPHSEQYYII EVNARLSRSSALASKATGYP LAYVAAKLALGLPLPDIKNS Tcas PLGIHTGESIVVAPSQTLSN REYNMLRTTAIKVIRHFGV- IGECNIQYAVNPNSEEFYII EVNARLSRSSALASKATGYP LAYIAAKLALGVPLPEINNS Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar PLGIHTGESIVVAPSQTLTN SEYNLLRTTAIKVVRHLKI- VGECNIQYALSPDSQLYYII EVNARLSRSSALASKATGYP LAYIAAKLALGYSLPNLKNS Tcal -------------------- -------------------- -------------------- -------------------- -------------------- Crog PLGIHTGXSIVVAPSQTLTD REYNFLRTTAIKVIRHLRS- -------------------- -------------------- -------------------- Dpul PLGIHTGESIVVAPSQTLTN REYNMLRTTAIKVVRHLGV- VGECNIQYALNPNSQEYYII EVNARLSRSSALASKATGYP LAYIAAKLALGIPLPVLRNS Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff -------------------- -------------------- -------------------- -------------------- -------------------- Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel VTGNTTACFEPSLDYCVVKI PRWDLAKFVRVSKHIGSSMK SVGEVMAIGRNFEEAFQKAL RMVDSDVLGFDPDVVPLNKE QLAEQLSEPTDRRPFVIAAA Tcas VTGVTTACFEPSLDYCVVKI PRWDLHKFSRVSTKIGSSMK SVGEVMAIGRKFEEAFQKAL RMVDENVMGFDPYL----KD VNDEELKEPTDKRMFVVAAA Pmon -------------------- -------------------- -------------------- -------------------- -------------MLVLAAA Smar VTNSTTACFEPSLDYCVVKI PRWDFGKFSHVSTQLGSSMK SVGEVMAIGRTFEETLQKAF RMADESLSGFNSTV----KG VSEEELIYPTDKRMLVLAAA Tcal -------------------- -------------------- -------------------- -------------------- -------------------- Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul VTESTTACFEPSMDYCVVKI PRWDLSKFMRVSAKIGSSMK SVGEVMAVGRRFEEAFQKAM RMVDENVLGFDPNL----NT VSDDELECPTDKRMFVLAAA Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff -------------------- ---MKNIINCYNTLEK---- -----------SSVTVSEKD MLTAKQLGFCDLQIAQLVGS TDTAIRALRIDMGIMPWVKQ Lcyp -------------------- -------------------- -------------------- -------------------- ------------------KQ Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel LQLGMSLRELHQLTNIDYWF LEKLERII-LLQSLLTR--- -----------NGSRTDAAL LLKAKRFGFSDKQIAKYIKS TELAVRHQRQEFGIRPHVKQ Tcas LKKGYSVDRLYDLTKIDRWF LEKMKKIVDWTTFLETI--- -----------DQLHLSHDI LLKAKQIGFSDKQIATAVKS TELAIRKQREEFGIKPYVKQ Pmon LKKGWDVEQLYNLTKIDKWF LYKMKNITDMYDKLESL--- -----------VDEELTEAV LQRAKQLGFSDKQIGNAVQC TDLAVRALREKHNIMPTVKQ Smar FRAGFTVEKLYSLTKIDPWF LNKMRNIILCELELEALEPK LKDAATNVQEAMNEILTREV LLKAKQLGFSDKQIADCVNT TESVVCEARKAQDVKPFVKQ Tcal -------------------- -------------------- -------------------- -------------------- -------------------- Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul LKKGYTVDRLYELTKIDRWF LVKMQNIIGCYNNLESQ--- -----------SEKELTSQL LLEAKRMGFSDKQIASCIGS TELAIRSKREEYAITPFVKQ Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- XTTHDMEFNSFEHVMVIGSG VYRIGSSVEFDWCAVRYIQE LRRLGYKTIMVNYNPETVST DYDMCDRLYFDEITYEVVMD Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff IDTVAAEWPATTNYLYLTYN GSTHDIEFNVEEHIMVLGSG VYRIGSSVEFDWCAVRSIQE LRRLGKKTIMLNYNPETVST DYDMCSRLYFDEISFEVVMD Lcyp IDTVAAEWPAATNYLYLTYN GGEHDVDFEPLSHIMVIGSG VYRIGSSVEFDWCAVSCIKE LRRLGRKTIMLNYNPETVST DYDMCDRLYFDQICFETVMD Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel IDTVAGEWPASTNYLYHTYN GSEHDVDFP-GGHTIVVGSG VYRIGSSVEFDWCAVGCLRE LRKLQRPTIMINYNPETVST DYDMCDRLYFEEISFEVVMD Tcas IDTVAAEWPATTNYLYLTYN AFEHDLTFE-EKHTMVIGSG VYRIGSSVEFDWCAVGCLRE LRRLGRKTIMINYNPETVST DYDMSDRLYFEEISFEVVMD Pmon VDTVSAEWPAATNYLYLTYN GNTHDLAFP-PGATLVIGSG VYRIGSSVEFDWCAVQCLRT LRKLGHRTIMVNYNPETVST DYDMCDRLYFDEVSFEVVMD Smar IDTVAAEWPAVTNYLYMTYN ASSHDLSFS-GDHVMVLGSG VYRIGSSVEFDWCAVGCIRE LRKLGKKTIMVNCNPETVST DYDMCDRLYFDEISFERVMD Tcal -------------------- ----DVEFSTQPHTMVIGSG VYRIGSSVEFDWCAVGCIRE LRRLGKKTIMVNYNPETVST DYDMCDRLYFDEISFEVVMD Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul IDTVAAEWPAHTNYLYLTYN GNAHDLTFP-GGYTMVIGSG VYRIGSSVEFDWCAVGCLRE LRNLGRKTVMINYNPETVST DYDMCDRLYFEEITFEVVMD Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin IYEMESPYGVIPSMGGQLPN NIAMDLYRSKVKVLGTSPES IDNAENRFXFSRMLDRIGVK QPRWKELTSMDTAKQFCNEV G------------------- Isca -----------MAQGSSLPS QT------------------ ---------FFLVL------ --------PLQNIKSFCEEV GYPCLVRPSYVLSGAAMNVA Eaff VYQLETPEGVILSMGGQLPN NIAMDLYRSNVKVLGTSPES IDNAENRFKFSRMLDRIGIK QPKWKELTNLESAKEFCDEV GYPCLVRPSYVLSGAAMNVA Lcyp IYELEGPEGVILSMGGQLPN NIALSLYLQHVRVLGTLPDM IDSAENRFKFSRLLDNLKVM QPRWKELQDLQSAKAFCQHV GYPCLVRPSYVLSGAAMNVA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel IYEMENSEGIILSMGGQLPN NIAMDLHRQQAKVLGTSPES IDCAENRFKFSRMLDRKGIL QPRWKELTNLQSAIEFCEEV GYPCLVRPSYVLSGAAMNVA Tcas IYNIEDPVGIILSMGGQLPN NIAIDLHRQQARILGTSPDS IDGAENRFKFSRMLDRIGIM QPRWKELTNLKSAIEFCEEV GYPCLVRPSYVLSGAAMNVA Pmon IYNLENPKGVILSMGGQLPN NIALDLHRQKARILGTSPES IDGAENRFKFSRMLDRIGIS QPQWKELTNLKSAQAFCEEV GFPCLVRPSYVLSGAAMNVA Smar IYELENPLGVILSMGGQLPN NIAMLLHMRNVRILGTSADS IDGAENRFKFSRMLDEKKIS QPQWKVLTNLESANEFCNTV GYPCLVRPSYVLSGAAMNVA Tcal IYQLEHPEGVILSVGGQLPN NIAMSLYRQKVNVLGTSPES IDNAENRYKFSRLLDTIEIK QPRWKELKDFHSARDFCQQV GFPCLVRPSYVLSGAAMNVA Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul IYNMEAPEGVILSMGGQLPN NIAMELHRQRAKILGTLPES IDCAENRFKFSRMLDRIGIL QPRWKELTNLKLAIEFCEDV GFPCLVRPSYVLSGAAMNVA Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca YSHRDLEGYLSEASAV--SK EHPVVISKFICEAKEIDVDA VAKDGVVVAMAVSEHVENAG VHSGDATLVTPAQDLNPETL TKIRAICQAIGQALLVSGPY Eaff DCHQDLERYLKQASDV--SK EHPVVISKFILDAKEIDVDA VACDGEVICMAVSEHVENAG VHSGDATLVTPPGDVNSETL AQIKQITSAIAKALVVSGPF Lcyp HNEKDLEHYLSAAEAVHLSN EHPVVISKFIMDAKEIDVDA VACDGVIYCMAVSEHVENAG VHSGDATLVTPPFDLNEETL DKIEQITRKIAKGLHVRGPF Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel YSNQDLETYLNAASEV--SR EHPVVISKFLTEAKEIDVDA VASDGRILCMAVSEHVENAG VHSGDATLVTPPQDLNAETL EAIKRITCDLASVLDVTGPF Tcas HSNQDLETYLNAASDV--SK EHPVVISKFILESKEIDVDA VACDGVILCMAVSEHVENAG VHSGDATLVTPPQDINDETL GKITQICKAIAASLEVTGPF Pmon HSPQDLETYLNQAAAV--SK EHPVVISKFILEAKEIDVDA VAADGELVCMAVSEHVENAG VHSGDATLVTPPQDLNSETL AKITSICAAIARALEVNGPF Smar YSDCDLKSYLSEATAV--SP KQPIVISKFILEAKEIDVDA VAKEGKVLCMAVCEHVENAG VHSGDATLILPPQDLNAETL EMISDICQKISESLCVTGPF Tcal HNVQDLETYLNEATAVRLSK EHPVVISKFITDAKEIDVDA VARKGEIICMAVSEHVENAG VHSGDATLVTP--------- -KIKDITYKIAQALFVSGPF Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul HSPQDLETYLSKASAI--SK EYPVVISKFILEAKEIDVDA VAQDGQLLCMAVSEHVENAG VHSGDATLVTPPQDLNNETL SKIQNICRAIAMSLEVSGPF Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca NMQLIAKDNQLKVIECNLRV SRSFPFVSKTLNCDFVALAT QVILG-LPIEPIEVTFGCG- KVGVKVPQFSYSRLAGADIR LGVEMASTGEVACFGENRYE Eaff NMQLIAKENKLKVIECNLRV SRSFPFVSKTLGHDFIATAT QIIIG-QRVEPIDVMFGEG- KVGVKVPVFSFSRLSGADIK LGVEMSSTGEVACFGEDRYE Lcyp NMQLIAKDNQLKVIECNVRV SRSFPFVSKTLDFDFIAIAT QVIVGGELPKPVGMLRGNGT KIGVKVPQFSFSRLAGADAT LGVEMSSTGEVACFGKHPEE Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- XGVEMASTGEVACFGENRHE Afra -------------------- -------------------- --MLG-EKVEPVNVLSGCG- RIGVKVPQFSFSRLQGADVT LGVEMASTGEVACFGDNRYE Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel NMQLIAKNNELKVIECNVRV SRSFPFVSKTLDHDFVATAT RAIVG-LDVEPLDVLHGVG- KVGVKVPQFSFSRLAGADVQ LGVEMASTGEVACFGDNRYE Tcas NMQLIAKDNDLKVIECNVRV SRSFPFVSKTLDHDFVAMAT RVMVG-ELVQPVDVLSGCG- KVGVKVPQFSFSRLAGADFM LGVEMASTGEVACFGDNRYE Pmon NMQLIAKDNHLKVIETNLRV SRSFPFVSKTLDFDFVACAT KVIVG-EKVAATDVLRGCG- RVGVKVPQFSFSRLAGADVM LGVEMASTGEVACFGENRYE Smar NLQLIAKDNQLSVIECNLRV SRSFPFVSKVLDCDFVAIAT RAIIG-LGDISCNI-DRMN- KVGVKVPQFSFSRLIGADVT LGVEMASTGEVACFGENRYE Tcal NMQLIAKDNELKVIECNLRV SRSFPFVSKTLGYDFIATAT NVIVG-NTPEPIDVLHGIG- KVGVKVPQFSFSRLAGADVT LGVEMSSTGEVACFGEGRFE Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul NMQLIAKDNELQVIECNLRV SRSFPFVSKTLEHDFIAMAT KVIVG-QRVDPVDVLRGCD- KVGVKVPQFSFSRLAGADVM LGVEMASTGEVACFGENRYE Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca AYLKALVSTGFCIPKKNIFL SIGSYKHKAEFLPSVRTLEK MGYKLYGSLGTSDFYMEHGI KIEAMTWPFHDAGEEGNANS SNVSSDGQSCSIADFLEQKG Eaff AYLKAMIGTGFTMPKKTILL SVGSYKHKVEMMASVEALHE MGYKLYGSSGTSDYYREHGV PVETVEWLFESIGDETD--- -IDKMAGQMVSMADYLSNKH Lcyp AYLKAIMSTGFIIPKDTILL SVGSYKHKREMLDSVRLLSQ MGYQLYGSMGTSDYYLEHGI QVQGVDWMFGDVGADGPD-- -IRPMADQMVSMSDFLSSGR Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp AYLKAMLSTGFRMPRKGILL SIGTFKHKSEFLSSAKILHQ LNYKLFASIGTADFYTEHGI PVETVEWAYENIAEQGA--- ----------------TDKE Afra AYLKGILSTGLVLPRKNILL SIGSYKHKDEFLPSAITLAE LGFNLYGSIGTADYYSNMGL KIESVDWAFENLGE------ --NGSSGQLKSLSDYIASKH Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel AYLKAMMSTGFQIPKNAVLL SIGSFKHKMELLPSIRDLAK MGYKLYASMGTGDFYAEHGV NVESVQWTFDKTTP------ --DDINGELRHLAEFLANKQ Tcas AYLKAMMSTGFSVPEKSILL SIGSFKHKMELLPSMRVLQK MGYKLYASLGTADFYNEHGV KVESVQWTFENIDA------ --ITSQGELKHLAEFLSKKQ Pmon AYLKSMISTGFVIPQRSILL SIGSYKHKNELLPAVRTLAQ MGYKLYASLGTADYYSTHGI QIEPVEWAYENIGE------ --TPTKGQLSSMADYLARKE Smar AYLKAMMSTGFRIPKKNILL SIGSYNQKRELTASVRSLEK MGYQLYGSRGTADFYSSYDI KINELS-TFANIDA------ -----KMDLSDIADSLAKME Tcal AYLKAMMSTGFKIPQSNILL SVGSYKHKVEILPSIRLLHE LDYKLYGSLGTSDYFREHGI PVEPIEWMYENLGDDIK--- -INSMAGQMVSMADYLSNKH Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul AYLKALMSTGMAIPKNSILL SVGSYKHKNEMLPSVRTLEK LGYKLYASLGTADFYNDHGI TVESIEWAYDDIGE------ --ITSKGQLNNMADFLAHKQ Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca FDLVVNLPMCSSGARRISTV L-----TQGYRTRRMAVDYA VPLVTD---------ALRLV RK-APPVKTHIDCMTSRKIV RLPGLIDVHVHLREPGASHK Eaff FDLVINLPMRNTGARRVSSF VP----TYGYKTRRMAVDYG VPLITDVKCAKLLVEAIQKT KG-KLTCK-FVDCITAKKIV RLPGLIDTHVHMREPGATHK Lcyp FDLVINLPMRTGGARRVSSF GLP---TNG----------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp LN-----------ARRVSSF Q-----TQGYRTRRMAVDYG VCLVTDVKCAKLLVEALHRL GGKSPVINTGIDCISSRRIV RLPGMIDVHVHLRDPGQTHK Afra FDLVINLPRRTAGSSRVSSF TSGYQRSRGYITRRMAVDLA VPLVTDIKCAKLLVEALRLV GG-NPPLKPHVDCITSRRLI RLPGLIDVHVHVREPGATHK Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel FDLVINLPMSGGGARRVSSF M-----THGYRTRRLAVDYS IPLVTDVKCTKLLVESMRMN GG-KPPMKTHTDCMTSRRIV KLPGFIDVHVHLREPGATHK Tcas FDLVINLPMRNGGARRVSSF M-----THGYRTRRLAIDYS IPLVTDVKCTKLLVEALRRI GT-APPMKTHTDCMSSRRLV KLPGLIDTHVHVREPGATHK Pmon FDLVINLPMRGGGARRVSSF M-----TQGYRTRRMAVDFS VPLVTDVKCAKLLVEALRLI GG-APDLKTHVDCVTSRRIV KLPGLIDIHVHVREPGATHK Smar FDLVINLSMQSSGSRRVSSI M-----TSGYKTRRMAVDYS IPLITDIKCAKLLIEALRLI GSKPPQVQTHIDSICSRRII RLPGLIDMHVHLREPGATHK Tcal FDMVINLPMRTCGAGRVSSF IP----TYGYRTRRMAIDYS VPLITDVKCAKLLIESIGKL KKQSPKLKTHIDCISSSRIV RLPGLIDPHVHLRDPGATHK Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul LDLVINLPMRHGGARRVSSF S-----THGYRTRRMAVDYA VPLITDIKCAKLLVEALRLV GK-APKMKPHVDCMTSRRLV RIPGLIDVHVHLREPGGTHK Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca ENFASGTAAALAGGFTLVCA MPNTKPPLCDGTALALCQQV AKAGARCDYALFAGASPTNA EEVLSLASSVVGLKMYLNDT FGPLCMDSVSDWLEHFEKWP Eaff EDFSSGTAAALAGGVTMVCA MPNTIPPVTDETVFNLCQKL ASEKAYCDYALMVGATSTNY ACIPKLASQASGLKMYLNRT FTDLMMESTTDWLHHFQHWP Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp EDFASGTAAALAGGVTMVMA MPNTKPAIIDRDSFQMAK-- -------------------- -------------------- -------------------- Afra EDYSTATAAALAGGVTLICA MPNTNPAITDKMALMTVKEA ATRGARCDYGLYLGATEENY ADAPALAPSVIGMKMYLNET FTTLKMDNMAAWMKHFENWP Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- ----------------ANWP Dmel EDFASGTAAALAGGVTLVCA MPNTNPSIVDRETFTQFQEL AKAGARCDYALYVGASDDNW AQVNELASHACGLKMYLNDT FGTLKLSDMTSWQRHLSHWP Tcas EDYASCTAAALAGGVTMICA MPNTNPAVTNQETLTLVENL ARKNARCDYAIYMGASSDNY SAIPELAPQVAGLKMYLNET FTTLRLNDLNTWTKHLANWP Pmon EDWASCTAAALAGGVTLICA MPNTQPPVTDLDTLTLSKEL ASRGARCDYAIFMGASNDNY STAPELAPRSAALKMYLNET YTTLKLDDTTVWLKHLESWP Smar EDFASGTAAALAGGITLVGV MPNTNPAVTDRESLDIMKEC AAKGARCDYAIIAGATTTNS MIISELSSEVIGLKMYLNDT FSTLKMNNVSALVQHFEHWP Tcal EDFATGTAAALAGGVTMMLV MPNTSPSIVDAETLTMAKDI ARQKAHCDYALNIGASASNA KLIAPLAKQVGALKMYLNET FTTLRLDNMTDWMTHFEHWP Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul EDFSSGTAAALSGGVTMVLA MPNTQPTITDKAALHLIKDL AKKGARCDYGIFMGASATNF EEIIELSSHVVGLKMYLNET FTTLKLDGIQQWLKHFENWP Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca KNVPLCCHAEGRTTAAVILL ASLYRRPVHICHVAREEEIL IIKRAKEQGHEVTCEVTPHH LFLTTEDVSAAAPGKGAVKP PLVTARDQKALWDNIDVIDC Eaff RNAPICVHAEGRTVAAVILM ASLFDRPLHICHVSSKDEIE IVKAAKIKGLPITCEVCPHH LFLTEQEIHELGDNMSDVRP RVGRQEDQEALWENMDYIDS Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -----------XXMAAAMMV AALANRPIHICHVAKKEEIL LIKAAKQRGFPVTCEVSPHH LFLTSSELGRLG-AMGQVKP PLMVEDDQRALWDNMAVIDC Afra KDLPICAHAEKSNTAAVILF ASLYQRSVHICHVARKEEIE VIKMAKLKGIQVTCEVAPHH LFLSENDLGSLD-SKGEVRP RLATLEDQQALWNNLEFIDC Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos KSAPLCVHAEGRTTAAIILL ANLHDRPVHICHVARREEIE IIKAAKLKGIPVTCEVAPHH LFLTEDDKISLGAKKSEVRP VLVTKDDQQALWDNMDYIDS Dmel KRSPIVCHAERQSTAAVIML AHLLDRSVHICHVARKEEIQ LIRSAKEKGVKVTCEVCPHH LFLSTKDVERLGHGMSEVRP LLCSPEDQEALWENIDYIDV Tcas KKAPICVHAEGQTTAAVILM ASLQNRPIHICHVARKEEIL IIKAAKEKGLNITCEVCPHH LFLSTEDVKTLGVCKSQVRP VLMSPEDQQALWDNLHVIDC Pmon AHIPVCVHAEARTMAAALMT ASLASRPIHICHVARKEEIL LIRAAKAKGMQVTCEVCPHH LFLTCDNLEQLG-QKGEVRP CLVTSEDQQALWDNLDIIDC Smar KTLPILCHAEGMTLASVVGL LSLYVRPVHICHVAKKEEID IIKQAKKMGLPISCEVCPHH LFLTEGDIADLGVCKSQVRP MIGTEEDRKALWENLNIIDC Tcal LTSPICVHAEGRSTAAAILL ASLYDRPLHICHVARKDEIE IIKAAKLKGLAITCEVCPHH LFLTEEHAKAMG-NAGQVRP NLVTKEDQNALWENLEFIDC Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul KGVPICVHAEGRTTAAVILL ASLNNRSVHVCHVATRDEIE IIKAAKKKGLPVTCEVCPHH LFLNSNDLPAFG-TKGEVRP RLASPEDQQALWDNLNIIDC Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca IATDHAPHTLEEKMDENAPP GFPGLETALPLMLTAVAEGK LTMEALVKKMYHNPKQIFNL PVQPDTYIEVDLDEEWTIPE APPYSKAQWTPFAGRKVRGQ Eaff IVTDHAPHTLEEKKSSVDSP GFSGLETMLPLMLTAVNEGK ITLQELEEKMYHSPRRIFGL PEQPDTYIEIDMDHEWTIPD KLTHSKAGWTPFAGRKVKGI Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp FATDHAPHTVAEKRSEKPPP GFPG---------------- -------------------- -------------------- -------------------- Afra FATDHAPHTLQEKTSDNPPP GFPGLETMLPLLLDAVSKGR LTVEDIVTRLHDNPRRIFNL PEQPSTWVEVDLDEEWIIPS SPAQSKCMWTPFAGRTVKGS Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos FATDHAPHLIAEKLSDKAPP GFPGLETMLPLMLTAVNDGR LTLEDLEDKMYHNPRRIFNL PEQPDTYIEVDMDKSWIIPE KTQFSKS------------- Dmel FATDHAPHTLAEKRSERPPP GFPGVETILPLLLQAVHEGR LTMEDIKRKFHRNPKIIFNL PDQAQTYVEVDLDEEWTITG NEMKSKSGWTPFEGTKVKGR Tcas FATDHAPHTLEEKTSSSPPP GFPGLETILPLLLNAVNENK LTIDDIVTKFYRNPKKIFNL PDQPNTYVEIDLDEEWTIPE ATTYSKAKWTPFAGRKVKGA Pmon FATDHAPHTLEEKTGGKAPP GFPGLETMLPLLLTAVTQGR LSMEDLINKLHHNPRRIFQL PRQPRTHIEIDLDAQWTIPE ALPFSKSQWTPFAGMKVTGR Smar FATDHAPHVLAEKLGDNPPP GYPGLETMLPLLLTAVVEGR LTLEEIEAKLHHNPKKIFKL PDQNNTYIEVDLDEEWVVGD KTSFTKAGWTPFTGHKLQGK Tcal FATDHAPHTLEEKNSEQSPP GFPGLETMLPLMLTAVNLGR MTLNDLKQKMHDNAKRIFNL PTQSDTYIEVNMDEAWTIPE ETTFSKAKWTPFAGMPVIGR Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul FATDHAPHTLEEKMSDNSPP GYPGLETMLPLLLTAVNKGQ LSLQDVVNKCHHNPKRIFKL PDQSNTYVEIDLEEDWVLPD ANVFSKAKWSPFAGRKVKGA Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca VRRVVVRGEVAFVDGQVLVE PGYGQD-------------V MTVPAQTELERTSSLVNLSA V------------------- -------------------- Eaff VRRVILRGEVAFVDGKVLVE PGYGQD-------------V KTWSSTNQVQFKTLPAVKKS SLMDAEIAPNRIRA------ -------------------- Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra VKRVILRGEVAYVDGNVVAA PGSG---------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel VHRVVLRGEVAFVDGQVLVQ PGFGQN-------------V RPK--QSPLASEASQDLLPS -------------------- -------------------- Tcas VHRVVLRGEVAFVDGQILVQ PGFGQN-------------V RTWDKKTFDEVIAPPTVTTG EY------------------ -------------------- Pmon VQRVVLRGEVAYVDGQVLLS PGFGED-------------V REA--QPLTTASSSVTGGPP V------FPSPLCAHPSTIT LPPHSQHTPAEPVLATPTTV Smar VRRVVLNGEVAYVDGQVLAK PGYGKD-------------V CKQG-EFKKSNLRRPIMHTG G------------------- -------------------- Tcal LKRVVLRGKLAFVDGQVLID PGFGED-------------V RTW--KQKLTTLTALAKDPV -------------------- -------------------- Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul VKRVVLRGEVVYIDGSIIAQ PGFGQDQLTMFLAVKHLAMV KTI--ELGIPKIRSLSVGPT -------------------- -------------------- Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------K MYNKMFQELGLPEHLQ---- MPSVSED------------- ----AKLLPRCPSP--LVP- ---PVGKWSLPEVPHALQGC Eaff ------------EGERHESD ITCERQRKESGHQGIR---S TSPIFDGLEHPHYEPYKRYH GSPTKTDRPDKAEPEMLPSN FLIPIGL-PIQESSLSLAGK Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel --------------DNDAND TFTRLLTSEGPGGGVHGIST KVHFVDGANFLR-------P NSPSPRIRLDSASN--TTLR EYLQRTT-NSNPVAHSLMGK Tcas -------------NDGQTNE IFKKLLSGGG---KVHFSAT NELHVDS------------- -----RLGVTSPTP--VGPR IRTGSFS-QMEQMHHSLANK Pmon TPSLSSPSRKVGQSLHQTSE LYSEMLMELGVGDSAE---- -----------R-------K GRSTARLKTRDASP--ARPT PSIPSGL-PGITTSHGLQGQ Smar -------------MEKQTNE LYQEMLKTLGVSKTIK--EP CAPERDG------------- -------------------- ----VNEWLARLSTLGLKGK Tcal --------------GPRSNS SLTNTSIKNA---------N MAPIVETKPSPR-------P SPQT------------LQKK LSIPVGI-PMIRTHHDLQNR Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul --------------LPTLRI SHPQQTDSSSTGRPVS---P VSRSFDS-SILS-------P PHQSKGISARPVSP--AASQ MATSSFSGSAALPHHGLQGQ Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca HVLSADMFSKDQMHAMFNLA HAFSLFVNKDRPLDHVLRGK VMASVFYEVSTRTSCSFAAA MQRLGGTVIHMAESSSSTQK GESLEDSIAVMAGYSDVVVL Eaff HIIKAGMFKKEQLNAIFDLA FTFHTCVVNERPIDHILKGK VMASVFYEVSTRTACSFSAA MQRLGGKVIYSDETSSSSKK GETIEDSVQVLSSYTDVVIM Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------YTDVVVL Dmel HILAVDMFNKDHLNDIFNLA QLLKLRGTKDRPVDELLPGK IMASVFYEVSTRTQCSFAAA MLRLGGRVISMDNITSSVKK GESLEDSIKVVSSYADVVVL Tcas HILSVDMFTKDQLNDIFNLA QTFRVNVSKERAVDHILKGK VMASIFYEVSTRTSCSFAAA MQRLGGGVIYMDETSSSVKK GETLEDSVAVMAGYADVVVL Pmon HVLSVQGLSKDQLNHIFNLA QTFRVCINKERPLEHILKGK LLALMFYEVSTRTFCSFQAA IQRLGGRTVTMDTNTSSVKK GETLEDSVIMMSGYADVVVL Smar NVLSVDMFNKEQLNVLFQFA HYLRHPLPRDKPVDSILKGK LMSLVFYEASTRTHHSFASA MHRLGGSFYCLDSMSSSIQK GESLEDTIRMVTNNCDVIVL Tcal HVLESTMFDKDTLYSIFNLA ETFRSCVALDQSIDHILKGK VMASMFYEASTRTSLSFSAA MQRLGGRVIQMDVSTSSVKK GESLEDSVQVMAGYSDVVVI Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul CILTVDMFSKEQLNAIFNLA QTFRLCVQKERSLDHILKGK IMASVFYEVSTRTSCSFSAA MQRLGGRVIYMDESSSSAKK GETLEDSITVMASYSDVVVL Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca RHPQPGAVMRAAKHCRKPVI NAGDGVGEHPTQALLDIYTI REEIGTVNGLTVTLVGDLKH GRTVHSLARLLTHYD-VQLR YVAPKNLGMPDSVKELVASR Eaff RHPATGTVERVSHVCKRPVI NAGDGVGEHPTQALLDVYTI REEIGTVNGLTITMVGDLKH GRTVHSLAKVLTKYN-VSLR YVSPAHLKMPEDVQQFVKSQ Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp ----XXAAGRAAEVSPRPVI NAGSGTGEHPTQALLDVFTI REEIGTVNGLTITMVGDLKN GRTVHSLARLLTLYK-VHLK YVCPPGLEMPQEVVDFVAAQ Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos RHPVPGAVSRAAQFCKRPVI NAGDGVGEHPTQALLDVYTI REEIGTVNGLTITMVGDLLN GRTVHSLAKLLTMYN-VRIR YVSPRNLQMPDDVKQYVAKK Dmel RHPSPGAVARAATFSRKPLI NAGDGVGEHPTQALLDIFTI REEFGTVNGLTITMVGDLKN GRTVHSLARLLTLYN-VNLQ YVAPNSLQMPDEVVQFVHQR Tcas RHPTPGSVMRASHHCRKPLI NAGDGVGEHPSQALLDIFTI REEIGTVNGLTITLVGDLKN GRTVHSLARLLTLYN-VQLR YVSPPSLKMPSHITSFVASK Pmon RHPEPGAVARAAAVSRRPVI NAGDGVGEHPTQALLDVFAI REEIGTVNGLIITMVGDLKH GRTVHSLARLLTLYN-VQLR YVAPPGLGMPDYVTQYAASQ Smar RHPQKGSAKKAAPFASVPVI NGGDGIGEHPTQALLDVFTI REEIGTVNNLTITLVGDLKN GRTVHSLAHLLTLYN-VVLR YVAAPTLGMPENVKAMISAR Tcal RHPEPGAVDRAAKVCLKPVI NAGDGVGEHPTQALLDVFTI RSEIGTVKNLTVTMIGDLKH GRTVHSLARILTLYEGVQLR YVSPKGLGMPKNVRDYVQAA Crog -------------------- ---SDLGEHPTQALLDLFTI RNEIGTIKGLTITMIGDLKH GRTVHSLARILTLYSGVTLH YCSPLNLRMPQEIRDFVSSH Dpul RHPEPGAVGRAAARSSRPLI NAGDGTGEHPTQALLDVFTI REEIGTVNGLTITMVGDLKH GRTVHSLARLLTLYN-VHLR YVSPANLGMPNEVMDYIGSK Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca GIPQEEIASLEAALPDTDVL YMTRIQKERFSSAEEYEKAC GLFVVTPQLMTRAKKRMIVM HPLPRVFEISPEF-DTDPRA AYFRQAEAGMYVRMALLAMV Eaff GIQQVEYTDMDEAIADADVL YMTRIQKERFECTKDYEDAL GQFVLTPAHMTKAKKKMAVL HPLPRNFELSPEV-DIDPRA AYFRQAENGMYVRMALLAMV Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp GVKQTHCTSLEEALPDSDVI YMTRVQRERFADTAEYERCA GRLVLTPQLMTLAGPRTVVL HPLPRVDEVSTEL-DGDPRA AYFRQAEYGMYVRMALLTTV Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos GIQQDEFESLEDALPETDVL YMTRIQKERFQSQAEYKTSI GQYVLNPHLMTKAKKRMAVL HPL----------------- -------------------- Dmel GVKQLFARDLKNVLPDTDVL YMTRIQRERFDNVEDYEKCC GHLVLTPEHMMRAKKRSIVL HPLPRLNEISREI-DSDPRA AYFRQAEYGMYIRMALLAMV Tcas GIPQNEHSTLEEVLPDTDVL YMTRIQRERFSSQEEYDKAC GHFIVTPQLMTRAKRKMVVL HPLPRVFEISPEF-DTDPRA AYFRQAECGMYVRMALLAMV Pmon GIHQEEFSSLEAALPDTDVL YMTRIQKERFGTPEDYERAC GHFIVTPHLMTRAKRKMIVL HPLPRNQEISPEF-DTDPRA AYFRQAEGGMYVRMALLAMV Smar GIKQEESDSLETAIVDTDVL YMTRIQKERFATEEEYKQAC GHFVITPKLMAKAKSKMIVM HPLPRLTEISPIVCIVIPEL RYFRQAENGLYVRMALLATI Tcal GVPQTDFPSLEKAIQDTDVL YVTRIQKERFESESEYEIAC QNYIVNDKTMHHAKEKMAVL HPLPRVFEISPEF-DNDTRA AYFRQAENGLYVRMALLAMV Crog GIIQKDFNTMEEAIVDTDVL YVTRIQKERFQNEADYQKAC ENYLVCPKSMSHAKEK---- -------------------- -------------------- Dpul GIPQTNFSSLEDALPETDVL YMTRIQRERFATQQEYDMAC GHFVVTPHLMRLAKRRMVVM HPLPRVFEISPDF-DSDPRA AYFRQAEAGMYVRMAILAMV Aver -------------------- -------------------S RIASLLHRKSAKQCKARWFE WLDPSIKKTEWSRQEDEKLL HLAKLMPTQWRTIAPIVGRT Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca LGRV----MPRIMIKGGVWR NTEDEILKAAVMKYGKNQWS RIASLLHRKSAKQCKARWYE WLDPSIKKTEWAREEEEKLL HLAKLMPTQWRTIAPIIGRT Eaff LGKC----MPRVMIKGGVWR NTEDEIMKAAVMKYGKNQWS RIASLLHRKSAKQCKARWFE WLDPSIKKTEWGKEEDEKLL HLAKLMPTQWRTIAPIVGRT Lcyp --------MPRVMIKGGVWR NTEDEILKAAVMKYGKNQWS RIASLLHRKSAKQCKARWFE WLDPSIKKTEWSRQEDEKLL HLAKLMPTQWRTIAPIVGRT Lsal --------MPRVMIKGGVWR NTEDEILKAAVMKYGKNQWS RIASLLHRKSAKQCKARWFE WLDPSIKKTEWSREEDEKLL HLAKLMPTQWRTIAPIVGRT Aamp LGRA---------------- -------------------- -------------------- -------------------- -------------------- Afra --------MGRVMIKGGIWR NTEDEILKAAVMKYGKNQWS RIASLLHRKSAKQCKARWYE WLDPSIKKTEWSREEDEKLL HLAKIMPTQWRTIAPIVGRT Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------S RIASLLHRKSAKQCKARWFE WLDPSIKKTEWSRQEDEKLL HLAKLMPTQWRTIAPIVGRT Afos --------MPRVMIKGGVWR NTEDEILKAAVMKYGKNQWS RIASLLHRKSAKQCKARWFE WLDPSIKKTEWSKEEDEKLL HLAKLMPTQWRTIAPIVGRT Dmel VGGRNTALMPRIMIKGGVWR NTEDEILKAAVMKYGKNQWS RIASLLHRKSAKQCKARWYE WLDPSIKKTEWSREEDEKLL HLAKLMPTQWRTIAPIIGRT Tcas LGKC----MPRIMIKGGVWR NTEDEILKAAVMKYGKNQWS RIASLLHRKSAKQCKARWFE WLDPSIKKTEWSREEDEKLL HLAKLMPTQWRTIAPIIGRT Pmon LGKC---------------- -------------------- -------------------- -------------------- -------------------- Smar LSR-----MPRIMIKGGVWR NTEDEILKAAVMKYGKNQWS RIASLLHRKSAKQ-----YE WLDPSIKKTEWTREEEEKLL HLAKLMPTQWRTIAPIIGRT Tcal LGKC----MPRVMIKGGVWR NTEDEILKAAVMKYGKNQWS RIASLIHRKSAKQCKARWFE WLDPSIKKTEWSRDEDEKLL HLAKLMPTQWRTIAPIVGRT Crog --------MPRVMIKGGVWR NTEDEILKAAVMKYGKNQWS RIASLLHRKSAKQCKARWFE WLDPSIKKTEWSREEDEKLL HLAKLMPTQWRTIAPIVGRT Dpul LGKC----MPRIMIKGGVWR NTEDEILKAAVMKYGKNQWS RIASLLHRKSAKQCKARWYE WLDPSIKKTEWSREEDEKLL HLAKLMPTQWRTIAPIVGRT Aver AAQCLERYEYLLDQAQKKEE GEDA------A-AQVDDPRK LKPGEIDPNPETKPARPDPV -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca AAQCLEHYEYLLDQAQKKEE DGEI----------LDDPRK LKPGEIDPNPETKPARPDPK DMDEDELEMLSEARARLANT QGKKAKRKAREKQLEEARRL Eaff AAQCLERYEHLLDMAQKKEE GTDP----------ADDPRK LKPGEIDPNPESKPARPDPK DMDEDELEMLSEARARLANT QGKKAKRKAREKQLEEARRL Lcyp AAQCLERYEYLLDQAQKKEE GDDA------SLSQADDPRK LKPGEIDPNPETKPARPDPV DMDEDELEMLSEARARLANT QGKKAKRKAREKQLEEARRL Lsal ASQCLERYESLLDRAQAKES GDTT-----SSSAPPGERNK LKPGEIDPNPETKPARPDPR DMDEDELEMLSEAR------ -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra AAQCLERYNYLLDQAQEKEE GEKP----------VDDPRK LRPGEIDPNPETKPARPDPQ DMDEDELEMLSEARARLANT QGKKAKRKAREKQLEEARRL Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda AAQCLERYEYLLDQAQKKEE GDDG--------XPTEDPRK LKPGEIDPNPETKPARPDPV -------------------- -------------------- Afos AAQCLERYEHLLDMAQKKEE GGEL----------ADDPRK LKPGEIDPNPESKPARPDPK DMDEDELEMLSEARARLANT QGKKAKRKAREKQLEEARRL Dmel AAQCLERYEYLLDQAQRKED GEDT----------MDDPRK LKPGEIDPNPETKPARPDPK DMDEDELEMLSEARARLANT QGKKAKRKAREKQLEEARRL Tcas AAQCLERYEYLLDQAQKKEE GEDV----------TDDPRK LKPGEIDPNPETKPARPDPK DMDEDELEMLSEARARLANT QGKKAKRKAREKQLEEARRL Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar AAQCLEHYEFLLDQAQKKEE GDEI----------GDDPRK LKPGEIDPNPETKPARPDPK DMDEDELEMLSEARARLANT QGKKAKRKAREKQLEEARRL Tcal AAQCLERYEYLLDQAQKKEE QGGAAAD-EAAAAAHEDPRK LKPGEIDPNPETKPARPDPQ DMDEDELEMLSEARARLANT QGKKAKRKAREKQLEEARRL Crog ASQCLERYESLLDRAQAKDA GGGGGGDLSSSASSLGERNK LKPGEIDPNPETKPARPDPR DMDEDELEMLSEARARLANT QGKKAKRKAREKQLEEARRL Dpul AAQCLERYEYLLDQAQRKED GEEP----------GDDPRK LRPGEIDPNPETKPARPDPK DMDEDELEMLSEARARLANT QGKKAKRKAREKQLEEARRL Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca AALQKRRELRMAGISLP--- -PR--RRKRHAIDYNKEIPF EKRPAPGLHDTSDEVY--DP TETD-FRRLRQQHLEGELRS EKEERERRKDKQKLKQRKEN Eaff AALQKRRELRAAGIKTR--- -LKYGTRRNRPIDYNNEIPF EKKPSQGFYDTASEVY--DK NDPD-FKRLRMDQMDLKRRD EAENKERNKDKKVMKQRKEN Lcyp ATLQKKRELRAAGIRVR--- -MF--YVKKGKMDYNSEIPF EKKPAIGFYDTSQDAY--ET PSQN-FRHLRQHQMDEKRRD EEEQRERKKDKQKLKDRKEN Lsal -------------------- -----YIKKGRMDYNAEVPF EKRPAIGFYDTAKEIQQEET DALDMSKGLRQHQLELKRRD EEENKLRKKDKEK---RKEN Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra ASLQKRRELRAAGIEIA--- -KR--RSKKRFIDYNAEIPL EKKPLPGFYDTSEEQY--DR LAPN-FKRLRQQDMDGELRS QKEEAERIKDKKK-KKENGD Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos AALQKRRELRAAGIQTR--- -LKYGTRRNRVIDYNKEIPF EKRPAAGFYDTASEVY--DK NDPD-FKRLRMDQMDLKRRD EEENRERQKDKKILKNRKEN Dmel ATLQKRRELRAAGIGSG--- -NR---KRIKGIDYNAEIPF EKRPAHGFYDTSEEHL--QK NEPD-FNKMRQQDLDGELRS EKEERERKRDKQKLKQRKEN Tcas AALQKRRELRAAGIEVN--- -SR--RKKKRGVDYNEEIPF EKRPAIGFYDTSTEIV--DP MAPD-FHKMRQQHLDGELRS EQEERERRKDKQKLKQRKEN Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar AALQKRRELRAAGIMLH--- -PR--RKRKRGVDYNDEVPF QKKPAPGFYDTSAEIY--EP LGPD-FRSLRQQNLDGELRS EREERERKKDKQKMKKRKEN Tcal AALQKRRELRAAGIGGR--- -RLI-RVKKGKINYNVEIPF EKKPAAGFYDTANEEV--DE SAGR-FRRVRQDQLDEKRRD EDEMKNRKKDKDKLKQRKEN Crog AALQKRRELRAAGVKVK--- -LR--YIKKGRMDYNAEVPF EKRPAIGFYDTASEIQEEEK HSLDLSRGLRQHQLELKRRD EEENRLRKKDK---RKGGEN Dpul AALQKRRELRAAGMGVRRGA LSH--NRRKRGVDYNAEIPF EKQPAIGFHNTAEEQF--DP FAPN-FHRLRQQQLEGELRS VKEDRERKKDKDRLKQRKEN Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca DLPPALLSGSSEPARKRSKL VLPEPQISESELEQVVKLGK ASETAREAAEESG------H KASEPLLADYSL-TPGGAGP LRTPKGPSLSRDTILMEAQN Eaff DIPQELLN-NDEPARKRSKL VLPSPQISDIEMEQIVKLGR HSEAARDAVIDGD-----SN RASDTLLSDYSV-TPGAA-- LRTPRTPMV-QDKILQEAQN Lcyp EIPSQLLN-NEEPAKKRSKL VLPEPQITDAEMEQIVKLGK ASEAARESVTSTSDNDSGAT RASDTLLADYSV-TPGSA-- MRTPRTPMPQQDKVLQEAQN Lsal EIPKAIFE-DDEPDRKRSKL VLPEPQISDTDMEQIVKLGR ASEAAKESV----------- -SSDALLADYNV-TPGPSLA SRTPRTPMPQGDKVLQEAQN Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra QIPAALLK-GEEPLKKRSKL VLPEPQISETELEAVVKLGK ASEAAQQLALADG------G RPSDALLGDYNLTSPGTA-- LRTPRTPAPATDRIMQEAHN Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos EIPQELLN-DEEPARKRSKL VLPSPQISDIEMEQIVKLGR HSEAARDSVVDGD-----SA KASDTLLADYSV-TPGAN-- LRTPRTPMA-QDKILQEAQN Dmel EVPTAMLQ-NMEPERKRSKL VLPTPQISDMELQQVVKLGR ASEMAKEIAGESG------I ETTDALLADYSI-TPQVA-- -ATPRTPAPYTDRIMQEAQN Tcas DIPQAMLQ-NQEPAKKRSKL VLPEPQISDLELQQVVKLGK ASEVAREVAAESG------I ESTDTLFNDYTVAAPQAA-- AVTPRTPAPQTDRILQEAQN Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar DIPLALIQGNAEPVRKRSKL VLPAPQISDQELEQVVKLGK ASEAAKEAAEDNG------N KASEALLSDYKM-TPSMAN- LRTPRIPAA-QDKILQEAQN Tcal SIPQALLN-NEEPAKKRSKL VLPEPQISDMEMEQIVKLGK ASEAAREAVASSE---GDSQ RASDTLLADYAV-TPGSA-- LRTPRTPMPQQDKILTEAQN Crog GAPKAVFM-EDEPERKRSKL VLPEPQISDMD--------- -------------------- -------------------- -------------------- Dpul EVPSALLQ-GDQPAAKRSKL VLPEPQISDRDLEQVVKLGR ASEAAQDAARETG------Q RVSDTLLADYSL-TQV---- NRTPRTPAPAMDKILQEAQN Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca IMALTNVDTPLKGGLNTPLH E--TEIGVATPKKAGTMTPN NLIVTPFRTPGGTLEGTTPR GG--RTPGSIP-------GS TPLSSAT------P-LRDKL Eaff IMALQNTDTPLKGGLNTPLH NEGGDFSSMTPSREIVATPN TVLTTPYRTRDGQ-VGLTPG ----QTPGRTP-------GA TPTPGAT------P-IRDKL Lcyp IMALTNVDTPLKGGYNNELV GNGANFGGVTPQPQAIQTPN TILATPFRTKEGQ-VGL--- -----TPRMMT--------P GSSTAGT------P-LRDKL Lsal IMALTNVDTPLKGGV----- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra LAALTNVETPLKGGANAPVV D--TDFSGITPRRDVIATPN TVLGTPISVREGM------- -----TPGSRP--------Q GPAVGVT------P-LRDRL Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos IMALQNTDTPLKGGMNTPLH NDGGDFSGVTPQRDAVATPN TVLTTPYRTKEGQ-VGLTPS ----QTPGKTP--------V GGGMTPT------P-IRDKL Dmel MMALTHTETPLKGGLNTPLH E--SDFSGVLPKAASIATPN TVIATPFRTQREG-GAATPG GF--QTPSSGALV-----PV KGAGGATGVVNTPAYVRDKL Tcas VMALTHVDTPLKGGRNTPLH N--SDFSGVLPQALTIATPN TVLATPFGAQ---------- -----TPGFMT-------PQ GPQGSFT------PSVRDKL Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar IMALTHVDTPLKGGLNTPLH E--SDFGGVTPRPQITQTPN TVFNTPFRTPKGQ-ESLTPA ----RTPVLTPAR----VIG EQTPGAT------P-LRDML Tcal IMALTNVDTPLKGGLNPQLH ENGGDFSSVTPQHAPIKTPN TVLTTPFRTKEGQ-IGL--- -----TPGRTP--------V NAAMGVT------P-IRDKL Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul LMALTHVETPLMGGANAPLV N--PDFSGATPSKEGVATPN TLLSTPFRTPGGA-AGSATP GMLSITSGATP-------RT GTLPGAT------PLVRDKL Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca NINPEDHLD--FDTNQSAKQ FQKQTKQHLLKALSSLPAPK NDYEIVVPEDDPSLLE---- ---SASQEHMVEDQADMDSA KEHERLEKLEAERKLQSLAV Eaff AINPDESVE-GFDGG---NL SRRENTAELKMGLSSLPTPK NDYEIVVPEDGDDAVEM--- ---QDDDNTYIEDQSDVDKR AAEIARLAREAALAKRSSAV Lcyp AINPNEGLE----SDLSNKF QQKEVRETLKMGLSSLPAPK NDFEIVVPETDEDEGEA--- QGPDDSSLTWTVDQSEANQK IAQEFRRQREAELKRRSQAV Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra SINPEEEMAIALADPKRAAQ FQK---ERLRELFTSLPTPR NLIQLEVPEEEADEGK---- ---LARDKITIEDQEEIDAR REAEIRSKYEAEWRKRSKVI Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos AINSEDYVE--FDGS---SL NRSEFSAELKMGLSSLPAPK NDYEIVVPEDAEDTVEM--- ---ADDKNTYIEDQADVDKR AEENARKAREEALAKRSSAV Dmel SINPEESMG-VTETPAHYKN YQKQLKSTLRDGLSTLPAPR NDYEIVVPEQEESERI---- ---ETNSEPAVEDQADVDAR LLAEQEARRKRELEKRSQVI Tcas NINEENTEM-VAQTPAEQRS LQNNLKEQLRLGLSSLPTPK NDYEIVVPEQEEEEKE---- ---EEKTPNIVEDQADVDAR ALEEAKIRAAQELALRSQVI Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar NINPEEGFG--FDEVQGNKQ FQKESREQLRRELSSLPQPV NDYEIVIPDDDPSLEND--- ---QQMEEESAEDAAELDAQ REAEIKAHMEREMKLRSQSV Tcal AINPNEGLE-SAD-----RF HQKQLRESLQQGLSSLPQPK NDFEIVVPENEEDTDV---- ---TEDDHTWVEDQAELDQQ TEEEYRKRREQELKRRSQAV Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul NINPEEPTE-VM-------- -QRTLKEQLKRGLSTLPAPK NDYEIVVPEEEMDTESGTPG EGELAGTYISVEDQADIDAR IEAERKKQREAELKRRSQAL Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca QRDLPRPLDVNASVLRPAH- TEPPLTDLQRAEELIKQEML VMQHYDALHHPTAHQRPGGG PR----------KGAPMDEA QHLAYLDRHPYRKYSREDLQ Eaff KRNMPRPLEMNHAVLRPLN- SDPPLTDLQRAEEMIKREML VMMHYDALETPALNQQGNAG KK---------GERGIVGEA VHRGYLDRHPYREYEQEDLQ Lcyp QRDLPRPLDMNHTILRPLN- VDPPLTELQKAEELIKREMI VMLHHDCLESPTAQQMSEAS AGKKRSSMSCLDERSIVNET QHRSYLDKHPYQKFSTEEID Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra QRNLPRPNDINTNILRPQG- QEAT-NPLQRAEELIKREML TMEYYDAIKNPTESQ----- ---------------SISQS AAVQYLERNPYDNFSDKDLQ Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos KRDLPRPLEMNHTTLRSLN- SDPPLSDFQRAEELIKREML VMMHKDALETPTLAQQGMGG KK---------GERGIVGED AHRAYLERHPYREFQKEEIE Dmel QRSLPRPTEVNTKILRPQS- EKQNLTEQQQAEELIKHEMI TMQLYDSVKDPVPGQ----- ------------SQHKL--E QLQSYFKANPYEDISQQELA Tcas QRGLPRPHDVNLAVLRPNH- ESHSLTELQKAEELIKCEMV TMLQFDNLKNPNQVK----- -------------RSALAQA QQLAFLEQHPYDDFKSDDLK Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar QRNLPRPLDVNSNVLRPTN- VDPPLTDLQKAEELIKAEML IMLHYDTVNNPSSSQMGMTI TSEK------IESTGIVNQA QHVAYLEQHQYERFTESELE Tcal QRDLPRPLDMNETILRPLN- SDPPLTALQKAEELIKREMV VMMHHDCVETPTAAQMGEGG NKKK------GLDRAIVNEQ LHRGYLEKHPYQKFSDEDLV Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul QRSLPRPHEVNNAILRPANS SDASLSDLQKAEELIKKEML TMMHYDSIRNPVNLSTEKGG GL----------SRKII--E TSQNFLSNNSYQEFEDKDID Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca AAEEVLKAEMEVVRRGMGHG DLSLEAYSQVWDECLAQVLF LPAQNRYTRANLASKKDRIE SLDKRLEQNRGHMTREAKKA AKVEKKLRVLLGGYQAIPIA Eaff QAKVLLEREMEIVKTGMQHG DLSLDAYTQVWEECLAQVLY LPSQQRYTRANLASKKDRIE SLEKRLDTNRTHMTKEAKRA AKVEKKLKILTGGYQSRAAG Lcyp NAKQLLEKEIKVVKESMGHG DLSQEAYAQVWEECLAQVLF LPSQGRYTRANLAGKKDRIE SLEKRLEQNRAHMKKEAKRA VKIEEKLKILTRGYQARASA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra AAEELLAAEMEIVKNGMNHG DLSQDAYNQVWEECLAQVLY LPNQGRYTRASLVSRKDRVD ALEKRLENNRNHMANEAKRA GKLEKKLRILTAGYQGRVTT Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos EAKRMLQVEMDVVKVGMQHG DLSLDAYTQVWEECLSQVLY MPSQQRYFRANLASKKERIE SMEKRLDCNRQHMTKEAKKA AKIEKKLKILTGGYQSRAAG Dmel KAKQMLTEEMEVVKERMAHG ELPLDVYAQVWQECLGQVLY LPSQHRYTRANLASKKDRLE SAEKRLETNRRHMAKEAKRC GKIEKKLKILTGGYQARAQV Tcas LAKQLLKREMEIVKYGMGHG ELPLEAYTQVWEECLGQVLF VPNLNKYTRANLVSKKERLE SAEKRLEQNRSHMAREAKKA AKMEKKLKILTGGYQSRAQA Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar VAKEMLKSEMEVVKQGMGHG DLSLDAYSQVWEECLSQVLF MPSQNRYTRANLASKKDRIE SLDKRLEQNRLHMTREAKRA AKMEKRLRILCGGYQSRAQV Tcal QAKALLEQEMTVVKEGMNHG DVSLEAYTQVWEECLAQVLY LPNQQRYTRANLANKKDRID SFKERLEQNRTHMTKEAKRA AKIEKKLKVLTGGYQARAQG Crog -------------------- -------------------- -------------------- -------------------- -------------------- Dpul QAKELLKVEMEKVKAGMGHG DLTMEAYTQVWDECLSQVLF VPSQNRYTRASLASKKDRLE SSSRHLETNRAHMAREAKKA AKLEKKLRTLTAGYQSRAQA Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca LIKQIQELAEQIEQTHLELK TFQALQEHESLAIPKRVEAL TEDVNRQVEREKALQKRYND LLQQKELVEEALVDVQS--- ----------------M--- Eaff LIKQLTDAADQLEQSRLELS TFKQLKISETVAIPRRLETI TEDVNLQRTRERELQSKYRD MVFKLEEAKQGRLVTET--- --PQERL---MEVEA-M--- Lcyp LTKQIQDLNEQIEQAQLELS TFSFLKDRETEAIPKRLHSL MEDVARQVEREKHLQNMFSQ ASLEIRDQVPEQQTSAS--- ----------------M--- Lsal -------------------- -------------------- -------------------- -------------------- ----------------M-SS Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra LAKQFEELVQQYDSATLEVD AFSRLRLNESEAIPRRLQVL EDDVEKQKQREKDLQSEYDS LVRELEELKGPELPA----- ----------------M--- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos LIKQLTDAAEQLEQSRLELD TFKQLKLSEEVAIPRRMDII TADVDKQKEREKDLQSHYRD SLFKLEEAKQGRFSEDT-RG --------GDMEIAND---- Dmel LIKQLQDTYGQIEQNSVSLS TFRFLGEQEAIAVPRRLESL QEDVRRQMDREKELQQKYAS LVEERDSLYSQIEHITGVRP -TAQQLL---PDQEA-M--- Tcas LIKQLADYYDQIDQANLELN TFKFLQEQEKAALPRRIQSL TEDVNRQMEREKGLQGRYGE LQGQIKELQSELEKLQQ--- --EIEVARGEQEGEAEM--- Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar LIKQVQDTHEQIEQTQLELR TFEYLRDHEIMAIPKRIETL TENVNRQMERENSLQKRYDE LMKQQEEFKHNSISTQQIRT FH--------------M--- Tcal LIKQIHDLEDQIEQSRLDLS TFTFLKDQESMAIPRRLESI SEDVSRQTERESELQKRFQE AQYQIQQLQPQPY------- ----------------M--- Crog -------------------- -------------------- -------------------- -------------------- ----------------MSSA Dpul LHKQTQDLIDQVEAARIELD TYSFLKKHEDAAIPSRLEKI RQDVLVQTERERELQKRFQL LQDKCFEASLAAP------- ----------------M--- Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca ----TQMLPIRFQEHLQLTN IGINAANVGFNTLTMESDKF ICVREKVGDA-AQVVIVDMA NPTSPIRRPISADSAIMNPA SRVIALK------ASRTLQI Eaff -----AILPIKFQEHLQLTN VGITAANIGFQSLTMESDKF ICVREKVGDT-SQVVIIDMS DSSNPIRRPISADSAIMNPV SKVIALK------AQKTLQI Lcyp ----AQSLPIKFQEHLQLTN VGINAANVGFNSLTMESDKF ICVREKVGET-NQVVIIDLA DPTNPIRRPISADSAIMNPA SKVMALK------AQKTLQI Lsal SGASNALLPIKFQEHLQLTN VGINSSNVTFASLTMESDKY ICVREKVGDT-NQVVIIDMA DPSN-------ADSAIMNPA SKVIALK------AQKTLQI Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra ----AQILPIKFQEHLQLTN AGIQPANIGFANLTMESDKF ICVREKVGEAGNQVVIIDMA DPTNPIRRPIAADSAIMNPK SKVIALK------AQKTLQI Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel ----TQPLPIRFQEHLQLTN VGINANSFSFSTLTMESDKF ICVREKVNDT-AQVVIIDMN DATNPTRRPISADSAIMNPA SKVIALK------AQKTLQI Tcas ---TQQLLPIKFQEHLQLTN VGINVANISFATLTMESDKF ICVREKVGDT-SQVVIIDMG DTANPIRRPITAESAIMNPA SKVIALKGKAGVEAQKTLQI Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar ----AQILPIRFQEHLQLTN VGIGAANIGFSTLTMESDKF ICVREKVGDS-SQVVIIDMN DATNPIRRPISADSAIMNPA -------------TQKTLQI Tcal ----TQILPIKFQEHLQLTN VGINATNVGFNSLTMESDKF ICVREKVGET-NQVVILDMA DPTNPIRRPISADSAIMNPA SKVIALK------AQKTLQI Crog GGANSALLPIKFQEHLQLTN VGINPNNVTFASLTMESDKY ICVREKVGET-NQVVIIDMA DPSNPTRRPITADSAIMNPA SKVIALK------AQKTLQI Dpul ----AQMLPIRFQEHLQLTS IGINAANIGFSTLTMESDKF ICVREKVGET-AQVVIIDLH DPTNPIRRPISADSAIMNPA SKVIALK------AGRTLQI Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca FNIEMKSKVKAHTMTEDVVF WKWINVNTIALVTEGAVYHW SMEGDSQPQKMFDRHSSLSG CQIINYRTDAKIQWLLLIGI SAQQNRVVGAMQLYSMERKV Eaff FNIEMKTKIKSFSMQDDVIF WKWISEKMIALVTETVVYHW SMDGDAQPVKMFERHSSLSG CQIINYRCDAAANWLLLIGI SAQQNRVVGAMQLYSVERKV Lcyp FNIEMKSKMKAHVMQEDVTF WKWINLNTIALVTETSVYHW SMEGESTPQKVFDRHASLAG CQIINYRCDPSQNWLLLIGI SAQQNRVVGAMQLYSVERKV Lsal FNIEMKSKMKAHIMQDDVVF WKWINLNTIALVTETTVYHW SVEGDSQPQKVFDRLSSLQG CQIINYRTDAAQNWLLLIGI TAQMNRVVGNMQLYSEERKV Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra FNIEIKSRMKQHNMTEEVIF WKWVTVNTIAIVTETAVYHW SMEGDSQPVKMFDRHASLNG CQIINYRADEKLQWLLLIGI TAQQNRVVGAMQLYSVERKV Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel FNIEMKSKMKAHTMNEDVVF WKWISLNTLALVTETSVFHW SMEGDSMPQKMFDRHSSLNG CQIINYRCNASQQWLLLVGI SALPSRVAGAMQLYSVERKV Tcas FNIEMKSKMKAHTMSEDVIF WKWISLNTLALVTETSVYHW SMEGDSTPVKMFDRHSSLNG CQIINYRTDPKQNWLLLVGI SAQQSRVVGAMQLYSVERKC Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar FNIEMKSKMKAHAMTDDVIF WKWISVNTIALVTETAVYHW GMEGDSSPQKVFDRHSSLNG CQIINYRTDHKQQWLLLIGI SAQQSRVVGAMQLYSVERKV Tcal FNIEMKSKMKAHVMTDDVIF WKWISLNTIALVTETSVYHW SMEGDSTPQKIFDRHSSLSG CQVINYRVDSSQNWLLLIGI SAQQNRVVGAMQLYSVERKV Crog FNIEMKSKMKAHVMQDDVVF WKWINLNTIALVTESAVFHW SVEGDSLPVKVFDRLTSLAN CQIINYRTDAAQNWLLLIGI TAQMNRVVGNMQLYSMERKV Dpul FNIEMKSKMKAHTMTEDVVF WKWISVNTIALVTEGAVYHW PMEGDSLPQKMFDRHSSLTG CQIINYRTDAKQTWLLLIGI SAQQNRVVGAMQLYSVERKV Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca SQPIEGHAAAFAQFKQEGNT EASTLFCFAVRTPHGGKLHI IEVGQPAAGNQAYPKKAVDV FFPPEAQNDFPVAMQMSPRH DVVYLITKYGYVHLYDLESG Eaff SQPIEGHAAAFVQFRMEGNQ QDSNLFIFAVRGAAGGKLHI IEVGTPPTGNTPFQKKAVDV FFPPEAQNDFPVAMQVSKKN AIAYLITKYGYVHLFDIESG Lcyp SQPIEGHAAAFVLFRMDGNP ADSTLFCFAVRTAQGGKLHI IEVGSAPSGNQPFQKKAVDV FFPPEAQSDFPVAMQVSQKF GVIYLITKYGYVHLYDLESG Lsal SQPIEGHAASFIQFRMEGNP ADSTLFCFAVRGAQGGKLHI IEVGNSPSGNQSFQKKAVDV F------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra SQPIEGHAAAFAQFKMDGNP LPSTIFCFAVRSAAGGKLHI IEVGTPPAGNQPFPKKAVDV FFPPEAANDFPVAMQISPKY DVIYLITKYGYIHLYDIETG Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel SQAIEGHAASFATFKIDANK EPTTLFCFAVRTATGGKLHI IEVGAPPNGNQPFAKKAVDV FFPPEAQNDFPVAMQVSAKY DTIYLITKYGYIHLYDMETA Tcas SQPIEGHAASFATFKMEGNP EPSTLFCFAVRTVQGGKLHI IEVGQSPAGNQPFPKKTVDV FFPPEAQNDFPVAMQVSAKY DVIYLITKYGYIHMYDIESA Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar SQPIEGHAAAFAQFKLEGNP EISTLFCFAVRTVQGGKLHI IEVGQPPTGNQPFPKKAMDV FFPAEAQNDFPVAMQISPKH DVIYLITKYGYIHLYDIETG Tcal SQPIEGHAAAFLQFKMEGNP HESTLFCFAVRTAQGGKLHI IEVGTPPTGNQPFQKKAVDV FFPPEAQNDFPVAMQVSTKH GVVYLITKYGYVHLYDVESA Crog SQPIEGHAASFIPFRLEGNP ADSNLFCFAVRGAQGGKLHI IEVGSAPSGNKAFQKKAMDV FFPPEAQNDFPVAMQVSEKH GVVYLITKYGYVHLYDIESG Dpul SQPIEGHAAAFSQFKMEGNP EFSTLFCFAVRSAQGGKLHI IEVGTPPTGNQPFAKKNVDV FFPPEAQNDFPVAMQVSPKH DVLYLITKYGYIHLYDMETG Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca TCIYMNRISADTIFVTAPHE ASSGIIGVNRKGQVLSVSVE EENIIPYI---TNVLQNPDL ALRMAVRNNLAGAEDLFVVK FNTLFGGGQYSEAAKVAANA Eaff ACIYTNRISADTIFVTALHE PSNGIIGVNRKGQVLSVSMD EETVVPYIQQTNTIPNNADL ALRMAVRNNLGGADQLFVAK FNDLFGRGAYSEAAKVAANA Lcyp TCIYMNRISAETIFVTAPYE SMSGIIGVNRKGQVLSVSID EDNIINYM---NGNLQNADM ALRFAVRNNLGGADELFVRK FNTFFGNGQYSEAAKIAANA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra TCIYMNRISSETIFVTAQHE GSSGIIGVNRKGQVLSVTVD EDNIVPYV---TNVLNNTDL ALRIAVRNNLPGAEELIVRK FNNLYASGQYAEAAKVAANA Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel TCIYMNRISADTIFVTAPHE ASGGIIGVNRKGQVLSVTVD EEQIIPYI---NTVLQNPDL ALRMAVRNNLAGAEDLFVRK FNKLFTAGQYAEAAKVAALA Tcas ICIYMNRISSETIFVTAPHE STGGIIGVNRRGQVLSVSVD EDSIIRYV---NQVLHNPDL ALRIATRNNLAGAEELFVNK FQMLFTNGQYAEAAKVAANA Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar ICIYMNRISGETIFVTAPHE PSSGIIGVNRKGQVLSVSVD EENIIAYI---TNVLQNSDL ALRIAVRNNLAGAEELFVRK FNTLFASGQYSDAAKVAANA Tcal VCIYMNRISAETIFVTAPHE PTNGIIGVNRKGQVLSVSVD EDNIINYI---NGNLQNPDM ALRFAVRNNLGGADELFVRK FNSSFSNGNYSEAAKIAANA Crog FCFYMNRISAETIFVTAPHE PTHGIIGVNRKGQVLSVSVD EENVVNYI---TNNMNNPDV ALRFAVRNNLGGGDDLLINK FNSLFSSGQYSEAAKIAANA Dpul TCIYMNRISAETVFVTAPHE PSSGIIGVNRKGQVLSVSVD EETIIQYI---TTAMQNPDL ALRIATRNNLAGAEELFVRK FNTLFQGGQYAEAAKVAANA Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca PKGILRTPQTIQRFQQVPNQ PGQTS-PLLQYFGILLDQGQ LNKYESLELCRPVLQQGRKQ LLEKWLKDDKLECSEELGDL VKQVDPTLALSVYLRANVPN Eaff PKGILRTPQTIAKFQQVPTQ PGQTS-PLLQYFGILLDQGQ LNKYESLELCRPVLAQGRKQ LLEKWLKEDKMECSEELGDM VKAADPTLALSVYLRANVPN Lcyp PKGILRTPQTIGKFQQVPTQ PGQTS-PLLQYFGILLDQGQ LNKYESLELCRPVLQQGRKQ LLEKWLKEDKLECSEELGDL VKASDPTLALSVYLRANVPS Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra PRGLLRTPGTIQKFQQVTAG PGQ-S-PLLQYFGILLDQGQ LNRHESLELCRPVLIQQRKQ LIEKWLKEEKLECSEELGDL VKQSDATLALSVYLRANVPM Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel PKAILRTPQTIQRFQQVQTP AGSTTPPLLQYFGILLDQGK LNKFESLELCRPVLLQGKKQ LCEKWLKEEKLECSEELGDL VKASDLTLALSIYLRANVPN Tcas PKGILRTPATIQMFQQVPTQ PGQNS-PLLQYFGILLDQGQ LNRYESLELCKPVLLQGRKQ LLEKWLKEDKLECSEELGDL VKQADSTLALSVYLRANVPA Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar PKGILRTPQTIARFQSVPTQ AGQTS-PLLQYFGILLDQGQ LNKFESLELCRPVLQQGRKQ LLEKWLKEDKLECSEELGDL VKQADPTLALSVYLRANVPN Tcal PKGILRTPQTISKFQQVPTP AGQTS-PLLQYFGILLDQGQ LNKFESLELCRPVLQQGRKQ LLEKWLKEDKLECSEELGDL VKAADPTLALSVYLRANVPN Crog PQGSLRTPQTIAKFQQVQSQ PGQTS-PLLQYFGILLDQGQ LNKYESLELCRPVIQQNRKQ LIEKWLKEDKLECSEELGDL VKATDPTLALSVYLRANVPN Dpul PKAILRTPATIQRFQAVAAQ PGQTS-PLLQYFGILLDQGQ LNKFESLELCRPVLQQGRKQ LLEKWLKEDKLECSEELGDL VKQADPTLALSVYLRANVPN Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca KVIQCFAETGQFQKIVLYAK KVGYVPDYVLLLRQVMRVNP DQGASFAQMLVQDE-EPLAD INQIVDVFMESNLVQQCTAF LLDALKNNRPSESNLQTRLL Eaff KVIQCFAETGQFQKIVLYAK KVGYTPDYVFLLRNVMRVNP DSGAQFAGMLVQDD-EPLAE ITQIVDVFMEQNLVQQCTAF LLDALKNNRPAEGPLQTRLL Lcyp KVIQCFAETNQFHKIVLYSK KVGYTPDYVFLLRTVMRSSP EQGPQFAQMLVQDDGEPLAD INQVVDIFMEQGMVQQCTAF LLDALKNNRPSEGPLQTRLL Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra KVIQCFAETGQYQKIVLYAK KVGYTPDYVFLLRSVMRANP EQGLAFAQMLVQDE-EPLAD VSQVVDIFLENNLIPQCTAF LLEALKNNRPTEGPLQTRLL Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel KVIQCFAETGQFQKIVLYAK KVNYTPDYVFLLRSVMRSNP EQGAGFASMLVAEE-EPLAD INQIVDIFMEHSMVQQCTAF LLDALKHNRPAEGALQTRLL Tcas KVIQSFAETGQFQKIVLYAK KVNYTPDYIYLLRSVMRTNP DQGAAFASMLVADE-EPLAD INQIVDIFMEQNMVQQCTAF LLDALKHNRPTEGHLQTRLL Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar KVIQCFAETGQFQKIVLYAK KVGYTPDYVFLLRNVMRINP DQGLQFAQMLVQDD-EPLAD INQIVDIFMEHNLVQQCTAF LLDALKNNRPSEGPLQTRLL Tcal KVIQCFAETGQFQKIVLYAK KVGYTPDYPFLLRNVMRVNP EQGAQFAQMLVQDD-EPLAD INQIVDIFMEQNMVQQCTSF LLDALKNNRPSEGPLQTRLL Crog KVTMCFAETGQYQKIVLYAK KVNYTPDYIFILRNIMRTNP DQGAQFAQMLVVDE-EPLAE IGQIVDVFMEKNMVQQCTAF LLEALKNNRPSEGPLQTRLL Dpul KVIQCFAETGQFSKIVLYAK KVGYTPDYVFLLRSVMRISP EQGAMFAQMLVQDD-EPLAD IAQIVDIFLEQNMVQPCTAF LLDALKNNRPAEGPLQTRLL Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca EMNLMTAPQVADAILGNQMF THYDRAHVAQLCEKAGLLQR ALEHYTDLYDIKRAIVHTHL LNAEWLVNYFGSLSVEDSLE CLRAMLTHNLRQNLQISVQV Eaff EMNLLAAPQVADAIMGNQMF SHYDRAHIASLCEKAGLLQR ALEHYTDLYDIKRAVVHTHL LNTDWLVNFFGTLSVEDSME CLKAMLQANIRQNLQVCVQV Lcyp EMNLMAAPQVADAIMGNQMF THYDRAHIASLCEKAGLLQR ALEHYTDLYDIKRAVVHTHM LKPEWLVSFFGTLSVEDTME CLKTMLQANIRQNLQVVVQI Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra EINLLSAPQVADAILGNNMF THYDRPHIAQLCEKAGLLQR ALEHYSDLYDIKRAVVHTHL LNPDWLLNYFGTLSVEDSLE CLKAMLTANIRQNLQICVQI Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel EMNLMSAPQVADAILGNAMF THYDRAHIAQLCEKAGLLQR ALEHYTDLYDIKRAVVHTHM LNAEWLVSFFGTLSVEDSLE CLKAMLTANLRQNLQICVQI Tcas EMNLMSAPQVADAILGNNMF THYDRAHIAQLCEKAGLLQR ALEHYTDLYDIKRAVVHTHL LPMDWLVNFFGTLSVEDSLE CLKAMLTANIRQNLQICVQI Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar EMNLISAPQVADAILGNQMF THYDRAHVAQLCEKAGLLQR ALEHYTDLYDIKRAVVHTHL LNSEWLVNYFGSLSVEDSLE CLRAMLQANIRQNLQICVQI Tcal EMNLMAAPQVADAIMGNQMF THYDRPHIASLCEKAGLLQR ALEHHTDLYDIKRAVVHTHL LKPDWLVTFFGTLSVEDSLE CLKTMLNANIRQNLQVCVQI Crog EMNLMAAPQVADAIMGNHMF TYYDKAHIAQLCEKAGLLQR ALEHYTDLYDIKRAVVHTNL LKTDWLVNFFGSLGVDDSLE CLKSMLQVNLRQNLQVCVQI Dpul EMNLLSAPQVADAILGNQMF THYDRAHVAQLCEKAGLLQR ALEHYTDLYDIKRAVVHTHL LNPEWLVNYFGSLSVEDSLE CLRAMLQANIRQNLQIGVQI Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca ATKYHEQLTTASLIDLFESF KSYEGLFYFLGSIVNFSQDP EVHFKYIQAACKTGQIKEVE RICRESNCYNAERVKNFLKE AKLTDQLPLIIVCDRFDFVH Eaff ATKYHEQLTTNTLIDLFESF KSFEGLFYFLGSIVNFSQDP EVHFKYIEAACKTGQIKEVE RICRESNCYAPERVKNFLKE AKLTDQLPLIIVCDRYDFVH Lcyp ASKYHEQLTTNALIDLFEQF KSFEGLFYFLGSIVNFSQDP EVHFKYIEAACKTGQIKEVE RICRESNCYNPERVKNFLKE AKLTDQLPLIIVCDRFDFVH Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra STKYYEQLGTNALIELFESF KSFEGLFYFLGSIVNFSQDP EVHFKYIQAACKTGQIKEVE RICRESNCYNAERVKNFLKE AKLTDQLPLIIVCDRFDFVH Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel ATKYHEQLTNKALIDLFEGF KSYDGLFYFLSSIVNFSQDP EVHFKYIQAACKTNQIKEVE RICRESNCYNPERVKNFLKE AKLTDQLPLIIVCDRFDFVH Tcas ATKYHEQLTTKALIDLFESF KSYEGLFYFLGSIVNFSQDP DVHFKYIQAACKTGQIKEVE RICRESNCYNPESVKNFLKE AKLTDQLPLIIVCDRFDFVH Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar ATKYHEQLSTQMLIDLFESF KSFEGLFYFLGSIVNYSQEP EVHFKYIQAACKTGQIKEVE RICRESNCYNPERVKNFLKE AKLTDQLPLIIVCDRFDFVH Tcal ATKYHEQLTTNALIDLFESF KSFEGLFYFLGSIVNFSQDP EVHFKYIEAACKTGQIKEVE RICRESNCYNPERVKNFLKE AKLTDQLPLIIVCDRFDFVH Crog ATKYHEQLTTNALIDLFENF KSYEGLFYFLGSIVNFSQEP EVHFKYIEAACKTGQIKEVE RICRESNCYNPERVKNFLKE AKLSDQLPLIIVCDRFDFVH Dpul ATKYHEQLSTNSLIELFESF KSFEGLFYFLGSIVNFSQDP EVHFKYIQAACKTGQIKEVE RICRESNCYNAERVKNFLKE AKLTDQLPLIIVCDRFDFVH Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca DLVLYLYRNSLQKYIEIYVQ KVNPSRLPVVVGGLLDVDCA EEVIKGLILVVRGQFSTDEL VA------------EVEKRN RLKLLLPWLEGRLHEGCQEP Eaff DLVLYLYRNNLQKYIEIYVQ KVNPSRLPVVVGGLLDVDCG EDIIKNLILVVRGQFNTDEL VE------------EVEKRN RLKLILPWLESRVHEGSVEP Lcyp DLVLYLYRNNLQKYIEIYVQ KVNQSRLPVVVGGLLDVDCS EDIIKNLIHVVRGQFSTDEL VE------------EVEKRN RLKLILPWLESRIHEGCDEA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra DLVLYLYRNNLQKYIEIYVQ KVNPSRLPVVVGGLLDVDCS EDIIKNLIFVVRGQFSTDEL VA------------EVEKRN RMKLLLPWLEARVHEGSVEP Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel DLVLYLYRNNLQKYIEIYVQ KVNPSRLPVVVGGLLDVDCS EDIIKNLILVVKGQFSTDEL VE------------EVEKRN RLKLLLPWLESRVHEGCVEP Tcas DLVLYLYRNSLQKYIEIYVQ KVNPSRLPVVVGGLLDVDCA EDIIKNLILVVRGQFSTDEL VE------------EVEKRN RLKLLLPWLESRVHEGCVEP Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar DLVLYLYRNNLQKYIEIYVQ KVNPSRLPVVVGGLLDVDCS EDVIKNLITVVRGQFSTDEL VE------------EVEKRN RLKLILSWLEMRIHDGCTEP Tcal DLVLYLYRNNLQKYIEIYVQ KVNPSRLPVVVGGLLDVDCS EDIIKNLITVVRGQFNTDEL VE------------EVEKRN RLKLILPWLESRIHEGSDEP Crog DLVLYLYRSNLQKYIEIYVQ KVNPSRLPVVVGGLMDVDCS EDIIKNLIAVVKGQFNTDEL VE------------EVEKRN RLKLILPWLESRVHEGSEEP Dpul DLVLYLYRNSLQKYIEIYVQ KVNPSRLPVVIGGLLDVDCS EDVIKSLILVVRGQFSTDEL VE------------EVEKRN RLKLLLPWLESRIHEGSVEP Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca ATHNALAKIYIDSNNNPERF LRENQFYESRVVGRYCEKRD PHLACLAYERGQCDRELVQV CNDNSLFKSEARYLVRRRDP DLWAEVLAESNPFRRPLIDQ Eaff ATHNAVAKIYIDSNNNAERF LKENPYYDSKVVGKYCEKRD PHLACVAYERGNCDRELIAV CNENSLFKSEARYLVKRRDM ELWAEVLNDENQFRRPLIDQ Lcyp ATHNALAKIYIDSNNNPERF LKENPYYDSKVVGRYCEKRD PHLACVAYERGQCDRELIAV CNENSLFKSEARYLVRRRDM ELWAEVLNDDNPYRRSLIDQ Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra ATHNALAKIYIDCNNNPERF LKENQYYDSHIVGKYCEKRD PHLACVAYERGKCDMELINV CNENSLFKSEARYLVKRRDP ELWAEVLLESNPYRRQLIDQ Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- ------FKSEARYLVKRRDM DLWAEVLNDENQYRRPLIDQ Dmel ATHNALAKIYIDSNNNPERY LKENQYYDSRVVGRYCEKRD PHLACVAYERGLCDRELIAV CNENSLFKSEARYLVGRRDA ELWAEVLSESNPYKRQLIDQ Tcas ATHNALAKIYIDSNNNAERF LKENQWYDSRVVGRYCEKRD PHLACVAYERGQCDRELIAV CNENSLFKSEARYLVRRRDP ELWAEVLQESNPYRRQLIDQ Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar ATHNALAKIYIDSNNNPEKF LKENQFYDSRVVGKYCEKRD PHLACVAYERGSCDRELINV CNENSLFKSEARYLVKRRDG EMWAEVLNESNQYRRQLIDQ Tcal ATHNALAKIYIDSNNNPERF LKENPYYDSKVVGRYCEKRD PHLACVAYERGECDRELIAV CNENSL-------------- -------------------- Crog ATHNALAKIYIDSNNNPERF LKENTFYDSAVVGRYCEKRD PHLACVAYERGECDRELISV CNENSLFKSQARYLVRRRDT DLWTEVLSDENIHRRPLIDQ Dpul ATHNALAKIYIDSNNNPERF LKENGYYDSRVVGKYCEKRD PHLACVAYERGQCDRELIKV CNENSLFKSEARYLVRRRDP DLWVEVLNESNQFRRQLIDQ Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca VVQTALSETQDPEDISVTVK AFMTADLPNELIELLEKIVL ENSVFSDHRNLQNLLILTAI KADRTRVMEYINRLDNYDAP DIANIAIGSELYEEAFAIFR Eaff VVQTALAETQDPEDISVTVK AFMAADLPNELIELLEKIVL ENSVFSDHRNLQNLLILTAI KADKTKVMEYISRLDNYDAP DIANIAIGAELYEEAFAIFK Lcyp VVQTALAETQDPEDISVTVK AFMAADLPNELIELLEKIVI DNSVFSDHRNLQNLLILTAI KADKSKVMEYIDRLDNYDAP DIANIAIQSQLYEEAFAIFK Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra VVQTALSETQDPDDISVTVK AFMTADLPNELIELLEKIVL DNSAFSDHRNLQNLLILTAI KADRTRVMEYINRLENYDAP DIANIAIQSQLYEEAFAIFK Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- --ANIAIQSQLYEEAFAIFK Afos VVQTALAETQDPEDISVTVK AFMASDLPNELIELLEKIVL ENSVFSDHRNLQNLLILTAI KADKTKVMEYINRLDNYDAP DIANIAIGAELYEEAFAIFK Dmel VVQTALSETQDPDDISVTVK AFMTADLPNELIELLEKIIL DSSVFSDHRNLQNLLILTAI KADRTRVMDYINRLENYDAP DIANIAISNQLYEEAFAIFK Tcas VVQTALSETQDPEDISVTVK AFMTADLPNELIELLEKIVL DSSVFSDHRNLQNLLILTAI KADATRVMDYINRLDNYDAP DIANIAINNHLYEEAFAIFK Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar VVQTALSETQDPEDISVTVK AFMTADLPNELIELLEKIVL ENSVFSDHRNLQNLLILTAI KADRTRVMEYINRLDNYDAP DIANIAIGSELYEEAFAIFR Tcal -------------------- -------------------- -------------------- -------------------- -------------------- Crog VVQTALAETTDPDDISVTVK AFMAADLPNELIELLEKIVI DSSTFSDHRNLQNLLILTAI KADTKKVMEYIDKLDNYDAP DIANIAIQNQLYEEAFAIFK Dpul VVQTALSETQDPEDISVTVK AFMTADLPNELIELLEKIVL DSSVFSDHRNLQNLLILTAI KADRTRVMEYINRLDNYDAP DIANIAISNQLYEEAFAIFK Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca KFDVNTSAIQVLIEHIQNLD RAYEFAERCNEPGVWSQLAR AQLGQGLVKEAIDSFIKAGD HTAYLDVVQTAHKTGSWEDL VRYLQMARKKGRESYVESEL Eaff KFEVNSSAVQVLIENVDNLD RAYEFAERCNEPAVWSQLGK AQLQQNLVKEAIDSYIKAND PSAYLDVVATASKTESWEDL VRYLQMARKKARDTYVESEL Lcyp KFEVNSSAVQVLIDNVQNLD RAYEFAERCNEPAVWSQLGK AQLQKGMVKEAIDSFIKAND PTDYMNVVETASSTNHWEDL VRYLQMARKKARDTYVESEL Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra KFEVNTSAIQVLIDHTRNLD RAYEFAERCNEPAVWSLLGR AQLAEGLVKEAIDSFIKADD PTVYMDVVQTAHSTGHWEDL VRYLQMARKKSRESYIESEL Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda KFEVNSSAVQVLIENVQNLD RAYEFAERCNEPAVWSQLGK AQLQKGLVKEAIDSFIKAND PTDYMAVVETASLTDHWEDL VRYLQMARKKARDTYVESEL Afos KFEVNSSAVQVLIENVENLD RAYEFAERCNEADVWSQLGK AQLQQNMVKEAIDSYIKAND PRAYLDVVATATKTESWEDL VRYLQMARKKARDTYVESEL Dmel KFDVNTSAIQVLIDQVNNLE RANEFAERCNEPAVWSQLAK AQLQQGLVKEAIDSYIKADD PSAYVDVVDVASKVESWDDL VRYLQMARKKARESYIESEL Tcas KFDVNTSAIQVLIEQVNNLD RAYEFAERCNEPAVWSQLAK AQLNQGLVKEAIDSYIKADD PSAYMAVVETASKNNSWEDL VRYLQMARKKSRESYIESEL Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar KFDVNTSAIQVLIEHVQNLD RAYEFAERCNEPAVWNQLAR SQLHHGMVKEAIDSFIKADD PSAYMDVVETAHKTGSWEDL VRYLIMARKKARESYIESEL Tcal -------------------- -------------------- -------------------- -------------------- -------------------- Crog KFEVNTSAIQVLIEKVKNLD RAYEFAERCNEPAVWSQLGK AQLKQDMVKEAIDSFIKAND PTDYMDVVETSSRTNNWEDL VRYLQMARKKARDTYIESEL Dpul KFDVNASAIQVLIENVNNLD RAYEFAERCNEPAVWSQLAK AQLQQGLVKEAIDSFIKADD PSAYLDVVSTSHRTGSWEDL VRYLQMARKKARESFIESEL Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- ---QRRVHGGARKANSTRTW KEVCFACVDNEEFRLAQMCG Isca IYAYAKTNRLADLEEFVSGP NHADVQRIGDRCFEDGLYEP AKLLYNNVSNFARLAITLVH LKEFQGAVDSARKANSTRTW KEVCFACVDNEEFRLAQMCG Eaff IFAYAKTSRFADLEEFVSSP NHADVGKIGDRCFDSGMYEA AKLLYNNISNFAKLAITLVH LKEYQGAVDSARKANSTRTW KEVCFACVENEEFRLAQMCG Lcyp IFAYAKTSRFADLEEFISSP NHADVSRIGDRCYDAKMFEA AKLLYNNVSNFAKLAITLVH LKEYQGAVDSARKANSTRTW KEVCFACVDNNEFRLAQMCG Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra IYAYAKTGRFADLEEFIAGP NHADVQRIGDRCFDEKMYEP AKLLYNNVSNFARLAITLVH LKEYQGAVDSARKANSTKTW KEVCFACVESGEFRLAQSCG Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda IYAYAKTSRFADLEEFISSP NHADVSKIGDRCFDAGMYEA AKLLYNNVSNFAKLAITLVH LKEYQGAVDSARKANSTRTW KEVCFACVDNNEFRLAQMCG Afos LFAYAKTSRFADLEEFISSP NHADVGKIGDRCFDAEMYEA AKLLYNNISNFAKLAITLVH LKEYQGAVDSARKANSTRTW KEVCFACVDNQEFRLAQMCG Dmel IYAYARTGRLADLEEFISGP NHADIQKIGNRCFSDGMYDA AKLLYNNVSNFARLAITLVY LKEFQGAVDSARKANSTRTW KEVCFACVDAEEFRLAQMCG Tcas IYSYAKTGRLADLEEFISGP NHADIQKIGDRCFDDKMYDA AKLLYNNVSNFARLAITLVH LKEFQGAVDSARKANSTRTW KEVCFACVDAEEFRLAQMCG Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar IYAYAKTNRLADLEEFISGP NHADIQKIGDRCFDDGMYEP AKLLYNNVSNFARLAITLVH LKEFQGAVDSARKANSTRTW KEVCFACVDSQEFRLAQMCG Tcal -------------------- -------------------- -------------------- -------------------- -------------------- Crog IYAYAKTNRLADLEEFISSP NHADFIKIGDRCFDDKMYEA AKLFYKNVSNFAKLAITLVY LKDYQGSVESARKANCTRTW KEVCFACVENNEFRLAQMCG Dpul IYAYARTNRLADLEEFIAGP NHADIQRIGDRCYDDGMYEP AKLLYNNVSNFARLAITLVH LKEFQGAVDSARKANSTRTW KEVCFACVDNKEFRLAQMCG Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin LHIVVHADELEDLITYYQDR GFFEELMALLEASLGLERAH MGMFSELAILYSRYKPDKLK EHLELFWSRVNIPKVLRAAE QAHLWAELVFLYDKYEEYDN Isca LHIVVHADELEDLIHYYQDR GFFEELIALLEAALGLERAH MGMFTELAILYSKYKPAKMR EHLELFWSRVNIPKVLRAAE QAHLWAELVFLYDKYEEFDN Eaff LHIVVHADELEDLITFYQDK GYFEELMSLLEASLGLERAH MGMFSELSILYSRYKPEKLR EHLELFWSRVNIPKVLRAAE QAHLWAELVFLYDKYEEYDN Lcyp LHIVVHADELDDLINYYQER GFFEELMSLLEASLGLER-- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra LHIVVHADELEDLINFYQDL GHFEELIQLLEAALGLERAH MGMFTELAILYSLYKTEKMR EHLELFWSRVNIPKVLRAAE KAHLWAELVFLYDKYEEFDN Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda LHIVVHADELEDLNNYYQER GYFEELMSLLEASLGLERAH MGMFTELAILYSKYKPGKLR EHLELFWSRVNIPKVLRAAE QAHLWAELVFL--------- Afos LHIVVHADELEDLITYYQDR GYFDELMSLLEASLGLERAH MGMFSELAILYSKYKPDKLK EHLELFWSRVNIPKVLRAAE QAHLWAELVFLYDKYEEYDN Dmel LHIVVHADELEDLINYYQNR GYFDELIALLESALGLERAH MGMFTELAILYSKFKPSKMR EHLELFWSRVNIPKVLRAAE SAHLWSELVFLYDKYEEYDN Tcas MHIVVHADELQDLINYYQDR GYFEELIGLLEAALGLERAH MGMFTELAILYSKYKPAKMR EHLELFWSRVNIPKVLRAAE QAHLWAELVFLYDKYEEYDN Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar LHIVVHADELEDLINYYQDR GYFEELINLLEAALGLERAH MGMFTELAILYSKFKPSKMR EHLELFWSRVNIPKVLRAAE QAHLWAELVFLYDKYEEYDN Tcal -------------------- -------------------- -------------------- -------------------- -------------------- Crog LHIVVHADELEDLINYYQDK GYFEELMALLEASLGLERAH MGMFTELAILYSKYKPSRLR DHLEHFWSRVNIPKVLRAAE QAHLWAELVFLYDKYEEYDN Dpul LHIVVHADELEDLINYYQDR GYFEELINLLEAALGLERAH MGMFTELGILYSKYKPEKMR EHLELFWSRVNIPKVLRAAE QAHLWAELVFLYDKYEEYDN Aver -ALAMMAHPTEAWRESHFKD IITKVANIELYYKAIQFYLD YKP-------------MMLN DLLLVLAPRMDHTRAVNFFS KVGHLQLVKPYLRSVQNLNN Csin AVLAMMAHPTEAWREGHFKD IITKVANIEMYHRAIQFYLD YKP-------------MLLN DLLLVLAPRLDHTRTVNYFT KTNHLQLVKPYLRSVQNLNN Isca AVVTMMQHPTEAWREAHFKE IITKSKQAETAEELLSWFLD DKNYACFGACLFQCYDLLHP DVILELAWR----HGIMDFA MPYFVQVMREYV-------S Eaff AALSMMAHPTEAWRESHFKD IMTKVANIELYYKAIQFYLD YKP-------------MLLN DLLLVLAPRLEHTRTVSYFT KTNHLQLVKPYLRSVQNLNN Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra AVVTMMAHPTEAWREGHFKD VITKVANIELYYKAIQFYLE HKP-------------LLLN DLLLVLAPRMDHTRAVNFFD KVNHLRLVKPYLRSVQSLNN Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos AALAMMAHPTEAWRESHFKD IITKVANIELYYKAIQFYLD FKP-------------MLLN DLLLVLAPRLDHTRTVTFFT KANHLQLVKPYLRSVQNLNN Dmel AVLAMMAHPTEAWREGHFKD IITKVANIELYYKAIEFYLD FKP-------------LLLN DMLLVLAPRMDHTRAVSYFS KTGYLPLVKPYLRSVQSLNN Tcas AVLAMMAHPTEAWREGHFKD IITKVANIELYYKAIQFYLD YKP-------------LLLN DLLLVLAPRMDHTRAVAFFT KTGHLQLVKSYLRSVQNLNN Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar AIVTMMGHPTEAWREGHFKE IITKVANIELYYKAIQFYLD YKP-------------MLLN DLLLVLAPRMDHTRAVNFFT KVDHLQLVKPYLRSVQSLNN Tcal -------------------- -------------------- -------------------- -------------------- -------------------- Crog AVLSMMAHPTEAWKESHFKD IITKVANIELYYKAIQFYLD YKP-------------MMLN DLLIVLAPRMDHTRAVAFFT KANHLQLVKPYLRSVQNLNN Dpul AVLTMMQHPTEAWREGHFKD VITKVANIELYYKGIQFYLD YKP-------------MMLN DLLLVLSPRMDHTRSVNFFS KYNHLEMVKPYLRSVQNLNN Aver KAVNEALNGLLIAEEDYNGL KTSIDAF------------- -------------------- -------------------- -------------------- Csin KVVGDKA------------- -------------------- -------------------- -------------------- -------------------- Isca KAINEALNGLLIDEEDFQGL RTSIDAFDNFDNIALAQRLE KHDLVEFRRLAAYLYKGNNR WKQSVELCKKDRLFK----- ---SKQAETAEELLSWFLDD Eaff KAVNEALNGLFINEEDFNAL KTSIDAFDNFDNIGLAQALE KHELIEFRRIAAYLYKGNNR WKQSVELCKKDNLFKDAMEY ASESKNAEVAEDLLAYFLEH Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra KAINEALNGLLVEEEDYQGL RASIDAFDNFDTIALAQKLE RHELIEFRRIAAYLYKGNNR WKQSVELCKKDRLFKDAMEF AAESKSSQLAEELIAWFLET Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos KAVNEALNGLLIDEEDYNAL KTSIDAFDNFDNIGLAQRLE KHELIEFRRIAAYLYKGNNR WSQSVALCKKDNLFKDAMEY AAESKNAEVAEDLLAYFLEH Dmel KAINEALNGLLIDEEDYQGL RNSIDGFDNFDNIALAQKLE KHELTEFRRIAAYLYKGNNR WKQSVELCKKDKLYKDAMEY AAESCKQDIAEELLGWFLER Tcas KAINEALNSLLIEEEDFQGL RTSIDAFDNFDNIGLAQKLE KHELTEFRRIAAYLYKGNNR WKQSVELCKKDRLFRDAMEY TAESKNQELAEELLAWFLER Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar KAINEALNGLLIQEEDYQGL RTSIDAFDNFDNIALAQMLE KHELIEFRRIAAYLYKGNNR WKQS-----------DAMEY AGESKNADIAEELLAWFLEE Tcal -------------------- -------------------- -------------------- -------------------- -------------------- Crog KAVNEALNGLLIDEEDYNSL KSSIDAFENFDNISLAQTLE KHELIEFRRIGAYLYKGNNR WKQSVELCKKDNLFKDAMEY AAESKNAEVAEELLAYFLDK Dpul KAINEALNSLLIDEEDYQGL RTSIDAFDNFDTIVLAQRLE KHELIEFRRIAAYLYKGNNR WKQSVELCKKDRLFKDAMEY ASESKNAEIAEELLAWFLEQ Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca KNYACFGACLFQCYDLLHPD VILELAWRHGIMDFAMPYFV QVMREYVSKVGAVALAALPR IR------------------ -------------------- Eaff RAFDCFAACLFQCYDLLHPD VILELAWKHNIMDFAMPYLI QVMREYVTKVDRLEDAENLR ITEKKEEEYTPVV-LESKPQ LMLT-GPGA-YPG------- Lcyp -------------------- -------------------- -------------------- -------------------- -------------------- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra ENQECFAACLYQCYDLLKPD VVLELAWRNGITDLAMPYLI QTIREYTAKVERLEELEAQR TEEKATEEVKPMM-M--QPQ LMLTSGPAGMLPPGY----- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos RAYDCFAACLFQCYDLLHPD VILELAWRHNIMDFAMPYLI QVMREYVSKVDRLEEAENLR ISEKKETEYKPVV-MESQPQ LMLT-GPAG-FPGAT----- Dmel DAYDCFAACLYQCYDLLRPD VILELAWKHKIVDFAMPYLI QVLREYTTKVDKLELNEAQR EKEDDSTEHKNII-Q-MEPQ LMITAGPAMGIPPQYAQNYP Tcas KAYDCFAACLYQCYDLLRPD VILELAWRHKIMDLAMPYLI QVTRELTTKVEKLEQSDAQR QSEAAEETHKPMM-I-NEPQ LMLTAGPGMGIPPQA---YV Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar KNYECFAACLFLCYDLLHPD VILELAWRHNIMDFAMPYMI QVMREYISKVDKLEEAENNR LEENSVHEQKPIL-I-NEPQ LMITAGPGM-MPP------- Tcal -------------------- -------------------- -------------------- -------------------- -------------------- Crog KAYDCFAACTFQCYDLLHPD VILELAWRHGIMDFAMPYLI QVMREYTSKVERLSEAEATR LEEKQEQEYKPVV-IDNQAQ LMLT-GPMT-FNNQG----- Dpul RNFDCFAGCLYQCYDLLHPD VILELAWRHKIIDFAMPYLI QVMREYVSKVDKLEAAESER IEENDSQSQPPSM-MIASQQ LMLT-APGF-APA------- Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff --GAYNNVGGVPQVGYGGA- -----PGPYGMP--GQMPSY QGYSMQTDPPTLPISSL--- ---FPSGNYPEGQIMEHPIA A---DDQKELAKDRFSSEEA Lcyp -------------------- -------------------- -----QTDPPTIPICEL--- ---YPTGNFPIGEILEHPKP KDL-DNTT--AINRMTSEEK Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -----QTDPPSIPVVEM--- ---YPKNTAPKGQLMEYPAV Q---DSRS--ARDRFTSEEA Afra -----------PQAVYPNT- ---------------YAPGY -GYGMQTDPPSIPIHEL--- ---FPNESFPVGQECEYPPS K---DERL--AKDRFTAEEK Hazt -------------------- -------------------- -----QTDPPSVPIVDL--- ---FPAGNFPVGETCEYVDY NT--DDRT--ASNRMTNPEK Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos --GTYNGSAAPPTTGAGATG GAGAGAGTYTIP--GQMPSY QGYSMQTEPPTVPICEL--- ---FPDGNFPVGQIMEHPIA N---DDAK--AKNRFNSEEA Dmel PGAATVTAAGGRNMGY---- ------------------PY L----QTDPPTIPIAKL--- ---YPDGNFPEGEIVEHPTP KDMPDDRT--AKDRFTSEEK Tcas PPQAYAQPGYAPQMPYGAY- -----------P-------- ---GMQTDPPTVPIVDL--- ---FPDQVFPIGEIQEYPTK Q---DDRT--AKDRFTSEEK Pmon -------------------- -------------------- -----QTDPPTVPIVDL--- ---YPDGNFPIGEICEYKIN K---DDRS--AINRMNSDEK Smar --------GYQNYGAYGAG- ----------------LPSY QGYSM--------------- -------------------- -------------------- Tcal -------------------- -------------------- -----QTYPPTIPIFDL--- ---YRGGPFPVGQQMEYPDV WN--DGRT--AQDRFGTEEK Crog --GGVNSAGVNPGGAVGTGG NFSGGGNSFVPPPGGMNASY QGYSMQTDPPSVPISQL--- ---FPDGNFPVGQEMEYLPL K---DGRM--AMERMTQEER Dpul ---------------YAPG- ---------------FTPGY -GYGMQTDPPTIPIVEL--- ---FPDGNFPVGEEMEYPVV G---DDRT--AKDRFTSEEK Aver -------------------- -------------------Q ICEELESTARRLINENGLQA GLAFPTGCSLNHCAAHYTPN AGDTTVLGADDVCKIDFGTH Csin -------------DQAGGGG HRQTRQHIQRWAKPGMKMID ICEELEKTARSLINENGLEA GLAFPTGCSRNHVE------ -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff RAIDRLQLDMYNDVRQAAEA HRQTRQHIQRWIKPGMKMID ICEELESTARKLINENGLEA GLAFPTGCSRNNVAAHYTPN AGDDTVLEYDDVVKLDFGTH Lcyp KALDQAHTDFYKDLRQAAEA HRQTRKYVQSWIKPGMKMID IAEKLEACSRQMIKENGLEA GLAFPTGCSLNNCAAHYTPN AGDETVLQYDDVCKIDFGTH Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp KARDTAYEEIHTELRIGAEA HRQTRQYMQKWIKPGMTMIE ICEKLESIGRATIVENGLKS GLAFPTGCSINHCAAHYTPN AGDKTVLQYDDVCKIDFGTH Afra RTLDRSQNDSYNEARRAAES HRQTRQYMQKYIKPGMTMFQ IVEELERVSRLLIGEDGLKA GLAFPTGCSLNHCAAHYTPN AGDSTVLQYDDVCKIDFGTH Hazt KALEISYDDMYRDIRIGAEV HRTTRQYFQKWVKAGTSCMD ICDTIENMNRKLIKENGLSA GLAFPTGCSLNHCAAHYTPN AGDKTVVEYSDVCKIDFGVH Meda -------------------- -------------------E ICEELENTARKLINENGLQA GLAFPTGCSLNHCAAHYTPN AGDKTVLGYDDVCKIDFGTH Afos RAIDRLQLDMYNEIRQAAEA HRQTRQYIQRWVKPGMKMID ICEELENTARRMIKENGLEA GLAFPTGCSRNHVAAHYTPN AGDNTVLEFDDVVKMDFGTH Dmel RALDRINTDIYQELRQAAEA HRQTRQYMQRYIKPGMTMIQ ICEELENTARRLIGENGLEA GLAFPTGCSLNHCAAHYTPN AGDPTVLQYDDVCKIDFGTH Tcas RALDRMHNDIYNEVRLAAEA HRQTRQHIQKWIKPGMTMIE ICEELENTARKLIAENGLKA GLAFPTGCSRNHCAAHYTPN AGDPTVLEYDDVVKIDFGTH Pmon KALETSFEEMYREIRIGAEV HRTTRKYFKENVKPGMSMIE ICHMIEETNRKLIKENGLKA GLAFPTGCSINHCAAHYTPN SGDKTVLNYDDVCKIDYGIH Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal RAIDRAQLDMYNEVRCAAEA HRQTRQHIQKWVKPGMKMID IVQELEDTARKLIKENGLEA GLAFPTGCSINHCAAHYTPN AGDETVLGQDDVVKMDFGTH Crog RALDRSQLDMYNEVRQAAEA HRQTRQYIQSWVKPGMKLID ICETLESTARKLIDEKGLEA GLAFPTGCSVNHCAAHFTPN AGDETVLNYDDVVKIDFGTH Dpul KALDRAQMDIYNEVRCAAEA HRQTRQYMQRYIKPGMTMIQ ICEELESTSRRLIAENGLQA GLAFPTGCSLNHCAAHYTPN AGDTTVLQADDVCKIDFGTH Aver INGRIIDCAWTLTFNEKYDP LVKAVREATEMGIRTAGIDV RLCDVGSAIQEVMESHEIEL DGKTYQVKSIRNLNGHSIAP YQIHAGKTVPIIRGGEATMM Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff IKGRIIDCAWTLAFNERYDP LLLAVKEATETGIRTAGIDA RLCDVGAAIQEVMESHEIEL DGKTYQVKSIRNLNGHSICP YQIHAGKSVPIIKGGETTRM Lcyp INGHIIDCAWTVSFNPKYDK LLEAVKAATNAGIKEAGIDV RLCDIGEAIQEVMESYEIDL DGKTYQVKCIRNLNGHSISP YRIHAGKSVPIVKGGEATRM Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp INGRIIDCAFTLTFNPKYDR LLDAVRDATNTGIKCAGIDV QLCDIGEAIQEVMESYEVEL DGKTYQVKSIRNLNGHSISP YRIHAGKTVPIVKGGEKERM Afra VNGRIIDCAFTLTFNNKYDK LLEAVREATNTGIREAGIDV RLCDIGEAIQEVMESYEVEI DGKTYQVKPIRNLNGHSIGL YRIHAGKTVPIVKGGEVDVM Hazt VNGRVIDCAFTLTFDNKYDK LVEAVRAATNTGIKEAGIDA RLNEIGAAIQETMESYELEL DGKLYPIKPIRNLNE----- --IHAGKTVPIVKGGERVLM Meda INGRIIDCAWTLTFNEKYDP LVKAVREATETGIRTAGIDV RLCDVGAAIQEVMESYEIEL EGKTYQVKSIRNLNGHSISP YQIHSGKTVPIIRGGEAVMM Afos IKGRIIDCAWTMTFNEKFDP LKKAVQEATETGIKTAGIDA RLCDVGAAIQEVMESHEIEL DGKTYQVKSIRNLNGHSISP YQIHSGKTVPIIKGGETVQM Dmel IKGRIIDCAFTLTFNNKYDK LLQAVKEATNTGIREAGIDV RLCDIGAAIQEVMESYEIEL DGKTYPIKAIRNLNGHSISP YRIHAGKTVPIVKGGESTRM Tcas INGRIIDCAFTHTFNPKYDK LVEAVRDATNTGIKAAGIDV QLCEIGAAIQEVMESYELEL DGKTYPIKSIRNLNGHSISP YRIHAGKTVPIVKGGEATVM Pmon INGRVIDCAFTLTFNDRYNN LVEAVRAATNTGIREAGIDA RLCDIGAAIQETMESYEIEL NGKTYPIKCIRNLNGHSIAP YRIHAGKTVPIVKGGEAEIM Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal INGRIIDCAWTMNFNPKFDP LKEAVRDATEMGIKTAGIDV RLCDVGAAIQEVMESHEIEL DGKTYQIKSIRNLNGHSISP YQIHAGKTVPIIKGGEATVM Crog IKGRIIDCAWTLTFNEKYDP LVEAVRSATEEGIKQAGVDA LLCDIGESIQEVMESHEIEL NGTTYPVKSIRNLNGHSISP YQIHSGKTVPITKGGEAVRM Dpul VNGRIIDCAFTLSFNPKYDR LLEAVKDATNTGIRESGIDV RLCDIGAAIQEVMESYEVEI DGKTYQVKPIRNLNGHSIGP YRIHAGKTVPIVRGGETTRM Aver EENEFYAIETFGSTGRGQ-- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff EENEFYAIETFGSTGKGHVH EDMECSHYMKEFDVGHIPLR LQKSKQLLNVINKNFGTLAF CRRWLDRLGETRYLMALKDL GEKGIVNPYPPLVDIKGCYT Lcyp EEGELYAIETFGSTGKGIVH DDMECSHYMKNFDVGHVPLR LPKAKSLLGTIQKHFGTLAF CRRWLDRAGETKYLMALKNL CDVGIVDPYPPLCDIKGCYT Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp EENEVYAIETFGSTGRGFVH EDMECSHYMKNFDVGHVPLR LNRSKQLLNTINQNFGTLAF CRRWLDRLGETKYLMALKDL CEKEIVQAYPPLCDVKGSYT Afra EEGEYYAIETFGSTGKGVVH DDMECSHYMKNFSAGHVPLR LATSKQLLNVINKNFDTLAF CRRWLDRLGQTKYLLALKDL CDKGAVDAYPPLCDVRGCYT Hazt EENEVYAIETFGSTGKGIVK DDMECSHYMKNFDVGHVPLR LAKSKQLLSVINKNFGTLAF CRRWVDRVGETKYLLALKDL CDKGLVEAYPPLCDTKGCYT Meda EENEFYAIETFGSTGRGQ-- -------------------- -------------------- -------------------- -------------------- Afos EENEFYAIETFGSTGKGFVH EDMECSHYMKNFDVGHVPLR LQKSKQLLNTINKHFGTLAF CRRWLDRIGETRYLMALKDL GEKGIVDPYPPLVDIKGCYT Dmel EEDEFYAIETFGSTGRGLVH DDMDCSHYMKNFDLPFVPLR LQSSKQLLGTINKNFGTLAF CKRWLDRAGATKYQMALKDL CDKGIVEAYPPLCDIKGCYT Tcas EENEFYAIETFGSTGRGVVH DDMDCSHYMKNFESSYVPLR LQSSKTLLNIINKNFGTLAF CKRWLDRAGATKYQMALKDL CDKGVVDAYPPLCDIKGCYT Pmon EENEVYAIETFGSTGRGYVH DDMETSHYMKNYDAGHVPLR LAKSKHLLNVINQNFGTLAF CRRWLDRLGESKYLMALKDL CEKGIIDPYPPLCDVKGCYT Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal EENEFYAIETFGSTGRGVVH DDMETSHYMKNFDVGHVPLR LQRSKQLLNTINKHFGTLAF CRRWLDRLGETRYLMALKDL GEKGIVEPYPPLCDVKGCYT Crog EENEFYAIETFGSTGRGYVK DDLETSHYMKNFDAPHVQLR LQRSKQLLNCINKNFSTLAF CRRWLDRLGESRYLMALKDL GEKGIVEPYPPLCDVKGSYT Dpul EENEFYAIETFGSTGRGYVH DDMETSHYMKNWDVSHVPLR LAKSKQLLNVINQNFGTLAF CRRWLDRLDQTKYLMGLKDL CDKGIVDPYPPLCDTKGCYT Aver -------------------- -------------------- -------------------- ---------QESGKGSFKYA WVMDKLKAERERGITIDIAL Csin -------------------- ---MGKEKTHVNIVVIGHVD SGKSTTTGHLIYQCGGIDKR TIEKFEKESQESGKGSFKYA WVLDKLKAERERGITIDIAL Isca -------------------- ---MGKEKTHINIVVIGHVD SGKSTTTGHLIYKCGGIDKR TIEKFEKEAQEMGKGSFKYA WVLDKLKAERERGITIDITL Eaff AQYEHTILLRPTCKEVISRG TDYMGKEKTHINIVVIGHVD SGKSTTTGHMIYQCGGIDKR TIEKFEKEAQEMGKGSFKYA WVLDKLKAERERGITIDIAL Lcyp AQYEHTILLRPTCKEVLSRG DDYMPKDKIHINIVVIGHVD SGKSTTTGHLIYQCGGIDKR TIEKFEKEAQEMGKGSFKYA WVLDKLKAERERGITIDIAL Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp AQYEHTIVLRPTCKEVVTRG DDY----------------- -------------------- -------------------- ---DKLKAERERGITIDIAL Afra AQFEHTILLRPTCKEVLSRG DDYMGKEKIHINIVVIGHVD SGKSTTTGHLIYKCGGIDKR TIEKFEKEAQEMGKGSFKYA WVLDKLKAERERGITIDIAL Hazt AQFEHTIVLRPTCKEVVTRG SDYMGKEKIHISIVVVGHVD SGKSTTTGHLIYKCGGIDKR TIEKFEKEATEMGKGSFKYA WVLDKLKAERERGITIDIAL Meda -------------------- -------------------- -------------------- ---------QEMGKGSFKYA WVLDKLKAERERGITIDIAL Afos AQFEHTILLRPTCKEVISRG DDYMGKEKTHINIVVIGHVD SGKSTTTGHLIYQCGGIDKR TIEKFEKEAQEMGKGSFKYA WVLDKLKAERERGITIDIAL Dmel AQYEHTIMLRPTCKEVVSRG DDYMGKEKIHINIVVIGHVD SGKSTTTGHLIYKCGGIDKR TIEKFEKEAQEMGKGSFKYA WVLDKLKAERERGITIDIAL Tcas AQFEHTIMLRPTCKEVVSRG DDYMGKEKTHINIVVIGHVD SGKSTTTGHLIYKCGGIDKR TIEKFEKEAQEMGKGSFKYA WVLDKLKAERERGITIDIAL Pmon AQFEHTIVLRPTCKEVVTRG DDY----------------- -------------------- -------------------- -------------------- Smar -------------------- -------------------- -------------------- -----------MGKGSFKYA WVLDKLKAERERGITIDISL Tcal AQFEHTILLRPTCKEVISRG DDYMGKEKFHINIVVIGHVD SGKSTTTGHLIYQCGGIDKR TIEKFEKEAQEMGKGSFKYA WVLDKLKAERERGITIDIAL Crog AQFEHTILLRPTCKEVISRG TDYMGKEKIHINIVVIGHVD SGKSTTTGHLIYQCGGIDKR TIEKFEKEAQEMGKGSFKYA WVLDKLKAERERGITIDIAL Dpul AQWEHTILLRPTCKEVISRG TDYMGKEKTHINIVVIGHVD SGKSTTTGHLIYKCGGIDKR TIEKFEKEAQEMGKGSFKYA WVLDKLKAERERGITIDIAL Aver WKFETPRYYVTIIDAPGHRD FIKNMITGTSQADCGVLIVA AGTGEFEAGISKNGQTREHA LLAYTLGVKQLIVGVNKMDS TEPPYSQSRFEEIHKEVSNY Csin WKFETPKYYVTIIDAPGHRD FIKNMITGTSQADCGVLIIA SGTGEFEAGISKNGQTREHA LLAYTLGVKQLIVAVNKMDS TEPPYSQARFEEIQKEVSGF Isca WKFETPRYYVTVIDAPGHRD FIKNMITGTSQADCAVLVVA AGTGEFEAGISKNGQTREHA LLAYTLGVKQMIVGVNKMDT TEPPFSQTRFEEIQKEVSAY Eaff WKFETPKYYVTIIDAPGHRD FIKNMITGTSQADCGVLIIA SGTGEFEAGISKNGQTREHA LLAYTLGVKQLIVGVNKMDS TEPPYSQARFEEIQKEVSGF Lcyp WKFETPKYYVTIIDAPGHRD FIKNMITGTSQADCGVLIVA AGTGEFEAGISKNGQTREHA LLAYTLGVKQLIVGVNKMDS TEPAYSQSRYEEIRKEVSSY Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp WKFETSKYYVTIIDAPGHRD FIKNMITGTSQADCAVLIVA SGVGEFEAGISKNGQTREHA LLAYTLGVKQMIIGVNKMDT TEPPFSEARFKEIVSEVSTY Afra WKFETAKYYVTIIDAPGHRD FIKNMITGTSQADCAVLIVA AGVGEFEAGISKNGQTREHA LLAYTLGVKQLIVGVNKMDS TEPPFSEARFEEIKKEVSAY Hazt WKFETTKFMVTIIDAPGHRD FIKNMITGTSQADCAVLIVA AGTGEFEAGISKNGQTREHV LLCFTLGVKQMIVAVNKMDS TEPKYSEERFKEIHKEVSAY Meda WKFETPKFYVTIIDAPGHRD FIKNMITGTSQADCGVLIVA AGTGEFEAGISKNGQTREHA LLAYTLGVKQLIVGVNKMDS TEPPYXQGRFEEIQKEVSNY Afos WKFETPKYYVTIIDAPGHRD FIKNMITGTSQADCGVLIIA SGTGEFEAGISKNGQTREHA LLAYTLGVKQLIVGVNKMDS TEPPYSQARFEEIQKEVSNF Dmel WKFETAKYYVTIIDAPGHRD FIKNMITGTSQADCAVLIVA AGTGEFEAGISKNGQTREHA LLAFTLGVKQLIVGVNKMDS SEPPYSEARYEEIKKEVSSY Tcas WKFETSKYYVTIIDAPGHRD FIKNMITGTSQADCAVLIVA AGTGEFEAGISKNGQTREHA LLAFTLGVKQLIVGVNKMDS TEPPYSEARYEEIKKEVSSY Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar WKFETPKFYITIIDAPGHRD FIKNMITGTSQADCAVLIVA AGTGEFEAGISKNGQTREHA LLAYTLGVKQLIVGVNKMDS TEPPYSGSRFDEIQKEVSSY Tcal WKFETPKYYVTIIDAPGHRD FIKNMITGTSQADCGVLIIA SGTGEFEAGISKNGQTREHA LLAYTLGVKQLIVGVNKMDS TEPPYSQARFEEIQKEVSGF Crog WKFETPKFYVTIIDAPGHRD FIKNMITGTSQADCGVLIIA SGTGEFEAGISKNGQTREHA LLAYTLGVKQLIVGVNKMDS TEPPYSQNRFEEIQKEVSGY Dpul WKFETAKFYVTIIDAPGHRD FIKNMITGTSQADCAVLIVA GGVGEFEAGISKNGQTREHA LLAYTLGVKQLIVGVNKMDS TEPPFSEARYEEIKKEVSSY Aver IKKIGYNPATVVFVPISGWH GDNMLAPSANMGWYKGWEIT RK-EGKASGTTLLEALDAIV PPARPTDKPLRLPLQDVYKI GGIGTVPVGRVETGIIKPGM Csin IKKVGYNPAAVPFVPISGWH GDNMLQTSSNMSWYKGWAVE RK-EGKASGTTLLEALDSII PPARPTDKPLRLPLQDVYKI GGIGTVPVGRVETGIIKPGM Isca IKKIGYNPATVPFVPISGWN GDNMLDASPNMGWYKGWTIE RK-SGKSEGKSLLQALDAME PPTRPTDKPLRLPLQDVYKI GGIGTVPVGRVETGLLKPGM Eaff IKKVGYNPAAVPFVPISGWH GDNMLATSPNMSWYKGWNIE RK-EGKASGTTLLEAFDAII PPTRPTDKPLRLPLQDVYKI GGIGTVPVGRVETGIIKPGM Lcyp IKKIGYNPDAVAFVPISGWH GDNMLTPSANMSWYKGWEVN RK-EGKASGVTLLDALDAII PPTRPTDKPLRLPLQDVYKI GGIGTVPVGRVETGILKPGM Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp IKKVGYDPKTVAFVPISGWH GDNMLEASDKMPWYKGWETT RK-SGSGSGKTLLEALDNIE PPTRPSDKPLRLPLQDVYKI GGIGTVPVGRVETGTIKPGM Afra IKKIGYNPAAVAFVPISGWH GDNMLEASDRLPWYKGWNIE RK-EGKADGKTLLDALDAIL PPSRPTEKPLRLPLQDVYKI GGIGTVPVGRVETGIIKPGM Hazt VKKVGYNPAIVPILPISGFN GDNMLERSDKMPWWKKQKIE RK-SGAYEFETLFDVLDNIE PPTRPTDKALRLPLQDVYKI GGIGTVPVGRVETGTLKPGM Meda IKKIGYNPATVAFVPISGWH GDNMLSPSANMGWYKGWEIT RK-EGKASGTTLLEALDAIV PPARPTDKPLRLPLQDVYKI GGIGTVPVGRVETGVLKPGM Afos IKKVGYDPKAVAFVPISGWH GDNMLSTSTNMPWFKGWQIE RKGESVAKGTTLLEALDAII PPTRPTDKPLRLPLQDVYKI GGIGTVPVGRVETGVLKPGM Dmel IKKIGYNPAAVAFVPISGWH GDNMLEPSTNMPWFKGWKVE RK-EGNADGKTLIDALDAIL PPARPTDKALRLPLQDVYKI GGIGTVPVGRVETGVLKPGT Tcas IKKIGYNPAAVAFVPISGWH GDNMLEPSTKMPWFKGWNIE RK-EGKAEGKCLIEALDAIL PPTRPTDKPLRLPLQDVYKI GGIGTVPVGRVETGVLKPGM Pmon -------------------- -------------------- ---------ETLFDALDNIE PPTRPLDKALRLPLQDVYKI GGIGTVPVGRVETGILKPGM Smar IKKIGYNPAAVPFVPISGWN GDNMLDASPNMPWHKGWDIE RK-EGKASGKTLLEALDSII PPARPTDKPLRLPLQDVYKI GGIGTVPVGRVETGTLKPGM Tcal IKKVGYNPAAVPFVPISGWH GDNMLATSPNMSWYKGWEIT RK-EGKASGTTLLEALDSIV PPSRPFDKPLRLPLQDVYKI GGIGTVPVGRVETGIIKPGM Crog IKKVGYNPAAVPFVPISGWH GDNMLQASKNMSWYKGWEIT RK-EGKATGTTLLDALDSII PPARPTDKPLRLPLQDVYKI GGIGTVPVGRVETGIIKPGM Dpul IKKIGYNPVTVPFVPISGFH GDNMIEASSNLPWYKGWAVE RK-EGKADGKTLLEALDAIV PPSRPTDKALRLPLQDVYKI GGIGTVPVGRVETGVIKPGM Aver VVTFAPVALTTEVKSVEMHH ESLPEACPGDNVGFNIKNVS VKDIRRGYVASDSKNHPAFA TKDFLAQVIVLNHPGQISNG YSPVLDCHTAHIACKFAEIK Csin VVTFAPNQLTTEVKSVEMHH ESLPEATPGDNVGFNIKNVS VKDIKRGYVASDSKNKPASG VSDFTAQVIVLNHPGQVSNG YSPVLDCHTAHIACKFAEIK Isca VVTFAPANITTEVKSVEMHH EALTEAVPGDNVGFNVKNVS VKELRRGYVCGDSKDSPPKS TEEFTAQVIVLNHPGQISNG YTPVLDCHTAHIACKFREIK Eaff VVTFAPGQLSTEVKSVEMHH ESLPEATPGDNVGFNVKNVS VKDIKRGNVASDSKNRPATG VQDFTAQVIVLNHPGQISNG YSPVLDCHTAHIACKFAEIK Lcyp VVTFAPVNLTTEVKSVEMHH EALTEAVPGDNVGFNVKNVS VKDIRRGYVASDSKSNPAFA AKDFLAQVIVLNHPGQISNG YSPVLDCHTAHIACKFAEIK Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp IVCFAPSGLTTEVKSVEMHH ESLPEAFPGDNVGFNVKNVS VKELRRGYVASDSKNKPATG CEDFTAQVIILNH------- -------------------- Afra IVTFAPANITTEVKSVEMHH ESLEQASPGDNVGFNVKNVS VKELRRGYVASDSKNNPARG SQDFFAQVIVLNHPGQISNG YTPVLDCHTAHIACKFAEIK Hazt VVTFAPTGLTTEVKSVEMHH EALVEATPGDNVGFNVKNVP VKDLKRGFVTSDSKNDAAKA AQDFVAQVIVLNHPGQIQAG YSPVVDCHTAHIACKFAELV Meda VVTFAPVNLTTEVKSVEMHH EALPEAVPGDNVGFNIKNVS VKDIRRGYVASDSKNQPAFA AKDFLAQVIVLNHPGQISNG YSPVLDCHTAHIACKFAEIK Afos LVTFAPTQLTTEVKSVEMHH ESLAEAVPGDNVGFNVKNVS VKDIKRGNVASDNKNKPATG VSDFTAQVIVLNHPGQISNG YSPVLDCHTAHIACKFAEIK Dmel VVVFAPANITTEVKSVEMHH EALQEAVPGDNVGFNVKNVS VKELRRGYVAGDSKANPPKG AADFTAQVIVLNHPGQIANG YTPVLDCHTAHIACKFAEIK Tcas VVVFAPANITTEVKSVEMHH EALPEAVPGDNVGFNVKNVS VKELRRGYVAGDSKASPPKG AADFLAQVIVLNHPGQISNG YTPVLDCHTAHIACKFAEIK Pmon VVNFAPTGPTTEVKSVEMHH EALTEAVPGDNVGFNVKNVS VKDLKRGFVASDSKNDPAKE AADFTAQVIVLNHPGQIQAG YSPVLDCHTAHIACKFAELL Smar VVTFAPVNLTTEVKSVEMHH EALQEAMPGDNVGFNVKNVS VKELRRGYVAGDSKNNPPKA VSDFTAQVIVLNHPGQISNG YTPVLDCHTAHIACKFAEIK Tcal VVTFAPVQLTTEVKSVEMHH ESLPEATPGDNVGFNVKNVS VKDIKRGFVASDSKNKPATG CKDFTAQVIVLNHPGQICNG YSPVLDCHTAHIACKFLEIK Crog VVTFAPNNLTTEVKSVEMHH ESLKEATPGDNVGFNVKNVS VKDIKRGYVASDSKNKPAVG CKDFTAQVIVLNHPGEICNG YTPVLDCHTAHIACKFNEIK Dpul VVTFAPCQLTTEVKSVEMHH EALEEAVPGDNVGFNVKNVS VKELRRGFVAGDSKNNPPKG AADFYAQVIVLNHPGQIGNG YTPVLDCHTAHIACKFAEIK Aver EKVDRRTGKSTEDNPKSIKS GDAAIVNLVPSKP-MCVEAF VDFPPLGR------------ -------------------- -------------------- Csin EKVDRRTGKSTEDNPKFIKS GDAAIVLLTPSKP-MCVEPF SQFPPLGRFAVRDMRQTVAV GVIKE--------------- ---------EDRQYKKIHAR Isca EKCDRRSGKKLEDNPKFIKS GDAAIIDLVPSKP-MCVETF TDFPPLGRFAVRDMRQTVAV GVIKSVKPKEASG-GKVTKA AEKAQKKK---MPITKIFAR Eaff EKVDRRTGKSTEDNPKFIKS GDAAIVRLVPSKP-MCVEAF SDFPPLGRFAVRDMRQTVAV GVIKATTPKDVA--GSATKS AAKAQKKK---MPIKKIHAR Lcyp EKVDRRTGKSVEDNPKFIKS GDAAIVNLVPSKP-MCVEAF SDFPPLGRFAVRDMRQTVAV GVIKSVQAKDVS--GTTTKA AQKAQKKK---MPIKKIFAR Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -----------MPIQKVHAR Afra EKCDRRTGKTTEAEPKFIKS GDAAMITLVPSKP-LCVEAF SDFPPLGRFAVRDMRQTVAV GVIKSVNFKDPTA-GKVTKA AEKAGKKK---MAIQKIHAR Hazt TKIDRRTGKEIESNPKAVKS GDSCIVKMVPSKP-MCVESF QQYPPLGRFAVRDMKQTVAV GVIKEVNKKEASG-GKTTKA AEKALKKK---MSVTKVFAR Meda EKVDRRTGKSVEDNPKSIKS GDAAIVNLVPSKP-MCVEAF SDFPPLGR------------ -------------------- -------------------- Afos EKVDRRTGKSTEDNPKFIKS GDAAIVKLIPSKP-MCVEPF SDFAPLGRFAVRDMRQTVAV GVIKATTPKEVA--GNLTKA AKTAASKKK--MPIKKIHAR Dmel EKVDRRSGKTTEENPKFIKS GDAAIVNLVPSKP-LCVEAF QEFPPLGRFAVRDMRQTVAV GVIKAVNFKDASG-GKVTKA AEKATKGKK--MTIKAIKAR Tcas EKVDRRSGKTTEENPKAIKS GDAAIVTLVPSKP-MCVESF QEFPPLGRFAVRDMRQTVAV GVIKSVNFKDAGA-GKVTKA AEKAAKKK---MPMKTIFAR Pmon TKIDRRTGKELEAGPKHVKS GDSCIVKDGSQQAHVCGDLP TVCSSW----------TFLL CVT----------------- -----------MSITKVFAR Smar EKCDRRSGKTVEENPKAIKS GDAAIVNLVPSKP-MCVESF SDFPPLGRFAVRDMRQTVAV GVIKSVNQKEATS-GKVTKA AEKAQKKK------------ Tcal EKVDRRTGKATETNPKSIKS GDAGIVELVPSKP-MCVEAF ADFPPLGRFAVRDMRQTVAV GVIKSVTLKELS--GTTTKA GAKAQKKK---MPIKKIHAR Crog EKVDRRTGKSTESNPKSIKS GDAGIVELVPSKP-MCVEAF SDFPPLGRFAVRDMRQTVAV GVIKSMCPKDIS--GTTTKA AQKAQKKK---MPIKEIHAR Dpul EKCDRRTGKTTEENPKFIKS GDAAMITLVPSKP-LCVESF SDFPPLGRFAVRDMRQTVAV GVIKSVNFKDLGAGGKVTKA AEKAGKKK---MSIQKIFAR Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin QIYDSRGNPTVEVDLTTEKG IFRAAVPSGASTGIYEALEM RDKAET-WHGKGVQKAVHNV NNLIAPEIVAKCLDPVEQEK IDSLML---ATDNKNKLGAN Isca QIFDSRGNPTVEVDLTTEKG LFRAAVPSGASTGIHEALEL RDGDKSMYHGKSVFKAVDNV NKVIAPQLIAKNFDVREQFQ IDEFMIELDGTENKGNLGAN Eaff QIYDSRGNPTVEVDLTTEKG IFRAAVPSGASTGIYEALEL RDKAET-WHGKGVTKAVNNV NNIIAPELIKNCLDPVEQEK IDELMLKLDGTDNKNSLGAN Lcyp QIYDSRGNPTVEVDLTTEKG IFRAAVPSGASTGIHEALEL RDNEKGKWHGKGVLKAVDNV NNVIAPALVNANLDPVDQTA IDELMLKLDGTDNKSSLGAN Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp SIFDSRGNPTVEVDLFTEKG LFRAAVPSGASTGVHEALEL RDGDKSKYMGKSVFKAVENI NKIIVPELLKKNLEPTQQKE IDEFMIQLDGTPNKSKLGAN Afra MIFDSRGNPTIEVDLVTEQG LFRAAVPSGASTGIYEALEL RDGVKAEYHGKGVFKAIRNV NEIIAPALIAKGLDVTQQEQ IDQFMLDLDGTPNKEKLGAN Hazt SIFDSRGNPTVEVDLYTAKG LFRAAVPSGASTGVHEALEM RDGDKKLYHGKSVFNAVKNV NDVIGPELIKSGLQVTQQKE IDEFMIKLDGTENKSKLGAN Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos QIYDSRGNPTVEVDLTTEKG IFRAAVPSGASTGIYEALEL RDKGDT-WHGKGVSKAVDNV NNLIAPELVKANLDPVEQVN IDEMMLKLDGTDNKNKLGAN Dmel QIYDSRGNPTVEVDLTTELG LFRAAVPSGASTGVHEALEL RDNDKANYHGKSVLKAVGHV NDTLGPELIKANLDVVDQAS IDNFMIKLDGTENKSKFGAN Tcas QIFDSRGNPTVEVDLITDLG LFRAAVPSGASTGVHEALEL RDNDKANYHGKSVQKAINNV NTIIAPELIKSNLEVTQQTE IDDLMLKLDGTENKSKLGAN Pmon TIFDSRGNPTVEVDLYTHKG LFRAAVPSGASTGVHEALEM RDGDKSKYHGKSVFKAVNNV NSIIAPEIIKSGLKVTQQKE CDDFMCKLDGTENKSRLGAN Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal QIFDSRGNPTVEVDLTTEKG IFRAAVPSGASTGIYEALEL RDQDKSKYMGKGVSKAVDNI NTIIAPKLVEMSLDPVDQTN VDKVMLDMDGTDNKNKLGAN Crog QIYDSRGNPTVEVDLTTERG IFRAAVPSGASTGVHEALEL RDKDST-WHGKSVLKAVKNV NEVLGPELVKKEFDPVKQEE IDDFMISLDGTENKSKFGAN Dpul MIFDSRGNPTVEVDLTTEKG LFRAAVPSGASTGIHEALEL RDDIKTEYHGKGVKKAVSNI NDLIAPALLKENLQVTDQEA IDNFMIKLDGTENKSKFGAN Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin AILGVSMAVCKAGAAHKGVP LYRHIADLAGVKDVFMPVPC LNVINGGSHAGNKLAMQEFM VLPLGASCFSRRVHGGSELY HHLKALIKKKYGLDATAVGD Isca AILGVSLAVCRAGAAQKGVP VYRHIADLAGNSKVILPVPA FNVINGGSHAGNKLAMQEFM ILPTGASSFSEAMRMGSEVY HHLKNVIKKK---------- Eaff AILGVSMAVCKAGAAHKGVP LYRHIADLAGVKDVIMPVPA LNVINGGSHAGNKLAMQEFM VLPTGATCFSEAMRMGSELY HHLKSIIKKKYGLDATAVGD Lcyp AILGVSMAVCKAGAAHKGVP LYRHIADLAGVKQVMMPVPA FNIINGGSHAGNKLAMQEFM ILPVGATSFTEAMKMGTETY HHLRTLIKAKYGLDATAVGD Lsal -------------------- --------------MMPVPA FNVINGGSHAGNKLAMQEFM ILPTGAPSFTEAMRMGSEIY HHLKALIKKKYGLDATAVGD Aamp AILGVSLAVCKAGAAAKGIP LYKHIADLAGNKNIVLPTPA FNVINGGSHAGNKLAMQEFM ILPTGAANFTEAMRMGSEVY HNLKAVIKKKFGLDATAVGD Afra AILGVSLAACKAGAKQKGVP LYRHIADLAGTPEIILPTPA FNVINGGSHAGNKLAMQEFM ILPTGAGSFSEAMRMGSEIY HHLKSVIKSRFGLDATAVGD Hazt AILGVSLAVCKAGAAELGLP LYRHLANLANYKDVILPVPA FNVINGGSHAGNKLAMQEFM ILPTGASSFTEAMRMGTEIY HHLKAVIKSKFGLDATAVGD Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos AILGVSMAVCKAGAAHKGVP LYRHIADLAGVKDVIMPVPA LNVINGGSHAGNKLAMQEFM VLPTGASCFSEAMRMGSELY HHLKGIIKKKYGLDATAVGD Dmel AILGVSLAVAKAGAAKKGVP LYKHIADLAGNKEIILPVPA FNVINGGSHAGNKLAMQEFM ILPTGATSFTEAMKMGSEVY HHLKNVIKAKFGLDATAVGD Tcas AILGVSLAVAKAGAAKKGVP LYKHLADLAGNKNIILPVPA FNVINGGSHAGNKLAMQEFM ILPTGAKSFTEAMKMGSEVY HHLKNVIKAQFGLDATAVGD Pmon AILGVSLAICKAGAAELGIP LYRHIANLANYSDVILPVPA FNVINGGSHAGNKLAMQEFM ILPTGATSFTEAMRMGSEVY HHLKAVIKGRFGLDATAVGD Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal AILGVSMAVCKAGAAHKGVP LYQHIADLAGVKEVKMPVPA FNVINGGSHAGNKLAMQEFM ILPTGAANFTEAMRMGSEIY HHLKAGIKAKYGLDATAVGD Crog AILGISMAVCKAGAAHKGVP LYRHIADLSGVKEVMMPVPA FNVINGGSHAGNKLAMQEFM ILPTGAPSFSEAMRMGSEIY HHLKALIKKKYGLDATAVGD Dpul AILGVSLAACKAGATHKGVP LYRHIADLAGTPEIILPTPA FNVINGGSHAGNKLAMQEFM ILPTGASSFTEAMRMGTETY HHLKKVINARFGLDATAVGD Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin EGGFAPNFQNNGEALDLLVE AIKKSGYEGKIMIGMDIAAA EFFK-NGK-YDLDFKNPNTK EADWISSDALLEMYKGFIKD YPVVSIEDPFDQDDWAGYAK Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff EGGFAPNFQNNGEALELLVE AIKKSGYEGKIQIGMDIAAA EFYK-NGK-YDLDFKNPESN EADWINSDQLGEMYKGFIKD YPVVSIEDPFDQDDWEGYTK Lcyp EGGFAPNFQNNADAIKLCTD AIEKAGYTGKIKIGMDVAAS EFYK-DGK-YDLDFKNPNSN PDDWITSDKLADMYRGFIAD APVVSIEDPFDQDDWQGWSA Lsal EGGFAPNFQANGEAIDLLVG AIEKAGYTGKIKIGMDVAAS EFYK-NGK-YDLDFKNEESK EADWLTSEALGEMYKGFIKD APVISIEDPYDQDDWEGRTA Aamp EGGFAPNIQNNEEALTMLME AIEKAGYTGKVDIGMDVAAS EFHKADGQ-YDLDFKTENND GSKVISGEALADMYRDWAKR YPIVSVEDPFDQDDWDSWVK Afra EGGFAPNILNNKDGLSLIVT AIEKAGYTGKVEIGMDVAAS EFYR-EGK-YDLDFKNPNSD KTAWLSGQELANLYQEFIKE FPVTSIEDPFDQDDWDAWSS Hazt EGGFAPNILNNKDALSLITD AIERAGYTGKIEIGMDVAAS EFYK-GNNIYDLDFKTENND GSQKISGEQLCDLYTSFCKD FPITSIEDPFDQDDWDNWTR Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos EGGFAPNFQNNGEALELLVE AIKKSGYEGKIQIGMDIAAS EFFK-NGK-YDLDFKNPESK EADWITSDQLGEMYKGFIKD YPVVSIEDPFDQDDWEGYTK Dmel EGGFAPNIQSNKEALNLISD AIAKAGYTGKIEIGMDVAAS EFYK-DGQ-YDLDFKNEKSD KSQWLPADKLANLYQEFIKD FPIVSIEDPFDQDHWEAWSN Tcas EGGFAPNIQNNEDALNLIIE AIKKAGYEGKIDIGMDIAAS EFYK-DGQ-YDLDFKNPKSD KSKWISGEKLLEMYKGFIKK FPVVSIEDPFDQDDWSSWSA Pmon EGGFAPNILNNKDALTLIQE SIEKAGYTGKIEIGMDVAAS EFYK-GENIYDLDFKTANND GSQKITGDQLRDMYMEFCKE FPIVSIEDPFDQDDWENWTK Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal EGGFAPNFQNNKEALELLVG AIEKAGYSGKIQIGMDVAAS EFRK-GDK-YDLDFKNPESK EADWISSDALGEMYKGFIKD FPVTSIEDPFDQDDWEGWTK Crog EGGFAPNFQANGEAIDLLVG AIEKAGYTGKIKIGMDVAAS EFYK-KGK-YDLDFKNDASK EADWISSDALGEMYKGFIKD APVLSIEDPYDQDDWEGWTK Dpul EGGFAPNILNNKDALDLITS AIEKAGYTGKIEIGMDVAAS EFHK-NGK-YDLDFKNPASD PATYLESNKLAELYQEFIKD FPMVSIEDPFDQDDWAAWTS Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin LTKETSIQIVGDDLLVTNPK RIQTAIEKKACNGLLLKVNQ IGSVTESIKAHNMAKAEGWG TMVSHRSGETEDCFIADLVV GLGTGQIKTGAPCRSERLAK Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff LTSETSIQIVGDDLLVTNPK RIQTAIDKKACNALLLKVNQ IGSVTESIRAHQMAKAQGWG TMVSHRSGETEDCFIADLVV GLGTGQIKTGAPCRSERLAK Lcyp LTGSTPIQIVGDDLTVTNPK RIQMAVDKKACNCLLLKVNQ IGSVTESIAAHNLAKANGWG TMVSHRSGETEDCFIADLVV GLCTGQIKTGAPCRSERLAK Lsal LTSQTDIQIVGDDLTVTNPK RIQMAVDKKSCNCLLLKVNQ IGSVTESIRAHNLAKSNGWG TMVSHRSGETEDCFIADLVV GLCTGQIKTGAPCRSERLSK Aamp YTASVEHQVVGDDLTVTNPQ RIQMGIDKKACNCLLLKVNQ IGSVTESIAAHQLAKSDGWG TMVSHRSGETEDPFIADLVV GLSTGQIKTGAPCRSERLCK Afra FTANTNIQIVGDDLTVTNPI RIQTGIDKKACNCLLLKVNQ IGSVTESIRAHKLAKANGWG TMVSHRSGETEDSFIADLVV GLSTGQIKTGAPCRSERLAK Hazt MTAGTNIQIVGDDLTVTNPK RITTAVEKKACNCLLLKVNQ IGSVTESINAHLLAKSNGWG TMVSHRSGETEDTFIADLVV GLCTGQIKTGAPCRSERLAK Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos LTSETSIQIVGDDLLVTNPK RIQTAIDKKACNALLLKVNQ IGSVTESIKAHQMAKGQGWG TMVSHRSGETEDCFIADLVV GLGTGQIKTGAPCRSERLAK Dmel LTGCTDIQIVGDDLTVTNPK RIATAVEKKACNCLLLKVNQ IGTVTESIAAHLLAKKNGWG TMVSHRSGETEDSFIGDLVV GLSTGQIKTGAPCRSERLAK Tcas ITSSTDIQIVGDDLTVTNPK RIQTAVEKKACNCLLLKVNQ IGSVTESIKAHLLAKSNGWG TMVSHRSGETEDTFIADLVV GLSTGQIKTGAPCRSERLAK Pmon MTSATNIQIVGDDLTVTNPK RIATAVEKKACNCLLLKVNQ IGSVTESIDAHLLAKKNGWG TMVSHRSGETEDCFIADLVV GLCTGQIKTGAPCRSERLAK Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal LTGETSIQIVGDDLTVTNPK RIQMAVDKKSCNCLLLKVNQ IGSVTESIEAHNLAKKNGWG TMVSHRSGETEDCFIADLVV GLCTGQIKTGAPCRSERLAK Crog LTAETDIQIVGDDLTVTNPK RIQMAVEKKACNCLLLKVNQ IGSVTESIRAHNLARSNGWG TMVSHRSGETEDCFIADLVV GLCTGQIKTGAPCRSERLAK Dpul LTGNTPIQIVGDDLTVTNPK RIQMAVDCKACNCLLLKVNQ IGTVTESIAAHKLAKANGWG TMVSHRSGETEDSFIGDLVV GLSTGQIKTGAPCRSERLAK Aver -------------------- -------------------- -------------------- -------------------- ------------VLWALFRD Csin YNQ----------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------VEMPQSSFP---P ALSPQCIALLKESIHLF--- ----EEPVQEQQVHVFIVLG ASGDLAKKKIYPTLWALFRD Eaff YNQLLRIEEELGPGAKFAGV NFRNPQ---MIDAEC----T EGNPEGLQLLRESLRKVQLK --D-----EGVHSNVFVVFG ASGDLARKKIYPTLWALYRD Lcyp YNQLLRIEEELGSAAKFAGE KFRNPCK--MDQNQWPLCLD CGNSEGLELLRKSLKSVQL- ----EAHVKEDACHTFVICG ASGDLAKKKIYPTLWAIFKD Lsal YNQLLRIEEELGSNAKYVGD KFRMPF-------------- -------------------- -------------------- -------------------- Aamp YNQILRIEEELGANAKYAGK NFRRPQ-------------- -------------------- -------------------- -------------------- Afra YNQILRIEEELGSNAKYAGK NFRHPL---MG-SKTKGSRT SCPQDSLDLIRRSLRSTHMS ---NSERFEESTPHVFIVLG ASGDLAKKKIYPTLWWLFRD Hazt YNQILRIEEELGASAKYAGK SFRMPC-------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- ------------VLWALFRD Afos YNQLLRIEEELGSGAKFAGA NFRCPQ---MTSSNI----S SGEPADL------------- ------------SNVFVVFG ASGDLARKKIYPTLWALFRD Dmel YNQILRIEEEIGAGVKFAGK SFRKPQ---MAT-------Q KEDHTALDLIIKSLKSPTMV --CEGTHFDGKIPHTFVIFG ASGDLAKKKIYPTLWWLYRD Tcas YNQILRIEEELGANAKYAGK AFRKPQ---MPLLKIDDDDA ANSEVCLALYRKSLKSKEMD --HGGTHFDGHHPHVFITLG ASGDLARKKIYPTLWWLYRD Pmon YNQILRIEEELGGNAKFAGK KFRKPC-------------- -------------------- -------------------- -------------------- Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal YNQLLRIEEELGANAKFVGE KFRNPDA--MDPLAVH---D DCNQKGLELLIKSLKKIQV- ----EYQSGQGCTHIFTIFG ASGDLAKKKIYPTMWALYRD Crog YNQLLRIEEELGSKAKYVGD KFRKPY---M---------- -ANNEGLELMRKSLRKITLS --SPQNEDPSKKCHIFVVMG ASGDLAKKKIYPTLWSLYFH Dpul YNQILRIEEELGAAAKYAGK NFRHPL---MS--------- -------------------- ---QAEVFEETLPHSFVIFG ASGDLARKKIYPTIWWLYRD Aver NLLPTNTRFVGYARSKITVQ AIRESCAPWCQVRENEEEKA DQFWALNSYVAGSYDQKSDF ENLDLVISEGESSSSDANRL YYLALPPSVFIPVTTHLKEA Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca GLLPPKTKFVGYARSNMTVE SLSEKIEPYLKVKEEEKEKF SNFLKLNTYISGKYDASEDF DNLDGELRKLEGSS--ANRI FYMALPPTVFQAVATNIKRH Eaff NLLPKGTQIFGYARSKMTVE ELRGKCAATVKAKDGEEAEL EGFWKANHYVAGSYDTKRDF ELLAQEMSAVEKGQ--NNRL FYLALPPSVFKPVTSMLKEA Lcyp NLLPSNTKFVGYARSKIDVQ TLRANSDPWCNVKPGEEAKA DEFWSRNFYVAGSYDQKRDF ELLNQEISNLEKSNSVGNRL FYLALPPSVFESVTTFIKEA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra NLLPSNTRFVGYARSSLSVA EVRDKCQKYMKVKPEEEQRY DEFWTRNSYFHGNYDSRHDF EILDQEIRRLAACRE-ANRI FYLALPPSVFEVVTSSIQTA Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda NLLPSNTRFVGYARSKITVE SIRENCAPWCQVQEGEEEKA DKFWSLNSYVAGSYDNQADF ENLDAAITELESGSGIGNRL FYLALPPSVFIPVTSHLKVA Afos NLLPKDTKIFGYARSKFTVQ QIREKCVGTVKAKPGEEEAL DKFWQSNYYVAGSYDTKRDF EMLAQEMGGVEKGR--NNRL FYLALPPSVFKPVTTMIKET Dmel DLLPKPTKFCGYARSMLTVD SIKEQCLPYMKVQPHEQKKY EEFWALNEYVSGRYDGRTGF ELLNQQLEIMENKNK-ANRI FYLALPPSVFEEVTVNIKQI Tcas NLLPVNTVFFGYARSKTSVQ EIKEKCKPYMKVRHGEEERF EDFWKLHYYVAGSYDSRTDF ERLNQELCPFEKGPA-ANRV FYLALPPSVFETVTVHIRNS Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal SLIPENTQVFGYARSDLKVE DIRKKCEPYIKLKSGEEETF EKFWAANQYVRGTYDKRTDF EHLNHALTRAEDNKRENNRI FYLALPSSVFMESTKHIRET Crog NLCPPNTKFIGYSRSKIDVK TIRERSAPWFSCPEEHKAKL EEFWSLNHYVAGSYDQKRDF ELLNQEMERLESGSSGRNRL FYLALPPSVFASVTVFLKEC Dpul NLLPKNTIFYGYARSHMKVE EVRAKSHQYMKVKEEEQERY EAFWEANRYFAGGYDSRRDF EMLDQEMIQHERGPA-ANRL FYLAVPPFVFESVTANIRSS Aver AMAKTG-WTRVIVEKPFGKD SESSATLSNHLSSLFKEXXL YRIDHYLGKEMVQNLMTI-- --------------RFGNRL FGPTWNRDNIASVVITFKEP Csin -------------------- -------------------- ---D---------------- --------------WFGNMI FGPTWNRDSIASVTITFKEP Isca CMSKKG-WTRVVIEKPFGKD SASSAELSNHLASLFDESQL YRIDHYLGKEMVQNLMAI-- --------------RFSNQI FGPTWNRNSIASVVISFKEP Eaff CMSTKG-WTRVIVEKPFGKD SASSADLSNHLMKLFAEDQL YRIDHYLGKEMVQNLISL-- --------------RFGNMI FAPTWNRDNIASVVITFKEP Lcyp VMAERG-WSRVIVEKPFGKD SESSAKLSNHLSSLFKEDQL YRIDHYLGKEMVQNLMTI-- --------------RFGNRI FGPTWNRDNIASVIITFKEP Lsal -------------------- -----------XSLFREDQL YRIDHYLGKEMVQNLITL-- --------------RFANRI FSPTWNRDNIASVVITFKEP Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra CMADRG-WTRIIIEKPFGRD LESSAKLSNHLGSLFKEEQI YRIDHYLGKEMVQNLMIL-- --------------RFANRI FGPTWNRESISSVIISFKEP Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda TMAKTG-WTRVIVEKPFGKD SASSAKLSNHLSSLFREEQL YRIDHYLGKEMVQNLMTI-- --------------RFGNRL FGPTWNRDNIASVVITFKEP Afos CMSDKG-WSRIIVEKPFGKD SESSAELSNHLQKLFTEEQL YRIDHYLGKEMVQNLISL-- --------------RFGNMI FGPTWNRDSIASVIISFKEP Dmel CMSVCG-WNRVIIEKPFGRD DASSQALSDHLAGLFQEDQL YRIDHYLGKEMVQNLMTI-- --------------RFGNKI LSSTWNRENIASVLITFKEP Tcas CMAPKG-WTRIIIEKPFGRD FDSSQKLSNHLGSLFTEQQI YRIDHYLGKEMVQNLMTL-- --------------RFGNRI FNPTWNRDNIASIQISFKEP Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal CMAERG-WTRVIIEKPFGYD ADSSEKLSKHLSGLFTEEQL YRIDHYLGKEMVQNLMTL-- --------------RFANNL YTRSWDRDSIASVTITFKEP Crog CMSSKG-WSRVIVEKPFGKD SASSAELSNHLSSLFTEDQL YRIDHYLGKEMVQNLITL-- --------------RFANRI FSPTWNRDNIASVVITFKEP Dpul CMASKG-WTRVIVEKPFGRD LESSAHLSAHLAALFREDQI YRIDHYLGKEMVQNLMIL-- --------------RFGNRL FGPTWNRESIASVLITFKEP Aver FGTQGRGGYFDEFGVIR--- -------------------- -------------------- -------------------- -------------------- Csin FGTQGRGGYFDEFGIIRDVM QNHLLQILCLAAMEKPVTTS PDDIRNEKVKVLKAIPSLSL SSCVLGQYSGDPDSEDPDAR LGYLEDQTVPEGSSCPTFAA Isca FGTQGRGGYFDSFGIIRDVM QNHLLQIMCLVAMEKPVSTN AEDIRNEKVKVLKCVPPITM NHVVLGQYVGKPDGTGE-ER LGYLDDPTVPAGSRTATYAT Eaff FGTQGRGGYFDEFGIIRDVM QNHLLQILCLTAMEKPVTTS PDDIRDEKVKVLKAVEVLSL DDVVLGQYQGNPEGADEDAR LGYLDDPTVPAGSTCPTFAA Lcyp FGTQGRGGYFDEFGIIRDIM QNHLLQILCLTAMEKPPSTC PDDIRNEKVKVLKSCKEIDL KDVVLGQYVGNPEGADEDSR MGYLDDPTVPAGSVTPTFAA Lsal FGTQGRGGYFDDFGIIRDIM QNHLLQIFCLTAMEKPCSTS PDDIRDEKVKVLKCCQEVVM DDVVLGQYVGNPEGKTEDAR MGYLEDKTVPDDSVTPTYAA Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra FGTQGRGGYFDEFGIIRDVM QNHLLQILCLTAMEKPASTS PNDIRDEKVKVLKSMPELKI EDVVLGQYVGDPNGEGE-AK EGYLDDRTVPKGSVTPTYAE Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda FGTQGRGGYFDEFGIIR--- -------------------- -------------------- -------------------- -------------------- Afos FGTQGRGGYFDEFGIIRDVM QNHLLQILCLTAMEKPVTTS PDHIRDEKVKVLKAVEELTM DDVVLGQYQGDPDSNDEDAR LGYLDDKTVPAGSTCPTYAA Dmel FGTQGRGGYFDEFGIIRDVM QNHLLQILSLVAMEKPVSCH PDDIRDEKVKVLKSIEALTL DDMVLGQYLGNPQGTNDDAR TGYVEDPTVSNDSNTPTYAL Tcas FGTQGRGGYFDEFGIIRDIM QNHLLQILTLAAMEKPASVH PDDIRNEKVKVLRCIKVIEK KDVVLGQYVGDPNGEGE-AK LGYLDDPTVPNDSVTPTYAL Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal FGTQGRGGYFDQSGIIRDIL QNHLLQILCLAAMEKPASTS PDDIRDEKVKVLKTIPAITI EDCVLGQYVGDPNGKDEDSK LGYKDDDTVPKDSVTPTYAA Crog FGTQGRGGYFDEFGIIRDIM QNHLLQIFCLTAMEKPCSTS PNDIRDEKVKVLKCCKEVDI QDVVLGQYVGDPEGKTEDAR LGYLDDKTVPEGSITPTYAC Dpul FGTEGRGGYFDEFGIIRDVM QNHLLQMLCLTAMEKPASTH PNDIRDEKVKVLKCIPALTM DDVVLGQYIGDPEGQGE-AK ESYLDDPTVPKDSTTPTYAS Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin AVLKINNERWDGVPFMLKCG KL------------------ -------------------- -------------------- -------------------- Isca AVAYINNERWEGVPFILRCG KALNERKAEVRIQYKEVPGD IFGGNSKRNELVLRVQPGEA IYVKLMSKKPGMAFDIEETE LDLTYGSRYKARATIRKPDF Eaff AHLKIKNERWDGVPFILRCG KALNERKAEVRIQYKDVPGD IFNGSTVRNELVIRVQPNES VYVKVMTKTPGMSFNLEETE LDLTYKSRYK---EARLPE- Lcyp AVIRINNERWDGVPFILKCG KALNERKAEVRIQYKEVAGD IFNGQAIRNELVLRVQPGEA IYAKVMTKTPGMSFTLEETE LDLTYNTRYK---KARLPD- Lsal CVLRINNERWDGVPFILKCG KA------------------ -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra AVCWIDNERWDGVPFVLRCG KALNERKAEIRIQYRDVPGD IFGRQAKRNELVIRVQPGEA VYIKMMTKSPGMSFDIEETE LDLTYGTRYK---DVKMPD- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos AALKIKNERWDGVPFILRCG KALNERKAEVRIQYRDVPGD IFNKQTVRNELVIRVQPNES VYAKVMTKTPGMSFTLEETE LDLTYNSRYK---DARLPE- Dmel GVLKINNERWQGVPFILRCG KALNERKAEVRIQYQDVPGD IFEGNTKRNELVIRVQPGEA LYFKMMTKSPGITFDIEETE LDLTYEHRYK---DSYLPD- Tcas AALHINNERWDGVPFILKCG KALNERKAEVRIQFKDVPGD IFDGKPKRNELVIRVQPGEA LYVKLMVKTPGMAFDMEETE LDLTYGHRYA---NVKLPD- Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal LVLRINNERWEGVPFIMRAG KALNERKAELRIQYRDVPGN IFSKTPSRNELVLRVQPNEA IYCKMMNKSPGMSFTMEESE LDLTYRNRYA---DAKLPE- Crog CVLRINNERWDGVPFILKCG KALNERKAEVRIQYKDVPGD IFNNSSVRNEMVVRVQPGEA VYSKVMTKTPGMNFNLEETE LDLTYKSRYK---DARLPE- Dpul AALRINNERWDGVPFILRCG KALNERKAEVRIQYRDVPGD IFQGQAKRNELVIRVQPGEA IYVKMVTKTPGMSFDMEETE LDLTYGARYK---HVKMPD- Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -----MAGKIGINGFGRIGR Isca RPERRLILDVFYGSQVHFVR SDELAEAWRIFTPLLHQIDR ERPQPVPYEYGSRGFKEADD LWKQVGFKFYGTYRWTNTAA -----M-AKVGINGFGRIGR Eaff -AYERLILDVFVGSQMHFVR SDELAEAWRIFTPLLHKIEE EKPAPILYKYGTRGPKEADE MATKANFLYTGRYKWSAPSP --SKMM-SKIGINGFGRIGR Lcyp -AYERLILDVFVGSQMHFVR TDELAEAWRIFTPLLKKIEG ERIQPIAYKYGSRGPDEANQ LAVANNFIYTGGYRWHGHQ- ---TDM-AKIGINGFGRIGR Lsal -------------------- -------------------- -------------------- -------------------- -----M-VKVGINGFGRIGR Aamp -------------------- -------------------- -------------------- -------------------- -----M-SKIGINGFGRIGR Afra -AYERLILDVFCGSQMHFVR TDELAEAWRIFTPLLHKIEK EKIKPIPYVFGSRGPKEADE LLAKVDFKYYGSYKWEQPN- -----M-AKVGINGFGRIGR Hazt -------------------- -------------------- -------------------- -------------------- -----M-SKIGINGFGRIGR Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -AYERLILDAFVGSQMHFVR SDELAEAWRIFTPLLHKIDA EKPKPIPYKYGSRGPKEADA LFAANDFKYTGRYKWQEPA- ---KLM-SKIGINGFGRIGR Dmel -AYERLILDVFCGSQMHFVR SDELREAWRIFTPILHQIEK EHIRPITYQYGSRGPKEADR KCEENNFKYSGSYKWHGGKA ATSNHM-SKIGINGFGRIGR Tcas -AYERLILDVFCGSQMHFVR SDELSEAWRIFTPLLHQIES ERVKPIPYVYGSRGPKEADE MLLNNNFTYTGSYKWPAPKM -----M-AKIGINGFGRIGR Pmon -------------------- -------------------- -------------------- -------------------- -----M-SKIGINGFGRIGR Smar -------------------- -------------------- -------------------- -------------------- -----M-SKIGINGFGRIGR Tcal -AYERLILDVFVGSQMHFVR TDELREAWRIFTPILHKIEG EKVQPIPYKYGTRGPKEADE LAAKNNFVYTGTYSWNSDL- -----M-SKIGINGFGRIGR Crog -AYERLILDVFLGSQMHFVR TDELAEAWRIFTPLLHKIEG EKIRPIPYKYGGRGPKEADE LTEQNNFKYTGRYIWKKD-- -----M-VKVGINGFGRIGR Dpul -AYERLILDVFCGSQMHFVR SDELAEAWRIFTPLLHQIEG EKVKPLPYKYGSRGPREADD LLARSNFKYSGSYKWVKPS- ---SIM-SKIGINGFGRIGR Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin LVLRAAVLKGATVVAINDPF IPLDYMVYMFKYDSTHGQFK GEVKEDGKFLYVNGNKITVF NERDPANIDWASAGAEYVVE STGVFTTTDKALAHTKGGAK Isca LVLRAAVQKGVEVVAINDPF IDVKYMVYMFKYDSTHGRFN GDVHEEGGMLVVNGRKIHVF QELKPASIPWGKVGAEYVVE STGVFTTLEKAQQHIDGGAK Eaff LVLRAAVEKGATVVAINDPF IPLDYMVYMFKYDSTHGQFK GEVKEDGTFLYVNGNKITVF NERDPVNINWASAGAEYVVE STGVFTTIDKALSHTKGGAK Lcyp LVLRAALDKGVDVVAVNDPF IPLDYMVYMFKYDSTHGKYS GDVSLNGDKLVINGKSICVF NERDPSAIPWESAGAEYVVE STGVFTTKEKAGAHFKGGAK Lsal LVLRAALDHGVDVVAVNDPF IPVDYMAYMFKYDSTHGMCK KDISYSDGKLIIDGKKITVF GERDPANIKWGEAGADYVVE STGVFTTIEKANAHIQGGAK Aamp LVVRAALEKGAEVVAVNDPF INLEYMVYMFKYDSTHGRYK GEVKAEDGCLVIDGKKITVF NEMKPNNIPWSKAGAEYIVE STGVFTTIEKASAHFDGGAK Afra LVLRAALEKGVDVVAVNDPF INLDYMVYMFKYDSTHGKHK GEIAAVDGKLVINGHAISVF QERDPKAIPWGSVGVEYVVE STGVFTTIEKANAHLEGGAK Hazt LVLRCAIEKGAE-------- -------------------- ----ADGGNLVVNGHVIKVF NEMKPDNIPWGSAGAEYIVE STGVFTTLDKAKAHFSNGGK Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos LVLRAAIEKGAMVVAINDPF IPLDYMVYMFKYDSTHGQFK GEVKEDGKFLYVNGNKITVF NERDPANINWASAGAEYIVE STGVFTTTDKALAHTKGGAK Dmel LVLRAAIDKGASVVAVNDPF IDVNYMVYLFKFDSTHGRFK GTVAAEGGFLVVNGQKITVF SERDPANINWASAGAEYVVE STGVFTTIDKASTHLKGGAK Tcas LVLRASLERGANVVAVNDPF IGLDYMVYLFKYDSTHGRFK GEVKAEGGFLVVNGNKISVF CERDPKSIPWGKVGADYVVE STGVFTTIEKASAHIEGGAK Pmon LVLRAALQKGAEVVAVNDPF IALDYMVYMFKYDSTHGQHK GEVKAEDGCLVVDGHKITVF NEMKPENIPWSKAGAEYIVE STGVFTTIEKASAHFQGGAK Smar LVLRACIDKGCEVVAINDPF IDINYMVYMFKYDSTHGRFK GDVHEEGGMLVVNGHKIHVF MEMKPNNIPWSKAGAEYVVE STGVFTTIEKAQAHFDGGAK Tcal LVLRSAVAKGAAVVAVNDPF IPLDYMVYMFKYDSTHGRFK GEVKHDGTFLYINDQKITVF GERDPANIDWASAGAEYIVE STGAFTTLEKAGVHLTKGAK Crog LVLRAALDNDVDVVAVNDPF IPVDYMAYMFKYDSTHGMCK KDISTSGDKLIIDGKEIVVF GERDPANIKWGASGVDYVVE STGVFTTIEKANAHIKGGAK Dpul LVLRACIEKGATVVAVNDPF ITLDYMVYMFKYDSTHGRFK GEVKEEGGKLVVNGHHIQVF SERDPKNIPWGAAGAEYVVE STGVFTTLDKAQAHIDGGAK Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin KVIISAPSADAPMFVMGVNH EKYDKSLQVVSNASCTTNCL APMAKVINDNFGIIEGLMTT VHAVTATQKTVDGPSGKDWR GGRGAAQNIIPSSTGAAKAV Isca KVIISAPSADAPMFVMGVNH NSYNPSMTIVSNASCTTNCL APLAKVINDNFGIVEGLMST VHATTATQKTVDGPSAKMWR DGRGAAQNIIPASTGAAKAV Eaff KVVISAPSADAPMFVMGVNH EKYDPSLQIVSNASCTTNCL APLAKVINDNYGILEGLMTT VHATTATQKTVDGPSGKDWR GGRGAAQNIIPSSTGAAKAV Lcyp KVIISAPSADAPMFVMGVNE DKYQPNMHVVSNASCTTNCL APLAKVIHDHFGIIEGLMTT VHATTATQKTVDGPSNKAWR DGRGAAQNIIPAATGAAKAV Lsal RVIISAPSADAPMFVMGVNH ESYDPSMKVISNASCTTNCL APLAKVIHDNFGIEQGLMTT VHAVTATQKTVDGPSAKNWR DGRGAGQNIIPASTGAAKAV Aamp KVVISAPSADAPMFVCGVNL DAYSPDMKVVSNASCTTNCL APVAKVIHDNFTIVEGLMTT VHATTATQKTVDGPSGKNWR DGRGAGQNIIPASTGAAKAV Afra HVIISAPSADAPMFVVGVNH EKYDPTMKIVSNASCTTNCL APLAKVINDKFGILEGLMTT VHAITATQKTVDGPSGKLWR DGRGAAQNIIPASTGAAKAV Hazt KVIISAPSADAPMFVMGVNH EKYSKDMTIVSNASCTTNCL APVAKVLNDSFGIEEGLMTT VHAVTATQKTVDGPSAKDWR GGRGAGQNIIPSSTGAAKAV Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos KVIISAPSADAPMFVMGVNH EKYDKSLQVVSNASCTTNCL APLAKVINDNYGIIEGLMTT VHAVTATQKTVDGPSGKLWR DGRGAAQNIIPASTGAAKAV Dmel KVIISAPSADAPMFVCGVNL DAYSPDMKVVSNASCTTNCL APLAKVINDNFEIVEGLMTT VHATTATQKTVDGPSGKLWR DGRGAAQNIIPAATGAAKAV Tcas KVIISAPSADAPMYVCGVNL DAYDPSAKVISNASCTTNCL APLAKVIHDNFEIVEGLMTT VHATTATQKTVDGPSGKLWR DGRGAGQNIIPAATGAAKAV Pmon KVIISAPSADAPMFVCGVNM EKYTKDMKVVSNASCTTNCL APVAKVLHENFEILEGLMTT VHAVTATQKTVDGPSAKDWR GGRGAAQNIIPSSTGAAKAV Smar KIIISAPSADAPMFVMGVNH ESYDPSMTVVSNASCTTNCL APLAKVVHDNFEIVEALMTT VHAVTATQKTVDGPSGKLWR DGRGAHQNIIPASTGAAKAV Tcal KVVISAPSADAPMYVMGVNH EQYESSQHVVSNASCTTNCL APLAKVINDNFGIVEGLMTT VHAVTATQKTVDGPSNKDWR GGRGAGQNIIPSSTGAAKAV Crog RVVISAPSADAPMFVMGVNH EKYDTSMTVISNASCTTNCL APLAKVIHDNFGIEQGLMTT VHAVTATQKTVDGPSAKNWR DGRGAGQNIIPASTGAAKAV Dpul KVIISAPSADAPMFVVGVNL EAYDPSMKIVSNASCTTNCL APLAKVINDNFGIIEGLMTT VHAITATQKTVDGPSGKLWR DGRGAAQNIIPASTGAAKAV Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin GKVIPELNGKLTGMAFRVPT PDVSVVDLTVRIEKEASYEE ICAKLKEASEG-SMKGILGY TDEDLVSSDFIGDDRSSIFD AKAGIQLSKTFVKLVSWYDN Isca GKVIPELNGKLTGMAFRVPT PDVSVVDLTCRLAKEASYDE IKAAVKAAAESDNWKGILGY TEDEVVSSDFIGDTHSSIFD AKAGISLNKNFVKLISWYDN Eaff GKVIPELNGKLTGMAFRVPT PDVSVVDLTVRLEKGASYED ICAKLKEAAEG-PMKGILGY TEDQVVSTDFLGDARSSIFD AKAGIQLSPNFVKLVSWYDN Lcyp GKVIPELNGKLTGMAFRVPT PDVSVVDLTVRLAKETTYEE ICAKIKEVSEG-ELKDILGY TEDEVVSTDFLGDARSSIFD AKAGIQLSSTFVKLVSWYDN Lsal GKVIPDLNGKLTGMAFRVPT PDVSVVDLTVILKKGATYEE ICAKIKEYSEG-PMKGILGY TEDAVVSCDFTSDPRSSIFD AKAGIQLSNNFVKLVSWYDN Aamp GKVIPDLNGKLTGMAFRVPT PDVSVVDLTCRLGQEATMDD IKAKIRAAAEG-PLKGILGY TEDEVVSQDFLGDSHSSIFD AKACIQLSGTFVKLISWYDN Afra GKVIPELNGKLTGMAFRVPV HDVSVVDLTCRLAKEASYED IKKAVKEASEG-AMKGILGY TEEEVVSTDFIGDNHSSIFD AKAGIQLSPTFVKLISWYDN Hazt GKVIPELNGKLTGMAFRVPT PDVSVVDLTVRLGKECSYDE IKAAMKAASEG-PLKGYLGY TEDDVVSSDFIGDHRSSIFD AKAGIQLSKTFVKVVSWYDN Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos GKVIPELNGKLTGMAFRVPT PDVSVVDLTVRLNKEASYEQ ICATVKAAAEG-PMKGILGF TDEQLVSTDFLGDNRSSIFD AKAGIQLSPTFVKLVSWYDN Dmel GKVIPALNGKLTGMAFRVPT PNVSVVDLTVRLGKGATYDE IKAKVEEASKG-PLKGILGY TDEEVVSTDFFSDTHSSVFD AKAGISLNDKFVKLISWYDN Tcas GKVIPALNGKLTGMAFRVPV PNVSVVDLTVRLGKPATYDD IKAKIKAAAEG-PLKGILGY TEEEVVSCDFVGDTHSSIFD AKAGIQLSPTFVKLISWYDN Pmon GKVIPELNGKLTGMAFRVPT PDVSVVDLTVRLGKECSYDD IKAAMKAAAEG-PLKGVLGY TEDDVVSTDFVGDLRSSIFD AKAGIQLSKTFVKVVSWYDN Smar GKVIPDLNGKLTGMAFRVPT PDVSVVDLTARIKKEATYDE IKAAMKSAAESDHWKGILGY TEDQVVSSDFIGDTHSSIFD ALAGISLNKTFVKLICWYDN Tcal GKVIPELNGKLTGMAFRVPT PDVSVVDLTVRLAKEATYAE ICAAVKAAADG-PLKGYLGY SDEDVVSSDFIGDSHSSIFD SKAGIQLSPTFVKLISWYDN Crog GKVIPDLNGKLTGMAFRVPT PDVSVVDLTVILKKGASYEE ICAKIKEVSEG-PMKGVLGY TEDQVVSCDFTSDPRSSIFD AKAGIQLSNNFVKLVSWYDN Dpul GKVIPELNGKLTGMAFRVPV HDVSVVDLTCRLSKEASYDE IKAVVKAAAEG-PMKGILGY CDEEVVSTDFIGDNHSSIFD AAAGIALNKTFVKLISWYDN Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin EMGYSNRVIDLITYMQSQD- -MSSNGDRRQSLAGK----- --AAKRF--------YRVDS QSDLSRYWDYGAYFSDNNRW CFECAWEVANKVGGIYTVIR Isca EFGYSCRVVDLIKHMRSKDQ -----------MAEN----- --CLARI------------- -----PCPAGGIYTVVRSKA VLD-----SVIVGGIYTVIR Eaff EFGYSNRVIDLIKHMQAKDA -M-ENLGRKMSLGGK----- --AAKRF--------YRVDS QGDLSKYYDHGSYFSDNNRW CFETAWEVANKVGGIYTVIR Lcyp EYGYSNRVVDLINHMYSKDH -------------------- --MSKRF--------YRTDS QWDLSRYWDFGEHFAHQNRW CFECAWEVANKVGGIYTVIR Lsal EYGYSNRVVDLVKYIATQE- -----------MERKGSVGS FRTSKRF--------YRSES IADLSRHLDYGEFFATNNRW CFECAWEVANKVGGIYTVIR Aamp EWGYSNRVVDLIKFMQTKDK -------------------- -------------------- -------------------- -------------------- Afra EFGYSCRVVDLIKYMHSRA- -----------MATN---SA TPINRRF--------YKVDS TNDLMGYLDRGESAATSNIW TFECAWEVANKVGGIYTVIR Hazt EYGYSNRVVDLIKHMQNVDA -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos EMGYSNRVIDLITYMQTKD- -----------MEQGI---- --QNDQFSRYRETSGYRMES GEDLVKFKEHQTYSFPENAW CFEASWEVANKQGGIYTVLR Dmel EFGYSNRVIDLIKYMQSKD- -------------------- --MNRRF--------SRVES GADLKDYFDRGDIASRENRW NFEVAWEVANKVGGIYTVIR Tcas EYGYSSRVVDLIKYISSKDS A----------MSRE----- KASSRRF--------YRSES YFNLMACMDRGTQAEEENRW TFEIAWEAANKVGGIYTVIR Pmon EFGYSNRVIDLLKHMQTVDA -------------------- -------------------- -------------------- -------------------- Smar EYGYSHRVVDLIKYMQARDS K------------------- --MSRRF--------YRTDG QPDTV--LDHGVSAAMENRW LFEVSWEVANKVGGIYTVIR Tcal EMGYSNRVIDLIQYMQSK-- -----------MTRQ----- --SSKRF--------YRSDS QGDLAKFWDHGEHFAMQNRW VFECAWEVANKVGGIYTVIR Crog EYGYSNRVVDLIKFIATKE- -----------MERKGSSGN FRTSKRF--------YRSES IADLSRHLDYGESYANSNRW CFECAWEVANKVGGIYTVIR Dpul EFGYSCRVVDLNKNRQPKD- -----------MSVK----- --AARRF--------YRVDS AHDL-QFLHSCESASAENRW TFEIAWEVANKVGGIYTVIR Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin SKTGVSVNELGDQYILLGPY KEFHARQEVEEEEFSYAHPL GQAVQSQREKGYKIVCGRWL VEGNPQVILFDVGSAAYKMG EFKQEFYDTAGIGAPHGDME Isca SKAEVTVEELGDQFCLIGPY NENLVRTEVEVLE-PPYSIF WNSVKALKEQGIKVVYGRWL IDGYPQVLLFDIGSAAWKLD EWKRDLWNTCNIGVPWHDRE Eaff SKTGVSVQELGDQYVLLGPY KEQHARQEVEEEDFSPAHPL GKSVEALRQRGYRVVCGRWL VEGNPQVILFDIGSAAYKLD EFKQDLYEKAGIGVPHGDVE Lcyp SKTGVSVNELGDQYILMGPY VEHKAKQEIEEEDFPFHHPL GQAVERARQKGYRIHCGRWL VDGNPQVILFDIGSAAHKMN EFKQQLFEKAGIGIPHEDIE Lsal SKTGVTVSELGDQYALLGPY IEHKAKQEIEEQEFELHHPL GQAVEQMRERGYVLHTGRWL VDGNPQVILFDIGSALGKF- -----LYFNTVIFIHY-NYN Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra SKASISVEELGNQYILLGPY KEQFARTEVEDFEFP-AGPL NNAVSKLRDSGFRIHTGSWL VDGNPLVILFDIGSASYNMD KYKHELFEKSGVGIPHLDIE Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos SKAQVSTREMGNRYVMLGPL KSAHVH-EVEEFEASECSPL GRAVSAMKKRGFNVLLGNWL IEGNPTVVLFDIGSASHCMN SWKQELYENTHIGVPHSDIE Dmel SKAYVSTEEMGEQLCMMGPY KEHCARTEMEEMEFPRGNPL LDAVNSLRSRGYKIHTGRWL VDGNPQLILFDIGSAAWKLD QFKSEMWEKCHIGIPHLDIE Tcas SKSYVSTEEMGDQYCLIGPY KEFHARTEVEEGPLG-SDPL NEAVQALRDKGFKVHTGRWL VDGNPQIILMDIGSAAWKLD EYKTELWEKCNVGVPHLDVE Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar SKAGITTEELGDQFTLMGPY NETLVQTEVELIE-PEADLF GPTINAIKEKGFKVHYGRWL IEGYPRVILFEIGSGAWKLD EWKRELWNVTNIGIPWHDRE Tcal SKTGVSVNELGDQYVLLGPY FEFKAKQEVEEEDFPYHHPL GQAVERARQKGYRIHCGRWL VEGNPQIILFDVGSAGAKMN EFKHELYEKAGIGIPHEDVE Crog SKAGITVSELGDQYALLGPY FEDKAKTEIEEQEFELHHPL GQAVEQMRQRGYNVHTGRWL VDGNPQVVLFDVGSAAYKLD EIKQDLYEKSSISVPYLDQE Dpul SKASASVEELGDHYILLGPY KEHCAKQEVETFELPPGTPL AIAVQKLRNRGFKVVTGNWL VDGNPLLVLFDIGSASWNLD NYKKELFEKSGIGIPNHDAE Aver -------------------- -------------------- -----------LIMARIWKI DLATVFTTHATXLGRFLCAG ATD-----FYNNLETFNCDE Csin VNDVTVFGFMVAQFLADFRI RAENYS------DSLPPRIS AHFHEWMAGVGLIMTRLWKV DVATLFTTHATQLGRHLCAG DTD-----FYNNLEKFDCDH Isca SNDAIIFGYLVAWFLSDVMT AE----------KG-PPFVV AQFHEWLAGIGLMLCRTRHL DVATVFITHATLLGRYLCAG NVD-----FYNNLDKFSLDK Eaff VNDTVIFGFMVAQFLGEFRY QSEDFS------DS-PPRIA AHFHEWMAGVGLIMSRMWKL DIATVFTTHATQLGRHLCAG DTD-----FYNRLESFDCDA Lcyp SNDVTIFGFMVAEFLGDFRY LSENYA------DA-APRIV THFHEWMAGVALIMVRIWKI EVATVFTTHATLLGRFLCAG ATD-----FYNNLERFNCDE Lsal NDLIXFYRNMVAEFLGSFHY WSQGYA------DV-PPHIV AHFHEWMSGVGLIFSRLWKL EIATVFTTHATLLGRMLCAG STD-----FYNNLSKFDLDE Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra SNDAVIFGFMVAQFIADFRY FSNRGG------EV-APKIV CHFHEWLSGIGLIMTRLWNI EVSTVFTTHATLLGRYLCAG NLD-----FYNNLDKFNIDA Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- ------MAGVALIMARIWKI DMATVFTTHATLLGRFLCAG ATD-----FYNNLQNFNCDE Afos CND----------------- -------------------- -------------------- ------RSHATQLGRHLCAG DTD-----FYNRLEQFDCDK Dmel TNDAIILGFMIAEFLEEFRN FAVTYS--QNN-ELSAPRIV AHFHEWQAGVGLIVLRTRLV EIATVFTTHATLLGRYLCAG NTD-----FYNNLDKFAVDE Tcas ANDAIILGNMVADFIANFKN CADRYG------DGIPARIV THFHEWQAGVGLITLRTRLV KVATVFTTHATLLGRYLCAG NTD-----FYNNLDKFVVDE Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar SNDSVIFGFLVTMFLTEFIN QARSHN------E--SPLVI AHFHEWQAGIGLLLCRVRHL DIATIFTTHATLLGRYLCAG NVD-----FYNNLDRFNIDK Tcal ANDVCIFGLMVAEFLGDFRF LAENYS------DS-PPRIV GHFHEWMAGVGLIMSRIWKI DIATVFTTHATLLGRFLCAG ALD-----FYNKLDQFNCDE Crog TNDITIFGHMVAEFLGSFHH WSTNYA------DA-PPRIV AHFHEWMAGVGLIFSRLWKL EIATVFTTHATLLGRMLCAG STD-----FYNNLSKFDLDK Dpul SNDSVVFGFMAAQFIAEFNY AAQQEHLALANGSP-APRIV AHFHEWLAGIGLVLLRLWGV QVATVFTTHATLLGRYLCAG NID-----FYNNLDKFNIDE Aver EAGKRGFYHRYCMERAAAHL CHTFTTVSDITGKEAEHLIK RKADIITPNGLNVVRDXXLH EFQNLHARSKEKINEFVRGH FYGHFDFDLDKTLYIFTAGR Csin EAGKRGIYHRYCIERASAHL AHVFTTVSEITGQECEHLVK RKPDILTPNGLNVKR--DLH EFQNLHAKCKEKINEFVRGH FHGHFDFDLDKTLYLFTAGR Isca EAGDRGIYHRYCMERAACHS AHVFATVSEVTAMEAEHLLK RKPDAITPNGLNVKKFSALH EFQNMHAIAKEKIHDFVRGH FYGHYDFDLDKTLYCFIAGR Eaff EAGKRGIYHRYCLERGAAHL AHIFTTVSEITGIESEHLIK RKPDIITPNGLNVKR--DLH EFQNLHAKSKESINEFVRGH FYGHFDFDLDNTLYFFTAGR Lcyp EAGKRGFYHRYCLERAATHL AHVFTTVSEITGRESEHLVK RKPDIITPNGLSVVR--DLH EFQNQHAKSKEKINQFVRGH FYGHFNFDLDKTLFFFSAGR Lsal EAGKRGFYHR---------- -------------------- --PDIITPNGLNVTR--DLH EFQNLHAISKNKINDFVRGH FYGHFDFDLDKTLYLFSAGR Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra EAGKRQFYHRYCIERAATHL AHIFTTVSEITGIEAEHLLK RKPDIITPNGLNVKKFSALH EFQNLHSVSKEKIHDFIRGH FYGHHDFDLDKTLYFFIAGR Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda EAGKRGFYHRYCVERAAAHL XHTFTTVSDITGKEAEHLIK RKADIITPNGLNVIR--DLH EFQNLHAKSKEKINEFVRGH FYGHFDFDLDKTLYXFXAGR Afos EAGKRQIYHRYCLERAAATL AHIFTTVSEITGIEAEHLIK RKPDIITPNGLNVKR--DLH EFQNLHAKSKESINEFVRGH FYGHFDFDLDNTLYFFSAGR Dmel EAGKRQIYHRYCLERGATHL AHVFTTVSEITGYEAEHLLK RKPDIITPNGLNVKKFSAIH EFQNLHAVAKEKINEFVRGH FYGHIDFDLDKTLYFFIAGR Tcas EAGKRQIYHRYCIERAATHL AHVFTTVSDITGFEAEHLLK RKPDVITPNGLNVKKFSALH EFQNLHAISKEKIHEFIRGH FYGHYDFDLDKTLYFFIAGR Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar EAGDRGIYHRYCMERASAHS AHCFTTVSEITALEAEHLLK RRADIITPNGLNVKKLSALH EFQNMHAIAKEKIHDFIRGH FYGNYDFSLDKTLYFFIAGR Tcal EAGKRGFYHRYCIERAAAHL CHCFTTVSDITGKEAEHLIK RKPDMITPNGLNVQR--DLH EFQNLHAESKEKINQFVRGH FYGHFDFDLDKTLYFFIAGR Crog EAGSRGFYHRYCLERSATAL ADCFTTVSDITSIEAEHLIK RKPDIVTPNGLNVNR--DLH EFQNLHAVSKNKINDFVRGH FNGHFDFDLDKTLYFFSAGR Dpul EAGRRQIYHRYCMERAATNL AHTFTTVSEITGLEAEHLLK RKPDVITPNGLNVKKFSALH EFQNLHAIYKEKINEFVRGH FYGHLDFDVDRTLYFFIAGR Aver YEFGNKGVDIFIESLARLN- --HKLKSESPDKTVVAFMIF PTATNSFNVESLRGHAVTKG LKDTIDEIQQEIGKRMYETC LRGHVPDSMDLMSKNDIVRL Csin YEFTNKGADMFIESLARLN- --HLLKKAGSDVTVVAFLIF PTKTNSFNVESLRGHAITKG LKDTIDSIEKDIGKRLYEKC LRGDVPESGDLLTRDDLV-- Isca YEFSNKGADLFIESLARLN- --HYLKSSGSEVTVIAFLIF PAKTNNFNVESLRGQAISKQ LRDTVQQMQSTIGKRMFEIC LSGKIPKGEELIYSEDLVRL Eaff YEFTNKGADIFIEALARLN- --HLLKQSNSEVTVVAFLIF PTPTNSFNVESLKGHAITKG LKDTIDAVQKDIGKRLYEKC LRGYIPDASDLLTRDDLTTL Lcyp YEFGNKGVDIFIEALARLN- --HQLKEQKSDKTVIAFLIF PTKTNSFNVESLRGHAVAKG LKDTIDEIQRDIGKRMYEIC LKGHIPDADELLAKNDIVRL Lsal YEFINKGVDIFIESLARLN- --FMLQQSGTDRTIVVFLIF PAMNKGFNVESLRGHAVTKA LKDTIDKVQKEIGERMFDIC SKGHLPESDDLLFKSDIVRL Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra YEFGNKGADVFIEGLARLN- --HMMKESGSDKTVVAFLIF PTRTNNYNVESLRGQAIAKS LRDTVHLVQQEIGSKMYEAC LRGRLPENDELLSQDDIVKL Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda YEFGNKGVDIFIESXARLN- --HRLKAENSDKTVVAFLIF PTATNSFNVESLRGHAVTKG LKDTIDEIQKEIGKRMYETC LRGHVPDAIDLLSKNDIVRL Afos YEFTNKGADIFIESLARLN- --HLLKSSGSDITVVAFLIF PTKTNSFNVESLKGHAITKG LKDTIDSVQKDIGKRLYEQC LRGKIPQPDEILTRDDLTKL Dmel YEFGNKGADIFIEALARLN- --AMLKHEKPDTTVVAFLIF PTKTNNFNVDSLRGHAVIKQ LRDTINNVQQAVGKRMFDTC LQGNIPNADDLLQKDDLVKI Tcas YEFSNKGADIFIEALARLN- --HYLKSTHPDITVVAFLIF PTRTNNFNVESLRGHAVTKS LRDTISDIQTRIGRRMYEVC LSGHLP-GDDLLKKEELVRL Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar YEFSNKGADMFIEALARLN- --HYLKSAGSDMTVIAFLIF PARTNNFNVESLRGQAIAKQ LHETINEIQTKIGRRMFEIS LGGRLPTNAELLQSEDIVKL Tcal YEFGNKGADIFIESLARLN- --HLLKEAKSDKTVVAFLIF PTKTNSFNVESLRGHAVTKG LKDTIDEIQKVVGNRLYETC LRGMVPDGNDLLSKNDIVKL Crog YEFINKGVDIFIESLARLN- --FQLQASGSNRTVIVFLIF PAPNKGFNVESLRGHAITKT LKDAIEEVKREIGQRMFDSC SRGHVPESEDLLTREHLIKL Dpul YEFGNKGADVFIEALARLN- --HMLKVSGSDKTIVAFLIF PAKTHNFNVETLRGQAVVKS LRDTIHDIQQKIGKRIYDVC LSGRLPDSEELLQKEDTVRL Aver KRCIFAQGASILPPITTHNI VNDATDPIMCALRRCQLFNN RYDRVKVIFHPEFLASTNPL FGLDYQDFVRGC-------- -------------------- Csin -------------------- -------------------- -------------------- ------------------LY YEPWGYTPAECTIMGIPNVS Isca KRCIYASQRTTLPPVCTHNM LDDSSDPVLCHIRRCQLFNR REDRVKVIFHPEFLSSTNPL FSMDYEEFVRGCHLGIFPSY YEPWGYTPAECTVMGIPSVT Eaff KRSIFAAQSSPLPPITTHNV INEYNDPILNAFRRCQLFNH RSDRVKVVFHPEFLSTTNPL FGLDYQEFVRGCHMGVFPSY YEPWGYTPAECTIMGIPSIT Lcyp KRCIFAQGANLLPPITTHNI VDDATDPIMNAIRRCHLFNN RYDRVKIIFHPEFLASTNPL FGLDYQEFVRGCHMGVFPSY YEPWGYTPAECTVMGIPSIT Lsal KRCVYAA-------ITTHNI VNDADDSIINAIRRCKLFNN KSDRVKIIFHPEFLSSTNPL FGLDYNEFVRGCHLGVFPSY YEPWGYTPAECTIMGIPSIT Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra KRCLFASQRSSLPPITTHNV VDDHADPVLNNLRRCQLFNS RNDRVKVIFHPEFLSSTSPL LGLDYEDFVRGCHLGVFPSY YEPWGYTPAECTVMGIPSVT Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda KRCIFAQGASLLPPITTHNI VNDATDPIMCALRRCQLFNN RXDRVKVIFHPEFLASTNPL FGLDYQDFVRGCHMGVFPS- -------------------- Afos KRSIFAAQSSPLPPITTHNI CDEGKDPVLNAFRRCHLFNN SHDRVKVVFHPEFLNSTNPL FGLDYQDFVRGCHMGVFPSY YEPWGYTPAECTIMGIPSIT Dmel KRCMFAMQRDSMPPVTTHNV ADDWNDPVLSSIRRCHLFNS RHDRVKMVFHPEFLTSTNPL FGIDYEEFVRGCHLGVFPSY YEPWGYTPAECTVMGIPSVT Tcas KRCIFSLQRDGLPPVTTHNI VDDWNDPVLASVRRCNLFNT KYDRVKIVFHPEFLSSTNPL FGLDYEEFVRGCHLGVFPSY YEPWGYTPAECTVMGIPSIT Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar KRCIFAAHRNSLPPICTHNM MDDSGDPVLTAIRRTQLFNN RLDRVKLIFHPEFLSPTNPL LGLEYDEFVRGCHLGVFPSY YEPWGYTPAECTVMGIPNVS Tcal KRCIFAQAHTNLPPITTHNI VDDAMDPVMNAFRRCQLFNN RTDRVKVVFHPEFLTSTNPL FNLDYQEFVRGCHMGVFPSY YEPWGYTPAECTIMGIPSIT Crog KRCVYAAENAGPPPVTTHNI IRDSEDQILNAIRRCKLFNG RHDRVKIIYHPEFLSSTNPL FGLDYNEFVRGCHLGVFPSY YEPWGYTPAECTIMGIPSIT Dpul KRCIYATQRDTLPPITTHNV VDDASDPVLNSFRRCKLFNE TSDRVKVIFHPEFLSSTNPL FGLDYEDFVRGCHLGVFPSY YEPWGYTPAECTVMGIPSIS Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin TNLS---------------- --GFGCFMDEHVVDPQSYGI YIVDRKLQSVEESVNQLAGF MFDYTKLNRRQRIIQRNRTE RLADLLDWKNLGVYYRQARV Isca TNLS---------------- --GFGCFIAEHVADPMSYGI YIVDRRFKSAEESVQQLAQY MFDFSCLSRRQRIIQRNRTE RLSDLLDWKNLGISSKL--- Eaff TNLS---------------- --GFGCFMEEHVTDPQSYGI YIVDRRKRGLEDSVQQLAGF MHDYTKLNRRQRIIQRNRTE RLSDLLDWKNLGIYYRQARM Lcyp TNLS---------------- --GFGCFMQENILDPQSYGI YIVDRLNIGLEDSIKQLCKY MYGFTRLNRRQRIIQRNRTE RLSDLLDWKSLGIYYRQARM Lsal TNLS---------------- --GFGCFMEEHVVDPQSYGI YVVDRRHKGLDESINDLSK- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra TNLS---------------- --GFGCFMNDHIADPTSYGI YIVDRRFISLDESISQLANY MHDFVRLNRRQRIIQRNRTE RLSDLLDWRTLAVYYRRARL Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos TNLS---------------- --GFGCFMEEHVTDPQSYGI YVVDRRNIGLEESVQQLARF MHDFTRLNRRQRIIQRNRTE RLSDLLDWKNLGIYYRQARM Dmel TNLS---------------- --GFGCFMEEHISDPKSYGI YIVDRRYIGLENSVQQLSSF MMEFSRLNRRQRIIQRNRTE RLSDLLDWRTLGIYYRQARV Tcas TNLS---------------- --GFGCFMQEHIADPMSYGI YVVDRRYISLEASVQQLAQY MYDFARLNRRQRIIQRNRTE RLSDMLDWRSLGVYYRQARM Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar TNLS---------------- --GFGCFMAEHVADPMSYGI YIIDRRYKSAEDSVQQLSQY LFDFTCLSRRQRVIQRNRTE RLSDLLDWKNLGIVIQN--- Tcal TNLS---------------- --GFGCFMQEQIVDPQSYGI YIVDRMHIGVEESVSQLAKC MMDFVGLNRRQRIIMRNRTE RLSDMLDWKSLGIYYRRARM Crog TNLS---------------- --GFGCFMEEHVMDPKSYGI YVVDRRHKGLDESINDLASS MYEFSLMNRRQRIIMRNRTE RLSDLLDWKSLGIYYRQARM Dpul TNLS---------------- --GFGCFMGDHIADPMSYGI YVVDRRFISLDDSLNQLAQY MFDFTRLNRRQRIIQRNRTE RLSDLLDWRNLSVYYRKARQ Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin MALEKVYPDFVDTAPSL-SG VGRMNYPRPISEPPSPCEHQ GSLPS--------------- -------------------- WEMARTKQTARKSTGGKAPR Isca -------------------- --QLRYPRPMSEPPSPSASR TSTPAPSEHGS--DEE-EDS DEGEELKH------------ -TMARTKQTARKSTGGKAPR Eaff KALQTVYPDISEEEAPP-RG VGRLNYPRPISEPPSPISTR AHSPVSSLADE--DDC-DSH DSDEELEQLQVAL-SKI--- -AMARTKQTARKSTGGKAPR Lcyp RALRCVFGDIDEDEPHP-RP LSSRLYPRPFSEPPSPSSSR ATTPPPGSDADGPDDDDASH DSEEEERELCLAIDTHL--- --MARTKQTARKSTGGKAPR Lsal -------------------- -------------------- -------------------- -------------------- --MARTKQTARKSTGGKAPR Aamp -------------------- -------------------- -------------------- -------------------- --MARTKQTARKSTGGKAPR Afra LALHEVFPELAVEEE---RG VRQIKYPRPISEPPSPTSSR ATTPAPSDSDE-------EI DDEKELEELGHKV-AKVIS- -LMARTKQTARKSTGGKAPR Hazt -------------------- -------------------- -------------------- -------------------- --MARTKQTARKSTGGKAPR Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos KALQSVFPDVSSEEAPP-AY AGRLNYPRPISEPPSPTSTR AHSPISSLNDD--DA--DSH DSDEELEQLQVAL-NNLD-- -NMARTKQTARKSTGGKAPR Dmel KALQAVYPDYVDELSLY-GS KNNLIFSRPHSEPPSPTSSR HTTPAPSVHGS--DDE-DSV DEETELKELGIK-------- --MARTKQTARKSTGGKAPR Tcas KALHSVFPDYKEEMD---NG IATLKYPRPISEPPSPSSSR VTTPAASLHGS--DDESDSV DEERELEELKINH------- -HMARTKQTARKSTGGKAPR Pmon -------------------- -------------------- -------------------- -------------------- --MARTKQTARKSTGGKAPR Smar -------------------- -------------------- -------------------- -------------------- --MARTKQTARKSTGGKAPR Tcal RALQNVFPDVSENEEAP-RL PSRLNYPRPISEPPSLAPSR ANSPNSSAPGS--DSE-ASH DSEEEEAELQTAL-SQLQA- -SMARTKQTARKSTGGKAPR Crog IALKHTFPDINDEDE---TL PGVINFPKPISEPPSPSLSR ASSVPPPEDSE--DS---DH DSEEEERELVIQLHNNAI-- --MARTKQTARKSTGGKAPR Dpul MALHAVFPEFDLDEDENGSG VGRLSYPRPISEPPSPTSSR ATTPIPSDQSD--ED--DEV DEERELRELSVGAEER---- -RMARTKQTARKSTGGKAPR Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin KQLATKAARKSAPATGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSSAVMALQEASE AYLVGLFEDTNLCAIHAKRV Isca KQLATKAARKSAPATGGIKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSSAVMAMQEACE AYLVSLFEDCNLCAIHAKRV Eaff KQLATKAARKSAPSTGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSAAIGALQEASE AYLVGLFEDTNLCAIHAKRV Lcyp KQLATKAARKSAPATGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSSAVAALQEASE AYLVGLFEDTNLCAIHAKRV Lsal KQLATKAARKSAPSTGGVKK PHRYRPGTVALREIRRYQKS TELLIRKPPFQRLVREIAQD FRTDLRFQSAAIGALQEASE AYLVGLFEDTNLCAIHAKRV Aamp KQLATKAARKSAPSTGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSAAIGALQEASE AYLVSLFEDTNLCAIHAKRV Afra KQLATKAARKSAPSTGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSAAIGALQEASE AYLVGLFEDTNLCAIHAKRV Hazt KQLATKAARKSAPATGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSSAVMALQEASE AYLVGLFEDTNLCAIHAKRV Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos KQLATKAARKSAPSTGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSAAIGALQEASE AYLVGLFEDTNLCAIHAKRV Dmel KQLATKAARKSAPATGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSSAVMALQEASE AYLVGLFEDTNLCAIHAKRI Tcas KQLATKAARKSAPSTGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSAAIGALQEASE AYLVGLFEDTNLCAIHAKRV Pmon KQLATKAARKSAPSTGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSAAIGALQEASE AYLVGLFEDTNLCAIHAKRV Smar KQLATKAARKSAPATGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSSAVMALQEASE AYLVGLFEDTNLCAIHAKRV Tcal KQLATKAARKSAPATGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSSAVMALQEASE AYLVGLFEDTNLCAIHAKRV Crog KQLATKAARKSAPATGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSSAVMALQEASE AYLVGLFEDTNLCAIHAKRV Dpul KQLATKAARKSAPATGGVKK PHRYRPGTVALREIRRYQKS TELLIRKLPFQRLVREIAQD FKTDLRFQSSAVMALQEASE AYLVGLFEDTNLCAIHAKRV Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin TIMPKDIQLARRIRGERALN ELKQELEIDVHKVSVEELCK RFKTQVERGLTDTQAKANFA EYGPNALTPPPQTPEWVKFC QQMFSGFACLLWLGAILCFL Isca TIMPKDMQLARRIRGERSLD DLKQEVSMDEHKIPIEELYA RLGTNPATGLTSQQAREIFE RDGPNSLTPPKKTPEWVKFC KNLFGGFSLLLWIGAVLCFI Eaff TIMPKDIQLARRIRGERALN DLKQELEIDVHKISQDEILK RFGTSLENGLTLDQVKKKQE EYGLNQLTPPPTTPEWIKFC KNLFSGFAMLLWLGAILCFV Lcyp TIMPKDIQLARRIRGERALN ALKQELELDVHKVDLDTLLK RFNSDVNRGLRKSQAEENQS KYGPNTLTPPPTTPEWIKFC KNLFGGFALLLWVGAILCFT Lsal TIMPKDIQSARRIRGERA-- -------------------- -------------------- -------------------- ----GGFAMLLWLGAILCFL Aamp TIMPKDIQLARRIRGERAVD DLKQELVLDEHQITIEELQQ RLGTSITAGLTEARAKENLD RYGPNALTPPKKIPEWVKFC KNLFYGFSLLLWIGAILCFV Afra TIMPKDIQLARRIRGERALN ELKKELDIDFHKIPIEECYQ RLGSNPETGLTNAQARSNIE RDGPNCLTPPKTTPEWIKFC KNLFGGFALLLWTGAILCFL Hazt TIMPKDIQLARRIRGERA-- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos TIMPKDIQLARRIRGERALN ELKKELEIDAHTVSLDELCK RHGTNIERGLTPEQAKEGLE KYGPNALTPPPKTPEWVKFC KNMFSGFALLLWIGAILCFV Dmel TIMPKDIQLARRIRGERALD DLKQELDIDFHKISPEELYQ RFQTHPENGLSHAKAKENLE RDGPNALTPPKQTPEWVKFC KNLFGGFAMLLWIGAILCFV Tcas TIMPKDIQLARRIRGERALD DLKQELDIDYHKITPEELYQ RFQTHPENGLSHAKAKENLE RDGPNALTPPKTTPEWVKFC KNLFGGFALLLWIGAILCFI Pmon TIMPKDIQLARRIRGERA-- -------------------- -------------------- -------------------- -------------------- Smar TIMPKDIQLARRIRGERALD DLKQELSMDEHQLAIEDLYI RLQTNPTTGLTNEQAKENLA RDGPNALTPPKTTPEWIKFC KNLFGGFALLLWVGAILCFV Tcal TIMPKDIQLARRIRGERALQ NLKQELELDVHRIDIEELCK RFNTNLNNGLTKRQAEENLG KYGRNALTPPPTTPEWIKFC NNLFGGFSLLLWFGAILCFI Crog TIMPKDIQLARRIRGE--LT NLKQELELDVHKISFDELCK RYGSDLDKGLSKSRVEENQK KYGLNALTPPPTTPEWIKFC QNLFGGFALLLWLGAILCFI Dpul TIMPKDIQLARRIRGERAMN ELKQELDIDDHKIPIEELYQ RLGTNPETGLTTAQAKAIFE RDGPNALTPPKTTPEWVKFC KNLFGGFSMLLWVGAILCFV Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin AYGIQASA-YEEPPDDNLYL GVVLTAVVTVTGIFSYYQES KSAAIMESFKNLVPQFAKVI RNGKKIDIEAKNVTLGDIVD VQFGDRMPADVRILESKGFK Isca AYSIQAGT-FEEPPDDNLYL GAVLAIVVIVTGCFSYYQEA RSSKIMESFKNMVPQYAIVI RDGQKLNLPAEEVVVGDIAE VKGGDRIPADMRVIQAQGFK Eaff AYTIQATN-FEEPPDDNLYL GVVLTAVVTVTGVFSYYQES KSAKIMESFKNLVPQYALVR RGGEKLNIEAKDLTIGDIVE VKFGDRLPADVRVLEARGFK Lcyp AYSIQATV-YEEPPDDNLYL GIVLAIVVIVTGIFSYYQES KSSKIMESFKNMVPQYALCL RDGEKLTIRAEELTYGDIIE VKFGDRLPADIRILEARGFK Lsal AYSIQAST-FEEPPDDNLYL GIVLTAVVVITGIFSYYQES KSSKIMESFKNMVPQYALCL REGVKVNIKAEQLTLGDVVE VKFGDRIPADIRVTESRGFK Aamp AYSIQAGT-FEEPPDDNLYL GIVLSAVVIITGCFSYYQES KSSRIMESFKNMVPQYALVI RDGSKATVRAEELTLGDLVE IKFGDRIPADVRIIEARNMK Afra AYGIEASSGNEDMLKDNLYL GIVLATVVIVTGIFSYYQEN KSSRIMDSFKNLVPQYALAL REGQRVTLKAEELTMGDIVE VKFGDRVPADLRVLEARSFK Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos AYSIQASA-FEEPPDDNLYL GIVLSAVVTVTGIFSYYQES KSDKIMESFKNLVPQYALAR RGGEKLNIKAEELTIGDVVE IKFGDRIPADVRVIDAKGFK Dmel AYSIQAST-SEEPADDNLYL GIVLSAVVIVTGIFSYYQES KSSKIMESFKNMVPQFATVI RGGEKLTLRAEDLVLGDVVE VKFGDRIPADIRIIEARNFK Tcas AYSIQAST-VEEPADDNLYL GIVLAAVVIVTGIFSYYQES KSSKIMESFKNMVPQFATVI REGEKLTLRAEDLVLGDVVE VKFGDRIPADIRIIESRGFK Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar AYGITAAT-QENPVADNLYL GIVLATVVIVTGIFSYYQEA KSSKIMESFKSMVPQYAIVI RNEQKLSIRAEELVVGDVVE IKFGDRVPADVRVLQAHGFK Tcal AYSIQAGA-YEEPPDDNLYL GIVLTVVVIVTGVFSYYQES KSSKIMESFKNLVPQYALAL RDGEKLTIKAEELTLGDIIE VKFGDRVPADIRVVEARGFK Crog AYSIQASA-YEEPPDDNLYL GIVLTVVVVVTGVFSYYQES KSSKIMESFKNLVPQYALCV RDGKKVEIKAEELTLGDIIE VKFGDRVPADMRVIESRGFK Dpul AYSIEVST-EEDVLGDNLYL GIVLTAVVVVTGVFSYYQES KSNKIMESFKNMVPQYAVVV REGLKQTMKAEEICIGDIVE VKFGDRIPADIRIIEARSFK Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin VDNSSLTGESEPQLRTNEYT HENPLETKNLAFFSTNAVEG TARGVVVNIGDNTVMGRIAG LASGLDSGETPIAKEIAHFI HIITGVAVFLGVSFFIIAFA Isca VDNSSLTGESEPQTRSPEMT NENPLETRNVAFFSTNCVEG TGMGVVINTGDRTVMGRIAN LASGLEMGETPIAREISHFI HLITGVAVFLGVTFFVIAFI Eaff VDNSSLTGESEPCSRSPEFT HENPLETKNLAFFSTNAVEG TCVGVVVHIGDNTVMGRIAG LASGLDTGETPIAKEIGHFI HLITGVAVFLGVTFFIIAFI Lcyp VDNSSLTGESEPQSRSPEFT HENPLETRNLAFFSTNAVEG TCRGIVVNIGDNTVMGRIAG LASGLDTGDTPIAKEIAHFI HIITGVAVFLGVTFFMIAFI Lsal VDNSSLTGEAEPQSRSPDFT HENPLETKNLAFFSTNAVEG TATGIVVNIGDKTVMGRIAG LASGLETGETPIAKEIA--- ----AVAVFLGVTFFIIAFI Aamp VDNSSLTGESEPQSRSPEYT AENPLETKNLAFFSTNAVEG TCKGVVINIGDNTVMGRIAG LTSSIDSGSTPIAREIEHFI HIITGVAVFLGVTFFVIALI Afra VDNSSLTGESEPQARSPEFT NDNPLETKNLAFFSTNAVEG TMRGIVIGIGDNTVMGRIAG LASGLDTGETPIAKEIAHFI HIITGVAVFLGVTFFIIAFV Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos VDNSSLTGESEPQSRGPECT HENPLETKNLAFFSTNAVEG TCVGIVVHIGDGTVMGRIAG LASGLSTGETPIAKEIAHFI HIITGVAVFLGVTFFIIAFI Dmel VDNSSLTGESEPQSRGAEFT HENPLETKNLAFFSTNAVEG TAKGVVISCGDHTVMGRIAG LASGLDTGETPIAKEIHHFI HLITGVAVFLGVTFFVIAFI Tcas VDNSSLTGESEPQSRSPEFT HENPLETKNLAFFSTNAVEG TAKGVVISCGDNTVMGRIAG LASGLDTGETPIAKEIHHFI HLITGVAVFLGVTFFVIAFI Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar VDNSSLTGESEPQSRNPEYT SENPLETKNLAFFSTNAVEG TCRGLVISTGDRTVMGRIAN LASGLESGETPIAKEIQHFI HIITGVAVFLGVSFFIIAFI Tcal VDNSSLTGESEPQARSAEFT HENPLETKNLAFFSTNAVEG TARGIVVNIGDNTVMGRIAG LASGLESGDTPIAKEIAHFI HIITGVAVFLGVTFFIIAFV Crog VDNSSLTGESEPQSRSPEFT HENPLETKNLAFFSTNAVEG TARGIVVNIGDNTVMGRIAG LASGLESGDTPIAKEIAHFI HLITGVAVFLGMTFFGIAII Dpul VDNSSLTGESEPQSRSSEFT NENPLETKNLAFFSTNAVEG TARAIVISIGDNTVMGRIAG LTSGLSSGETPIAREIAHFI HLITGVAVFLGVTFFVIALI Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin LGYNWLDAVIFLIGIIVANV PEGLLATVTVCLTLTAKRMA SKNCLVKNLEAVETLGSTST ICSDKTGTLTQNRMTVAHMW FDNKIVEADTSEDQSGTSFN Isca LGYHWLDAVIFLIGIIVANV PEGLLATVTVCLTLTAKRMA AKNCLVKNLEAVETLGSTST ICSDKTGTLTQNRMTVAHMW FDNQIIEADTTEDQSGVQYD Eaff LGYHWLDAVIFLIGIIVANV PEGLLATVTVCLTLTAKRMA SKNCLVKNLEAVETLGSTST ICSDKTGTLTQNRMTVAHMW FDNKIHEADTSEDQSGNAFN Lcyp LGYHWLDAVIFLIGIIVANV PEGLLATVTVCLTLTAKRMA SKNCLVKNLEAVETLGSTST ICSDKTGTLTQNRMTVAHMW FDNQIHDADTSEDQSGSSNY Lsal LGYHWLDAVIFLIGIIVANV PEGLLATVTVCLTLTAKRMA SKNCLVKNLEAVETLGSTST ICSDKTGTLTQNRMTVAHMW FDNQIVEADTSEDQSGVSMN Aamp LGYNWLDAVIFLIGIIVANV PEGLLATVTVCLTLTAKRMA SKNCLVKNLEAVETLGSTST ICSDKTGTLTQNRMTVAHMW YDNQIMEADTTEDQSGASYD Afra LGYHWLDAVVFLIGIIVANV PEGLLATVTVCLTLTAKRMA SKNCLVKNLEAVETLGSTST ICSDKTGTLTQNRMTVAHMW FDGTITEADTTEDQSGAQFD Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos LGYHWLDAVIFLIGIIVANV PEGLLATVTVCLTLTAKRMA SKNCLVKNLEAVETLGSTST ICSDKTGTLTQNRMTVAHCW FDNKIQDVDTSEDQSGKGFD Dmel LGYHWLDAVIFLIGIIVANV PEGLLATVTVCLTLTAKRMA SKNCLVKNLEAVETLGSTST ICSDKTGTLTQNRMTVAHMW FDNQIIEADTTEDQSGVQYD Tcas LGYHWLDAVIFLIGIIVANV PEGLLATVTVCLTLTAKRMA SKNCLVKNLEAVETLGSTST ICSDKTGTLTQNRMTVAHMW FDNQIIEADTTEDQSGVQYD Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar LQYQWLEAVIFLIGIIVANV PEGLLATVTVCLTLTAKRMA AKNCLVKHLEAVETLGSTST ICSDKTGTLTQNRMTVAHMW FDNQIIEVDTTENQSGLQYD Tcal LGYHWLDAVIFLIGIIVANV PEGLLATVTVCLTLTAKRMA SKNCLVKNLEAVETLGSTST ICSDKTGTLTQNRMTVAHMW FDNQIVEADTSEDQTGSSNY Crog LGYHWLDAVIFLIGIIVANV PEGLLATVTVCLTLTAKRMA SKNCLVKNLEAVETLGSTST ICSDKTGTLTQNRMTVAHMW FDSQIIEADTSEDQSGVSMN Dpul LGYQWLDAVIFLIGIIVANV PEGLLATVTVCLTLTAKRMA SKNCLVKNLEAVETLGSTST ICSDKTGTLTQNRMTVAHMW FDGQIIEADTTEDQSGAQYD Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin KEASGWKTLERVACLCNRAE FKPQQENVPILRREVNGDAS EAAILKCTELSKGNVMDYRK RNKKVCEIPFNSANKYQVSI HET-EDPNDNRYLLVMKGAP Isca KTSAGWKSLARNCCLCSRAE FKAGQENVPILKRDCTGDAS ESAILKCMELAIGNVNAYRQ RNPKVCEIPFNSTNKYHVTV HET-EDPDDPSYIILMKGAP Eaff KNAPGWKTLERVGALCNRAE FKSGQDNVPILKREVNGDAS EAAILKCTELSKGNIIQYRN ANKKVCEIPFNSSNKFQVSI HEQ-EDKNDQRYLLVMKGAP Lcyp KNMGGWKRLERCAALCNRAE FKPGQSGIPVLKRDVNGDAS ESALLKCVELSIGNVVKFRE QNRKVCEIPFNSTNKYQVSI HET-ND-GDDRYLLVMKGAP Lsal KNAPGWKALCRIAALCNRAE FKPGQDNVPILKREVNGDAS EAALLKCCELSMGQVMEYRR RNKKVCELPFNSTNKYQVSI HET-DDKNDNRYLLVMKGAP Aamp RTTEGWKALSRVAALCNRAE FKVGQESMPVLKRDVNGDAS EAALLKCCELAMGNVMGYRD KYKKVCEIPFNSTNKFQVSI HDIRHENPKNPNLLVMKGAP Afra KSSAGWKALVKIAALCSRAE FKPNQSTTPILKREVTGDAS EAAILKCVELTTGETEAIRK RNKKICEIPFNSANKFQVSI HEN-EDKSDGRYLLVMKGAP Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos KNSPGWGPLQRVAMLCNRAE FKAGQADTPILKREVNGDAS EAAILKCTELTHGNVLDYRA KNKKVCEIPFNSTNKFQVSV HENGEDPSDKRYFLVMKGAP Dmel RTSPGFKALSRIATLCNRAE FKGGQDGVPILKKEVSGDAS EAALLKCMELALGDVMNIRK RNKKIAEVPFNSTNKYQVSI HET-EDTNDPRYLLVMKGAP Tcas RTSPGFKALSRIATLCNRAE FKGGQNDVPILKREVNGDAS EAALLKCMELALGDVMSIRR KNKKVCEIPFNSTNKYQVSI HEN-EDASDPRHILVMKGAP Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar KTSIGFLALARVAALCNRAE FKIGQENAPILKRETTGDAS ESALLKCIEIAIGNVATMRQ RNKS-------------VSI HE--DDSKEPGYLLVMKGAP Tcal KTLPGWKPLERIGTLCNRAE FKPGQAGVSVLKREVNGDAS EAAILKCTELSTGDAMAYRN KHKKVCEVPFNSTNKYQVSI HEV-EGK--DSYLLVMKGAP Crog KNAPGWTALSRVAALCNRAE FKPGQDNVPILKREVNGDAS EAALLKCCELSMGQVMEYRR RNKKVCEIPFNSTNKYQVSV HET-DDKNDNRYLLVMKGAP Dpul KTSSGWKALSRVAGLCSRAE FKPGQDNIPILKREVNGDAS EAALLKCIELATGEAMAIRA RNKKVCEVPFNSTNKYQVSL HDN-EDKNDGRYFLAMKGAP Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin ERILERCTTIVVDGREMPLT EEWKNSFETAYMELGGLGER VLGFCDFMLPADKFPNGYPF DADDVNFPVEGLRFVGLMSM IDPPRAAV--PDAVLKC--- Isca ERILDRCSTIFINGKEKVLD DELKEAFNNAYLELGGLGER VIGFCDYKLPTEKYPPGYPF DADEQNFPLTGLCFLGLVSM IDPPRAAV--PDAVAKC--- Eaff ERILERCSTIIIDGTERELN QEWQDSFNNAYMELGGLGER VLGFCDMLLPADKYPRGYPF DADEENFPLEGLRFVGLMSM IDPPRAAV--PDAVAKC--- Lcyp ERILERSTTIYVDGTDIELN DYWRSAFNRAYLELGGLGER VLGFCDLRLPVNEFPRGFNF DSEEVNFPVANLRFLGLMSM IDPPRAAV--PEAVAKC--- Lsal ERIMDRCGSILVNGEEKELN DDWRDAFNSAYLELGGLGER VLGFCDFILP---------- -------------------- -----AAV--PDAVTKC--- Aamp ERILDRCSTILINGQDKPLD QEMKDAFNNAYLELGGLGER VLGFCDFSLSGDKYPSDYPF DSDEVNFPLQDLRFVGLMSM IDPPRAAV--PDAVSKC--- Afra ERILERCSTIFMNGKEIDMT EELKEAFNNAYMELGGLGER VLGFCDYLLPLDKYPHGFAF NADDANFPLTGLRFAGLMSM IDPPRAAV--PDAVAKC--- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos ERILDRCSTIIVDGTERPLN DEWKDAFNTAYMSLGGLGER VLGFCDYTLPADKYPRGYPF DPDESNFPLEGLRFVGLMSM IDPPRAAV--PDAVMKC--- Dmel ERILERCSTIFINGKEKVLD EEMKEAFNNAYMELGGLGER VLGFCDFMLPSDKYPNGFKF NTDDINFPIDNLRFVGLMSM IDPPRAAV--PDAVAKC--- Tcas ERILERCSTIFICGKEKVLD EEMKEAFNNAYLELGGLGER VLGFCDFMLPTDKYPIGYKF NCDDPNFPLDGLRFVGLMSM IDPPRAAV--PDAVAKC--- Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar ERILERCTTILMDDKEITMS EDWKDAFNQAYLELGGLGER VLGFCDRKLSPEKFPSGYPF DSDEENFPLTGLRFVGLMSM IDPPRAAV--PDAVSKC--- Tcal ERILDRCSTILIDGEELEMS QEWKDNFNNAYMELGGLGER VLGFCDFELPANKFPKGYPF NQDDINFPIEGLRFSGLMSM IDPPRAAV--PDAVAKC--- Crog ERIMDRCRTILVNGEEKELT DDWRDAFNSAYMELGGLGER VLGFCDFILPADKFPEGYPF DADDANFPLEGLRFVGLMSM IDPPRAAV--PDAVAKC--- Dpul ERILDVCSTILLNGVEKPLD NEMRDAFNTAYMELGGLGER VLGFCDTLLPLDKFPKGYAF NADDPNFPLTGLRFVGLISM IDPPRAAV--PDAVAKC--- Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin RSAGIKVIMVTGDHPITAKA IARSVGIISEGTDTVEDIAA RTGVDVKDVNPREARAAVIH GGEIKDMNEKQIDEILMYHT -----EIVFARTSPQQKLII Isca RSAGIKVIMVTGDHPITAKA IAKAVGIISEGNETVEDIAQ RLNIPVEEVNPRDAKAAVIH GSELRDITPEQLDDILRYHT -----EIVFARTSPQQKLII Eaff RSAGIKVIMVTGDHPITAKA IAKSVGIISDGQETVDDIAE RLNIDVSKVNPRDAKAAVVH GGELKDMSEKALDDLLMYHT -----EIVFARTSPQQKLII Lcyp RSAGIKVIMVTGDHPITAKA IAKAVGIISENQETVEDIAQ RLNVPVEQVDPTQAKACVVH GNDLKSMSASEIDGLLRAHS -----EIVFARTSPQQKLII Lsal RSAGIKVIMVTGDHPITAKA IAKSVGIISEGTETVDDIAT RLNIPLEDVNPREAKAAVVH GGELKDLTTVQLDEILLYHT -----EIVFARTSPQQKLII Aamp RSAGIKVIMVTGDHPITAKA IAKS---------------- -------------------- -------------------- -------------------- Afra RSAGIKVIMVTGDHPITAKA IAKSVGIISEGNETVEDIAA RLNIPVSEVNPRDAKAAVVH GGELRDITPDALDEILRHHP -----EIVFARTSPQQKLII Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos RSAGIKVIMVTGDHPITAKA IAKSVNIIMEGSETVEDIAE RLGCDVSKVNPRDARAAVVH GGELKDMDGKQLDDILMYHN -----EIVFARTSPQQKLII Dmel RSAGIKVIMVTGDHPITAKA IAKSVGIISEGNETVEDIAQ RLNIPVSEVNPREAKAAVVH GAELRDVSSDQLDEILRYHT -----EIVFARTSPQQKLII Tcas RSAGIKVIMVTGDHPITAKA IAKSVGIISEGNETVEDIAQ RLNIPVSEVNPREAKAAVVH GSDLRDLSSDQLDEILRYHT -----EIVFARTSPQQKLII Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar RSAGIKVIMVTGDHPITAKA IAKSVGIISEGNETVEDIAT RMEIPLEEVNLQEANAAVVH GSELKEMTQEQLDDVLRNHT -----EIVFARTSPQQKLII Tcal RSAGIKVIMVTGDHPITAKA IAKSVGIISEGNETVEDIAE RQGIPVDKVNPRDARAAVVH GGELKDITEDQLDEILMYHT -----EIVFARTSPQQKLII Crog RSAGIKVIMVTGDHPITAKA IAKSVGIISEGNETVEDIAS RLNIPINEVNPRDAHAAVVH GGELKEITEDHLDEILMYHT -----EIVFARTSPQQKLII Dpul RSAGIKVIMVTGDHPITAKA IAKSVGIISEGNETVEDMAQ RLNIPVEEVDKRLAKAAVVH GGELRDMDSDDLDDVLRNHT -----EIVFARTSPQQKLII Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin VEGCQRMGAIVAVTGDGVND SPALKKADIGVAMGIAGSDV SKQAADMILLDDNFASIVTG VEEGRLIFDNLKKSIAYTLT SNIPEISPFLLFILADVPLP Isca VEGCQRLGAIVAVTGDGVND SPALKKADIGVAMGISGSDV SKQAADMILLDDNFASIVTG VEEGRLIFDNLKKSIAYTLT SNIPEISPFLLFILADVPLP Eaff VEGCQRMGAIVAVTGDGVND SPALKKADIGVAMGIAGSDV SKQAADMILLDDNFASIVTG VEEGRLIFDNLKKSIAYTLT SNIPEISPFLLFILADVPLP Lcyp VEGCQRQRAIVAVTGDGVND SPALKKADIGVAMGIAGSDV SKQAADMILLDDNFASIVTG VEEGRLIFDNLKKSIAYTLT SNIPEITPFLIYMITDIPLP Lsal VEGCQRMGAIVAVTGDGVND SPALKKADIGVAMGIAGSDV SKQAADMILLDDNFASIVTG VEEGRLIFDNLKKSIAYTLT SNIPEISPFLLFILADIPLP Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra VEGCQRQGAIVAVTGDGVND SPALKKADIGVAMGIAGSDV SKQAADMILLDDNFASIVTG VEEGRLIFDNLKKSIVYTLT SNIPEISPFLLFILFDIPLP Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos VEGCQRMGAIVAVTGDGVND SPALKKADIGVAMGIAGSDV SKQAADMILLDDNFASIVTG VEEGRLIFDNLKKSIAYTLT SNIPEISPFLLFILADVPLP Dmel VEGCQRMGAIVAVTGDGVND SPALKKADIGVAMGIAGSDV SKQAADMILLDDNFASIVTG VEEGRLIFDNLKKSIAYTLT SNIPEISPFLAFILCDIPLP Tcas VEGCQRMGAIVAVTGDGVND SPALKKADIGVAMGIAGSDV SKQAADMILLDDNFASIVTG VEEGRLIFDNLKKSIAYTLT SNIPEISPFLAFILCDIPLP Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar VEGCQRLGAIVAVTGDGVND SPALKKADIGVAMGIAGSDV SKQAADMILLDDNFASIVTG VEEGRLIFDNLKKSIAYTLT SNIPEISPFLFFIVANIPLP Tcal VEGCQRMGAIVAVTGDGVND SPALKKADIGVAMGIAGSDV SKQAADMILLDDNFASIVTG VEEGRLIFDNLKKSIAYTLT SNIPEISPFLLFILADVPLP Crog VEGCQRMGAIVAVTGDGVND SPALKKADIGVAMGIAGSDV SKQAADMILLDDNFASIVTG VEEGRLIFDNLKKSIAYTLT SNIPEISPFLLFILADVPLP Dpul VEGCQRLGAIVAVTGDGVND SPALKKADIGVAMGIAGSDV SKQAADMILLDDNFASIVTG VEEGRLIFDNLKKSIAYTLT SNIPEISPFLLFICCDIPLP Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin LGTVTILCIDLGTDMVPAIS MAYEQAESDIMKRQPRNPFT DKLVNERLISMAYGQIGMIQ ASAGFFVYFVILCENGFWPS RLFGIRRAWDSAAVNDLEDS Isca LGTVTILCIDLGTDMLPAIS LAYETAESDIMKRQPRNPLK DKLVNESL-SLFKGRLCSVG GMSKFRVAGMQKRQKEMQAH FLVS------SHAVNDLMDS Eaff LGTVTILCIDLGTDMVPAIS MAYEQAESDIMKRQPRNPFT DKLVNERLISMAYGQIGMIQ ASAGFFVYFVILCENGFWPS HLLGLRRAWDSVAVNDLEDS Lcyp LGTITILCIDLGTDMVPAIS LAYEKAENDIMKRRPRDPQH DRLVNERLISMAYGQIGMIQ ASAGFFVYLVIMAENGFWPS RLLGLRKSWESKTINDLEDS Lsal LGTVTILCIDLGTDMIPAIS MAYEEAESDIMKRMPRNPFS DKLVNERLISMAYGMIGMIQ AA------------------ -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra LGTVTILCIDLGTDMVPAIS LAYEEAESDIMKRRPRNPVT DKLVNERLISLAYGQIGMIQ ASAGFFVYFVIMAECGFLPW DLFGLRKHWDSRAVNDLTDS Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos LGTVTILCIDLGTDMVPAIS MAYEQAESDIMKRQPRNPFT DKLVNERLISMAYGQIGMIQ ASAGFFVYFVILAENGFWPG KLFGLRRAWDSLAINDLEDS Dmel LGTVTILCIDLGTDMVPAIS LAYEHAEADIMKRPPRDPFN DKLVNSRLISMAYGQIGMIQ AAAGFFVYFVIMAENGFLPK KLFGIRKMWDSKAVNDLTDS Tcas LGTVTILCIDLGTDMVPAIS LAYEAPESDIMKRQPRDPYR DNLVNRRLISMAYGQIGMIQ AAAGFFVYFVIMAENGFRPT DLFGIRKQWDSKAVNDLTDS Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar LGTVTILCIDLGTDMVPAIS LAYEKAETDIMKRKPRDPFR DKLVNERLISMSYGQIGMIQ ASAGFFSYFVIMAENGFWPS KLFGLRKSWDASSINDLRDS Tcal LGTVTILCIDLGTDMVPAIS MAYEEAESDIMKRQPRNPFT DKLVNERLISMAYGQIGMIQ ASAGFFVYFVILAENGFLPS RLFGLRRAWDSQAVNDLEDS Crog LGTVTILCIDLGTDMIPAIS MAYEEAESDIMKRQPRNPFT DKLVNERLISMAYGQIGMIQ ASAGFFVYFVILAENGFFPS KLLGLRRAWDSPAINDLQDS Dpul LGTVTILCIDLGTDMVPAIS LAYESAENDIMKRPPRCPKK DKLVNERLISMAYGQVGMIQ ASAGFFVYFVIMAENGFRPD LLFGIRKNWDSRAVNDLQDS Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin YGQEWTYSDRKILEYTCHTA FFVSIVVVQWADLIICKTRK NSVFQQGMKNHFMNFGLCFE TALAAFLSYTPGMDKGLRMY PLKINWWLPALPFSLAIFCY Isca YGQEWTYKNRKTLEYTCHTA FFVSIVIVQWADLIICKTRR NSILHQGMRNHVLNIGLIFE TALAAILSYTPGMDKGLRMY PLKINWWLPAMPFSLLIFVY Eaff YGQEWTYKDRKVLEYTCHTA FFVSIVIVQWADLIICKTRK NSVFQQGMKNWFMNFGLVFE TLLAAFLSYTPGMDKGLRMY PLKFNWWLPALPFSLIIFIY Lcyp YGQEWTFSQRKVLEYTCHTA FFVSIVIVQWADLIICKTRR NSLYHQGMTNWMLNFGLVFE TVLAAALCYTPYLDKGLNMY PLKFYWWLPALPFSLAIFIY Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra YGQEWTYDARKQLESSCHTA YFVSIVIVQWADLIISKTRR NSVFQQGMRNNILNFALVFE TCLAAFLSYTPGMDKGLRMY PLKINWWFPALPFSFLIFVY Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos YGQEWTYKDRKILEYTCHTA FFVSIVVVQWADLIICKTRK NSVFQQGMRNWFMNFGLVFE TVLAAFLSYTPGMDKGLRMY PLKINWWLPAMPFSLLIFVY Dmel YGQEWTYRDRKTLEYTCHTA FFISIVVVQWADLIICKTRR NSIFQQGMRNWALNFGLVFE TVLAAFLSYCPGMEKGLRMY PLKLVWWFPAIPFALAIFIY Tcas YGQEWTYRDRKTLEYTCHTA FFVSIVVVQWADLIICKTRR NSILHQGMRNWALNFGLVFE TALAAFLSYTPGMDKGLRMF PLKFVWWLPAIPFMLSIFIY Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar YNQEWTYDDRKKLEYTCQTA FFVSIVVVQWADLIICKTRR LSLFHQGMTNHVMNFGLCFE TVLACILCYTPGLDKGLRMY PLKFVWWLPAIPFSITIFIY Tcal YGQEWTYRDRKVLEYTCHTA FFVSIVIVQWADLIICKTRR LSVFQQGMKNHFMNFGLVFE TVLAAFLCYTPGMDKGLRMY PLKFNWWLPALPFSLLIFVY Crog FGQEWTYHDRKTLEYTCHTA FFVSIVVVQWADLIICKTRR NSVFQQGMNNMFMNFGLIFE TALAAFLSYTPGMDKGLRMY PLKFHWWLPAMPFSLLIFVY Dpul YGQEWTYDARKQLEYTCHTA FFVSIVVVQWADLIICKTRR NSIVHQGMRNHVLNFGLLFE TAMAAFLSYTPGMDKGLRMY PLKINWWLPAIPFSILIFVY Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin DETRKFLLRRN-PGGWIEKE T-YY-------------XTD IALIGLAVMGQNLILNMNDN GFKVVAYNRTTAKVDDFLKN EAKNTDVVGAHSLEEMVAKL Isca DEIRRFILRRN-PGGWVEME T-YYLL--------SLCRAD IGLIGLAVMGQNLILNMNDH GHVVCAFNRTTEKVDEFLKK EAKGTKVIGAHSLEELVSKL Eaff DESRKFLLRRN-PGGWIEQE T-YYMG---------EPTGD IALIGLAVMGQNLILNMNDH GFVVVAYNRTTAKVDQFLEN EAKGTKVVGAHSLEEMVAKL Lcyp DEVRKYIIRRN-PGGWVEQE T-YYMS--------DEGVAD IALIGLAVMGQNIILNMNDH GFKVCAFNRTVDKVEAFLKN EAKGTNVIGAKSLEDMVKKL Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra DEARKFILRRN-PGGWVEQE T-YY---------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos DECRKYLLRRNGPGSWIEQE T-YYMS---------EPVGD IALIGLAVMGQNLILNMNDH GFTVVAYNRTTAKVDNFLEN EAKGTKVVGAHSLEEMVAKL Dmel DETRRFYLRRN-PGGWLEQE T-YYMS----------GQAD IALIGLAVMGQNLILNMDEK GFVVCAYNRTVAKVKEFLAN EAKDTKVIGADSLEDMVSKL Tcas DETRRFYLRRN-PGGWLEQE T-YYMA---------QGKGD IGLIGLAVMGQNLILNMADH GFTVVAFNRSVEKVHAFLAN EAKGKCIIGAESIPDLVSKL Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar DECRKYILRRN-PGGWGKKK NEKMMGNSPCSKHEKEHIAD IAMIGLAVMGQNLVLNMNDH GFVVCAYNRTTSKVDEFLAK EAKGTLVVGAHTLEEMISKL Tcal DESRKYILRHQPHGAWLERE T-YYMAP-------QEPVAD IALIGLAVMGQNIILNMNDH GFVVCAYNRTQEKVKEFLET GAKGTKVVGATSVEDMVGKL Crog DECRKLLIRRLPPGNWVERE T-YYMS---------EPVAD IALIGLAVMGQNIILNMNDH GYVVCAYNRTTEKVDNFLAN EAKGTKIVGAHSLEEMVAKL Dpul DECRKFILRRN-PGGWVERE T-YYMS--------AEQVAD IGLIGLAVMGQNLILNMADH GFVVCAFNRTTSKVDDFLHN EAKGKSVVGAHSVRELVAKL Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin KKPRRVMMLVKAGSAVDAFI EKLVPLLEAGDIIIDGGNSE YQDTVRRTQDLEKKGILFVG SGVSGGEEGARYGPSLMPGG NPAAWPAIKPIFQAICAKV- Isca KTPRRIVLLVKAGQAVDDFI NKLTPLLTKGDILIDGGNSE YQDSERRCEALKAKGILFVG SGVSGGEEGARYGPSLMPGG NKEAWPHIKDIFQGIAAKAD Eaff KKPRKVMMLVKAGSAVDDFI AKLVPLLEQGDIIIDGGNSE YQDTRRRTKDLESKGLLFVG SGVSGGEEGARYGPSLMPGG NPAAWPALKPIFQSICAKSG Lcyp KKPRRVMLLVKAGSAVDAFI DQLVPLLEAGDIIIDGGNSE YQDTNRRCQTLDGKGILYVG SGVSGGEEGARHGPSLMPGG NIKAWPAIQPIFQSICAKVD Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos KRPRKVMMLVKAGSAVDDFI EKLVPLLEKGDIIIDGGNSE YQDTRRRTADLEKRGILYVG SGVSGGEEGARYGPSLMPGG NPAAWPSIKPIFQAICAKSG Dmel KSPRKVMLLVKAGSAVDDFI QQLVPLLSAGDVIIDGGNSE YQDTSRRCDELAKLGLLFVG SGVSGGEEGARHGPSLMPGG HEAAWPLIQPIFQAICAKAD Tcas KTPRRVMMLVKAGDAVDSFI DQLVPHLQKGDIIIDGGNSE YQDSERRCKDLRAKGIRFVG AGVSGGEDGARYGPSLMPGG NKEAWPYIKDIFQSVAAKTD Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar KKPRRVMMLVKAGTAVDDFI EKLLPLLENGDIIIDGGNSE YQDTQRRCQSLKAKGIWFVG SGVSGGEDGARYGPSLMPGG QREAWPHIKPIFQGIAAKVD Tcal KKPRRVMMLVKAGDPVDAFI KQVVPFLEKGDIIIDGGNSE YLDTIRRVKELSEKGILFVG SGVSGGEEGARYGPSMMPGG NPEAWPHVKDIFQSICAKSN Crog KKPRRVMMLVKAGAAVDAFI DKLVPLLEAGDIIIDGGNSE YQDTRRRTKDLSEKGILFVG SGVSGGEEGARYGPSLMPGG NPKAWPHIKPIFQAICAKSN Dpul KKPRRVMMLVQAGKAVDQFI DQLVEFLEAGDIIIDGGNSE HGDTTRRCTTLREKGILYVG SGVSGGEEGARYGPSLMPGG HIEAWPHIKPIFQSISAKSD Aver -------------------- -----------LICEAYHIM KDVLGMSHDEMAETFEEWNK GELDSFLIEISANILKYKDD SGDHLVEKIRDSAGQKGTGK Csin -GEXXXXXXXXXXTGHFVKM VHNGIEYGDMQLICEAYHLM KDTLGMDNDEMSQTFKSWNE GELDSFLIEISTNILKFRDD SGEFLLEKIRDSAGQKGTGK Isca -GEPCCDWVGDGGSGHFVKM VHNGIEYGDMQLIGEAYHLI KDATGILHFE--QVFDEWNK GVLDSFLIEITSNILKYKDT DGEPLVTKIRDAAGQKGTGK Eaff -DEPCCDWVGEDGSGHFVKM VHNGIEYGDMQLICEAYHLM KDALNMDNEEMSNSFTEWNK GELDSFLIEISSNILKYKDE SGDYLLEKIRDSAGQKGTGK Lcyp NGEPCCDWVGEEGSGHFVKM VHNGIEYGDMQLICEAYHLM KNVLGMDHDAMADTFAEWNK GELDSFLIQITANILKFKDD DGKPLLEKIKDSAGQKGTGK Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -----------LICEAYHIM KDFLGMNHDDMADTFLEWNK GELDSFLIEITAHILKHRDD DGDHLVEKIRDSAGQKGTGK Afos -EEPCCDWVGEDGSGHFVKM VHNGIEYGDMQLICEAYHLM KDALGLNNDEMSSIFSEWNK GELDSFLIEISANILKYKDE SGDFLLEKIRDSAGQKGTGK Dmel -GEPCCEWVGDGGAGHFVKM VHNGIEYGDMQLICEAYHIM Q-SLGLSADQMADEFGKWNS AELDSFLIEITRDILKYKDG KG-YLLERIRDTAGQKGTGK Tcas -GQPCCDWVGNDGAGHFVKM VHNGIEYGDMQLIGEVYHMM Q-AIGVDQGKMAKTFAEWNK GELDSFLIDITKDIMGFKDT DGKYLLPKIRDTAGQKGTGK Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar -NEPCCDWVGEDGSGHFVKM VHNGIEYGDMQLICEAYHLL KDALDLSHDEMSHIFGEWNK GELDSFLIEITRDILKYKDD DGKPLVEKILDSAGQKGTGK Tcal -GEPCCDWVGEGGSGHFVKM VHNGIEYGDMQLICEAYNIM KDVLGMSHDEMSEVLNEWNK GELDSFLVEISANILAYKDK DGQPLVEKIRDSAGQKGTGK Crog -GEPCCDWVGEDGSGHFVKM VHNGIEYGDMQLICEAYHLM KDTLGLGHDEMSDIFKEWNK GELDSFLIEISTNILKYKDA DGSPLLEKIRDAAGQKGTGK Dpul -GEPCCDWVGEGGAGHFVKM VHNGIEYGDMQLIAEAYHLM KSVLGMTPPEMADVFDEWNK GELDSFLIEITANILRFQDD KGDYLVEKIRDSAGQKGTGK Aver WTAISALDYGMPVTLIGEAV FSRCLSSLKDERICASQVLS GPDNQGFTGDKSLFVEQIRQ ALYASKIISYAQGFMLLREA AKVFNWNLNYGGIALMWRGG Csin WTAISALEYGMPVTLIGESV FARCLSSLKDEREKASTILH GPETTKYEGDKKEFVEAIRQ ALYASKIVSYAQGFMLLRQA AKEFGWNLNYGGIALMWRGG Isca WTAISALQHGIPVTLIGEAV FARCLSSLKDQRVEASKILK GPNG-KYEGQASDFVEHVRK ALYASKIVSYAQGFMLLRSA AQEYKWSLNYGAIALMWRGG Eaff WTAISALEYGMPVTLIGESV FARCLSSLKGERERASKILK GPEGAEFTGEKAAFVEDIRQ ALYASKIVSYAQGFMLLRQA AQEFGWNLNYGGIALMWRGG Lcyp WTAISALDYGMPVTLIGEAV FARCLSSLRDERVRASAILK GPADVCFQGDKQQFIEQIRQ ALYASKIVSYAQGFMLLREA AKVFNWKLNYGGIALMWRGG Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda WTAISALDYGMPVTLIGEAV FARCLSSLKDERLSASGVLA GPALKSFDGDTADFVEQIRE ALYASKIVSYAQGFMLLREA AKVFNWNLNYGGIALMWRGG Afos WTAISALEYGMPVTLIGESV FARCLSSLKGERERASSILK GPDAPSFDGDKDKFVEDIRQ ALYASKIVSYAQGFMLLRQA AVEFGWNLNYGGIALMWRGG Dmel WTAIAALQYGVPVTLIGEAV FSRCLSALKDERVQASSVLK GPSTKAQVANLTKFLDDIKH ALYCAKIVSYAQGFMLMREA ARENKWRLNYGGIALMWRGG Tcas WTAIAALNYGMPVTLIGEAV FSRCLSALKNERITASKVLP GPTA-KFTGNVDQFLDELRQ ALYASKIVSYAQGFMLLREA AGVHNWDLDYGSIALMWRGG Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar WTAIASLEYGMPVTLIGESV FARCLSSLKADRVNASKQLK GPTETKYKGDKKQFAEHIRK ALYASKIVSYAQGYMLLREA AKQFKWDLNYGGIALMWRGG Tcal WTAISALQYGMPVTLIGESV FARCLSSIKDERTLASKSLK GPDAPKFDGDKKAFIEQIRQ ALYASKIISYAQGFMLLREA AKEEDWKLNYGGIALMWRGG Crog WTAISALEYGMPVTLIGESV FARCLSSLKDERVRASKILK GPSNTKFNGDKKEFVEQIRQ ALYASKIISYAQGFMLLREA AKVFGWNLNYGGIALMWRGG Dpul WTAIAALDYGVPVTLIGEAV FARCLSSLQAERIEASKVLP APAFKAYSGERASFIEAIRK ALYASKIVSYAQGFMLLREA AKQYDWTLNYGGIALMWRGG Aver CIIRSVFLGNIKSAYDKNPD LTNLLLDDFFRDAIHGSQAA WRNVVATAVQSGVPAPCFST ALAFYDGYRSARLPANLIQA QR------------------ Csin CIIRSRFLGNIKAAFDKNPA LDNLLLDDFFRDAIHASQKS WRKVVSKAVELGVPTPCFST ALAFYDGYRCKKLPANLIQA QRDILEL----ILTSFWQNL Isca CIIRSAFLGNIKAAFDKNPE LSCLLLDSFFVDAIQDCQAS WRLVVASAAQLGIPVPAFST ALAFYDGFRAEKLPANLIQA QRDYFGAHTYERLSEPGKFV Eaff CIIRSRFLGNIKDAFDKNPA LDNLLVDDFFRDAIHNAQGA WRRVVSQAVLMGVPTPCFST ALAFYDGYRSDMLPANLIQA QRDYFGAHTYELLGQPGAYH Lcyp CIIRSVFLGNIKAAFDKDPE LQNLLLDDFFRDAIHRCQDA WRRVLSTAVERGVPTPCFST ALAFYDGYRSARLPANLIQA QRDYFGAHTYELLSNPGTFV Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda CIIRSVFLGKIKAAFDKNPE LTNLLLDDFFRDAVHKCQAS WRNVVSAAVQAGIPTPCFST ALAFYDGYRCARLPANLIQA QR------------------ Afos CIIRSRFLGNIKAAFDKNPA LDNLLVDDFFRDAIHNAQAA WRRVVSQAVLMGIPTPCFST ALAFYDGYRSSMLPANLIQA QRDYFGAHTYELLSAPGTYV Dmel CIIRSVFLGNIKDAYTSQPE LSNLLLDDFFKKAIERGQDS WREVVANAFRWGIPVPALST ALSFYDGYRTAKLPANLLQA QRDYFGAHTYELLGQEGQFH Tcas CIIRSVFLGQIKLAFDRDPS LKSLLLAPFFLNAITRSQNA WRNVVSTAIKLGVPTPALST ALAFYDGYRSERLPANLLQA QRDYFGAHTYELLGQEGKFV Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar CIIRSAFLGNIKSAFDKNKS LSNLLLDDFFRKAIDDCQES WRLVIMEAVKLGIPTPCFAT ALAFYDGFRLANLPANLIQA QRDYFGAHTYERIDAPGKVV Tcal CIIRSVFLGNIKSAYDKNPQ LENLLLDDFFRDAIHNCQKG WRKVVSTAVEMGIPTPCFST ALAYYDGYRSERLPANLIQA QRDYFGAHTYELLASPGKFV Crog CIIRSVFLGNIKNAYDKSPK LENLLLDDFFKDAVHKCQDS WRKVVSKAVELGVPTPCFST ALAFYDGYRSSKLPANLLQA QRDYFGAHTYELLNNPGKHV Dpul CIIRSVFLGNIKLAFERNPD LKSLLMDDFFRQAVGTCQES WRDVIATAAQYGVPVPAFST ALSFYDAYRCQRLPANLIQA QRDYFGAHTYELLDQPGVFH Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin ASMSTLTGLALGAMFQHQLT QLEMSLTDQLLQHVI----- -------------------- -------------------- -------------------- Isca HTNWTGTGGNVSSS------ -----------SYNA----- -------------------- -------------------- -------------------- Eaff HTNWTGTGGNVSAS------ -----------TYSA-MSQV PCSKFTDNYELKEELGKGAF SIVKRCVQRHTGLEFAAKII NTKKLSARDFQKLEREARIC Lcyp HTNWTGLGGNVSAS------ -----------TYDV-MAQT ASTKFTDNYELKEELGKGAF SVVRRCVQKNTGLEFAAKII NTKKLSARDFQKLEREARIC Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- ----------------M-NN ACTRFSDNYELKEELGKGAF SIVKRCVQKATGLEFAAKII NTKKLSARDFQKLEREGRIC Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos HTNWTGTGGNVSAS------ -----------TYSA----- -------------------- -------------------- -------------------- Dmel HTNWTGTGGNVSAS------ -----------TYQAMAAPA ACTRFSDNYDIKEELGKGAF SIVKRCVQKSTGFEFAAKII NTKKLTARDFQKLEREARIC Tcas HTNWTGHGGNVSSS------ -----------SYNAMAVPI ACTRFSDNYDLKEELGKGAF SVVRRCVQKSTGLEFAAKII NTKKLSARDFQKLEREARIC Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar HTNWTGHGGDVSAS------ -----------TYKAMASQN TSTKFSDNYELKEELGKGAF SIVRRCVQKSTGLEFAAKII NTKKLSSRDFQKLEREARIC Tcal HTNWTGTGGNISAS------ -----------TYDA-MAQN PSTKFTDNYELKEELGKGAF SVVRRCVQKATGLEFASKII NTKKLSARDFQKLEREARIC Crog HTNWTGTGGNVSAS------ -----------TYDA-MAQN PTTKFTDNYELKEELGKGAF SVVRRCVQKSTGLDFASKII NTKKLSARDFQKLEREARIC Dpul HANWTGHGGRTSAS------ -----------TYQA-MALN ATTRFSDNYELKEELGKGAF SIVRRCVQKSTGLEFAAKII NTKKLSARDFQKLEREARIC Aver -------------------- -------------------- ---------------LESVN HCHMNGVVHRDLKPENLLLA SKQKGAAVKLADFGLAIEVQ Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca ---------RLHDSIQEEGY HYLIFDLVTGGELFEDIVAR EYYSEADASHCIQQILESVN HCHMNNVVHRDLKPENLLLA SKAKGAAVKLADFGLAIEVQ Eaff RKLQHPNIVRLHDSIQEESF HYLIFDLVTGGELFEDIVAR EFYSEADASHCIQQILESVN HCHSNGVVHRDLKPENLLLA SKSKGAAVKLADFGLAIEVQ Lcyp RKLQHPNIVRLHDSIQEESF HYLVFDLVTGGELFEDIVAR EFYSEADASHCIQQILESVN HCHSNGVVHRDLKPENLLLA SKQKGAAVKLADFGLAIEVQ Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra RKLQHPNIVRLHDSIQEESF HYLVFDLVTGGELFEDIVAR EFYSEADASHCIQQILESVN HCHVNGVVHRDLKPENLLLA SKLKGAAVKLADFGLAIEVQ Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- ---------------LESVN HCHMNGVVHRDFKPENXLLA SKQKGAAVKLADFGXAIEVQ Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel RKLHHPNIVRLHDSIQEENY HYLVFDLVTGGELFEDIVAR EFYSEADASHCIQQILESVN HCHQNGVVHRDLKPENLLLA SKAKGAAVKLADFGLAIEVQ Tcas RKLQHPNIVRLHDSIQEENF HYLVFDLVTGGELFEDIVAR EFYSEADASHCIQQILESVN HCHQNGVVHRDLKPENLLLA SKAKGAAVKLADFGLAIEVQ Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar RKLQHPNIVRLHDSIQEESF HYLVFDLVTGGELFEDIVAR EFYSEADASHCIQQILESVN HCHQNCVVHRDLKPENLLLA SKAKGAAVKLADFGLAIEVQ Tcal RKLQHPNIVRLHDSIQEENF HYLVFDLVTGGELFEDIVAR EFYSEADASHCIQQILESVN HCHQNGVVHRDLKPENLLLA SKQKGAAVKLADFGLAIEVQ Crog RKLQHPNIVRLHDSIQEENF HYLVFDLVTGGELFEDIVAR EFYSEADASHCIQQILESVN HCHCNGVVHRDLKPENLLLA SKLKGDS--------AIEVQ Dpul RKLQHPNIVRLHDSIQEESF HYLVFDLVTGGELFEDIVAR EFYSEADASHCIQQILESVN HCHQNGVVHRDLKPENLLLA SKAKGAAVKLADFGLAIEVQ Aver GEQQAWFGFAGTPGYLSPEV LKKEPYGKPVDIWACGVILY ILLVGYPP------------ -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca GEQQAWYGFAGTPGYLSPEV LKKDPYGKPVDIWACGVILY ILLVGYPPFWDEDQHRLYMQ IKAGAYDYPSPEWDTVTPEA KNLINSMLTVNPAKRITAAE Eaff GDQQAWFGFAGTPGYLSPEV LKKEPYGKPVDIWACGVILY ILLVGYPPFWDEDQHRLYAQ IKAGAYDYPSPEWDTVTPEA KNLINQMLTVNPAKRIRAEE Lcyp GDQQAWFGFAGTPGYLSPEV LMKEPYGKPVDIWACGVILY ILLVGYPPFWDEDQHRLYAQ IKAGAYDYPSPEWDTVTPEA KNLINQMLTVNPAKRIRSDV Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra GEQQAWFGFAGTPGYLSPEV LKKEPYGKPVDIWACGVILY ILLVGYPPFWDEDQHRLYAQ IKAGAYDYPSPEWDTVTPEA KNLINQMLTVNPAKRITSTE Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda GEQQAWFGFAGTPGYLSPEV LKKEPYGKPVDIWACGVILY ILLVGYPP------------ -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel GDHQAWFGFAGTPGYLSPEV LKKEPYGKSVDIWACGVILY ILLVGYPPFWDEDQHRLYSQ IKAGAYDYPSPEWDTVTPEA KNLINQMLTVNPNKRITAAE Tcas GEQQAWFGFAGTPGYLSPEV LKKEPYGKPVDIWACGVILY ILLVGYPPFWDEDQHRLYAQ IKAGAYDYPSPEWDTVTPEA KNLINQMLTVNPGKRITASE Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar ADQQGWFGFAGTPGYLSPEV LKKEPYGKPVDIWACGVILY ILLVGYPPFWDEDQHRLYAQ IKAGAYDYPSPEWDTVTPEA KNLINSMLTVNPAKRIVAAD Tcal GDQQAWFGFAGTPGYLSPEV LKKEPYGKAVDIWACGVILY ILLVGYPPFWDEDQHRLYAQ IKAGAYDYPSPEWDTVTPEA KNLINQMLTVNPQKRIKSEE Crog GDQHAWFGFAGTPGYLSPEV LKKEPYGKAVDIWACGVILY ILLVGYPPFWDEDQHRLYAQ IKAGAYDYPSPEWDTVTPEA KNLINQMLTVNPAKRIRSDE Dpul GEQQAWFGFAGTPGYLSPEV LKKEPYGKPVDIWACGVILY ILLVGYPPFWDEDQHRLYAQ IKAGAYDYPSPEWDTVTPEA KNLINQMLTVNPAKRITAAE Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca ALKHPWICQRERVASTLHRQ ETVDCLKKFNARRKLKGAIL TTMLAT-RNFS-S------- -KGEGSQVKESTD-SSTTIE DD--DVK------------- Eaff ALKHPWICQRERVASVFHRQ ETVDCLKKFNARRKLKGAIL TTMLVS-RNFS-TKSLVNK- -GSK---------------- -------------------- Lcyp ALKHPWICQRERVASMVHRQ ETVDCLKKFNARRKLKGAIL TTMLVS-RNFS-TRSMVGAG VKGKSGDVKESTD-SSTTIE EDEKDVKMNHV------RGS Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra ALKHPWICQRERVASVVHRQ ETVDCLKKFNARRKLKGAIL TTMLAT-RNFS-SKSIIK-- -KESGSQVKESSD-SNTTLE DD--DSKEEKAKGV--DRSS Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel ALKHPWICQRERVASVVHRQ ETVDCLKKFNARRKLKGAIL TTMLAT-RNFS-SRSMITK- -KGEGSQVKESTDSSSTTLE DD--DIK------------- Tcas ALKHPWICQRERVASVVHRQ ETVDCLKKFNARRKLKGAIL TTMLAT-RNFS-SRSIIVK- -KGDGSQVKESTD-SSTTLE DD--DIK------------- Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar ALKHPWICQRERVASVVHRQ ETVDCLKKFNARRKLKGAIL TTMLAT-RNFS-TRSIVNK- -KGDGSQVKESTD-SSTTIE ED--DVKDASVMHLAPDRSK Tcal ALKHPWICNRDRVASVVHRQ ETVDCLKKFNARRKLKGAIL TTMLVS-RNFS-SKGA---- -------------------- -------------------- Crog ALKHPWICQRERVASVVHRQ ETVDCLKKFNARRKLKGAIL TTMLVS-RNFS-TRSMASKG -KSDGSQVKESTD-SSTTIE DD--DKDEKKVV----DRSS Dpul ALKHPWICQRERVASVVHRQ ETVDCLKKFNARRKLKGAIL TTMLAT-RNFS-SRSIINK- -KSDGSNVKESTD-SSTTIE ED--DVKEKSKGVV--DRSS Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- ----------------ARKQ EIVKLTEQLIESINGGDYET YTKLCDPHLTAFEPEALGNL VEGMEFHKFYFDNGAGKS-- Eaff -------------------- -------------------- -------------------- -------------------- -------------------- Lcyp SG------------------ AVQIRTSGSQSDPSSIARKS EIIRSTELLLEAINTSDFES YARLCDPHLTAFEPEALGNL VEGLEFHKFYFDN-LKSQ-- Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra TVIAKDPD------------ ----------------ARKQ EVLRMTEQLVEAISCGDFEN YTKLCDPHLTAFEPEALGNL VQGMEFHKFYFDNVLGKN-- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -------------------- Dmel -------------------- ---------------AARRQ EIIKITEQLIEAINSGDFDG YTKICDPHLTAFEPEALGNL VEGIDFHKFYFENVLGKN-- Tcas -------------------- ----------------ARRQ EIIKMTEQLIEAINTGDFEA YTKICDPHLTAFEPEAMGNL VEGMDFHKFYFDNVLGKN-- Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar TVIAREPEEDRYSLHIMAQC DAIAEAVKNDSFISLSPRKQ EIVKITEQLIDAINTGDYEA YTKICDPHITSFEPESLGNL VEGMDFHKFYFENVLGKN-- Tcal -------------------- -------------------- -------------------- -------------------- --------FLFEM------- Crog TVIARDTAEDMKLNHVKNSS SLQIRNSNSQGDPSVSARKN EIIRCTELLLEAICSGDFES FTRLSDSSLTTFDPEALGNC VEGLEFHKFYFDNVLGKNDE Dpul TVIAKEPEDVR-------LT ATAKTCSQLPSNWNGSARKQ EILKLTEQLLEAISAGDYET YAKICDPHVTSFEPEALGNL VEGLEFHKFFFDNLLGKN-- Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca YKSQNTTIINPTVHLLGDDA ACIAYIRLMQYIDRAGIART RQTEETRVWHRKDTKWQNVH FHRSGNS---SGMHPDPAAK -------------------- Eaff -------------------- -------------------- -------------------- -------------------- -----------MNPHSGLPF Lcyp RHISNINIINPHVHLLGDDA AAIAYVRMTQFIDKQGSPQT QQSEETRIWHRRDGRWINVH FHRSTLA---VDSPFASKTQ -----------INPYTSQPY Lsal -------------------- -------------------- -------------------- -------------------- -----------MNPHSALPY Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra CKAVNTLILNPHVHLLGEDA ACIAYVRLTQFIDKQGQAHT QQSEETRVWQRKDSRWQHVH FHRSGCP---S---FTLGHK -----------INPYNGQVY Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -------------------- -------------------- -------------------- -------------------- -----------MNPHTGLPF Dmel CKAINTTILNPHVHLLGEEA ACIAYVRLTQYIDKQGHAHT HQSEETRVWHKRDNKWQNVH FHRSASAKISGATTFDFIPQ ----------KMNPLTNTPY Tcas CKAVNTTILNPHVHLLGEDA ACIAYVRLTQYMDKHGQAHT HQSEESRVWHKRDNKWQNVH FHRSGGT---GGAAFGFSSH ----------KINPHTGLPY Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar CKAINTTLLNPHVHLMGDDA ACIAYVRLIQYMDKTGGAYT QQSEETRVWHRRDGKWQHVH FHRSRSP---ANIFSTVAAT ----------KLNPFTTLPY Tcal -------------------- -------------------- -------------------- -------------------- -----------LNPHTGLPF Crog SRTLNVNIINPLVHLLGEDS AAIAYVRLTQSIDKSGKIST SQCEETRIWYRRETRWLNVH VHRSNNC---SSSSSISSST AINKSISTNKSMNPHTSLPY Dpul CKSINTLILNPHIHLMGEDA ACIAYVRLTQFVDKQGQAHT QQNEETRVWYRRDGKWLNVH FHRSGAS---TPCTLPYHQN ----------KINPLTGLPY Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff SPRYFELFRKRCQLPVWDYQ EKFLDLLARHQNICLVGETG SGKTTQIPQWCVDFSKSMG- KKTVACTQPRRVAAMSVAQR VAEEMDVSLGQEVGYSIRFE Lcyp TPRYFELFRKRIGLPVWEYQ EKFLELLNKHQIICLVGETG SGKTTQIPQWCVDYARKLG- TKRVSCTQPRRVAAMSVAQR VSEEMDVPLGQEVGYSIRFE Lsal TPRYFELFRKRITLPVWEYR DKFLDLLGQHQCICLVGETG SGKTTQIPQWCAEYA-SKE- RKSVACTQPRRVAAMSVAQR -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra TPRYYGLFRKRIGLPVWEYR EKFFDLLNKYQTIVLVGETG SGKTTQIPQWCVEFAKQKGV KKGVACTQPRRVAAMSVAQR VSEEMDVVLGQEVGYSIRFE Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos SPRYFEIFRKRCQLPVWDYQ EKFLDLLARHQSICLVGETG SGKTTQIPQWCVDFSKKMG- KKGVACTQPRRVAAMSVAQR VAEEMDVALGQEVGYSIRFE Dmel SQRYQNLYKKRIALPVFEYQ ADFMRLLSLHQCIVLVGETG SGKTTQIPQWCVDFAVSKG- RKGVSCTQPRRVAAMSVAQR VSEEMDVKLGEEVGYSIRFE Tcas TNKYHELYRKRITLPVFEYR NDFMRLLAENQCIVLVGETG SGKTTQIPQWCVEFARSVG- KKGVCCTQPRRVAAMSVAQR VSEEMDVALGQEVGYSIRFE Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar TPRYNELYRKRINLPVWEYR EDFLEIINTNRIMVLVGETG SGKTTQIPQWCVEFVRSRG- KRGVACTQPRRVAAMSVAQR VSEEMDCQLGQEVGYSIRFE Tcal TPRYHEIFKKRKALPVWEYQ DKFLDLLQKHQILCLVGETG SGKTTQIPQWCVDFSKKVG- KKCCACTQPRRVAAMSVAQR VAEEMDVSLGQEVGYSIRFE Crog TPRYFELFRKRISLPVWEYR EKFMDLLSSHQCICLVGETG SGKTTQIPQWCAEYA-ARE- SKSVACTQPRRVAAMSVAQR VSEEMDVSLGQEVGYSIRFE Dpul TQKYYDIYRKRIGLPVWEYR EKFFELLENNQAIVLVGETG SGKTTQIPQWSAEFARKLGV KKGVACTQPRRVAAMSVAQR VADEMDVVLGQEVGYSIRFE Aver -------------------- -------------------- -------------------- ------------------YF DNAPLMNVPGRTHPVEIFYT Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff DCSGPRTLLKYMTDGMLLRE AMSDPMLENYQVILLDEAHE RTLATDILMGVLKTVVTHRP DLKLVIMSATLDAGKFQGYF DNAPLMNVPGRTHPVEIFYT Lcyp DCSDQKTLLKYMTDGMLLRE AMSDPMLEAYQVILLDEAHE RTLATDILMGVLKTVTQHRS DLKLVIMSATLDAGKFQNYF DNAPLMNIPGRTHPVEIFYT Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- --------XGRTHPVEIFYT Afra DCSSPRTLLKYMTDGMLLRE GMSDPMLENYQVVLLDEAHE RTLATDILMGVLKEILKQRT DLKLVVMSATLDAGKFQNYF DGAPLLNVPGRTHPVEIYYT Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -----------------NYF DNAPLMNVPGRTHPVEIFYT Afos DCSGPRTLLKYMTDGMLLRE AMSDPMLENYQVILLDEAHE RTLATDILMGVLKTVITHRP DLKLVIMSATLDAGKFQSYF DNAPLMNVPGRTHPVEIFYT Dmel DCSTAKTLLKYMTDGMLLRE AMSDPMLDQYQVILLDEAHE RTLATDILMGVLKEVIRQRS DLKLVVMSATLDAGKFQQYF DNAPLMKVPGRTHPVEIFYT Tcas DCSSAKTILKYMTDGMLLRE GMSDPMLDAYQCILLDEAHE RTLATDILMGVLKEVIKQRS DLKLVIMSATLDAGKFQQYF DNAPLMNVPGRTHPVEIFYT Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar DCSSQKTILKYMTDGMLLRE AMSDPLLEAYGVILLDEAHE RTLATDILMGVLKEVVKQRP DLKIIIMSATLDAGKFQHYF DNAPLMNVPGRTHPVEIFYT Tcal DCSGPKTLLKYMTDGMLLRE AMSDPMLENYQVILLDEAHE RTLSTDILMGVLKTVIGHRP DLKLVIMSATLDAGKFQNYF DNAPLMNVPGRTHPVEIFYT Crog DCSGPRTILKYMTDGMLLRE AMSDTMLDHYKVILLDEAHE RTLATDILMGVLKTVIGHRN DLKLVIMSATLDAGKFQNYF DNAPLMNVPGRTHPVEIFYT Dpul DCSSPKTVLKYMTDGMLLRE AMSDPLLDSYQLVLLDEAHE RTLATDILMGVLKEVIKQRR DLKLIIMSATLDAGKFQSYF DNAPLMNVPGRTHPVEIFYT Aver PEPERDYLEAAIRTVIQIHM CEEDDGDILLFLTGQEEIEE ACKRIKREIDNLGPEVGDMK CIPLYSTLPPNLQQRIFEAA PSRKANGAIGRKVVVSTNIA Csin -------------------- -------------------- -------------------- -------------------- -----------KIVVSTYIA Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff PEPERDYLEAAIRTVVQIHM CEEVDGDLLLFLTGQEEIEE ACKRLKREIDNLGPDVGDMK CIPLYSTLPPNLQQRIFEPP PGKKANGAIGRKIVVSTNIA Lcyp PEPERDYLEAAIRTVIQIHM CEEDDGDILLFLTGQEEIEE ACKRIKREIDNLGPEVGDLK CIPLYSTLPPNLQQRIFEPA PARKANGAAGRKVVVSTNIA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp PEPERDYLEAAIRTVVQIHM CEEVEGDMLLFLTGQEEIEE ACKRLKREIDNVGPEIGELK CIPLYSTLPPALQQRIFEPA PANRPNGAVGRKVVVSTNIA Afra PEPERDYLEAAIRTVIQIHM CEEIAGDVLLFLTGQEEIEE ACKRLKREIDNLGNEVGDLK CIPLYSTLPPNLQQRIFEPP PPNKASGAIGRKVVVSTNIA Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda PEPERDYLEAAIRTVIQIHM CEEXXGDILLFLTGQEEIEE ACKRIKXEIDNXGXEVGDMK CIPXYSTLPPNLQQRIFEXA PXRKSNGAIGRKVVVSTNIA Afos PEPERDYLEAAIRTVIQIHM CEETDGDMLLFLTGQEEIEE ACKRLKREIDNLGPEVGDLK CIPLYSTLPPNLQQRIFEAP PGKKANGAIGRKVVVSTNIA Dmel PEPERDYLEAAIRTVIQIHM CEEIEGDILMFLTGQEEIEE ACKRIKREIDNLGSEIGELK CIPLYSTLPPNLQQRIFEPA PPPNANGAIGRKVVVSTNIA Tcas PEPERDYLEAAIRTVIQIHM CEEIAGDILLFLTGQEEIEV ACKRIKREIDNLGPEVGELK CIPLYSTLPPNLQQRIFEEA PPNKANGAIGRKVVVSTNIA Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar PEPERDYLEAAIRTVIQIHM CEETEGDILLFLTGQEEIEE ACKRIKREVDNLGPEIGELK CIPLYSTLPPNLQQRIFEPA PPRKATGGIGRKVVVSTNIA Tcal PEPERDYLEAAIRTVIQIHM CEEEAGDILMFLTGQEEIEE ACKRIKREIDNLGPDAGDLK CIPLYSTLPPNLQQRIFEAA PPRKSNGAIGRKVVVSTNIA Crog PEPERDYLEAAIRTVIQIHM CEEQEGDALLFLTGQEEIEE ACKRIKREIDNMGNEVGDLK CIPLYSTLPPNLQQRIFEPA PPKKANGAIGRKIVISTNIA Dpul PEPERDYLEAAIRTVMQIHM CEDIVGDVLLFLTGQEEIDE ACKRLKREIDNLGPEVGEMK CIPLYSTLPPNLQQRIFEAA PPVRPNGAIGRKVVISTNIA Aver ETSLTIDGVVFVIDPGFSKQ KVYNPRIRVESLLVSPISKA SAQQRAGRAGRTKPGKCFRL YTEKAYK------------- -------------------- Csin ETSLTIDGVVFVIDPGISKQ KVYNLRIRVEHLLVFPISKA SAQQRAGRAGRTKPGKCFRL YTEKAYKNEMQDNTYPEILR SNLGAVVIQLKKLGIDDLVH Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff ETSLTIDGVVFVIDPGFSKQ KVYNPRIRVESLLVSPISKA SAQQRAGRAGRTKPGKCFRL YTEKAYKNEMQDNTYPEILR SNLGAVVIQLKKLGIDDLVH Lcyp ETSLTIDGVVFVIDPGFSKQ KVYNPRIRVESLLVSPISKA SAQQRAGRAGRTKPGKCFRL YTEKAYKNEMQDNTYPEILR SNLGSVVLQLKKLGIDDLVH Lsal -------------------- -------------------- -------RAGRTKPGKCFRL YTEKAFKNEMQENTYPEILR SNLGSVVIQLKKLGIDDLVH Aamp ETSLTIDGVVFVIDPGFSKQ KVYNPRIRVESLLVSPISKA SAQQRAGRAGRTKPGKCFRL YTEKAFKSEMQDNTYPEILR SNLGTVVLQLKKLGIDDLVH Afra ETSLTIDGVVFVIDPGFAKQ KVYNPRIRVESLLVSPISKA SAQQRAGRAGRTRPGKCFRL YTEKAYKQEMQDNTYPEILR SNLGSVVLQLKKLGIDDLVH Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda ETSXTIDGVVFVIDPGFSKQ KVYNPRIRVESLLVSPIXKA SAQQXAGRAGRTKPGKCFRL YTEKAYKN------------ -------------------- Afos ETSLTIDGVVFVIDPGFSKQ KVYNPRIRVESLLVSPISKA SAQQRAGRAGRTKPGKCFRL YTEKAYKNEMQDNTYPEILR SNLGAVVIQLKKLGIDDLVH Dmel ETSLTIDGVVFVIDPGFAKQ KVYNPRIRVESLLVSPISKA SAQQRSGRAGRTRPGKCFRL YTEKAFKNEMQDNTYPEILR SNLGTVVLQLKKLGIDDLVH Tcas ETSLTIDGVVFVIDPGFAKQ KVYNPRIRVESLLVSPISKA SAQQRAGRAGRTRPGKCFRL YTEKAYKNEMQDNTYPEILR SNLGSVVLQLKKLGIDDLVH Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar ETSLTIDGVVFVIDPGFSKQ KVYNPRIRVESLLVSPISKA SAQQRAGRAGRTQPGKCFRL YTEKAYKQEMQDNTYPEILR SNLGSVVLQLKKLGIDDLVH Tcal ETSLTIDGVVFVIDPGFSKQ KVYNPRIRVESLLVSPISKA SAQQRAGRAGRTKPGKCFRL YTEKAFKNEMQENTYPEILR SNLGSVVLQLKKLGIDDLVH Crog ETSLTIDGVVFVIDPGFSKQ KVYNPRIRVESLLVSPISKA SAQQRAGRAGRTKPGKCFRL YTEKAFKNEMQDNTYPEILR SNLGSVVLQLKKLGIDDLVH Dpul ETSLTIDGVVFVIDPGFAKQ KVYNPRIRVESLLVSPISKA SAQQRAGRAGRTRPGKCFRL YTEKAYKQEMQDNTYPEILR SNLGSVVINLKKLGIDDLVH Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin FDFMDPPAPETLMRALELLN YLAALDDDGNLTELGAIMAE FPLDPQLAKMLIASCEYQCS NEILSIVAMLS--------- -VPQCFVRPNEAKKASDDSK Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff FDFMDPPAPETLMRALELLN YLAALDDDGNLTELGAIMAE FPLDPQLAKMLIASCEYNCS NEILSIVSMLS--------- -VPQCFVRPNEAKKASDDSK Lcyp FDFMDPPAPETLMRALELLN YLAALDDDGNLTELGAIMAE FPLDPQLAKMLIASCEYNCS NEILSITAMLS--------- -VPQCFVRPNEAKKAADDSK Lsal FDFMDPPAPETLMRALELLN YLAALDDDGNLTELGAIMAE FPLDPQLAKMLIASCENNCS NEILSITAMLS--------- -VPQCFVRPNDAKKAADDSK Aamp FDFMDPPAPETLMRALELLN YLSALDDSGNLTDLGAIMAE FPLDPQLAKMLIASTEYNCS NEILSITAMLS--------- -VPQCFVRPNDARKAADESK Afra FDFMDPPAPETLMRALELLN YLAALDDDGNLTELGAIMAE FPLDPQLAKMLIASCEFNCS NEILSITAMLS--------- -VPQCFVRPNEAKKAADDAK Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos FDFMDPPAPETLMRALELLN YLAALDDDGNLTELGAIMAE FPLDPQLAKMLIASCEYNCS NEILSITSMLS--------- -VPQCFVRPNEAKKASDDSK Dmel FDFMDPPAPETLMRALELLN YLAALDDDGNLTDLGAVMSE FPLDPQLAKMLIASCQHNCS NEILSITAMLS--------- -VPQCFVRPNEAKKAADEAK Tcas FDFMDPPAPETLMRALELLN YLAALDDDGNLTDLGAVMAE FPLDPQLAKMLIASCNHNCS NEILSITAMLS--------- -VPQCFIRPNEAKKAADDAK Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar FDFMDPPAPETLMRALELLN YLASLDDDGNLTELGSIMAE FPLDPQLAKMLISSCDYNCS NEILSITAMLS--------- -VPQCFVRPNEAKKAADEAK Tcal FDFMDPPAPETLMRALELLN YLAALDDDGNLTELGAIMAE FPLDPQLAKMLIASCENNCS NEILSVTAMLS--------- -VPQCFVRPNEAKKAADDSK Crog FDFMDPPAPETLMRALELLN YLAALDDDGNLTDLGAIMAE FPLDPQLAKMLIASCENNCS NEILSITAMLS--------- -VPQCFVRPNDAKKAADDSK Dpul FDFMDPPAPETLMRALELLN YLGALDDDGNMTELGAIMAE FPLDPQLAKMLIASTEFNCS NEILSITAMLS--------- -VPQVFMRPLEAKKAADEAK Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin LRFA----HIDGDHLTLLNV YHAFKQNMEDPQWCYDNFVN YRSLKSSDNVRQQLCRIMDR FNLKRTSTDFTSKDYYMKV- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------- Eaff LRFA----HIDGDHLTLLNV YHAFKQNMEDPQWCYDNFVN YRSLKSADNVRQQLCRIMDR FNLKRTSTDFTSKDYYLNIR KALCSGFFMQVAHLERTGHY Lcyp LRFA----HIDGDHLTLLNV YHAFKQNMEDPQWCYDNFVN YRSLKSADNVRQQLCRIMDR FYLKRTSTEFTSKDYYINIR KALCSGFFMQVAHLERTGHY Lsal LRFA----HIDGDHLTLLNV YHAFKQNMDDPQWCYDNFV- ------ADNVRQQLCRIMDR FNLKRTSTDFASKDYYVNIR KALCAGFFMQVAHLERSGHY Aamp MRFA----HIDGDHLTLLNV YHAFKQNMEDPHWCHDNFVN YRSLKSADNVRQQLSRIMDR FNMPRRSTDFTSRDYYINIR KALVSGFFMQVAHLERTGHY Afra MRFA----HIDGDHLTLLNV YHAFKQNMEDPQWCFENFIN YRSLKSSDNVRAQLSRIMDR FGLKRSSTEFTSRDYYINIR KALVSGFFMQVAHLERSGTY Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos LRFA----HIDGDHLTLLNV YHAFKQNMEDPQWCYDNFVN YRSLKSADNVRQQLCRIMDR FNLKRTSTDFTSKDYYINIR KALCSGFFMQVAHLERTGHY Dmel MRFA----HIDGDHLTLLNV YHAFKQSSEDPNWCYENFIN FRSLKSADNVRQQLARIMDR FNLRRTSTEFTSKDYYVNIR KALVQGFFMQVAHLERTGYY Tcas MRFA----HIDGDHLTLLNV YHAFKQSMEDPQWCYDNFVN YRSLKSADNVRQQLSRIMDR FNLKRTSTDFTSKDYYINIR KALVNGFFMQVAHLERTGHY Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar MRFA----HIDGDHLTLLNV YHAFKQNHEDPQWCYDNFVN YRSLKSADNVRQQLARIMDR FNLRRTSTDFTSKDYYINIR KVLVSGFFMQVAHLERTGHY Tcal LRFA----HIDGDHLTQLNV YHAFKQNMEDPQWCYDNFVN YRSLKSADNVRQQLCRIMDR FNLKRTSTEFTSKDYYINIR KALCAGFFMQVAHLERTGHY Crog LRFA----HIDGDHLTLLNV YHAFKQNMEDPQWCYDNFVN YRSLKSADNVRQQLCRIMDR FNLKRTSTNFASKDYYINIR KALCAGFFMQVAHLERSGHY Dpul MRFA----HIDGDHLTMLNV YHAFKQNMEDPQWCYDNFVN YRSMKSADNVRQQLSRIMDR FNLKRTSTEFTSKDYYVNIR KALISGFFMQVAHLERTGHY Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- ------MADD-EYEADDVGG Eaff LTIKDNQVVQLHPTTCLDHK PEWILYNEFVLTTKNYIRTC TDVKPEWLVRVAPQYYDMNN FPQCEAKRQLEQIIAKINSR QYQKGFMADD-EYEPDFD-- Lcyp LTIKDNQIVQLHPSTCLDHK PEWVLYNEFVLTTKNYIRTV TDVKPEWLIKTAPQYYDMDN FPQCEAKRQLEQIITKVNSR QYQRGFM-AD-DYEDNDF-- Lsal LTVKDNQIVQLHPSTCLDHK PEWVLYNEFVLTTKNYIRTV TDVKPDWLIKAAPQYYDMNN FPQCEAKRQLEQVIQRINSR QYQKGFM-GD-EYEENDF-- Aamp LTCKDNQVVQLHPSTCLDHK PEWVLYNEFVLTTKNYIRTV TDIKAEWLVKIAPQYYDMAN FPQCEAKRQLELLIAKLESK QFQQGY-------------- Afra LTIKDNQVVQLHPSTCLDHK PEWVLYNEFVLTTKNYIRTI TDVKPEWLLKIATQYYDMSN FPQGEARRQLEAILAKLESK QYKEGF-------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos LTIKDNQVVQLHPTTCLDHK PEWVLYNEFVLTTKNYIRTC TDVKPEWLVRVAPQYYDMNN FPQCEAKRQLEQIIAKINSR QYQKGFMADD-EYEPDYD-- Dmel LTIKDNQNVQLHPSTCLDHK PDWVIYNEFVLTTKNYIRTV TDVKPEWLCCLAPQYYDLNN FPQCEAKRQLELLQQRLETK QYQKGFMDDA-DYDNDDV-G Tcas LTIKDNQNVQLHPSTCLDHK PEWVIYNEFVLTTKNYIRTV TDIKPDWLIKIAPQYYDLQN FPQCEAKRQLEIIQNRLDSK QYQHGFMNDE-EFDGDDV-- Pmon -------------------- -------------------- -------------------- -------------------- ------MADE-EFDGDDV-- Smar LTIKDNQVVQLHPSTCLDHR PEWVVYNEFVLTTKNYIRTV TDIKPEWLIKLAPQYYEMSN FPQCEAKRQLELIADKLESQ QYKEGFM-DD-DYEPDDG-- Tcal LTVKDNQIVQLHPSTCLDHK PEWVLYNEFVLTTKNYIRTV TDVKPDWLVKTAPQYYDMDN FPTCEAKRQLEQIIARVNSR QYKKGFM-GD-EYDNDND-F Crog LTVKDNQIVQLHPSTCLDHK PEWVLYNEFVLTTKNYIRTV TDVKPDWLIKAAPQYYDMNN FPQCEAKRQLEQVIQRVNSR QYQKGFM-GD-EYEENDF-- Dpul QTIKDNQVVQLHPSTCLDHK PEWVIYNEFVLTTKNYIRTC TDVKPEWLIKVAPSYYDMSN FPEGPAKRQLEQIINRLESR EYRN--M------------- Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca GD-DF--DDVDEDENLD--- EIDQ------NDDENIELLQ ASD--------GQPQQNQKR ITTMYMTKYERARVLGTRAL QIAMCAPVMVELEGETDPLQ Eaff DN-DFVGDDIDGEDIDD--- AVDD--AD--AGEGNIDILS AGQ-------EGAGQKTTKR ITTPYLTKYERARVLGTRAL QISMCAPVMVELEGETDPLQ Lcyp DD-DY----GDADDADDMMD EMEE-GAEQGAEQEHVEILH AGE----DGISGEGVNSPNR TTTRYMTKYERARVLGTRAL QIAMCAPVMVELEGETDPLE Lsal DD-DY----QDVDEPDEMC- NLDD---D--ADADNIDVLP TNEAD-NDPSSGDSKSKEKR TTTPYMTKYERARVLGTRAL QIAMCAPVMVELEGETDPLQ Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra -------------------- -------------------- -------------------- -------------------- -------------------- Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos DN-DFGGDDIDGEDLDE--- AADE--TA--GPEGGIDVLP AGE------GGAEGQKQTKR ITTPYLTKYERARVLGTRAL QIAMCAPVMVELEGETDPLQ Dmel GD-DF--DDVD-EDVDE--- DINQ---E--EEADNIEIIA PGG------AGGGGVPKSKR ITTKYMTKYERARVLGTRAL QIAMCAPIMVELDGETDPLQ Tcas GD-DF-DDDVD-DDNIE--- ELEQ--PE--EEGDNIDILA HGQ-------AGGGVPKNKR ITTKYMTKYERARVLGTRAL QIAMCAPVMVELDGETDPLQ Pmon GD-DF--EEAEEDENLD--- DLQE--GE--EDENQMEILA AGE--------GNQVPTQKR ITTPYMTKYERARVLGTRAL QIAMCAPVMVEIEAESDPLQ Smar PE-EF--DDVEDDDNLD--- EIDQ--AE--DDGDNIDLLP MNE-------ASHSQQPNKR ITTPFITKYERARVLGTRAL QIAMCAPVMVELEGETDPLQ Tcal EE-DY----QEADEPEELE- GMNDEEAD--GDQENVEVLP AGE------GTGEGQKSAKR VTTPYMTKYERARVLGTRAL QIAMCAPVMVELEGETDPLQ Crog DD-DY----QDVDEPDDMC- NLEE-------DGDNVELIP AHEADGGDPSSGDPKSKEKR TTTPYMTKYERARVLGTRAL QIAMCAPVMVELEGETDPLQ Dpul -------------------- --EQ--PD---DDAQIDLLQ QGE-------GGAGQLQTKR ITTPYMTKYERARVLGTRAL QIAMCAPVMVELEGETDPLQ Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca IAMKELKARKIPIIIRRYLP DGSYEDWGIDELIITD-TTS MTSVPKPLKFLKPHYKTLQE VYEKITETETKSF---CADI VSILAMTISEE-RECLKYRL Eaff IALKELKQRKIPIIIRRYMP DGSHEDWGIDELIVID-IS- -------LKF---------- -------------------- -------------------- Lcyp IAMKELKQRKIPIIIRRYLP DGSYEDWSIDELIITDLTTS MTSVPKPLKFMIPHYNTMKE VYEKIDAKAMKSVKIQCADI LSVLSMTMSEN-NDCLKYKL Lsal IAMKELKQRKIPIIIRRYLP DGSYEDWGIDELIIIDM--- -------------------- -------------------- -------------------- Aamp -------------------- -----------------TTS MTSVPKPLKFMRPHFETMKQ IQANLTDAKVKGT---CADV VSVLAMTMSDK-RECLKYKL Afra -------------------- -----------------TTS MTSVPKPLKFLKPYFDSLKE IYEKIEDVMTKKL---CADI ISVLAMTNAEG-RESLKYRL Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos IAMKELKQRKIPIMIRRYMP DGSHEDWGIDELIYVD---- -------------------- -------------------- -------------------- Dmel IAMKELKQKKIPIIIRRYLP DHSYEDWSIDELIMVDNTTS MTSVPKPLKFMRPHYETMKT VYKHMPNEQARQL---CADI ISVLSMTMGSG-KDCLAYRF Tcas IAMKELKQRKIPIIIRRYLP DHSYEDWGIDELIIIDHTTS MTSVPKPLKFMKPHYGTMKN VYEKIRDPNVKSV---CADV ISVLAMTMGEG-RECLKYRL Pmon IAAKELRERKIPIIIRRYLP DGSYEDWGIDELIISDFTTS MTSVPKPLKFMRSHYQTMKD IYNNIKDNALKKF---AADI VSVLAMTMSEE-RECLKYRL Smar IAMKELKARKIPIIIRRYLP DNSHEDWAIDELILNE-TTS MTSVPKPLKFLRPHFGTLKE VYAKITTEDTKRF---CADI VSILAMTLSDN-RECLTYRL Tcal IAMKELKQRKIPIIVRRYMP DGSYEDWGIDEMIIVDMTTS MTSVPKPLKFLMPHYNTMKV SFEKLPPGQNRRE---CADI ISVLAMTAVGP-NECLKFKL Crog IAMKELKQRKIPIIIRRYLP DGSYEDWGIDELIIIDMTTS MTSVPKPLKFLRPHYARIQG TYEALTPGSPQKP--YLADV LSVLSMTEDNNLRNTLRYKL Dpul IAMKELKQKKIPIIIRRYLP DGSYEDWGIDELVIND-TTS MTSVPKPLKFLRPHYAVLKT IVEKITDPNTKAL---CADI ISVLAMTNTEG-TECLQYRL Aver -------------------- RHLAGEXVAEWNSIG---DE P-VEGATDQEMLDLTKKDQX MKLVTQIVPSQMKHHAEAEA CDLLMEVERLDIL--XEFVD Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca LG--SRED--IGS-WGHEYV RHLAGEISQEWSEVG---EG P------E----QEAKREAL LRLAQQIVPYHMAHNAEAEA CDLLMEIERLDLL--QAYVD Eaff -------------------- -------------------- -------------------- -------------------- -------------------- Lcyp LGDTSLES--IDS-WGHEYV RHLAGEIVHEWNSMG---EE SVVSSDEDQAMVDEHKKDKL IDLVIQIVPSQMRHHAEAEA CDLLMEVERLDLL--EKFVD Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp LG--YSND--IGD-WGHEYV RHLAGDIAAEWAEPA---DP A---EGTDEEA-TERRRARL VKLSAQLVAYLMEHNAEAEA CDLLMEVERLDLL--EQHVS Afra LG--TPGG--LVD-WGHEYV RHISGEIVGEWDEIP---EV P------E----SEEQKKVL IELTKQIAPYQMKLNAEAEA CDLLMEIERLDML--EQYVD Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- RHLAGEIVSEWHSLE---EE T-TTEGQDQEMADLSRKDQL TKLVMQIVPSQMKHHAEAEA CDLLMEVERLDVL--EQFVD Afos -------------------- -------------------- -------------------- -------------------- ----MEVEQLDQL--IQYVD Dmel LCD-RKQR--IGD-WGHEYV RHLSGEISAHYHDTT---GD ---------------FRVQL IELVKQIIPYNMEHNAEADA CDLLIEIDHLHLL--SDFVD Tcas SS--KLDG--IGE-WGHEYV RHLAGEIAAEWAETD---VC ------------EDKDKDVL IELAKQIVPYNMSHNAEAEA CDLLMEIERLDLL--EVYVD Pmon QG--QRGD--IGD-WGHEYV RHLAGEIAQEWETLG---ED ------------DDARRAEL ISEAHVIVPYHMQHNAEAEA CDLLMEMEQLELLTSQDYVD Smar LG--SKEE--IGS-WGHEYV RHLAGEIAVEWVDLS---EK ------------DGEKRERL VQLSEEIVPYNMAHNAEAEA CDLLMEIERLDLL--EKFVD Tcal QG--HTDGPNLDA-WGHEFI RHLSGEIVTEWAELD---ED E-----------QPELKKQI EDLVREIIPLQMKHHAEAEA CDLLMEVELLDLI--LQYVD Crog EG--AKDA--VDNLWGHEYI RHLSKEIVAAWNDDE---EE E-----------KAVSKDIL LGLVKDILPYQMKHQAEAEA CDLLMEVEQMDLI--LDFVD Dpul IG--SKEG--LVE-WGHEYV RHLAGEIAQEWDEIPFEGDE ------------GKAKRAQL SALVEQIIPFQMTHNAEAEA CDLLMEIEQLDML--EQHVD Aver QAAFNRVXLYLTSCVPYVPE PENXTLLTTAXEIFRKFDRY PQAXRLALQXNDSKLIXEIF MDCKDPVMXXQLXFMLGRQQ HFXPDLEE-XE-FDEVIEXM Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca QEAYPRVCLYLTSCVPYVPE PENTNLLKTAMEIFLKYERY PESSAAGHAAQQPRGGPEDL HTVQGP---KQMAFMLGRQQ MFLEPSDEIEN-YDDLAEIV Eaff --CCPRVCLYLTSCVPYVPD PENTNLLVTALNIFRKFNQL PQAMRLALQLNDRDKVEDIF NTCPDSTVKRQLAFMLGRHQ FYLELPADSED-YDDLNEIM Lcyp KAAYNRVCLYLTSCVPFVPE PENTNLLKTALQIFRKFDQN PQALRLALQLNDHELVMDIF NQCEDPTMQKQLAFMLARHQ DFSQYMDESKD-DDEAKEIM Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp KDTYQRVCLYLTSCVPYVPD PENTRQLHVALQLFRKFEQY PQALRIAMQLQDQALIQEIF FDCKDKSLQKQLAYMLARQG VFVDLNE--DE-YGDLVEII Afra ESVYQRVCLYLTSCVPYVPA PENTNLLLCALKLYRKFGQA PHAMRLAMQLNDKKLIEDIF NSCSDWSMKKQLAFMMGRQN TVVQLNDDEDDRNEDLVEIM Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda QAAYNRVCLYLTSCVPYVPE PENTTLLKTALDIFRKFDKF PQALRLALQLNDQKLIHEIF LSCKDPIMQKQLAFMLGRHQ HFLADLDE-ND-YDDVIEIM Afos ESAYPRVCLYLTSCVPYVPD PENTNLLNTALDIFKKFNQL PQAMRLALQLNDREKVEEIF NNCTDTTIRRQLAFMLGRQQ FYLELPEDTED-YDDLNDIM Dmel ESAYPRVCLYLQSCYPYVPD PDNTIILETALQLSRKFNQY TQAMRLALMLNDMDKIGEIF KEPKEPAMQKQLAFMLARQQ ICLELDELVPD-YDDLMEIM Tcas ENTYPRVCLYLISCVPYVAD PENTTLLQTALLLFRNFEQY PQALRLAMQLNDHNLIEEIF TSCPDSTVQKQLAFMLGRQQ IYIEIPESTPE-YEDLVEIM Pmon KDAYSRVCLYLTSCVPYVPD PENTNLINTALQLYRKFGQY PQAMRLALQLHDFDLIKQLF DECPDKLVRMQVAFMLGRQQ VFLELPEDMDD-YEDLTEIL Smar ESAYSRVCLYLISCVPYVPD PENTNLLTTALNILRKFNCY PESLRLAMMLNDMPLIEKIF TNCKDTYVQKQMAFMLGRQQ IYLELTESVED-YDDLMEIM Tcal KSAFQRVCLYLTSCVPYVPD PENTNLLKTTYKIFRKFEQY PQAMRVAMQINDPELIKAVF MECPEPLLQKQLAYMMGRQQ HYMELDE--ND-FDEVVEIM Crog SGAYNRVCLYLTSCVPYVPS PENIMLLETSVKIFRKFDQY PRAMRLALQLNRPELVLDIF MSCKDPLMQKQLAYMLSRQQ HYVELDE--EE-FDEINEIL Dpul EAAHNRVCLYLSSCVPYVPD PENVNLLKTALSIFRKFQQW PQALRLALQINDHALIEEVF LACNDGTMRKQLAFMLGRQQ IFLELNEELED-YDDLIEIM Aver SNSHLNNNFLNLAREL---- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca SNTSINDHFMALARELDIME PKTPEDIYKSHLD-NTR--- -------------------- -------------------- ---------MFSATASLGLI Eaff SNVQLNNHFLNLARELDIME AKTPDDVYKSHLD-NVRPGF G--GGAVDSARQNLASSFVN GFINTGFGQDKLLM-EDGNK WLYKNKEHGMLSATASIGLV Lcyp SNSHLNNYFLNLARELDIME AKTPDDVYKSHLD-NVVRAF G--SSSVDSARQNLASSFVN GFVNAGFGQDKLLLVEDGQK WLYKNKEHGMMSAAASIGLI Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp NNTDLNTNFLSLARELDIME PKTPEDIYKSHLD-NARPSF G---ANVDSARQNLASSFVN GLVNAGFGKDKLMT-DDGNK WLYKNKEHGMMSAMASFGLV Afra SNTQLNANFLSLARELDIME PKTPEDIYKSHLE-NSRPSY A--SAQVDSARQNLASSFVN GFVNAGFGKDKLLLCEDGSK AIYKNKEHGMFSTTASLGLL Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda SNSHLNNNFLNLAREL---- -------------------- -------------------- -------------------- -------------------- Afos SNVQLNNHFLNLGRELDIME AKIPDDVYKSHLD-NVRS-Y G--GSSVDSARQNLASSFVN GFINTGFGKDKLLM-EEGNK WLYKNKEHGMLSATASIGLV Dmel SNANLNKHFLNLARELDIME PKTPEDIYKSHLD-NSRSRF A--SIQVDSAKQNLAASFVN GFVNAGFGVDKLLS-EDGNK WLYKNKEHGMLSATASLGLI Tcas ANCHLNNHFLNLARELDIME PKTPEDVYKSHLE-NTRPQF G--SNQVDSARQNLAASFVN GFVNAAFGQDKLLM-EDGNK WLYKNKEHGMLSATASLGLV Pmon SNSHLNTHFLSLGRELDIMD PKTPEDIYKSHLE-NNRPTF G--PGQVDSARQNLASSFVN GFVNAAFGTDKLLT-EDGNK WLYKNKEHGMLSATASLGLI Smar SNAHLNNHFLSLARELDIME PKTPEDIYKSHLE-SSRPTF GPTGSQVDSARQNLASSFVN GFVNAAFGQDKLLV-EDGNR WLHKNKEHGMMSAMASLGLI Tcal SNIHLNHHFLNLARELDILE PKTPDDVYKTHLD-NVRP-F G--GGGMDSAKHNLASSLVN GFVNAGFGKDKLLM-EDGNK WLYKHKDAGMMSATASIGLV Crog SNSHLNGHFLNLARELDILE PKTPEDVYKSHLD-NIRTPF G--SSSVDSARQNLASSFVN GFVNAAFGSDKLIV-DEGNK WICKNKEHGMMSAMASLGMI Dpul SNTHLNNHFLSLARELDIME PKTPEDIYKSHLDNNSRSAF G--GGQVDSARQNLASSFVN GLVNAAFGQDKLLM-EDGNK WLYKNKEHGMLSATASLGLL Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca LLWNVDGGLTQIDKYLYSTE DYIKAGAILACGIVNCGVRN ECDPALALLSDYVLHSSTLM RIGSILGLGLAYAGSNNKEV IVLLLPVFT-----DPKSTM Eaff LLWDVDGGLTQIDKYLYSPE DWIKSGALLACGIVNTGVRN ECDPAFALLCDYVLHSSNVM RLGAIFGLGLAYAGSNRADV IELLLRVFA-----DSKSNM Lcyp LLWDLDGGLAQIDKYLYLND DNIKAGTFLACGIVNARVRN ATEPAYGLLSDYVSKPPNVT RIGAIFGLGLAYAGTNNANA LSCILKVFA-----DAKANM Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp LLWDVDGGLTQIDKYLYSNE DFIKAGALLACGIVNSGVRN ECDPALALLSDYLLHQNNLI RVGSILGLGIAYGGTNREDV LSNLLPAMQ-----DPKSNK Afra LLWDLDGGLTQIDRFMYSSD ENLKAGALLACGIVSCGVKN DCDPAWALLSDYVLNDKPTV RIGSIFGLGLAYSGTDRLDI TSHLCTVLS-----DPKSSN Hazt -------------------- -------------------- ----------------MFIL RVGSVLGLGLAYAGSNRDDV IKVLLPLLT-----DEKSSL Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos LLWDVDGGLTQIDKYLYSRE DWIKSGALLACGIVNTGVRN DCDPALALLSDYVLHSSNVM RLGAIFGLGLAYAGSNRTEV IQLLLPVFA-----DSKSNM Dmel LLWDVDGGLTMIDKYLYSTD DNIKSGALLACGIVNCGIRN EVDPAHALLSDYIDNQNSCM RVGAILGLGIAYAGSNRSIV IDTLKTVFSFGSNNKSSASV Tcas LLWDVDGGLTPIDKYLYSSE DHIKSGALLACGIVNCGVRN ECDPALALLSDYVLHNTNTM RIGAIVGLGLAYVGSNREAV LSLLTPVFS-----DSKSNM Pmon LLWDVDGGLTQIDKYLYSSE DFIKSGALLACGIVNSGVRN ECDPALALLSDYIGHKTMVI RIGAILGLGLAYSGSNREAV LNVLTPVLS-----DEKSSL Smar LLWDVDGGLTQIDRYLYSSE DYIKSGALMACGIVNCGVRN ECDPALALLSDYVLHNTTII RIGAIVGLGLAYAGSNREDV LSLLIPVMS-----DPKSTM Tcal LLWDVDGGLTQIDKYLYSPE DHIKSGALLACGIVNTGVRN DCDPALALLSDYITHDSMIM RAGATLGLGLAYSGSNREEV IGHLLPVFA-----DSKASM Crog LLWDVDGGLLKIDKYLYCQE DPIKAGALLACGIVNAGVRN DCDPALALLSDYILHENEIM RCGAIFGLGLAYAGSNRSDV ISLLLPVFG-----DDKVSM Dpul LLWDVDGGLTQIDKYLYSSE EYIKAGALLACGIVNTGVRN ECDPALALLSDYVLHSSNVM RIGAILGLGLAYAGSNRDDV LSLLLPVLS-----HPKSSM Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca EVLAVTSIACGMVAVGSCNG DVTSTIMTALLEKSET---D LKDTYARFLPLGLGLCYLGK QEGAETITAALEVLPEPFRS MATTLVDICAYAGTGNVLKI Eaff EVIGVTALATGMVAVGSCNG DVTSTILQTLMEKSGA---D LKDSFAKYLPLGIGLCYLGK QDASEATIAALEVIPEPFRQ IAVTLVEICAYAGTGNVLKI Lcyp EVVGITALACGLIAVGSCNN DVTTTLLQTLMEKSEA---D LKDPFAKLLPLGIGLCYLGK QDAAEATLAALEVLPEPFKS MAMTTVDICAYAGTGNVLKI Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp EVVAVTALACGMIAVGSGNP EVAPAILQVIMDRTSSG--D TKDAFVKFLPLALGLIYLGK QEDAEVITCALEVCDEPFRS MATTMVEVCAYAGTGHVLKI Afra EVIGVTALSLGMIAVGTCNT DVTQALLLTLMEMKETREAS LKEPFAKFLPLGLGLCFLGK QEEAEATIAALEGLPEPFHS MASTLIDVCAYAGTGNVLKI Hazt EVVGVTSVALGLVAVGTTNQ EVGEALVTTLLAKFPF---Q LKDPFAKFISLGLALTYLGC QDKCEVVLSCVEGLPSPFRQ MTKTLIEVCAYAGTGNVLKV Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos EVIGVTSLAVGMIAVGSCNG DVTSTILQTLMEKSAT---D FKDSFAKYLPLGIGLCYLGK QDAAEATIAALEVIPEPFRQ TATTLVEICAYAGTGNVLKI Dmel EILGITALSLGLISVGSCNS EITEILLQTIMGLTKA---D LKDTYTRFLFLGLGLLYLGR QKSTEAVMMTLEVLEEPYRS MATTMVDICAYAGTGNVLKI Tcas EVIGMAALACGMIAVGSGNS QITTAIMQTLMEKSEA---D LKDTYARFLPLGLGLCHLGK QEGIETIIAALEVIPEPFKS MAVTMVDICAYAGTGNVLKV Pmon EVVGITALACGMIAVGTTNQ LVVEALVTTLLAKSET---E LKDTYARFISLGLALAYLGC QDKCEVVLSCIENLPAPFRQ MTATLIEVCAYAGTGNVLKV Smar EVTAMAALSCGMIAVGSCNG EVTSTILQTLMEKTEQ---D FKDTYARFLPLGLGLCYLGK QESIEAIIAALEVIPEPFKS MSTTMVDVCAYAGTGNVLKV Tcal ENISLTALALGLIGVGSCNN EITTVLLQTLMEKSES---D LKDPFAKFLPLGIGLCYLGK QEAAEATIATLEVLSDPFKS MAMTLVDVCAYAGTGNVLKI Crog EIVGITALACGLIAVGSCNS DVTSTILQILMEKKEA---D LKDPFAKFLPLGIGLCYLGK QEMSEATLAALEAIPKPFNF MATTLVDICAYAGTGNVLKI Dpul EVVGVAALACGLVAVASCNG DVTSALLQTLMEKSEV---E LKDTFSRFLPLGLGLTYLGK QEAVEAVVLALEVLAEPFKS MASTMVEVCAFAGTGNVLRV Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca QHLLHICSEHYEVQE----- -KEEKKDDK------KDKKE DKEE--------------KS TGPPDLSSQQSVAVLGIALI AMGEEIGSEMAFRAFGHLLR Eaff QQLLHICSEHYEQEK----- -ETEKKDKK------KDEKK DEKKDEKKDDKKE---EKEE EASHDMSGQQAVAVLGLGLI AMGEDIGSEMLYRTLGHLMR Lcyp QGLLHICSDHYEPPE----- -KEDKKESSTGSSSSSKSKK EEKK--------------DE NSPLDLSSQQAVAVIGLALI AMGEDIGSEMLLRHFGHLLR Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp QKLLHICSDHYEPEK----- -ADDKKDDK------KDDKK SGSASAKDKEDKGAAAAKKE DKPVDHSSQQSVAVLGLALI AMGEDIGSDMMLRMFGHLLR Afra QQLQHICSEHYEPEE----- ----KNKEN------KKEKK EKEE--------------AK DDKADMSMQQAVATLGLGLI AMGEDIGSDMAYRSFGLLLR Hazt QEMLHICTDHYETDDSSSSS KAKDKKEKTNKD---KQDKE KKDEAAKEKDAKE-SEKKED DKEVDLSSQQSIAVLGIALI AMGEDIGADMCFRQFGNLLR Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos QQLLHICSEHYEAEK----- -EPEKKDKK------KEEKK EGEGESSKDG--------EG SGSVDLSGQQAIAVLGLGLI AMGEDIGSEMMYRTLGHLMR Dmel QQLLHICSDHYETSS----- -ADDEKEKS------KKDKG KDKEKEKEKE-------KEK EREKDLSATQSIAVLGIALI AMGEDIGAEMAYRSFGNLLR Tcas QHLLHICSEHYEPAD----- -KDESRDKNK-----DKSKE KEDK--------------EK ----DLSARQAVAVLGIALI SMGEDIGSDMAFRTFGHLLR Pmon QEMLHICTDHYDQEE----T KSKDKKDK---------DKD KKED--KDKDKKE-EKDKAE EKEVDLSSQQAVAVLGIALI AMGEDIGAEMSFRQFGNLLR Smar QSLLHICSEHYDHGD----- -KDEKKDDKK-----DKDDK DKKE--------------EK TPTVDLSSQQAIAVIGIALI AMGEDIGSEMAFRTFGHLLR Tcal QHLLHICSEHYEPSN----- -DDDDKKDK------KKDKK DDKK--------------TT TDEVDLSMQQSVAVIGLALV AMGEDIGSEMLFRTFGHLLR Crog QELLHICSEHHEETN----- -SKESSKSK------SSSKK EDEK--------------KE DAALDLSMQQAVAVLGLALV AMGEDIGSEMLFRTFGHLLR Dpul QRLLHICSEHHEPQE----- -KEDRKESKE-----TAAKK DE------------------ ---TDLSSQQAVAVIGLALI GMGEDIGAEMAFRTLGHLLR Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca YGEPVIKKAVPLALALISVS NPRLNILETLSKFSHDSDNE VAHNAIFGLGIVGAGTNNAR LAAMLRQLAQYHAKDPNHLF MVRLAQGLAHMGKGTLTLGP Eaff YSEPCIRRAVPLALSLISVS NPQLNILDTLSKFSHDPDPE VAQNSIFGLGLIGAGTNNAR LAATLRQLAQYHAKEQNNLF MVRIAQGLVHLGKGTLTLNP Lcyp YCEPVIRRAVPLALGLISVS NPQLNILDTLSKFSHDADAE VAHNSIFAMGLLGAGTNNAR LAALLRQLAQYHAKDTNNLF MVRIAQGLVHMGKGTMSLDP Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp YCEPCIRRAVPLALGLVSVS NPKLSILDTLSKFSHDADQE VAHNAIFAMGLVGAGTNNAR LAATLRQLAQYHARDPNNLF MVRIAQGLTHMGKGTLTLNP Afra YSELAIRRVVPLALGLLYVS NPKLNAIDTLSKFSHDADPE VAYNAILAMGLLGAGTNHAR LATMLRQLAQYHAKDANHLF MVRIAQGLVHMGKGTLTLSP Hazt YCEPVIRRAVPLALALSSVS NPKLNILDTLSKFSHDSDHE VAHNAIFAMGLVGAGTNNAR LAAMLRQLAQYHAKDPNNLF MVRLAQGLTHLGKGTMSLSP Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos YCEPVIRRAVPLALALTSVS NPKLNLLDTLSKFSHDSDAE VAQNAIFGLGMIGAGTNNAR LAATLRQLAQYHAKDQNNLF MVRIAQGLVHLGKGTLTLNP Dmel YCEPAIRRAVPLALGLISAS NPKLNIIDTLSKFSHDSDAE VAHNAIFAMGLVGAGTNNAR LASMLRQLAQYHSKDPSNLF MVRIAQSLTHLGKGTLSLSP Tcas YCEPVIRRAVPLALGLISVS NPKLSILDTLSKFSHDSDAE VAHNAIFAMGLVGAGTNNAR LAAMLRQLAQFHAKDPNNLF MVRIAQGLTHLGKGTLTLSP Pmon YCEPVIRRAVPLALGLISVS NPRLNILDTLSKFSHDSDTD VAHNAIFAMGLVGAGTNNAR LAAMLRQLAQYHAKDPNNLF MVRLAQGLTHLGKGTMTLSP Smar YGEPTIRRAVPLALGLVSVS NPKLNILDTLSKFSHDSDAE VAHNAIFALGLVGAGTNNAR LAAMLRQLAQYHAKEPNNLF MVRIAQGLAHLGKGTLTLCP Tcal YCEPVIRRAVPLALGLISVS NPQLPILDTLSKFSHDADPE VAHNSIFALGLIGAGTNNAR LAAMLRQLAQYHSKDPNNLF MTRVAQGLVHMGKGTLTLNP Crog YCEPVIRRTVPLALGLISVS NPQLIILDTLSKFSHDSDSE VAHNSIFAMGLIGAGTNNAR LSAMLRQLAQYHSKDQNNLF MVRIAQGLLHMGKGTLSLNP Dpul YGEPCIRRAVPLALGLISVS NPRLNVLDTLSKFSHDSDSE VALNSILALGLVGAGTNNAR LAAMLRQLAQYHAKDSNALF MVRLAQGLTHLGKGTLTLQP Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca YHSDRQLMSPVATAGLLATL LAFLDVKSIILGKSHYLLYC LVTAIQPRMLVTFDEKLQPL PVPVRVGQAVDVVGQAGKPK TITGFQTHTTPVLLAYGERA Eaff FHSDRTLMSPVAVAGLLSVL VALLDVKNTILGKSHYLLYG LATAMQPRMLVTFDTELRPL PVSVRVGQAVDVVGQAGKPK TITGFQTHTTPVLLAHGERA Lcyp FHSDSQLMSPVAVAGLLGCI FSFLDVKSTILGKAHYLLYS LAPAIQPRMLVTFDEELNPL PVSVRVGQAVDVVGQAGKPK TITGFQTHMTPVLLSHGERA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp WHSDRALMSPVAVAGLMATL TAFLDVKSLILGKSHYLLFC LTTAMQPRMLVTFDEELKPL PVSVRVGQAVDVVGQAGKPK TITGFQTHTTPVLLAYGERA Afra YHSDRQLMRPVAVAGLLGLL VACIDVKQTILGKSHYLFYS VAAAIQPRMLVTFDEELKAL PVSVRVGTAVDVVGQAGKPK TITGFQTHTTPVLLSHGERA Hazt YHSNRQLMAPVAVAGLLATC MAFLDTKTLILGKSHYLLYC LVSAMQPRMLVTFDEHLNPL PVAVRVGQAVDVVGQAGRPK AITGFQTHTSPVLLAYGERA Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos FHSDRQLMSPVAMAGLMSVL VAMLDVKTTILGKSHYLLYG LSTAMQPRMLVTFDEELRPL PVSVRVGQAVDVVGQAGKPK TITGFQTHTTPVLLAYGERA Dmel YHSDRQLMNPMAVAGLMATL VSLLDVKNLILNRSHYLLYT LVPAMQARMLITFDEELNQL QVPVRVGIAIDVVGQAGKPK TITGFQTHTTPVLLAIGERA Tcas YHSDRQLMSPVAVAGLMATL VGFLDVKNIILGKSHYLLYT LAAAMQPRMLVTFDEDLNPL PVPVRVGLAVDVVGQAGKPK TITGFQTHTTPVLLAHGERA Pmon YHSNRQLMSPVAVAGLLATC MAFLDTKTLILGKSHYLLYC LVTAIQPRMLVTFDEQLNPL PVSVRVGQAVDVVGQAGKPK TITGFQTHTTPVLLAHGERA Smar YHSDRQLMNVVATGALLATL TAFLDVKTIILGKSHYLLYY LVAAMQPRMLVTFDENLRPL PVAVRVGQAVDVVGQAGKPK TITGFQTHTTPVLLAYGERA Tcal YHSDSQLMSPVAVAGLLGCI ISFLDVKSTILGKSHYLLYT LATALQPRMLVTFDEELRPL SVSVRVGQAVDVVGQAGKPK TITGFQTHTTPVLLASGERA Crog YHSDNQLMSPVAVAGLLGVL ISFLDVKQTILSKSHYLLYG LCTAMQPRMLVTFDENLSPL PVSVRVGAAVDVVGQAGKPK TITGFQTHTTPVLLSCGERA Dpul YHSERQLMNPVAVAGLLSTV IACLDVKNIILSKSHYLLYT LAASLQPRMLITFDEELRPL PVSVRVGQAVDVVGQAGKPK TITGFQTHTTPVLLAHGERA Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca ELATEEYI------------ ---SLTPVLEGFVILKKNEN F-TTMMDIRPNHTIYINNLN EKVKKDELKKSLYAIFSQFG QILDIVALKTLKMRGQAFVV Eaff ELATEEYI------------ ---PVTTIMEGFVILKKNPD Y---MMENRPNHTIYINNLN EKIKKEDLKKSLYAIFSQFG QILDIVALKTLRMRGQAFVI Lcyp ELATEEYT------------ ---PYSPIMEGFVILKKNPD Y----ME-RPNQTIYINNLN EKVKKDELKKSLYAIFSQFG QILDIVALKTLKMRGQAFVI Lsal -------------------- -------------------- -----MDARPSHTIYINNLN EKVKKEDLKKSLYAIFSQFG QILEIVALKTLKMRGQAFVI Aamp ELATEEYV------------ ---PLTSVLEGFVILRKNPD Y-VA-MDIRPNQTIYINNLN EKVKKPELKESLYGLFSQFG PILDVVALKTPKMRGQAFIV Afra ELATDEYL------------ ---PLTPVLEGFVILRKNPY F-EK-MDIRPNHTIYINNLN EKIKKEELKKSLYAIFSQFG AILDIIALKTLKMRGQAFVI Hazt ELATDEYL------------ ---PLTPIMEGFVILRKNPD F-QA---------------- -----------LYAIFSQFG QILDIIALKTLKMRGQAFVV Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos ELATEEYL------------ ---PVTTIMEGFVILKKNPD Y----MDNRPNHTIYINNLN EKIKKEDLKKSLYAIFSQFG QILDIVALKTLKMRGQAFVI Dmel ELATDEYL------------ ---ALTPVMEGFVILKKNPN F-VK-MEMLPNQTIYINNLN EKIKKEELKKSLYAIFSQFG QILDIVALKTLKMRGQAFVI Tcas ELATEEYI------------ ---ALTPIMEGFVILRKNPD FYPS-MDIRPNNTIYINNLN EKIKKEELKKSLYAIFSQFG QILDIVALKTLKMRGQAFVI Pmon ELATDEYL------------ ---PLTSIMEGFVILKKNPD Y-ETMLDIRPNHTIYVNNLN EKVKKEELKRSLYAIFSQFG QILDIVALKTLKMRGQAFVI Smar ELATEECIFLKFDFYSFEIE VVSSLMPIMEGFVILH-SCE F--G-MSTQPNNTIYINNLN EKTKLSELKKSLFAIFSQFG QILDIVALKTLKKKGQAFVI Tcal ELATEEYI------------ ---PVTPIMEGFVILKKNPD Y----MENRPNHTIYINNLN EKVKKEDLKKSLYAIFSQFG QILDIVALKTLKMRGQAFVV Crog ELATEEYT------------ ---PMTPIMEGFVILKKNPN Y----MDVRPNHTIYINNLN EKVKKDDLKKSLYAIFSQFG QILDIVALKTLKMRGQAFVI Dpul ELATEDYV------------ ---SLTPIMEGFVILRKKKV D----MDVRPNSTIYINNLN EKVKKEELKKSLYAIFSQFG QILDIVALKTLKMRGQAFVI Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca FKDLNSATNALRSMQGFPFY DKPM-------VSVIVLPRR WTF----------------- -------------------C -------------------- Eaff FKEISSSTNALRSMQGFPFY DKPMKIAYGKTDSDVIAKIK GTFQERPKRAPV-------D KKKGKKGGKSGATVGA---- --------AGAG-------- Lcyp FKDISAATSALKSMQGFPFY DKPMRIAFAKTDSDVVAKQK GTFQERPKRLPGA--GAGEA KKKKKKPHAEGAGAGRH--G --------GGGG-------- Lsal FKEITSATNAMRSMQGFPFY DKPMRIAFSKTDSDVIAKIK GTYQERPKKAAS-------D SKKAKKRAAKEAAARQI--C --------ALAG-------- Aamp FKEIGAATNALRSMQGFPFY DKQMRLQYGKSESDAVSKMK GTFRQEGGKRKDP-----SA PKKAKKAKTSSTAAATT--A KP------SEDG-------- Afra FKDIGAATNALRSMQGFPFY DKPMRIQYAKVDSDAIAKVK GTFTEKKKKVKE-------I KKDKKKEQRKEAPLPPPAYG APAPFTPSAMPAV------- Hazt FQEIHSATTALRAMQGFPFY DKPMKIAYSKSDSDVIAKIK GTYEERAHKNKD-------D KKKRKKEAKAAAAAAAAASA ATSAAVAPATAAAGSALAAA Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos FKEIGSATNALRSMQGFPFY DKPMRIAYSKTDSDLIAKMK GTFTERPKKAPM-------D RKKGKKGKSGGAAAGA---G AMGS----AGAGMG------ Dmel FKEIGSASNALRTMQGFPFY DKPMQIAYSKSDSDIVAKIK GTFKERPKKVKPPKPAPGTD EKKDKKKKPS---------- --------SAEN-------- Tcas FKEIQSSTNALRSMQGFPFY DKPMRIQYAKTDSDVISKMK GTFQERPKKIRPP--PSKED EAPKKKKKNKDPN------- -------------------- Pmon FKEIQSATNAMRAMQGFPFY DKPMKIAYAKTDSDLIAKQK GTYKERGSKRKE------ED KKKKKGKEAKGATAVPA--G AAAAAKAGAGAGV----VPP Smar FKQIESGTNAMHAMQGFPFY DKPMRIQYAKSDSDVIAKIK GTFVERPKKKPQR--P--AE AKKAKKKTKEQAKSQQTH-- --------PAAS-------- Tcal FKDISSATQAMRSMQGFPFY DKPMRINYSKTDSDAVAKLK GTFTERPKRPAGG--PAGAE SKKAKKRAAKEAAVRQ---G --------GGSG-------- Crog FKEITSGTNALRSMQGFPFY DKPMRISFSKTDSDIIAKLK GTFTERPKKASG-------D SKKAKKKAAKEAAARQL--C --------ALAG-------- Dpul FKEVTSATNALRGMQGFPFY DKPMRIQYAKTDSDVIAKMK GTFQERPAKPKP-----EGE PKKKKKKESKQQQVVTP--G --------SFGGP------- Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -------------------- -------------------- -------------------- -------------------- -------------------S Eaff -------------------- ---MQTQG--VENAPPNQIL FLTNLPSETNEMMLSMLFNQ FPGFKEVRLVPGRHDIAFVE FENEMQSAAARDALQGFKIT Lcyp -------------------- ---SASNS--NMEAPPNQIL FLTSLPEETNEVMLSMLFNQ FPGYKEVRLVPGRHDIAFVE FENEIQSAAARDALQGFKIT Lsal -------------------- ---ANAVH--PGEAPPNQIL FLTNLPDETNEMMLSMLFNQ FPGFKEVRLVPNRHDIAFVE FENEVQSAAARGSLQGFKIT Aamp -------------------- ---DGADE--AADLPPNQIL FLTSLPEETNEMMLQMLFNQ FPGFKEVRLIPGRHDIAFVE FDTDAQSAAARSALQGFKIT Afra --------QP---------- --PIQAAP--VLEQPPNQIL FLTGLPEETNEMMLSMLFNQ FPGFKEVRLVPGRHDIAFVE FESEIQSSAARNALQGFKLT Hazt GGGISLAAQPPKPAAARSTL FSGATGVGGVVPEQPPNQIL FLTNLPDETSEMMLSMLFTQ FPGFKEVRLVPGRHDIAFVE FENEIQSATAKEALQGFKIT Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos --G----------------- --GASMQG--VDNAPPNQIL FLTNLPQETNEMMLSMLFNQ FPGFKEVRLVPGRHDIAFVE FENELQSAAARDALQGFKIT Dmel -------------------- ---SNPNA--QTEQPPNQIL FLTNLPEETNEMMLSMLFNQ FPGFKEVRLVPNRHDIAFVE FTTELQSNAAKEALQGFKIT Tcas -------------------- --RIPGGS--NAEQPPNQIL FLTNLPDETSEMMLSMLFNQ FPGFKEVRLVPNRHDIAFVE FENELQSGAAKDALQGFKIT Pmon RPG--LFNQPP--------P VHGAGGIG--VPEQPPNQIL FLTNLPDETSEMMLSMLFTQ FPGFKEVRLVPGRHDIAFVE FENEMQSAAAKDALQGFKIT Smar -------------------- ---VVGFG--GEQQPANQIL FLTNLPENTNEVMLSMLFSQ FPGLKEVRLVPGRCDIAFVE YENDLQSAAARQALQGFRIT Tcal -------------------- ---TSGGP--VLEAPPNQIL FLTNLPEETNEMMLSMLFNQ FPGFKEVRLVPGRHDIAFVE FENEVQSTGARDALQGFKIT Crog -------------------- ---ANAVH--PGEAPPNQIL FLTNLPDETNEMMLSMLFNQ FPGFKEVRLVPNRHDIAFVE FENEVQSAAARESLQGFKIT Dpul --A--TYGYP---------- --AIGGAG--VPEQPPNQIL FLTNLPEETNEMMLSMLFTQ FPGFKEVRLVPGRHDIAFVE FENEVQSAGARESLQGFKIT Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca PC--------------MCG- RIPVLLCAVLATVL-----R YTAAFYLPGLAPVNYCKEGA TSSQCQSKVNLYVNRLDSDE SVIPYEYQHFDFCT--SSE- Eaff PTTAMKISFAKKMHSLISEK MLKILLISLLL--------G PVWSFYLPGLAPVTYCKS-A DVTTCQNDIKLFVNRLNSEE SVIPFEYHHFDFCE--AAE- Lcyp PTAAMKISFAKK----MMR- ---SATWTWLLTFS-----G LAQCFYLPGLAPVTYCDNPG -DDQCQSEIKLYVNRLNSEQ SILPYEYKDFDFCP--APED Lsal PNASMKISFAKK-------- -------------------- -------------------- -------------------- -------------------- Aamp PTHAMRISFAKK-------- -------------------- -------------------- -------------------- -------------------- Afra PTHGMKISFAKK----MKN- ------FAKLLVIF--SCTY GVSCFYLPGLAPVNYCKADN EKNNCKSTVQLFVNRLTSEE HILPYDYSQFDFCT--ASE- Hazt PTHAMKIVFAKK-------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos PTTAMKISFAKK-------- -------------------- RSQGFYLPGLAPVTYCDRDE -TNICTKEIKLFVNRLNSEE SVIPYEYQHFDFCQ--TKE- Dmel PTHAMKITFAKKM-ILLSG- ------LLPLLGVVLLHLAT PTQAFYLPGLAPVNFCKKTD VSSTCKSEILLYVNRLNTEE SVIPYEYHHFDFCL--GEE- Tcas PTHAMKISFAKK----M--- ------YLPLLCLLFLWHET RVEAFYLPGLAPVNYCRKGE -SDTCKSEVLLYVNRLNTEE SVIPYEYNHFDFCQ--PDEN Pmon PTHAMKIAFAKK-------- -------------------- -------------------- -------------------- -------------------- Smar AANAMKVSFAKK----MTR- LSRVMLVVKFILVF-----E LSSAFYLPGLAPVNYCRT-- ESPNCKSKVALYVNKLDSEE SVIPYEYHHFDFCT--VDE- Tcal PTTSMKISFAKK----MKS- ------LALLVGVV-----A VCHAFYLPGLAPVTYCERAD -DGKCQTEIKLYVNRLNSEE SVIPYEYDHFDFCK--SDS- Crog PNASMKISFAKK----MRN- ---RLSGGHLLLLL-TFCAL NSHGFYLPGLAPVTYCEVPD DQNRCQTQIPLFVNRLNSDE SVIPYEYDHFDFCP--APES Dpul PTHSMKISFAKK----MST- ---KQIFSSILLLL-----H LSYGFYLPGLAPVNYCIKNK QSDSCKNDVPVFVNRLNSEE AIIPYEYHHFDFCT--DDH- Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca ATSPAENLGQVVFGERIRLS PYIMNFM----ENK-TCTPL C-SKFYSK---SQPESMAKL ELLKKGMMKQYKHHWIVDNM PV-TWCYLVEPNSQ-FCSMG Eaff DSSPAENLGQVVFGERIRPS PYTIKFG----EPQ-TCTIL CATKKYRS---NDAESVKKL AQLKKGIFMNYQHHWIVDNM PV-TWCYQVENQMH-YCSTG Lcyp ATSPSENLGQVVFGERIRPS PYKISFN----KDSGKCKRV C-KKSYDL---SKKEDKDKV MFMKRGMSMNYQHHWIVDNM PV-TWCYQVENNQQ-YCATG Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra EVSPVENLGQVVFGERIKSS PYELKFL----EDA-SCSQV C-TKEYDV---NDKDSKRKL DFLLEGIKKNYQHHWIVDNM PV-TWCYNIESNRQ-YCNRG Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos DHSPAENLGQVVFGERIRPS PYSIRFN----EPK-KCVKV CDTKVYKA---NDNEAKKKL ALLKKGMLMNYQHHWIVDNM PI-TWCYQVENQQH-YCATG Dmel QNSPVENLGQVVFGERIRPG PYKIQFL----ENQ-QCATT C-VKTYKG---DDPASNRRM MVLKKGISLNYQHHWIVDNM PV-TWCYPLENGKQ-YCGIG Tcas QPSPVENLGQVVFGERIRPS PYILEFM----KNI-TCKEV C-TRKYSG---SDPSANRRL SILRKGISLNYQHHWIVDNM PV-TSCYETEDQKQ-FCTTG Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar SDSPVENLGQVVFGERIRPS PYKILFG----TDE-ECVTL C-SRRYSG---DNKESAAKL S--------------IIDNM PV-TWCYKAEGGSN-YCATG Tcal SSGPSENLGQVVFGERIRPS PYKIVFN----KNNDKCQTV C-TKEYNL---RNADSQKKL IQLRKGMSMNYQHHWIVDNM PV-TWCYPVESGQK-YCATG Crog AYTPAENLGQVVFGERIRPS PYKIMFG----KKV-ECATV C-TKTYSP---STKESLKKL KQVKRAIKMNYKHHWIMDNM PI-TWCYHVKNEEQLYCARG Dpul ETGPVENLGQVVFGERIRSS PYKLEFK----NNQ-EWNYA C-KKSYQP---GNQDDLKKI KELIHGISLNYQHHWIVDNM PV-TWCYQGEPGQQ-FCSTG Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca FPMGCFTYRTSQPKGMCGIY -SAYS-KPDTFYLFNHVDLT VSYHKSDKESWGSSF----- ------IEEGGRIISVKVQP K---------SLKHKAGPN- Eaff FPMGCYVDKEGKPKDACVIS -HEYS-QSDTYYIFNHVDIT ISYHNGQDEDWGKYL----- -----GNVLGGRIVAVKLVP R---------SINHEGAEKG Lcyp FPMGCYVNKNGSPQDACVIS -KDYS-QRDTFYIFNHVDIV ITYHNGKQEDWGKFLLN--- -----SNEVGGRIVSVKLEP R---------SIDHSLGSSE Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra FPIGCYIDPKGRKSEGCYLS TSNFD-QKDSYFVYNHIDLT IKYHSGKTEPWGIDL----- ------GEGGGRVVAIKVEP R---------SIKHTADGKC Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos FPMGCYVDKQGEAKDACVIN -REYN-KKDTYYLFNHVDIT IYYHSGQNEDWGKYLGGGNV GGGAAGSTVRGRIVAVKLVP K---------SIDHGDDPEK Dmel FPMGCLVRSDG---EGCPIN -SIYN-QPMHYYPFNHVDLE ITYHSGQSEDWGIQF----- -------GNSGRIISVKVTP K---------SIKHTDKENP Tcas FQMGCFA-KDG--RDTCLRT -PD---KQDAYYIYNHVDLT ITYHSGEQEEWGNKF----- ------KSNGGRIISVKVVP R---------SIDHRDKIDC Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar FPMGCYVNKVGKPKYACVLN -RAYK-TPDSYYIFNHVDIT ITYHPGTNEDWGSSL----- -------KESGRIISAKVFM KRWVINIGFYSIKHMAPGPR Tcal FPMGCFVDKQGNPKDACVIS -RDYT-KPNHFYIFNHIDLE ISYHPGNNEDWGRYL----- -----SDQVGGRIVSVKATP R---------SIDHGASPTD Crog FPVGCYVNKNGKPKDSCVMS -NKFR-TPDSYYVFNHIDLV VTFNPGENEDWSRYIK---- -----SEEVGGRIVSVKATP R---------SINHKNLPKD Dpul FPMGCYLPKSGKPKDACVMN -PAFS-KPDTYYIFNHIDLT ITYHGGKGETWGAEL----- ------DDNIGRIL---IGL R---------SL---SVEKD Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca -MC-----DTGEPLTLGV-- -KDEDDINITYTYSVSFVRN DHIRWSSRWDYILESMPQTN IQWFSIMNSLIIVLFLTGMV AMILLRTLHKDIARYNQMDS Eaff -KCT-D--PAAKPMAIPA-- -TGTADIDITYSYSITFQQN QATKWSSRWDYILESMPHTN IQWFSILNSLVIVLFLSGMV AMILLRTLHKDIARYNQIDS Lcyp QDCN-AELSAGRPLSLSN-- -EHTGKFDIVYSYTVSFKED NTFRWSSRWDYILESMPHTN IQWFSILNSLVIVLFLSGMV AMILLRTLHKDIARYNESDR Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra --------DTNEYLRIPG-- -KPQGKIAITYTYSYKFQET -ETKWSSRWDYLLDSMPNSN IQWFSILNSLVIVLFLSGMV AMILLRTLHKDIARYNQIDS Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos -ACE-N--PTSPPMAIPG-- -EQREDLKISYTYSVSFEEN SNIKWSSRWDYILESMPHTN IQWFSILNSLVIVLFLSGMV AMILMRTLHKDIARYNQIES Dmel -NC-----LSTEPLAISENS LKAGEQLEIVYTYSVKFVKN DSIKWSSRWDYILESMPHTN IQWFSILNSLVIVLFLSGMV AMIMLRTLHKDIARYNQMDS Tcas -SKQ-N--TKLLELKTSL-- -KPKEEYQITYTYSVTFIQN NAVKWSSRWDYILESMPHTN IQWFSILNSLVIVLFLSGMV AMIMLRTLHKDIARYNQIDS Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar -GCS----DNAPPMEIPGSP LKDGDKLQINYTYSVFFKED QNVKWSSRWDYILESMPHAN IQWFSILNSLVIVLFLSGMV AMIMLRTLHKDIARYNQIES Tcal -DCS-ASLQSKAPLAIPATP -ENNGKLSITYSYTVRFIAN ADVKWSSRWDYILESMPHTN IQWFSIMNSLVIVLFLSGMV AMILLRTLHKDIARYNQIDS Crog GTCKISNPKSDDPLVIPGG- -DLKGDFSITYSYSVTFEPN YNTKWSSRWDYILESNPHTN IQWFSIVNSLVIVLFLSGMV AMIILRTLHRDIARYNQIDN Dpul --------PTSPPMIVPK-- -ELKEPLTITYTYSVKFIDD PMTKWSSRWDYLLESMPSAN IQWFSILNSLVIVLFLSGMV AMILLRTLHKDIARYNQIDS Aver -----------LVHGDVFRP PRKGMILSVFLGSGTQILCM TAITLVFACLGFLSPANRGA LMTCAMVLFVCL-------- -------------GTPAGYV Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca GDDAQEEFGWKLVHGDVFRT PRKGMLLSVFLGSGTQIFFM TFITLLFACLGFLSPANRGA LMTCAMVLFVCL-------- -------------GTPAGYV Eaff GEDAQEEFGWKLVHGDIFRP PRKGMLLSVFLGSGIQLFSM ASITLVFACLGFLSPANRGA LMTCALVLYVN--------- -------------------- Lcyp GEGTQEESGWKLVHGDVFRP PRKGMLLSVFLGSGVQILCM AGITLVFACLGFLSPANRGA LMTCALVLFVCL-------- -------------GTPAGYA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra GDDAQEEFGWKLVHGDVFRP PRKGMLLSVFVGSGVQVFLM TLVTLVFACLGFLSPANRGA LMTCAMVLFVCM-------- -------------GTPAGYV Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda -----------LVHGDVFRP PRKGMLLAVFLGSGTQILCM TAITLVFACLGFLSPANRGA LMTCAMVLFVCL-------- -------------GTPAGYV Afos GEDAQEEFGWKLVHGDVFRP PRKGMLLSVLLGSGAQLISM VSITLAFACLGFLSPANRGA LMTCALVLYVCL-------- -------------GTPAGYV Dmel GEDAQEEFGWKLVHGDVFRP PRKGMLLSVFLGSGVQVLVM AMITLAFACLGFLSPANRGA LMTCSMVLFVSL-------- -------------GTPAGYV Tcas GEDAQEEFGWKLVHGDVFRP PRKGMFLSVLLGSGVQVFFM TLVTLAFACLGFLSPANRGA LMTCAMVLYVLL-------- -------------GSPAGYV Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar GEDAQEEFGWKLVHGDVFRP PRKGMLLSVFLGSGIQVLFM TLITLVFACLGFLSPANRGA LMTCAMVLYVCL-------- -------------GTPAGYV Tcal GEDAQEEFGWKLVHGDVFRP PRKGMLLSVFLGSGAQILAM SGITLIFACLGFLSPANRGS LMTCALVLYVCL-------- -------------GTPAGYV Crog GEDAQEEFGWKLVHGDVFRP PRYGMLLSVFLGSGTQVLLM SSITLLFACMGFLSPANRGS LMTCALVLFACL-------- -------------GTPAGYI Dpul GEDAQEEFGWKLVHGDIFRP PRKGMLLSVFVGSGVQVFIM TLITLIFACLGFLSPANRGA LMTCALVLYVCL-------- -------------GTPAGYV Aver SARVYKSFGGEKWKSNVLLT SILCPGVVFALFFIMNLVLW YEGSSAAIPFFTLVALLALW LCVSVPLTFVGAFFGFRKRA IEHPVRTNQIPRQIPEQSIY Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca SARIYKAFGGEKWKSNVLLT ALVCPGVVFSLFFVLNLLLW AKDSSAAVPFTTLLALLALW FGISLPLTFVGAYFGFKKRV MEYPVRTNQIPRQIPEQSLY Eaff -------------KSNVLLT SMLCPGIVFAHFFIMNLVLW YYGSSAAIPFFTLVALLALW FGVSVPLTFVGAYFGFRKPV IEQPVRTNQIPRQIPDQSIY Lcyp SARVYKSFGGEKWKSNVLLT SMCCPGIVFAHFFIMNLVLW YEGSSAAIPFLTLVALLALW FCVSVPLTFVGALFGFRKRA IEHPVRTNKLPRIIPEQSIY Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra SARIYKSFGGERWKMNVLLT SMLCPGFIFSIFFLLNIVLW ANSSSATVPFPTLVALLALW FGISLPLTFVGAFFGFRKRG IEHPVRTNQIPRQIPEQSFY Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda SARIYKSFGGEKWKSNVLLT SVFCPGVVFALFFIMNLVLW YEGSSAAIPFFTLVALLALW FCVSVPLTFVGAFFGFRKRA IEHPVRTNQIPRQIPEQSIY Afos SSRIYKSFGGEKWKSNVLLT SMLCPGIVFAHFFVMNLVLW YYGSSAAIPFFTLVALLALW FGVSVPLTFVGAYFGFRKPC IEQPVRTNQIPRQIPDQSLY Dmel SARIYKSFGGLKWKSNVILT SIVCPGVVFSLFFVMNLVLW GENSSGAVPFSTLIALLALW FGVSVPLTFVGAYFGFRKRA LEHPVRTNQIPRQIPDQSIY Tcas SARIYKSFGGEKWKSNVLLT SMLAPGIVFGLFFVMNLVLW SKGSSAAVPFSTLVGLLALW LLVSVPLTFVGAFFGFRKRA LEHPVRTNQIPRLIPEQSIY Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar SSRIYKSFGGEKWKSNVLLT SLFCPGVVFVLFFTMNLLLW GMGSSAAIPFTTLLALLALW FGISLPLTFVGAYFGFRKRI IEHPVRTNQIPRQIPEQSIY Tcal SARIYKSFGGEKWKSNVLLT SMLCPGVVFGHFFIMNLVLW YKDSSAAIPFFTLVALLALW FGVSVPLTFVGAFFGFRKRA LEHPVRTNQIPRQIPDQSFY Crog SARIYKSFYGEKWKSNIMLT SLLCPGVVFAHFFVMNLVLW YKGSSAAIPFFTLLGLLALW ILVCVPLTFLGSIFGFRKRS LEHPVRTNPIPRQIPEQTIY Dpul SSRIYKSFGGERWKLNVLLT SMLCPGIVFGVFFILNLVLW SKGSSGAISFGILVALLALW FGISVPLTFVGAFFGFRKRP IEHPVRTNQIPRQVPDQSVY Aver TQPIPGIIMGGVLPFGCIFI QLFFVLNSIWSSQI------ -------------------- -------------------- -------------------- Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca TQALPAIFMGGILPFGCIFI QLFFILNSIWSSQMYYMFGF LFLVFIILIITCSETTAPLG LWRLGTTDYHWWWRSFLTSG CTAFYLFVYCVHYF-SRLSI Eaff TQDANLMV------------ -------------------- -------------------- HFQQCG------WR------ -------------------- Lcyp TQPIPGIIMGGVLPFGCIFI QLFFVLNSIWSSQIYYMYGF LFLVFIILIITCSETTILLC YFHLCAEDYHWWWRSFLTSG FTAFYLFIYCIHYFFTKLEI Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra TKPLPGIIMGGILPFGCIFI QLFFILNSIWSNQMYYMFGF LFLVFIILVITCSETTILLC YFHLCAEDYQWWWRSFMTSG FTAFYLFAYCIHYYMTKLNI Hazt -------------------- -------------------- -------------------- -------------------- -------------------- Meda TQPIPGIIMGGVLPFGCIFI QLFFVLNSIWSSQI------ -------------------- -------------------- -------------------- Afos TQPVPGIIMGGVLPFGCIFI QLFFVLNSIWSSHIYYMYGF LFLVYLILIITCSETTILLC YFHLCAEDYHWWWRSFLTSG FTAFYLAMYCIHYFFTKLDI Dmel TQPIPGIVMGGVLPFGCIFI QLFFILSSLWSSQIYYMFGF LFLVFVILVITCSETTILLC YFHLCAEDYHWWWRSFLTSG FTAVYLFIYCCHYFVTKLSI Tcas TQPIPGIVMGGVLPFGCIFI QLFFILNSIWSSQMYYMFGF LFLVFIILVITCAETTILLC YFHLCAEDYHWWWRSYLTSG FTAVYLFLYCCHYFFTKLQI Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar SQPLPGIV------------ -------------------- -------------------- -------------------- -------------------- Tcal TQPIPGIAMGGVLPFGCIFI QLFFVLNSIWSSQIYYMYGF LFLVFIILLITCSETTILLC YFHLCAEDYHWWWRSFLTSG FTAFYLAVYCIHYFVTKLEI Crog TQPIPAIAMGGVLSFGCIFI QLFFVLNSIWASHIYYMYGF LFLVFIILIITCSETTILLC YFQLCAEDYHWWWRSFLTSG FTAFYLFLYCIHYFATKLEI Dpul TRPAPGIVMGGVLPFGCIFI QLFFILNSLWSNQMYYMFGF LFLVFIILVITCSETTVLLC YFHLCAEDYHWWWRSFLTSG FTAFYLFLYCVHYFVTKLEI Aver -------------------- -------------------- -------------------- -------DKATIEGICNTLK SADTDPKVDVVVGVSPCYLE Csin -------------------- -------------------- -------------------- -------------------- -------------------- Isca TGLASTFLYFGYTTIIVFLF FLLTGTVGFFSCFWFVRKIY GVVKV----DM-SGRKFCVG GNWKMNGNKSSIKEICDMLK TAKLDPNTEVVLGCPAPYLD Eaff -------------------- -------------------- ----------M--GRKFFVG GNWKMNGTKESIDKIVDFLT KGPLDPNTEVVVGVSPCYLE Lcyp EGAASTFLYFGYTSIMVFIV FLLTGTIGFLACFWFVRKIY SVVKV----DM--GRKFFVG GNFKMNGDKASLETICSTLA KADTDKDVEVVVGVPACYLA Lsal -------------------- -------------------- ----------MGGGRKFFVG GNWKMNGDKKSIDGIVDFLS KGDLDPNCEVVVGASPCYLD Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra DPGASSFLYFGYTFIMVALF FIMTGTIGFFACFWFVRKIY SVVKV----DMSAPRNFFVG GNWKLNGNKQEIGNIINFLT SGNLDPNTEVVCAPPTIYLE Hazt -------------------- -------------------- -------------------- -------------------- ---------VVVGCPQCYLA Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos EGAASTFLYFGYTSIMVFCF FLLTGTIGFFASFWFVRKIY SVVKV----DM--GRKFFVG GNWKMNGTKESIDKIVEFLS AGPLDPNTEVVVGCPAIYMD Dmel KDSASTFLYFGYTAIMVFLF FLLTGTIGFFACFWFIRKIY SVVKV----DM--SRKFCVG GNWKMNGDQKSIAEIAKTLS SAALDPNTEVVIGCPAIYLM Tcas EDTASAFLYFGYTLIMVFLF NLLTGSIGFFACFWFIRKIY SVVKV----DM--GRKFVVG GNWKMNGDKKQISEIINTLK TGPLSPNTEVIVGVPAIYLE Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal EGPASTFLYFGYTSIMVFLF FLLTGTIGFFACFWFVRKIY SVVKV----DM--GRKFFVG GNWKMNGDKESMDKIIDFLK AGPLDPNCDVVVGVPAPYLM Crog DGTASTFLYFGYTSIMVFIF FLMTGTIGFFACFWFTRKIY SVVKVKERRGMAGGRKFFVG GNWKMNGDKKSIDGIVDFLS KGDLDPNCEVVVGASPCYLD Dpul QDATSTFLYFGYTFIMVFMF FLLSGTIGFFACFWFVRKIY SVVKV----D---------- -------------------- -------------------- Aver FVRNHLPADRFGVAAQNCYK VASGAFTGEISPMMIKDCGC DWVILGHSERRHVFGESDAL IGEKVAFALENGLHIIPCIG EKLEERESGKTEEVCFHQLK Csin -------------------- -------------------- -------------------- -------------------- --LEERESGATMDVCYKQLT Isca YVRRILPA-AIAVSAQNCYK VEKGAFTGEISPAMIKDCGA TWVILGHSERRNVFKESDEL IGDKVHHALESGLNVIACIG ELLEEREAGKTEEVVYRQTA Eaff YVRSKLPQ-TIGVAAQNCYK ADSGAFTGEICPAMIKDCGC EWVILGHSERRNVFGETDQL IGEKVGFALKQGLKVVPCIG EQLEEREAGKTTEVCFRQLK Lcyp FVRAHLPD-RFGVAAQNCYK AASGAFTGEIAPKMIEDCGC HWVILGHSERRHVFGESDAL IGDKVAFALQSGLSIIPCIG EKLEERESGKTEEVCFHQLK Lsal YSRSKLPA-NIGVAAQNCYK VAKGAFTGEISPQMIKDVGC EWAILGHSERRNVFGESDEL IGEKVAFALESGLKIIPCIG EKLDERESGKTEEVCFKQLK Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra HVRKTLPS-SVGVAAQNCYK VPKGAFTGETSPAMIKDVGV EWAILGHSERRNVFGESDEL IGAKVGHALEAGLKVIPCIG EKLEERESGKTEEVVFRQLK Hazt YSRETVPH-NIGVAAQNCYK AAKGAYTGEIAPGMIKDLGC EWVILGHSERRNVFGESDQL ISEKIGFALSEGLKVIPCFG EQLAERESGRTQEVVFSQLA Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos YVRTKLPA-SIGVAAQNCYK AEKGAFTGETSAAMIKDVGC EWVILGHSERRNVFGESDQL VGEKVGFALQSGLKVIPCIG ELLEEREAGKTTEVCFRQLK Dmel YARNLLPC-ELGLAGQNAYK VAKGAFTGEISPAMLKDIGA DWVILGHSERRAIFGESDAL IAEKAEHALAEGLKVIACIG ETLEEREAGKTNEVVARQMC Tcas HVRTNLPQ-SIEVAAQNCYK VPKGAFTGEISPAMIKDIGV NWVILGHSERRQIFGETDEL IAEKVAHALEAGLKVIACIG ETLEEREGGKTEEVVFRQTK Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal YCRERLPE-NVGVAAQNCHK AAKGAFTGEIAAAMIKDCGC KWVILGHSERRNVFGETDEL IGEKVAFALENGLHIIPCIG EKLEEREAGKTEEVCFKQLK Crog YSRSKLPA-NIGVAAQNCYK AAKGAFTGEISPQMIKDVGC NWVILGHSERRNVFGESDEL IGEKVAFALESGLHIIPCIG EKLEERESGRTEEVCFKQLK Dpul -------------------- -------------------- -------------------- -------------------- -------------------- Aver AIADKVS--DWSRVVLA--- -------------------- -------------------- -------------------- -------------------- Csin AIAGGVS--DWSRVVLAYEP VWAIGTGKTATPAQAQEVHA ACRAWLEKNVSPAVAKSTRI LYGGSVTPANCRDLAKCPDI DGSLVGGASLKPDFVQIVNA Isca AIAAKVT--DWNRVVLAYEP VWAIGTGKTASPEQA-EVHA QLRQWLSKNVSPDVAKKVRI QYGGSVTAANCQELAKKPDV DGFLVGGASLKPEFVEIINA Eaff AIADNVS--DWSKVVIAYEP VWAIGTGKTASPEQAQEVHA AIRNWLAENVSAEVAESTRI LYGGSVSAGNCRELAACPDI DGSLVGGASLKPDFVQIINA Lcyp AIADKVK--DWSKVVLAYEP VWAIGTGKTATPQQAQDVHL ALRKWLSEHVSAEVSETVRI LYGGSVTAANCKELAACPDI DGFLVGGASLKPEFVNIINA Lsal AISDKVS--DWDRVVLAYEP VWAIGTGKTATPAQAQETHL ALRKWLKENVSEEVSQKVRI LYGGSVSAGNCKELGTQPDI DGFLVGGASLKPDFVQIINA Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra AIADNIKPDQWQNVVIAYEP VWAIGTGKTASPAQAQEIHV KLRKWLNDNVSADVAQKTRI IYGGSVTADNCRELAREGDI DGFLVGGASLKPDFVQIVNA Hazt AMKPNIT--DWSRVVLAYEP VWAIGTGKTATPQQAQEVHA QLRQWLRDNVSEEVANSTRI IYGGSVTAATCKELASMPDI DGFLVGGASLKPEFVAIINA Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos AIADNVS--DWSRVVIAYEP VWAIGTGKTATPEQAQEVHS QLRTWLADNVNPEVAAATRI LYGGSVTAANCRELAACPDI DGSLVGGASLKPDFVAIANA Dmel AYAQKIK--DWKNVVVAYEP VWAIGTGQTATPDQAQEVHA FLRQWLSDNISKEVSASLRI QYGGSVTAANAKELAKKPDI DGFLVGGASLKPEFVDIINA Tcas AIAGKIK--DWSNVVIAYEP VWAIGTGKTATPQQAQEVHK ALRQWFCTHVNADVGNSIRI QYGGSVTGANCKELAAQPDI DGFLVGGASLKPEFVNIVNA Pmon -------------------- -------------------- -------------------- -------------------- -------------------- Smar -------------------- -------------------- -------------------- -------------------- -------------------- Tcal AIADKVS--DWSRVVLAYEP VWAIGTGKTATPEQAQETHA ALRKWLSENVSPEVAENLRI LYGGSVTAANCKELAKCADI DGSLVGGASLKPEFVEIINA Crog AIADKVS--DWDRVVLAYEP VWAIGTGKTATPQQAQDTHL ALRKWVKENVSEEVANKLRI LYGGSVSAGNCKELGGQADI DGFLVGGASLKPDFVQIINA Dpul -------------------- -------------------- -------------------- -------------------- -------------------- Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin TQ------------------ -------------------- -------------------- -------------------- -------------------- Isca RQM-----PEVRSAAVASKE HALAVSRDYISQPRLVYKTV CGVNGPLVILDEVKFPKYAE IVHLVLADGTTRTGQVLEVS GSKAVVQVFEGTSGIDAKNT Eaff TQM-----TATISIRQGLID QTLAITRDYIAEPRITYKTV SGVNGPLVILDNVKFPKFAE IVNLKLPDGSYRAGQVLEVS GSKAVVQVFEGTSGIDAKRT Lcyp NKMTMA--APTISLRHGLVE HAMAVTRDYVAQPRITYRTV SGVNGPLVILDNVKFPKFAE IVNLQLPDGSHRAGQVLEVT GSKAVVQVFEGTSGIDAQKT Lsal TK------------------ -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra RQM-----NGIITHKQANNE HKLAVTRDFISQPRLSYRTV SGVNGPLVILDDVKFPKYAE IVNLRLADGSIRSGQVLEVS GNKAVVQVFEGTSGIDAKNT Hazt KCM----------PSQGHFD QVAAVTRDYIAQPHLCYKTV TGVNGPLVILDDVKFPKFAE IVNLHLADGSERKGQVLEVS GSKAVVQVFEGTSGIDAKHT Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos TQ------------------ --------YIAQPRITYRTV SGVNGPLVILDDVKFPKYAE IVNLNLPDGTQRAGQVLEVS GSKAVVQVFEGTSGIDAKRT Dmel RQ---------MNAQQAQRE HVLAVSRDFISQPRLTYKTV SGVNGPLVILDEVKFPKFAE IVQLRLADGTVRSGQVLEVS GSKAVVQVFEGTSGIDAKNT Tcas KQMSY---QNSISSKQAARE HVLAVSRDFVSQPRLTYKTV TGVNGPLVILDDVKFPKFNE IVQLKLSDGSIRSGQVLEVS GSKAVVQVFEGTSGIDAKHT Pmon --M----------TSLGHLQ QVAAVQRDYIAQPRLCYKTV TGVNGPLVILDDVKFPKFAE IVNLHLADGTERKGQVLEVS GSKAVVQVFEGTSGVDAKHT Smar --MASKVVARTLSGDQAFKE HTLAVSRDYISQPRLTYRTV SGVNGPLVILDDVKFPKYAE IVQLRLADGSLRSGQVLEVS GSKAVVQVFEGTSGIDAKNT Tcal SQMSP---HPTVEIRQGMVD QFMAITRDYVAQPRLTYRTV SGVNGPLVILDNVKFPKFAE IVNLKLPDGSYRAGQVLEVT GSKAVVQVFEGTSGIDAKKT Crog TK--------MIEIRQNKIE EIMAVTRDYIAQPRITYRTV SGVNGPLVILEDVKFPKFAE IVNLKLPDGSFRAGQVLEVS GSKAVVQVFEGTSGIDAKKT Dpul --MAHK--TGTLNEAQARLE HKMAVNRDYIFQPRMSYRTV SGVNGPLVILDDVKFPKYAE IVNLRLHDGTIRSGQVLEVS GSKAVVQVFEGTSGIDAKNT Aver -------------------- -------------------- -------------------- --GISAIDVMNSIARGQKIP IFSANGLPHNEIAAQICRQG Csin ------------------RR V------------------- -------------------- -------------------- -------------------- Isca VCEFTGDILRIPVSEDMLGR VFNGSGKPIDKGPPVLAEDF LDIQGQPINPWARIYPEEMI QTGISAIDVMNSIARGQKIP IFSAAGLPHNEIAAQICRQG Eaff TCEFTGDILRSPVSEDMLGR VFNGSGKPIDKGPSVMAEDY LDIQGQPINPWSRIYPEEMV QTGISAIDVMNSIARGQKIP IFSANGLPHNEVAAQICRQA Lcyp TCEFTGDILRTPVSEDMLGR IFNGSGKPIDKGPNVLAEDF LDIQGQPINPYSRIYPEEMV QTGISAIDVMNSIARGQKIP IFSANGLPHNEIAAQICRQG Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra ICDFTGDILRTPVSEDMLGR IFNGSGKPIDKGPSILAEEF LDIQGQPINPWSRIYPEEMI QTGVSSIDVMNSIARGQKIP IFSAAGLPHNEIAAQICRQA Hazt VCEFTGDIMRTAVSEDMLGR VFNGSGKPIDNGPAVLAEDF LDIQGQPINPWSRTYPQEMI QTGISSIDVMNSIARGQKIP IFSAAGLPHNEIAAQICRQA Meda -------------------- -------------------- -------------------- --GISAIDVMNSIARGQKIP IFSANGLPHNEIAAQICRQG Afos TCEFTGDILRTPVSEDMLGR VFNGSGKPIDKGPTVMAEDY LDIQGQPINPWSRIYPEEMV QTGISAIDVMNSIARGQKIP IFSANGLPHNEVAAQICRQA Dmel LCEFTGDILRTPVSEDMLGR VFNGSGKPIDKGPPILAEDF LDIQGQPINPWSRIYPEEMI QTGISAIDVMNSIARGQKIP IFSAAGLPHNEIAAQICRQA Tcas VCEFTGDILRTPVSEDMLGR VFNGSGKPIDKGPPILAEDF LDIQGQPINPWSRIYPEEMI QTGISAIDVMNSIARGQKIP IFSAAGLPHNEIAAQICRQA Pmon VCEFTGDILRTPVSEDMLGR VFNGSGKPIDQGPTVLAEDF LDIQGQPINPWSRTYPEEMI QTGISSIDVMNSIARGQKIP IFSAAGLPHNEIAAQICRQA Smar VCEFTGDILRTPVSEDMSGR VFNGSGKPIDKGPNVLAEDY LDIQGQPINPWSRIYPEEMI QTGISAIDVMNSIARGQKIP IFSAAGLPHNEIAAQICRQG Tcal TCEFTGDILRTPVSEDMLGR VFNGSGKPIDKGPAVMAEDY LDIQGQPINPYSRIYPEEMV QTGISAIDVMNSIARGQKIP IFSANGLPHNEIAAQICRQG Crog TCEFTGDILRTPVSEDMLGR VFNGSGKPIDKGPNVMAEDY LDIQGQPINPYSRIYPEEMV QTGISAIDVMNSIARGQKIP IFSANGLPHNEIAAQICRQG Dpul VCEFTGDILKSPVSEDMLGR VFNGSGKPIDKGPTVLAEDF LDIQGQPINPHSRIYPEEMI QTGISAIDIMNSIARGQKIP IFSAAGLPHNEIAAQICRQG Aver SLV---RLPGKSVLDDHEDN FAIVFAAMGVNMETARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTTAEFLA YQCEKHMLVILTDMSSYAEA Csin ----------HGVLDDHQDN FAIVFAAMGVNMETARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTAAEFMA YQCEMHMLVILTDMSSYAEA Isca GLV---KLPGKSVLDTSDDN FAIVFAAMGVNMETARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTTAEFLA YQCEKHVLVILTDMSSYAEA Eaff GLV---RLPGKSVLDDHQDN FAIVFAAMGVNMEAARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTAAEFMA YQCEMHMLVILTDMSSYAEA Lcyp SLV---KLPGKSVLDDHEDN FAIVFAAMGVNMETARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTTAEFLA YQCEKHMLVILTDMSSYAEA Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra GLV---KLPGKSVLDDHEDN FAIVFAAMGVNMETARFFKL DFEENGSMENVCLFLNLAND PTIERIITPRLALTAAEYLA YQCEKHVLVILTDMSSYAEA Hazt GLVNAAQATKGSVIDDHHDN FAIVFAAMGVNMEAARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTTAEYLA YQCEKHVLIILTDMSSYAEA Meda SLV---KLPGKSVLDDHEDN FAIVFAAMGVNMETARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTTAEFLA YQCEKHMLVILTDMSSYAEA Afos GLV---RLPGKSVLDDHQDN FAIVFAAMGVNMEAARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTTAEFMA YQCEKHMLVILTDMSSYAEA Dmel GLV---KLPGKSVLDDHTDN FAIVFAAMGVNMETARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTAAEFLA YQCEKHVLVILTDMSSYAEA Tcas GLV---KVPGKSVLDDHEDN FAIVFAAMGVNMETARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTAAEFMA YQCEKHVLVILTDMSSYAEA Pmon GLV---NLPSKGVLDDHKDN FAIVFAAMGVNMETARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTTAEYLA YQCEKHVLIILTDMSSYAEA Smar GLV---KVPGKSVLDDHSDN FAIVFAAMGVNMETARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTTAEFLA YQCEKHVLVILTDMSSYAEA Tcal SLV---RLPGKSVLDDHQDN FGIVFAAMGANMETARFFKQ DFEENGSMESTCLFLNLAND PTIERIITPRLALTTAEFLA YQCEKHMLVILTDMSSYAEA Crog SLV---RLPGKSVLDDHKDN FAIVFAAMGVNMEAARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTTAEFLA YQCEKHMLVILTDMSSYAEA Dpul GLV---KVPGKSVLDDHDDN FAIVFAAMGVNMETARFFKQ DFEENGSMENVCLFLNLAND PTIERIITPRLALTAAEFLA YQCEKHVLVILTDMSSYAEA Aver LREVSAAREEVPGRRGFP-- -------------------- -------------------- -------------------- -------------------- Csin LREVSAAREEVPGRRGFPGY MYTDLATIYERAGRVEGRNG SITQIPILTMPNDDITHPIP DLTGYITEGQIYVDRQLHNR QIYPPINVLPSLSRLMKSAI Isca LREVSAARE----------- ---------ERAGRVEGRNG SITQIPILTMPNDDITHPIP DLTGYITEGQVYVDRQLHNR QVYPPINVLPSLSRLMKSAI Eaff LREVSAAREEVPGRRGFPGY MYTDLATIYERAGRVEGRNG SITQIPILTMPNDDITHPIP DLTGYITEGQIYVDRQLHNR QIYPPINVLPSLSRLMKSAI Lcyp LREVSAAREEVPGRRGFPGY MYTDLATIYERAGRVEGRNG SITQIPILTMPNDDITHPIP DLTGYITEGQIYVDRQMHNR QIFPPINVLPSLSRLMKSAI Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra LREVSAAREEVPGRRGFPGY MYTDLATIYERAGRVEGRNG SITQIPILTMPNDDITHPIP DLTGYITEGQIYVDRQLYNR QIYPPINVLPSLSRLMKSAI Hazt LREVSAAREEVPGRRGFPGY MYTDLATIYERAGRVEGRQG SITQIPILTMPNDDITHPIP DLTGYITEGQIYVDRQLHNR QIYPPINVLPSLSRLMKSAI Meda LREVSAAREEVPGRRGFP-- -------------------- -------------------- -------------------- -------------------- Afos LREVSAAREEVPGRRGFPGY MYTDLATIYERAGRVEGRNG SITQIPILTMPNDDITHPIP DLTGYITEGQIYVDRQLHNR QVYPPINVLPSLSRLMKSAI Dmel LREVSAAREEVPGRRGFPGY MYTDLATIYERAGRVEGRNG SITQIPILTMPNDDITHPIP DLTGYITEGQIYVDRQLHNR QIYPPVNVLPSLSRLMKSAI Tcas LREVSAAREEVPGRRGFPGY MYTDLATIYERAGRVEGRNG SITQIPILTMPNDDITHPIP DLTGYITEGQIYVDRQLHNR QIYPPINVLPSLSRLMKSAI Pmon LREVSAAREEVPGRRGFPGY MYTDLATIYERAGRVEGRQG SITQIPILTMPNDDITHPIP DLTGYITEGQIYVDRQLHNR QIYPPINVLPSLSRLMKSAI Smar LREVSAAREEVPGRRGFPGY MYTDLATIYERAGRVEGRNG SITQIPILTMPNDDITHPIP DLTGYITEGQIYVERQLHNR QIYPPINVLPSLSRLMKSAI Tcal LREVSAAREEVPGRRGFPGY MYTDLATIYERAGRVEGRNG SITQIPILTMPNDDITHPIP DLTGYITEGQIYVDRQLHNR QIYPPINVLPSLSRLMKSAI Crog LREVSAAREEVPGRRGFPGY MYTDLATIYERAGRVEGRNG SITQIPILTMPNDDITHPIP DLTGYITEGQIYVDRTMHNR QIYPPINVLPSLSRLMKSAI Dpul LREVSAAREEVPGRRGFPGY MYTDLATIYERAGRVEGRNG SITQIPILTMPNDDITHPIP DLTGYITEGQIYVDRQLHNR QIYPPINVLPSLSRLMKSAI Aver -------------------- -------------------- -------------------- -------------------- -------------------- Csin GEGMTRKDHSDVSNQLYACY AIGKDVQAMKAVVGEEALTA DDLLYLEFLGKFEKNFIAQG NYENRTVFETLDIGWQLLRI FPKEMLKRIPAATLAEFYPR Isca GEGMTRKDHADVSNQLYACY AIGKDVQAMKAVVGEEALSP EDLLFLEFLGKFEKNFISQG SYENRTIFESLDIGWQLLRI FPKEMLKRIPQALLQEFYPR Eaff GEGMTRKDHSDVSNQLYACY AIGKDVQAMKAVVGEEALTP DDLLYLEFLGKFEKNFIAQG SYENRTVFESLDIGWQLLRI FPKEMLKRIPTSILAEFYPR Lcyp GEGMTRKDHSDVSNQLYACY AIGKDVQAMKAVVGEEALTQ DDLLYLEFLGKFEKNFIAQG RYENRTVFESLDIGWQLLRI FPKEMLKRIPANVLAEFYPR Lsal -------------------- -------------------- -------------------- -------------------- -------------------- Aamp -------------------- -------------------- -------------------- -------------------- -------------------- Afra GEGMTRKDHSDVSNQLYACY AIGKDVQAMKAVVGEEALTP DDLLYLEFLTKFEKNFISQG SYENRTVFESLDIGWQLLRI FPKEMLKRIPASVLAEYYPR Hazt GEGMTRRDHSDVSNQLYACY AIGKDLQAMKAVVGEEALTS DDLLYLEFLAKFEKNFLTQS SYSKRSVFESLDIGWQLLRI FPKEMLKRIPASTLAEFYPR Meda -------------------- -------------------- -------------------- -------------------- -------------------- Afos GEGMTRKDHSDVSNQLYACY AIGKDVQAMKAVVGEEALTP DDLLYLEFLAKFEKSFITQG SYENRTVFESLDIGWQLLRI FPKEMLKRIPASILAEYYPR Dmel GEGMTRKDHSDVSNQLYACY AIGKDVQAMKAVVGEEALTP DDLLYLEFLTKFEKNFISQG NYENRTVFESLDIGWQLLRI FPKEMLKRIPASILAEFYPR Tcas GEGMTRKDHSDVSNQLYACY AIGKDVQAMKAVVGEEALTP DDLLYLEFLSKFEKNFITQG SYENRTVFESLDIGWQLLRI FPKEMLKRIPAATLAEFYPR Pmon GEGMTRKDHSDVSNQLYACY AIGKDLQAMKAVVGEEALTS DDLLYLEFLAKFEKTFISQG PYMKRTIFESLDIGWQLLRI FPKEMLKRIPAATLAEFYPR Smar GEGMTRKDHADVSNQLYACY AIGKDVQAMKAVVGEEALGP DDLLYLEFLSKFEKNFIAQG NYENRTVFESLNIGWQLLRI FPKEMLKRIPQATLAEFYPR Tcal GEGMTRKDHSDVSNQLYACY AIGKDVQAMKAVVGEEALTP DDLLYLEFLSKFEKNFIAQG SYENRTVFESLDIGWQLLRI FPKEMLKRIPASTLAEFYPR Crog GEGMTRKDHSDVSNQLYACY AIGKDVQAMKAVVGEEALTP DDLLYLEFLTKFEKNFIAQG NYENRSVFESLDIGWQLLRI FPKEMLKRIPASTLAEFYPR Dpul GEGMTRKDHSDVSNQLYACY AIGKDVQAMKAVVGEEALTP DDLLYLEFLTKFEKNFIAQG NYENRTVFESLDIGWQLLRI FPKEMLKRIPASVLAEFYPR Aver ---------- Csin DSRH------ Isca DGRQGADAKQ Eaff DSRH------ Lcyp DARH------ Lsal ---------- Aamp ---------- Afra DARGRHNE-- Hazt DRPQ------ Meda ---------- Afos DARH------ Dmel DSRH------ Tcas DSRH------ Pmon DRPQ------ Smar DSRAT----- Tcal DARH------ Crog DSRH------ Dpul DARQGK---- ; END;